Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine

Kidney and Blood Pressure Research

Volumn 40, Issue 5, 2015, Pages 490-499

  Alesutan, Ioana ^a   Musculus, Katharina ^a   Castor, Tatsiana ^a   Alzoubi, Kousi ^a   Voelkl, Jakob ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Alkaline phosphatase; Calcification; H+ pump; NFAT5; Osteoinductive signaling; Phosphate; Senescence; TGF 1; Vesicular pH

Indexed keywords

ALKALINE PHOSPHATASE; BAFILOMYCIN A1; CALCIUM; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; MESSENGER RNA; METHYLAMINE; PHOSPHATE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT5; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; MACROLIDE;

ALKALINIZATION; ARTICLE; BLOOD VESSEL CALCIFICATION; BONE DEVELOPMENT; CHONDROGENESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TONOPLAST; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; ANTAGONISTS AND INHIBITORS; BONE MINERALIZATION; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; VASCULAR CALCIFICATION; VASCULAR SMOOTH MUSCLE;

CALCIFICATION, PHYSIOLOGIC; CELLS, CULTURED; CHONDROGENESIS; HUMANS; MACROLIDES; METHYLAMINES; MUSCLE, SMOOTH, VASCULAR; OSTEOGENESIS; PHOSPHATES; SIGNAL TRANSDUCTION; VASCULAR CALCIFICATION;

EID: 84942645254     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000368524     Document Type: Article

References (51)

