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Volumn 14, Issue 5, 2012, Pages 445-454

Managing macrophages in rheumatoid arthritis by reform or removal

Author keywords

Depletion; Inflammation; Joint recruitment; Macrophage; Management; Polarization; Reform; Removal; Rheumatoid arthritis; Therapy; TRAIL

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CD163 ANTIGEN; CD68 ANTIGEN; CLODRONIC ACID; COLONY STIMULATING FACTOR 1; DEATH RECEPTOR 5; FAS ANTIGEN; FAS LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOSOME; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84869210018     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-012-0272-4     Document Type: Review
Times cited : (131)

References (54)
  • 1
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • DOI 10.1016/j.it.2004.09.015, PII S1471490604002959
    • Mantovani A, Sica A, Sozzani S, et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004; 25: 677-86. (Pubitemid 39457982)
    • (2004) Trends in Immunology , vol.25 , Issue.12 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 2
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008; 8: 958-69.
    • (2008) Nat Rev Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 3
    • 46249090513 scopus 로고    scopus 로고
    • Colony-stimulating factors in inflammation and autoimmunity
    • DOI 10.1038/nri2356, PII NRI2356
    • Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008; 8: 533-44. (Pubitemid 351913679)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.7 , pp. 533-544
    • Hamilton, J.A.1
  • 4
    • 80053156515 scopus 로고    scopus 로고
    • Dendritic cell and macrophage heterogeneity in vivo
    • Hashimoto D, Miller J, Merad M. Dendritic cell and macrophage heterogeneity in vivo. Immunity. 2011; 35: 323-35. The authors discuss how recent discoveries in the origin of the DC and macrophage lineage help establish key functional differences between tissue DC and macrophage subsets. The authors also emphasize the need to further understand the functional heterogeneity of the tissue DC and macrophage lineages to better comprehend the complex role of these cells in tissue homeostasis and immunity.
    • (2011) Immunity. , vol.35 , pp. 323-335
    • Hashimoto, D.1    Miller, J.2    Merad, M.3
  • 5
    • 66049110306 scopus 로고    scopus 로고
    • The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases
    • Hamilton JA, Tak PP. The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases. Arthritis Rheum. 2009; 60: 1210-21. This is one of the most comprehensive review discussing the macrophage heterogeneity in autoimmunity.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1210-1221
    • Hamilton, J.A.1    Tak, P.P.2
  • 6
    • 80355136629 scopus 로고    scopus 로고
    • Studying the mononuclear phagocyte system in the molecular age
    • Chow A, Brown BD, MeradM. Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol. 2011; 11: 788-98.
    • (2011) Nat Rev Immunol. , vol.11 , pp. 788-798
    • Chow, A.1    Brown, B.D.2    Merad, M.3
  • 7
    • 0033840205 scopus 로고    scopus 로고
    • The colony-stimulating factors and collagen-induced arthritis: Exacerbation of disease by m-csf and g-csf and requirement for endogenous m-csf
    • Campbell IK, Rich MJ, Bischof RJ, et al. The colony-stimulating factors and collagen-induced arthritis: Exacerbation of disease by m-csf and g-csf and requirement for endogenous m-csf. J Leukoc Biol. 2000; 68: 144-50.
    • (2000) J Leukoc Biol. , vol.68 , pp. 144-150
    • Campbell, I.K.1    Rich, M.J.2    Bischof, R.J.3
  • 8
    • 0034851864 scopus 로고    scopus 로고
    • Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): Requirement for GM-CSF in the effector phase of disease
    • DOI 10.1186/ar318
    • Cook AD, Braine EL, Campbell IK, et al. Blockade of collageninduced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (gm-csf): Requirement for gm-csf in the effector phase of disease. Arthritis Res. 2001; 3: 293-8. (Pubitemid 32821522)
    • (2001) Arthritis Research , vol.3 , Issue.5 , pp. 293-298
    • Cook, A.D.1    Braine, E.L.2    Campbell, I.K.3    Rich, M.J.4    Hamilton, J.A.5
  • 9
    • 38349059063 scopus 로고    scopus 로고
    • The orally-active and selective c-fms tyrosine kinase inhibitor ki20227 inhibits disease progression in a collagen-induced arthritis mouse model
    • Ohno H, Uemura Y, Murooka H, et al. The orally-active and selective c-fms tyrosine kinase inhibitor ki20227 inhibits disease progression in a collagen-induced arthritis mouse model. Eur J Immunol. 2008; 38: 283-91.
