Role of TGF-β1 in bone matrix production in vascular smooth muscle cells induced by a high-phosphate environment

Nephron - Experimental Nephrology

Volumn 115, Issue 3, 2010, Pages

  Wang, Ningning ^a   Wang, Xiaoyun ^a   Xing, Changying ^a   Sun, Bin ^a   Yu, Xiangbao ^a   Hu, Jianming ^a   Liu, Jia ^a   Zeng, Ming ^a   Xiong, Mingxia ^b   Zhou, Shuqin ^b   Yang, Junwei ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Bone matrix protein; Phosphate; Transforming growth factor 1; Vascular smooth muscle cells

Indexed keywords

CALCIUM; COLLAGEN TYPE 1; OSTEOCALCIN; OSTEOPONTIN; PHOSPHATE; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; BONE MATRIX; CELL STIMULATION; CONTROLLED STUDY; IMMUNOFLUORESCENCE; MALE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; STAINING; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BONE MINERALIZATION; CELL CULTURE; DRUG EFFECT; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; BONE MATRIX; CALCIFICATION, PHYSIOLOGIC; CELLS, CULTURED; COLLAGEN TYPE I; CORE BINDING FACTOR ALPHA 1 SUBUNIT; MALE; MUSCLE, SMOOTH, VASCULAR; OSTEOCALCIN; OSTEOPONTIN; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 77951223391     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000313831     Document Type: Article

References (46)

