Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: Relevance to human hyperhomocysteinaemia

Clinical Science

Volumn 129, Issue 6, 2015, Pages 477-487

  Hung, Ching Hsia ^a   Chan, Shih Hung ^b   Chu, Pei Ming ^c   Tsai, Kun Ling ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Heat shock transcription factor 1; Hyperhomocysteinaemia; Lectin like oxidized low density lipoprotein receptor 1; Protein kinase C; Sirtuin 1

Indexed keywords

HEAT SHOCK TRANSCRIPTION FACTOR 1; HOMOCYSTEINE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTEIN KINASE C BETA; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; DNA BINDING PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR; HSF1 PROTEIN, MOUSE; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; METHIONINE; OLR1 PROTEIN, HUMAN; OLR1 PROTEIN, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SIRT1 PROTEIN, HUMAN; SIRT1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ACETYLATION; ANIMAL MODEL; APOPTOSIS; ARTICLE; BINDING AFFINITY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPERHOMOCYSTEINEMIA; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; ANIMAL; BINDING SITE; C57BL MOUSE; CELL CULTURE; ENZYME ACTIVATION; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; VALIDATION STUDY;

ANIMALS; APOPTOSIS; BINDING SITES; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; LIPOPROTEINS, LDL; METHIONINE; MICE; MICE, INBRED C57BL; NADPH OXIDASE; PHOSPHORYLATION; PROTEIN KINASE C BETA; PROTEIN PROCESSING, POST-TRANSLATIONAL; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SCAVENGER RECEPTORS, CLASS E; SIRTUIN 1; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84942780755     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20150127     Document Type: Article

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