    • (2008) Eur J Immunol. , vol.38 , pp. 283-291
    • Ohno, H.1    Uemura, Y.2    Murooka, H.3
  • 11
    • 70349952401 scopus 로고    scopus 로고
    • G-CSF and GMCSF as therapeutic targets in rheumatoid arthritis
    • Cornish AL, Campbell IK, McKenzie BS, et al. G-CSF and GMCSF as therapeutic targets in rheumatoid arthritis. Nat Rev Rheumatol. 2009; 5: 554-9. The authors postulate that antagonism of GCSF or GM-CSF could represent a novel therapeutic approach for a variety of autoimmune-mediated inflammatory diseases, including rheumatoid arthritis.
    • (2009) Nat Rev Rheumatol. , vol.5 , pp. 554-559
    • Cornish, A.L.1    Campbell, I.K.2    McKenzie, B.S.3
  • 12
    • 84870963756 scopus 로고    scopus 로고
    • Regulation of macrophagemediated chronic inflammation by jak inhibitors
    • Anna Yarilina KX, Chan C, et al. Regulation of macrophagemediated chronic inflammation by jak inhibitors. Arthritis Res Ther. 2012; 14: 53-4.
    • (2012) Arthritis Res Ther. , vol.14 , pp. 53-54
    • Anna Yarilina, K.X.1    Chan, C.2
  • 13
    • 70149090443 scopus 로고    scopus 로고
    • IL-10 suppresses calciummediated costimulation of receptor activator nf-kappa b signaling during human osteoclast differentiation by inhibiting trem-2 expression
    • Park-Min KH, Ji JD, Antoniv T, et al. IL-10 suppresses calciummediated costimulation of receptor activator nf-kappa b signaling during human osteoclast differentiation by inhibiting trem-2 expression. J Immunol. 2009; 183: 2444-55.
    • (2009) J Immunol. , vol.183 , pp. 2444-2455
    • Park-Min, K.H.1    Ji, J.D.2    Antoniv, T.3
  • 14
    • 84863049411 scopus 로고    scopus 로고
    • Synthetic peptides containing itim-like sequences of irem-1 (cd300f) differentially regulate myd88 and trif-mediated tlr signalling through activation of shp and/or pi3k
    • Lee SM, Suk K, Lee WH. Synthetic peptides containing itim-like sequences of irem-1 (cd300f) differentially regulate myd88 and trif-mediated tlr signalling through activation of shp and/or pi3k. Clin Exp Immunol. 2012; 167: 438-46. The authors describe the generation of immunomodulatory molecules that can regulate the inflammatory activation of macrophages.
    • (2012) Clin Exp Immunol. , vol.167 , pp. 438-446
    • Lee, S.M.1    Suk, K.2    Lee, W.H.3
  • 15
    • 84863195086 scopus 로고    scopus 로고
    • Endogenous activation of adaptive immunity: Tenascin-c drives il-17 synthesis in arthritic joint disease
    • Ruhmann M, Piccinini AM, Kong PL, et al. Endogenous activation of adaptive immunity: Tenascin-c drives il-17 synthesis in arthritic joint disease. Arthritis Rheum. 2012.
    • (2012) Arthritis Rheum.
    • Ruhmann, M.1    Piccinini, A.M.2    Kong, P.L.3
  • 16
    • 75749152060 scopus 로고    scopus 로고
    • Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis
    • Kokkonen H, Soderstrom I, Rocklov J, et al. Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis. Arthritis Rheum. 2010; 62: 383-91. The data show that prior to development of RA, "prepatient" individuals already had significantly increased levels of GM-CSF, M-CSF, and other proinflammatory cytokines and chemokines, indicating activation of the immune. system, as compared with controls, who did not develop RA. After disease onset, the involvement and activation of the immune system was more general and widespread.
