TNF induction of NF-κB RelB enhances RANKL-induced osteoclastogenesis by promoting inflammatory macrophage differentiation but also limits it through suppression of NFATc1 expression

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Zhao, Zhijun ^a   Hou, Xiaodong ^a,b   Yin, Xiaoxiang ^a,b   Li, Yanyun ^b   Duan, Rong ^b   Boyce, Brendan F ^b   Yao, Zhenqiang ^b  

^a HENAN UNIVERSITY   (China)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; COLONY STIMULATING FACTOR 1; GLYCOPROTEIN P 15095; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEASOME; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; TRANSCRIPTION FACTOR RELB; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; NFATC1 PROTEIN, MOUSE; TNFSF11 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; MACROPHAGE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CYTOLOGY; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; INFLAMMATION; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICE, INBRED C57BL; NF-KAPPA B P52 SUBUNIT; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; RANK LIGAND; RNA, MESSENGER; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84942636568     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135728     Document Type: Article

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