LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells

Biochemical Journal

Volumn 393, Issue 1, 2006, Pages 107-115

  Murphy, Jane E ^a   Tacon, Daryl ^a   Tedbury, Philip R ^a   Hadden, Jonathan M ^a   Knowling, Stuart ^a   Sawamura, Tatsuya ^b   Peckham, Michelle ^a   Phillips, Simon E V ^a   Walker, John H ^a   Ponnambalam, Sreenivasan ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Ca2+; Lectin like oxidized low density lipoprotein receptor 1 (LOX 1); Liposomes; Phosphatidylserine; Protein lipid overlay; Recombinant protein

Indexed keywords

ANTIBODIES; CALCIUM; CELL MEMBRANES; MAGNESIUM PRINTING PLATES; OXIDATION; PHOSPHOLIPIDS; POSITIVE IONS;

CA2+; LECTIN-LIKE OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR-1 (LOX-1); LIPOSOMES; PHOSPHATIDYLSERINE; PROTEIN-LIPID OVERLAY; RECOMBINANT PROTEIN;

PROTEINS;

CALCIUM; CALCIUM ION; CARDIOLIPIN ANTIBODY; CATION; LECTIN; LIPOSOME; MAGNESIUM ION; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PHOSPHATIDYLSERINE; PHOSPHOLIPID; PROTEIN ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNITY; BINDING AFFINITY; CALCIUM TRANSPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; MATHEMATICAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN GLYCOSYLATION; PROTEIN QUATERNARY STRUCTURE; RECEPTOR UPREGULATION;

ANIMALS; APOPTOSIS; CALCIUM; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; PHOSPHATIDYLSERINES; PROTEIN BINDING; SCAVENGER RECEPTORS, CLASS E;

ANIMALIA; MAMMALIA;

EID: 30044443918     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051166     Document Type: Article

References (43)

1. Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., Tanaka, T., Miwa, S., Katsura, Y., Kita, T. and Masaki, T. (1997) An endothelial receptor for oxidized low-density lipoprotein. Nature (London) 386, 73-77
2. Kume, N., Murase, T., Moriwaki, H., Aoyama, T., Sawamura, T., Masaki, T. and Kita, T. (1998) Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ. Res. 83, 322-327
3. Chen, M., Masaki, T. and Sawamura, T. (2002) LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol. Ther. 95, 89-100
4. Yoshida, H., Kondratenko, N., Green, S., Steinberg, D. and Quehenberger, O. (1998) Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor. Biochem. J. 334, 9-13
5. Aoyama, T., Chen, M., Fujiwara, H., Masaki, T. and Sawamura, T. (2000) LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells. FEBS Lett. 467, 217-220
6. Chen, M., Kakutani, M., Naruko, T., Ueda, M., Narumiya, S, Masaki, T. and Sawamura, T. (2001) Activation-dependent surface expression of LOX-1 in human platelets. Biochem. Biophys. Res. Commun. 282, 153-158
7. Cominacini, L., Pasini, A. F., Garbin, U., Davoli, A., Tosetti, M. L., Campagnola, M., Rigoni, A., Pastorino, A. M., Lo Cascio, V. and Sawamura, T. (2000) Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-κB through an increased production of intracellular reactive oxygen species. J. Biol. Chem. 275, 12633-12638
8. Li, D. and Mehta, J. L. (2000) Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation 101, 2889-2895
9. Li, D., Liu, L., Chen, H., Sawamura, T., Ranganathan, S. and Mehta, J. L. (2003) LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells. Circulation 107, 612-617
10. Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Moriwaki, H., Murase, T., Sawamura, T., Masaki, T., Hashimoto, N. and Kita, T. (1999) Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions. Circulation 99, 3110-3117
11. Mango, R., Clementi, F, Borgiani, P., Forleo, G. B., Federici, M., Contino, G., Giardina, E., Garza, L., Fahdi, I. E., Lauro, R. et al. (2003) Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction. J. Med. Genet. 40, 933-936
12. Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T. and Masaki, T. (1998) Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 95, 9535-9540
13. Kakutani, M., Masaki, T. and Sawamura, T. (2000) A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1. Proc. Natl. Acad. Sci. U.S.A. 97, 360-364
14. Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T. and Yonehara, S. (2001) LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria. J. Immunol. 166, 5108-5114
15. Murphy, J. E., Tedbury, P. R., Homer-Vanniasinkam, S, Walker, J. H. and Ponnambalam, S. (2005) Biochemistry and cell biology of mammalian scavenger receptors. Atherosclerosis 182, 1-15
16. Park, H., Adsit, F. G. and Boyington, J. C. (2005) The 1.4 anstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1. J. Biol. Chem. 280, 13593-13599
17. Yamanaka, S., Zhang, X. Y., Miura, K., Kim, S. and Iwao, H. (1998) The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile. Genomics 54, 191-199
18. 2+-dependent sugar recognition by animal lectins. Biochem. Soc. Trans. 24, 146-150
19. Cerwenka, A. and Lanier, L. L. (2001 ) Ligands for natural killer cell receptors: redundancy or specificity. Immunol. Rev. 181, 158-169
20. Raulet, D. H. (2003) Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3, 781-790
21. Ohki, I., Ishigaki, T., Oyama, T., Matsunaga, S., Xie, Q., Ohnishi-Kameyama, M., Murata, T., Tsuchiya, D., Machida, S., Morikawa, K. and Tate, S. (2005) Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL. Structure 13, 905-917
22. Shi, X., Niimi, S., Ohtani, T. and Machida, S. (2001) Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor. J. Cell Sci. 114, 1273-1282
23. Chen, M., Inoue, K., Narumiya, S., Masaki, T. and Sawamura, T. (2001) Requirements ol basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein. FEBS Lett. 499, 215-219
24. Chen, M., Narumiya, S., Masaki, T. and Sawamura, T. (2001) Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding. Biochem. J. 355, 289-296
25. Murase, T., Kume, N., Kataoka, H., Minami, M., Sawamura, T., Masaki, T. and Kita, T. (2000) Identification of soluble forms of lectin-like oxidized LDL receptor-1 Arterioscler. Thromb. Vasc. Biol. 20, 715-720
26. Prescott, A. R., Lucocq, J. M., James, J., Lister, J. M. and Ponnambalam, S. (1997) Distinct compartmentalization of TGN46 and β-1,4- galactosyltransferase in HeLa cells. Eur. J. Cell Biol. 72, 238-246
27. 2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP. J. Biol. Chem. 271, 24333-24336
28. Zhao, Y., Chapman, D. A. and Jones, I. M. (2003) Improving baculovirus recombination. Nucleic Acids Res. 31, E6-6
29. Dowler, S., Kular, G. and Alessi, D. R. (2002) Protein lipid overlay assay. Sci STKE 2002, PL6
30. Towler, M. C., Prescott, A. R., James, J., Lucocq, J. M. and Ponnambalam, S. (2000) The manganese cation disrupts membrane dynamics along the secretory pathway. Exp. Cell Res. 259, 167-179
31. Li, D., Liu, L., Chen, H., Sawamura, T. and Mehta, J. L. (2003) LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells. Arterioscler. Thromb. Vasc. Biol. 23, 816-821
32. Hu, B., Li, D., Sawamura, T. and Mehta, J. L. (2003) Oxidized LDL through LOX-1 modulates LDL-receptor expression in human coronary artery endothelial cells. Biochem. Biophys. Res. Commun. 307, 1008-1012
33. 2+- dependent carbohydrate-binding protein. Biochem. Biophys. Res. Commun. 208, 68-74
34. Cominacini, L., Fratta Pasini, A., Garbin, U., Pastorino, A., Rigoni, A., Nava, C., Davoli, A., Lo Cascio, V. and Sawamura, T. (2003) The platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells. J. Am. Coll. Cardiol. 41, 499-507
35. Steinberg, D. (1997) Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem. 272, 20963-20966
36. Navab, M., Ananthramaiah, G. M., Reddy, S. T., Van Lenten, B. J., Ansell, B. J., Fonarow, G. C., Vahabzadeh, K., Hama, S., Hough, G., Kamranpour, N. et al. (2004) The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J. Lipid Res. 45, 993-1007
37. George, J., Blank, M., Hojnik, M., Bar-Meir, E., Koike, T., Matsuura, E., Lorber, M., Aviram, M. and Shoenfeld, Y. (1997) Oxidized low-density lipoprotein (Ox-LDL) but not LDL aggravates the manifestations of experimental antiphospholipid syndrome (APS). Clin. Exp. Immunol. 108, 227-233
38. Sambrano, G. R., Terpstra, V. and Steinberg, D. (1997) Independent mechanisms for macrophage binding and macrophage phagocytosis of damaged erythrocytes. Evidence of receptor cooperativity. Arterioscler. Thromb. Vasc. Biol. 17, 3442-3448
39. Ellis, R. E., Yuan, J. Y. and Horvitz, H. R. (1991) Mechanisms and functions of cell death. Annu. Rev. Cell Biol. 7, 663-698
40. Draude, G., Hrboticky, N. and Lorenz, R. L. (1999) The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin. Biochem. Pharmacol. 57, 383-386
41. Dini, L. and Carla, E. C. (1998) Hepatic sinusoidal endothelium heterogeneity with respect to the recognition of apoptotic cells. Exp. Cell Res. 240, 388-393
42. Dini, L., Lentini, A., Diez, G. D., Rocha, M., Falasca, L., Serafino, L. and Vidal-Vanaclocha, F. (1995) Phagocytosis of apoptotic bodies by liver endothelial cells. J. Cell Sci. 108, 967-973
43. Hess, K. L., Tudor, K. S., Johnson, J. D., Osati-Ashtiani, F., Askew, D. S. and Cook-Mills, J. M. (1997) Human and murine high endothelial venule cells phagocytose apoptotic leukocytes. Exp. Cell Res. 236, 404-411