    • (2010) Arthritis Rheum. , vol.62 , pp. 383-391
    • Kokkonen, H.1    Soderstrom, I.2    Rocklov, J.3
  • 17
    • 0030066502 scopus 로고    scopus 로고
    • Synovial tissue macrophage populations and articular damage in rheumatoid arthritis
    • DOI 10.1002/art.1780390116
    • Mulherin D, Fitzgerald O, Bresnihan B. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum. 1996; 39: 115-24. (Pubitemid 26036386)
    • (1996) Arthritis and Rheumatism , vol.39 , Issue.1 , pp. 115-124
    • Mulherin, D.1    Fitzgerald, O.2    Bresnihan, B.3
  • 19
    • 0029091161 scopus 로고
    • Flow cytometric analysis of intracellular cd68 molecule expression in normal and malignant haemopoiesis
    • Strobl H, Scheinecker C, Csmarits B, et al. Flow cytometric analysis of intracellular cd68 molecule expression in normal and malignant haemopoiesis. Br J Haematol. 1995; 90: 774-82.
    • (1995) Br J Haematol. , vol.90 , pp. 774-782
    • Strobl, H.1    Scheinecker, C.2    Csmarits, B.3
  • 21
    • 77950627035 scopus 로고    scopus 로고
    • Scavenger receptor CD163, a jack-of-all-trades and potential target for cell-directed therapy
    • Van Gorp H, Delputte PL, Nauwynck HJ. Scavenger receptor CD163, a jack-of-all-trades and potential target for cell-directed therapy. Mol Immunol. 2010; 47: 1650-60.
    • (2010) Mol Immunol. , vol.47 , pp. 1650-1660
    • Van Gorp, H.1    Delputte, P.L.2    Nauwynck, H.J.3
  • 22
    • 0347951196 scopus 로고    scopus 로고
    • Hemoglobin Scavenger Receptor CD163 Mediates Interleukin-10 Release and Heme Oxygenase-1 Synthesis: Antiinflammatory Monocyte-Macrophage Responses In Vitro, in Resolving Skin Blisters In Vivo, and after Cardiopulmonary Bypass Surgery
    • DOI 10.1161/01.RES.0000109414.78907.F9
    • Philippidis P, Mason JC, Evans BJ, et al. Hemoglobin scavenger receptor cd163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery. Circ Res. 2004; 94: 119-26. (Pubitemid 38064106)
    • (2004) Circulation Research , vol.94 , Issue.1 , pp. 119-126
    • Philippidis, P.1    Mason, J.C.2    Evans, B.J.3    Nadra, I.4    Taylor, K.M.5    Haskard, D.O.6    Landis, R.C.7
  • 23
    • 0036096031 scopus 로고    scopus 로고
    • Macrophage subpopulations in rheumatoid synovium: Reduced CD163 expression in CD4+ T lymphocyte-rich microenvironments
    • DOI 10.1002/art.10207
    • Fonseca JE, Edwards JC, Blades S, et al. Macrophage subpopulations in rheumatoid synovium: Reduced cd163 expression in cd4+ t lymphocyte-rich microenvironments. Arthritis Rheum. 2002; 46: 1210-6. (Pubitemid 34525827)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.5 , pp. 1210-1216
    • Fonseca, J.E.1    Edwards, J.C.W.2    Blades, S.3    Goulding, N.J.4
  • 25
    • 84855346705 scopus 로고    scopus 로고
    • Systematic validation of specific phenotypic markers for in vitro polarized human macrophages
    • Ambarus CA, Krausz S, van Eijk M, et al. Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. J Immunol Methods. 2011; 375: 196-206.
    • (2011) J Immunol Methods. , vol.375 , pp. 196-206
    • Ambarus, C.A.1    Krausz, S.2    Van Eijk, M.3
  • 26
    • 79951671510 scopus 로고    scopus 로고
    • Irf5 promotes inflammatory macrophage polarization and th1-th17 responses
    • Krausgruber T, Blazek K, Smallie T, et al. Irf5 promotes inflammatory macrophage polarization and th1-th17 responses. Nat Immunol. 2011; 12: 231-8. The data suggest a critical role for IRF5 in M1 macrophage polarization and define a previously unknown function for IRF5 as a transcriptional repressor.