1. Kapustin A, Shanahan CM: Targeting vascular calcification: softening-up a hard target. Curr Opin Pharmacol 2009;9:84-89.
2. Peacock M: Calcium metabolism in health and disease. Clin J Am Soc Nephrol 2010;5:S23-S30.
3. Weissen-Plenz G, Nitschke Y, Rutsch F: Mechanisms of arterial calcification: spotlight on the inhibitors. Adv Clin Chem 2008;46:263-293.
4. Shroff R, Long DA, Shanahan C: Mechanistic insights into vascular calcification in CKD. J Am Soc Nephrol 2013;24:179-189.
5. Giachelli CM: Vascular calcification: in vitro evidence for the role of inorganic phosphate. J Am Soc Nephrol 2003;14:S300-S304.
6. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G: Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 2005;112:2627-2633.
7. Staude H, Jeske S, Schmitz K, Warncke G, Fischer DC: Cardiovascular risk and mineral bone disorder in patients with chronic kidney disease. Kidney Blood Press Res 2013;37:68-83.
8. Mizobuchi M, Towler D, Slatopolsky E: Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol 2009;20:1453-1464.
9. Steitz SA, Speer MY, Curinga G, Yang HY, Haynes P, Aebersold R, Schinke T, Karsenty G, Giachelli CM: Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res 2001;89:1147-1154.
10. Dalle Carbonare L, Innamorati G, Valenti MT: Transcription factor Runx2 and its application to bone tissue engineering. Stem Cell Rev 2012;8:891-897.
11. Moe SM, Chen NX: Pathophysiology of vascular calcification in chronic kidney disease. Circ Res 2004;95:560-567.
12. Kuro-o M: Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism. Nat Rev Nephrol 2013;9:650-660.
13. Lin ME, Chen T, Leaf EM, Speer MY, Giachelli CM: Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice. Am J Pathol 2015;185:1958-1969.
14. Voelkl J, Alesutan I, Leibrock CB, Quintanilla-Martinez L, Kuhn V, Feger M, Mia S, Ahmed MS, Rosenblatt KP, Kuro-o M, Lang F: Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice. J Clin Invest 2013;123:812-822.
15. Hu MC, Shi M, Zhang J, Quinones H, Griffith C, Kuro-O M, Moe OW: Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol 2011;22:124-136.
16. Weng JJ, Su Y: Nuclear matrix-targeting of the osteogenic factor Runx2 is essential for its recognition and activation of the alkaline phosphatase gene. Biochim Biophys Acta 2013;1830:2839-2852.
17. Murshed M, McKee MD: Molecular determinants of extracellular matrix mineralization in bone and blood vessels. Curr Opin Nephrol Hypertens 2010;19:359-365.
18. Hiyama A, Gogate SS, Gajghate S, Mochida J, Shapiro IM, Risbud MV: BMP-2 and TGF-beta stimulate expression of beta1, 3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. J Bone Miner Res 2010;25:1179-1190.
19. Caron MM, van der Windt AE, Emans PJ, van Rhijn LW, Jahr H, Welting TJ: Osmolarity determines the in vitro chondrogenic differentiation capacity of progenitor cells via nuclear factor of activated T-cells 5. Bone 2013;53:94-102.
20. Neven E, Persy V, Dauwe S, De Schutter T, De Broe ME, D'Haese PC: Chondrocyte rather than osteoblast conversion of vascular cells underlies medial calcification in uremic rats. Arterioscler Thromb Vasc Biol 2010;30:1741-1750.
21. Xu Z, Ji G, Shen J, Wang X, Zhou J, Li L: SOX9 and myocardin counteract each other in regulating vascular smooth muscle cell differentiation. Biochem Biophys Res Commun 2012;422:285-290.
22. Liu X, Bai C, Gong D, Yuan Y, Han L, Lu F, Han Q, Tang H, Huang S, Xu Z: Pleiotropic effects of transforming growth factor-beta1 on pericardial interstitial cells. Implications for fibrosis and calcification in idiopathic constrictive pericarditis. J Am Coll Cardiol 2011;57:1634-1635.
23. Pai AS, Giachelli CM: Matrix remodeling in vascular calcification associated with chronic kidney disease. J Am Soc Nephrol 2010;21:1637-1640.
24. Tachi K, Takami M, Sato H, Mochizuki A, Zhao B, Miyamoto Y, Tsukasaki H, Inoue T, Shintani S, Koike T, Honda Y, Suzuki O, Baba K, Kamijo R: Enhancement of bone morphogenetic protein-2-induced ectopic bone formation by transforming growth factor-beta1. Tissue Eng Part A 2011;17:597-606.
25. Liu D, Cui W, Liu B, Hu H, Liu J, Xie R, Yang X, Gu G, Zhang J, Zheng H: Atorvastatin Protects Vascular Smooth Muscle Cells From TGF-beta1-Stimulated Calcification by Inducing Autophagy via Suppression of the beta-Catenin Pathway. Cell Physiol Biochem 2014;33:129-141.