1. Sarnak MJ: Cardiovascular complications in chronic kidney disease. Am J Kidney Dis 2003; 41(5 suppl):11-17.
2. Fox CS, Larson MG, Vasan RS, Guo CY, Parise H, Levy D, Leip EP, O'Donnell C J, D'Agostino RB Sr, Benjamin EJ: Cross-sectional association of kidney function with valvular and annular calcification: the Framingham Heart Study. J Am Soc Nephrol 2006; 17: 521-527.
3. Zitt E, Rosenkranz AR: Vascular calcification and increased mortality in dialysis patients: is the baroreflex sensitivity the answer? Nephrol Dial Transplant 2005; 20: 2580.
4. Towler DA: Vascular calcification in ESRD: another cloud appears in the perfect storm - but highlights a silver lining? Kidney Int 2004; 66: 2467-2468.
5. Block GA: Control of serum phosphorus: implications for coronary artery calcification and calcific uremic arteriolopathy (calciphylaxis). Curr Opin Nephrol Hypertens 2001; 10: 741-747.
6. Sigrist M, Bungay P, Taal MW, McIntyre CW: Vascular calcification and cardiovascular function in chronic kidney disease. Nephrol Dial Transplant 2006; 21: 707-714.
7. Menon V, Gul A, Sarnak MJ: Cardiovascular risk factors in chronic kidney disease. Kidney Int 2005; 68: 1413-1418.
8. Kestenbaum B, Sampson JN, Rudser KD, Patterson DJ, Seliger SL, Young B, Sherrard DJ, Andress DL: Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 2005; 16: 520-528.
9. Boaz M, Weinstein T, Matas Z, Green- Smetana S: Peripheral vascular disease and serum phosphorus in hemodialysis: a nested case-control study. Clin Nephrol 2005; 63: 98-105.
10. Jono S, Shioi A, Ikari Y, Nishizawa Y: Vascular calcification in chronic kidney disease. J Bone Miner Metab 2006; 24: 176-181.
11. Steitz SA, Speer MY, Curinga G, Yang HY, Haynes P, Aebersold R, Schinke T, Karsenty G, Giachelli CM: Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res 2001; 89: 1147-1154.
12. Jayalath RW, Mangan SH, Golledge J: Aortic calcification. Eur J Vasc Endovasc Surg 2005; 30: 476-488.
13. Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K, Morii H, Giachelli CM: Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 2000; 87: E10-E17.
14. Reynolds JL, Joannides AJ, Skepper JN, Mc- Nair R, Schurgers LJ, Proudfoot D, Jahnen- Dechent W, Weissberg PL, Shanahan CM: Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 2004; 15: 2857-2867.
15. Towler DA: Inorganic pyrophosphate: a paracrine regulator of vascular calcification and smooth muscle phenotype. Arterioscler Thromb Vasc Biol 2005; 25: 651-654.
16. Massague J, Blain SW, Lo RS: TGF-β signaling in growth control, cancer, and heritable disorders. Cell 2000; 103: 295-309.
17. Verrecchia F, Mauviel A: Transforming growth factor-β signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol 2002; 118: 211-215.
18. Yang J, Liu Y: Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 2002; 13: 96-107.
19. Dennler S, Goumans MJ, ten Dijke P: Transforming growth factor-β signal transduction. J Leukoc Biol 2002; 71: 731-740.
20. Bonewald LF, Dallas SL: Role of active and latent transforming growth factor-β in bone formation. J Cell Biochem 1994; 55: 350-357.
21. Bonewald LF: Regulation and regulatory activities of transforming growth factor-β . Crit Rev Eukaryot Gene Expr 1999; 9: 33-44.
22. Robey PG, Young MF, Flanders KC, Roche NS, Kondaiah P, Reddi AH, Termine JD, Sporn MB, Roberts AB: Osteoblasts synthesize and respond to transforming growth factor-β in vitro. J Cell Biol 1987; 105: 457-463.
23. Strong DD, Beachler AL, Wergedal JE, Linkhart TA: Insulin-like growth factor II and transforming growth factor-β regulate collagen expression in human osteoblastlike cells in vitro. J Bone Miner Res 1991; 6: 15-23.
24. Grainger DJ: Transforming growth factor-β and atherosclerosis: so far, so good for the protective cytokine hypothesis. Arterioscler Thromb Vasc Biol 2004; 24: 399-404.
25. Ross R: The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol 1971; 50: 172-186.
26. Rossi GL, Alroy J, Rothenmund S: Morphological studies of cultured swine aorta media explants. Virchows Arch B Cell Pathol 1973; 12: 133-144.
27. Yang J, Zhang X, Li Y, Liu Y: Downregulation of Smad transcriptional co-repressors SnoN and Ski in the fibrotic kidney: an amplification mechanism for TGF-β 1 signaling. J Am Soc Nephrol 2003; 14: 3167-3177.
28. Yang J, Shultz RW, Mars WM, Wegner RE, Li Y, Dai C, Nejak K, Liu Y: Disruption of tissue- type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest: 2002; 110: 1525-1538.
29. Wickert L, Steinkruger S, Abiaka M, Bolkenius U, Purps O, Schnabel C, Gressner AM: Quantitative monitoring of the mRNA expression pattern of the TGF-β isoforms (β1 ,β2 ,β3 ) during transdifferentiation of hepatic stellate cells using a newly developed realtime SYBR Green PCR. Biochem Biophys Res Commun 2002; 295: 330-335.
30. Wang N, Yang J, Yu X, Hu J, Xing C, Ju X, Shen X, Qian J, Zhao X, Wang X: Radial artery calcification in end-stage renal disease patients is associated with deposition of osteopontin and diminished expression of α- smooth muscle actin. Nephrology (Carlton) 2008; 13: 367-375.
31. Ducy P: Cbfa1: a molecular switch in osteoblast biology. Dev Dyn 2000; 219: 461-471.
32. Tyson KL, Reynolds JL, McNair R, Zhang Q, Weissberg PL, Shanahan CM: Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol 2003; 23: 489-494.
33. Ziros PG, Gil AP, Georgakopoulos T, Habeos I, Kletsas D, Basdra EK, Papavassiliou AG: The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. J Biol Chem 2002; 277: 23934-23941.
34. Chodon T, Sugihara T, Igawa HH, Funayama E, Furukawa H: Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-β 1 can abrogate this resistance. Am J Pathol 2000; 157: 1661-1669.
35. Shanahan CM: Vascular calcification - a matter of damage limitation? Nephrol Dial Transplant 2006; 21: 1166-1169.
36. Olesen P, Nguyen K, Wogensen L, Ledet T, Rasmussen LM: Calcification of human vascular smooth muscle cells: associations with osteoprotegerin expression and acceleration by high-dose insulin. Am J Physiol 2007; 292: H1058-H1064.
37. Tintut Y, Alfonso Z, Saini T, Radcliff K, Watson K, Bostrom K, Demer LL: Multilineage potential of cells from the artery wall. Circulation 2003; 108: 2505-2510.
38. Lee JH, Kosinski PA, Kemp DM: Contribution of human bone marrow stem cells to individual skeletal myotubes followed by myogenic gene activation. Exp Cell Res 2005; 307: 174-182.
39. Furumatsu T, Shen ZN, Kawai A, Nishida K, Manabe H, Oohashi T, Inoue H, Ninomiya Y: Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. J Biochem 2003; 133: 633-639.
40. Massague J: How cells read TGF-β signals. Nat Rev Mol Cell Biol 2000; 1: 169-178.
41. Mulsow JJ, Watson RW, Fitzpatrick JM, O'Connell PR: Transforming growth factor-β promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen-activated protein kinase cell signaling. Ann Surg 2005; 242: 880-889.
42. Schulick AH, Taylor AJ, Zuo W, Qiu CB, Dong G, Woodward RN, Agah R, Roberts AB, Virmani R, Dichek DA: Overexpression of transforming growth factor-β 1 in arterial endothelium causes hyperplasia, apoptosis, and cartilaginous metaplasia. Proc Natl Acad Sci USA 1998; 95: 6983-6988.
43. Watson KE, Bostrom K, Ravindranath R, Lam T, Norton B, Demer LL: TGF-β 1 and 25- hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest 1994; 93: 2106-2113.
44. Kanno Y, Into T, Lowenstein CJ, Matsushita K: Nitric oxide regulates vascular calcification by interfering with TGF signalling. Cardiovasc Res 2008; 77: 221-230.
45. Simionescu A, Philips K, Vyavahare N: Elastin- derived peptides and TGF-β 1 induce osteogenic responses in smooth muscle cells. Biochem Biophys Res Commun 2005; 334: 524-532.
46. Janssens K, ten Dijke P, Janssens S, Van Hul W: Transforming growth factor-β 1 to the bone. Endocr Rev 2005; 26: 743-774.