    • (2011) Nat Immunol. , vol.12 , pp. 231-238
    • Krausgruber, T.1    Blazek, K.2    Smallie, T.3
  • 27
    • 84866146612 scopus 로고    scopus 로고
    • Treatment of arthritis by macrophage depletion and immunomodulation: Testing an apoptosis-mediated therapy in a humanized death receptor mouse model
    • Li J, Hsu HC, Yang P, et al. Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model. Arthritis Rheum. 2012; 64: 1098-109. This is the first demonstration and proof of the principle that an anti-human DR5 apoptosis therapy can be used to prevent and treat arthritis in a CIA mouse model. The authors utilized a novel hu/mo chimeric DR5 mouse to demonstrate the efficacy of an antihuman DR5 therapy and showed that induction of apoptosis of macropghages was the major mechanism of action leading to decreased inflammatory macrophages and Th17 cells and increased Treg cells.
    • (2012) Arthritis Rheum. , vol.64 , pp. 1098-1109
    • Li, J.1    Hsu, H.C.2    Yang, P.3
  • 28
    • 77953421610 scopus 로고    scopus 로고
    • Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death
    • Parihar A, Eubank TD, Doseff AI. Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death. J Innate Immun. 2010; 2: 204-15. This review summarizes the contribution of the caspases and their regulators in monocyte/macrophage cell fate and discusses how these molecules orchestrate the initiation, maintenance, and resolution of inflammation. More provocatively, we discuss possible strategies for controling inflammation by manipulating leukocyte life span.
    • (2010) J Innate Immun. , vol.2 , pp. 204-215
    • Parihar, A.1    Eubank, T.D.2    Doseff, A.I.3
  • 29
    • 0030584786 scopus 로고    scopus 로고
    • Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I
    • Zhou T, Edwards 3rd CK, Yang P, et al. Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor i. J Immunol. 1996; 156: 2661-5. (Pubitemid 126660608)
    • (1996) Journal of Immunology , vol.156 , Issue.8 , pp. 2661-2665
    • Zhou, T.1    Edwards III, C.K.2    Yang, P.3    Wang, Z.4    Bluethmann, H.5    Mountz, J.D.6
  • 30
    • 0025020303 scopus 로고
    • Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (tnf): Similarities between tnf-alpha and interleukin 1
    • Jacob CO, Aiso S, Michie SA, et al. Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (tnf): similarities between tnf-alpha and interleukin 1. Proc Natl Acad Sci USA. 1990; 87: 968-72.
    • (1990) Proc Natl Acad Sci USA. , vol.87 , pp. 968-972
    • Jacob, C.O.1    Aiso, S.2    Michie, S.A.3
  • 31
    • 79651471957 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha signaling in macrophages
    • Parameswaran N, Patial S. Tumor necrosis factor-alpha signaling in macrophages. Crit Rev Eukaryot Gene Expr. 2010; 20: 87-103.
    • (2010) Crit Rev Eukaryot Gene Expr. , vol.20 , pp. 87-103
    • Parameswaran, N.1    Patial, S.2
  • 32
    • 12344297311 scopus 로고    scopus 로고
    • Evidence that anti-tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints: Extended report
    • DOI 10.1002/art.20764
    • Catrina AI, Trollmo C. af Klint E, et al. Evidence that antitumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints: extended report. Arthritis Rheum. 2005; 52: 61-72. (Pubitemid 40129233)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.1 , pp. 61-72
    • Catrina, A.I.1    Trollmo, C.2    Af Klint, E.3    Engstrom, M.4    Lampa, J.5    Hermansson, Y.6    Klareskog, L.7    Ulfgren, A.K.8
  • 35
    • 78650907772 scopus 로고    scopus 로고
    • Lopez-Olivo MA Tocilizumab for rheumatoid arthritis: A cochrane systematic review
    • Singh JA, Beg S. Lopez-Olivo MA Tocilizumab for rheumatoid arthritis: a cochrane systematic review. J Rheumatol. 2011; 38: 10-20.
    • (2011) J Rheumatol. , vol.38 , pp. 10-20
    • Singh, J.A.1    Beg, S.2
  • 36
    • 77952924538 scopus 로고    scopus 로고
    • Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis
    • Bluml S, Binder NB, Niederreiter B, et al. Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis. Arthritis Rheum. 2010; 62: 1608-19. The data indicate that selective blockade of TNFRI, leaving the antiinflammatory effects of TNFRII unaltered instead of unselectively blocking TNF, might be advantageous in patients with RA.
