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Volumn 9, Issue 2, 2009, Pages 84-89

Targeting vascular calcification: softening-up a hard target

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCIMIMETIC AGENT; DOXERCALCIFEROL; ETIDRONIC ACID; FETUIN A; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INFLIXIMAB; MATRIX G1A PROTEIN; MATRIX PROTEIN; OSTEOPONTIN; OSTEOPROTEGERIN; PARICALCITOL; PHOSPHATE BINDING PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; SEVELAMER; UNCLASSIFIED DRUG; VITAMIN K GROUP;

EID: 62249090222     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2008.12.004     Document Type: Review
Times cited : (29)

References (43)
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    • This study from the Demer group showed that recombinant osteoprotegerin treatment inhibits vascular calcification in diabetic ldlr(-/-) mice, fed an atherogenic diet. Subcutaneous injections of recombinant osteoprotegerin significantly reduced the calcified lesion areas and tissue levels of osteocalcin, a marker of mineralization, highlighting the protective role of OPN. Fc-OPG treatment affected neither plasma calcium and phosphate levels nor aortic tissue cytokine levels or atherosclerosis progression suggesting the effect was specific to calcification.
    • Morony S., Tintut Y., Zhang Z., Cattley R.C., Van G., Dwyer D., Stolina M., Kostenuik P.J., and Demer L.L. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation 117 (2008) 411-420. This study from the Demer group showed that recombinant osteoprotegerin treatment inhibits vascular calcification in diabetic ldlr(-/-) mice, fed an atherogenic diet. Subcutaneous injections of recombinant osteoprotegerin significantly reduced the calcified lesion areas and tissue levels of osteocalcin, a marker of mineralization, highlighting the protective role of OPN. Fc-OPG treatment affected neither plasma calcium and phosphate levels nor aortic tissue cytokine levels or atherosclerosis progression suggesting the effect was specific to calcification.
    • (2008) Circulation , vol.117 , pp. 411-420
    • Morony, S.1    Tintut, Y.2    Zhang, Z.3    Cattley, R.C.4    Van, G.5    Dwyer, D.6    Stolina, M.7    Kostenuik, P.J.8    Demer, L.L.9
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    • 48249133229 scopus 로고    scopus 로고
    • Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration
    • Clarke M.C., Littlewood T.D., Figg N., Maguire J.J., Davenport A.P., Goddard M., and Bennett M.R. Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration. Circ Res 102 (2008) 1529-1538
    • (2008) Circ Res , vol.102 , pp. 1529-1538
    • Clarke, M.C.1    Littlewood, T.D.2    Figg, N.3    Maguire, J.J.4    Davenport, A.P.5    Goddard, M.6    Bennett, M.R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.