26. Mackenzie NC, MacRae VE: The role of cellular senescence during vascular calcification: a key paradigm in aging research. Curr Aging Sci 2011;4:128-136.
27. Wang JC, Bennett M: Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res 2012;111:245-259.
28. Leibrock CB, Alesutan I, Voelkl J, Pakladok T, Michael D, Schleicher E, Kamyabi-Moghaddam Z, Quintanilla-Martinez L, Kuro-o M, Lang F: NH4Cl Treatment Prevents Tissue Calcification in Klotho Deficiency. J Am Soc Nephrol DOI: 2015;10. 1681/ASN. 2014030230
29. Ling H, Ardjomand P, Samvakas S, Simm A, Busch GL, Lang F, Sebekova K, Heidland A: Mesangial cell hypertrophy induced by NH4Cl: role of depressed activities of cathepsins due to elevated lysosomal pH. Kidney Int 1998;53:1706-1712.
30. Basque J, Martel M, Leduc R, Cantin AM: Lysosomotropic drugs inhibit maturation of transforming growth factor-beta. Can J Physiol Pharmacol 2008;86:606-612.
31. Jara A, Felsenfeld AJ, Bover J, Kleeman CR: Chronic metabolic acidosis in azotemic rats on a high-phosphate diet halts the progression of renal disease. Kidney Int 2000;58:1023-1032.
32. Mendoza FJ, Lopez I, Montes dO, Perez J, Rodriguez M, Aguilera-Tejero E: Metabolic acidosis inhibits soft tissue calcification in uremic rats. Kidney Int 2008;73:407-414.
33. Jara A, Chacon C, Ibaceta M, Valdivieso A, Felsenfeld AJ: Effect of ammonium chloride and dietary phosphorus in the azotaemic rat. I. Renal function and biochemical changes. Nephrol Dial Transplant 2004;19:1986-1992.
34. Gagliardi S, Rees M, Farina C: Chemistry and structure activity relationships of bafilomycin A1, a potent and selective inhibitor of the vacuolar H+-ATPase. Curr Med Chem 1999;6:1197-1212.
35. Seglen PO, Grinde B, Solheim AE: Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin. Eur J Biochem 1979;95:215-225.
36. Beers MF: Inhibition of cellular processing of surfactant protein C by drugs affecting intracellular pH gradients. J Biol Chem 1996;271:14361-14370.
37. Heming TA, Traber DL, Hinder F, Bidani A: Effects of bafilomycin A1 on cytosolic pH of sheep alveolar and peritoneal macrophages: evaluation of the pH-regulatory role of plasma membrane V-ATPases. J Exp Biol 1995;198:1711-1715.
38. Sweatt JD, Connolly TM, Cragoe EJ, Limbird LE: Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets. J Biol Chem 1986;261:8667-8673.
39. Ewence AE, Bootman M, Roderick HL, Skepper JN, McCarthy G, Epple M, Neumann M, Shanahan CM, Proudfoot D: Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization. Circ Res 2008;103:e28-34.
40. Balogh P, Katz S, Kiss AL: The role of endocytic pathways in TGF-beta signaling. Pathol Oncol Res 2013;19:141-148.
41. Johnson LS, Dunn KW, Pytowski B, McGraw TE: Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif. Mol Biol Cell 1993;4:1251-1266.
42. Wang N, Wang X, Xing C, Sun B, Yu X, Hu J, Liu J, Zeng M, Xiong M, Zhou S, Yang J: Role of TGF-beta1 in bone matrix production in vascular smooth muscle cells induced by a high-phosphate environment. Nephron Exp Nephrol 2010;115:e60-e68.
43. Kanno Y, Into T, Lowenstein CJ, Matsushita K: Nitric oxide regulates vascular calcification by interfering with TGF-signalling. Cardiovasc Res 2008;77:221-230.
44. Moe SM, Drueke T, Lameire N, Eknoyan G: Chronic kidney disease-mineral-bone disorder: a new paradigm. Adv Chronic Kidney Dis 2007;14:3-12.
45. Koleganova N, Piecha G, Ritz E, Schirmacher P, Muller A, Meyer HP, Gross ML: Arterial calcification in patients with chronic kidney disease. Nephrol Dial Transplant 2009;24:2488-2496.
46. London GM, Guerin AP, Marchais SJ, Metivier F, Pannier B, Adda H: Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 2003;18:1731-1740.
47. Foley RN, Parfrey PS, Sarnak MJ: Epidemiology of cardiovascular disease in chronic renal disease. J Am Soc Nephrol 1998;9:S16-S23.
48. Hernandez-Ochoa EO, Robison P, Contreras M, Shen T, Zhao Z, Schneider MF: Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle. Exp Biol Med (Maywood) 2012;237:1068-1083.
49. Snell-Bergeon JK, Budoff MJ, Hokanson JE: Vascular calcification in diabetes: mechanisms and implications. Curr Diab Rep 2013;13:391-402.
50. Neuhofer W: Role of NFAT5 in inflammatory disorders associated with osmotic stress. Curr Genomics 2010;11:584-590.
51. Villanueva S, Suazo C, Santapau D, Perez F, Quiroz M, Carreno JE, Illanes S, Lavandero S, Michea L, Irarrazabal CE: NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney. PLoS One 2012;7:e39665.