LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells

Cardiovascular Research

Volumn 84, Issue 1, 2009, Pages 127-136

  Sugimoto, Koichi ^a   Ishibashi, Toshiyuki ^a   Sawamura, Tatsuya ^b,c   Inoue, Nobutaka ^b   Kamioka, Masashi ^a   Uekita, Hironori ^a   Ohkawara, Hiroshi ^a   Sakamoto, Takayuki ^a   Sakamoto, Nobuo ^a   Okamoto, Yasuo ^d   Takuwa, Yoh ^d   Kakino, Akemi ^b   Fujita, Yoshiko ^b   Tanaka, Takeshi ^c   Teramoto, Tamio ^e   Maruyama, Yukio ^a,f   Takeishi, Yasuchika ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^e TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f HOSHI GENERAL HOSPITAL   (Japan)

Author keywords

Endothelial dysfunction; LOX 1; MT1 MMP; Rac1; RhoA

Indexed keywords

LOW DENSITY LIPOPROTEIN; MATRIX METALLOPROTEINASE 14; NITRIC OXIDE SYNTHASE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MMP14 PROTEIN, HUMAN; OLR1 PROTEIN, HUMAN; OXIDIZED LOW DENSITY LIPOPROTEIN; RAC1 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHOA PROTEIN, HUMAN;

AORTA; ARTICLE; CELL INVASION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; FLUORESCENCE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; OXIDATION; PRIORITY JOURNAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; LIPOPROTEINS, LDL; MATRIX METALLOPROTEINASE 14; NADPH OXIDASE; NITRIC OXIDE SYNTHASE TYPE III; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; RHOA GTP-BINDING PROTEIN; SCAVENGER RECEPTORS, CLASS E; SIGNAL TRANSDUCTION;

EID: 70449706057     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp177     Document Type: Article

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