Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis

Biochemical Pharmacology

Volumn 88, Issue 2, 2014, Pages 189-200

  Tsai, Kun Ling ^a   Huang, Po Hsun ^a,b   Kao, Chung Lan ^a,c   Leu, Hsin Bang ^a,b   Cheng, Yung Hsin ^a,b   Liao, Yi Wen ^a,b   Yang, Yi Ping ^a,b   Chien, Yueh ^a,b   Wang, Chien Ying ^a   Hsiao, Chen Yuan ^a   Chiou, Shih Hwa ^a,b   Chen, Jaw Wen ^a,b   Lin, Shing Jong ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c Institute of Pharmacology National Yang Ming University ^*  (Taiwan)

Author keywords

AMPK; Inflammation; Reactive oxygen species; SIRT1; Vinorelbine

Indexed keywords

ACETYLSALICYLIC ACID; ADENYLATE KINASE; BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NAVELBINE; PROTEIN KINASE C; PROTEIN KINASE LKB1; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE P47PHOX; SIRTUIN 1; TAB1 PROTEIN; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL INFLAMMATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

AMPK; INFLAMMATION; REACTIVE OXYGEN SPECIES; SIRT1; VINORELBINE;

AMP-ACTIVATED PROTEIN KINASES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ASPIRIN; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; SIRTUIN 1; VINBLASTINE;

EID: 84895516738     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.12.005     Document Type: Article

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