    • (2010) Arthritis Rheum. , vol.62 , pp. 1608-1619
    • Bluml, S.1    Binder, N.B.2    Niederreiter, B.3
  • 37
    • 0028223847 scopus 로고
    • Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    • DOI 10.1016/0092-8674(94)90375-1
    • Takahashi T, Tanaka M, Brannan CI, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand. Cell. 1994; 76: 969-76. (Pubitemid 24106378)
    • (1994) Cell , vol.76 , Issue.6 , pp. 969-976
    • Takahashi, T.1    Tanaka, M.2    Brannan, C.I.3    Jenkins, N.A.4    Copeland, N.G.5    Suda, T.6    Nagata, S.7
  • 38
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in fas antigen that mediates apoptosis
    • Watanabe-Fukunaga R, Brannan CI, Copeland NG, et al. Lymphoproliferation disorder in mice explained by defects in fas antigen that mediates apoptosis. Nature. 1992; 356: 314-7.
    • (1992) Nature. , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3
  • 40
    • 84857733516 scopus 로고    scopus 로고
    • Requirement of myeloid cell-specific fas expression for prevention of systemic autoimmunity in mice
    • Cuda CM, Agrawal H, Misharin AV, et al. Requirement of myeloid cell-specific fas expression for prevention of systemic autoimmunity in mice. Arthritis Rheum. 2012; 64: 808-20.
    • (2012) Arthritis Rheum. , vol.64 , pp. 808-820
    • Cuda, C.M.1    Agrawal, H.2    Misharin, A.V.3
  • 42
    • 69449085100 scopus 로고    scopus 로고
    • GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type i interferon signaling
    • Fleetwood AJ, Dinh H, Cook AD, Hertzog PJ, Hamilton JA. GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling. J Leukoc Biol. 2009; 86: 411-21. The findings demonstrate that constitutive and LPS-induced type I IFN play significant roles in regulating the differences in phenotype and function between M-CSF-induced macrophages and GM-CSF-induced macrophages.
    • (2009) J Leukoc Biol. , vol.86 , pp. 411-421
    • Fleetwood, A.J.1    Dinh, H.2    Cook, A.D.3    Hertzog, P.J.4    Hamilton, J.A.5
  • 43
    • 0242579588 scopus 로고    scopus 로고
    • Rheumatoid arthritis synovial fluid macrophages express decreased tumor necrosis factor-related apoptosis-inducing ligand R2 and increased decoy receptor tumor necrosis factor-related apoptosis-inducing ligand R3
    • DOI 10.1002/art.11302
    • Perlman H, Nguyen N, Liu H, et al. Rheumatoid arthritis synovial fluid macrophages express decreased tumor necrosis factor-related apoptosis-inducing ligand r2 and increased decoy receptor tumor necrosis factor-related apoptosis-inducing ligand r3. Arthritis Rheum. 2003; 48: 3096-101. (Pubitemid 37409320)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.11 , pp. 3096-3101
    • Perlman, H.1    Nguyen, N.2    Liu, H.3    Eslick, J.4    Esser, S.5    Walsh, K.6    Moore, T.L.7    Pope, R.M.8
  • 45
    • 80053361349 scopus 로고    scopus 로고
    • Evaluation of the bcl-2 family antagonist abt-737 in collagen-induced arthritis
    • Lawlor KE, Smith SD, van Nieuwenhuijze A, et al. Evaluation of the bcl-2 family antagonist abt-737 in collagen-induced arthritis. J Leukoc Biol. 2011; 90: 819-29.
    • (2011) J Leukoc Biol. , vol.90 , pp. 819-829
    • Lawlor, K.E.1    Smith, S.D.2    Van Nieuwenhuijze, A.3
  • 46
    • 0343091223 scopus 로고    scopus 로고
    • Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability
    • Perlman H, Georganas C, Pagliari LJ, et al. Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability. J Immunol. 2000; 164: 5227-35. (Pubitemid 30305200)
    • (2000) Journal of Immunology , vol.164 , Issue.10 , pp. 5227-5235
    • Perlaman, H.1    Georgnas, C.2    Pagliari, L.J.3    Koch, A.E.4    Haines III, K.5    Pope, R.M.6
  • 48
    • 33750347729 scopus 로고    scopus 로고
    • Regulation of Mcl-1 expression in rheumatoid arthritis synovial macrophages
    • DOI 10.1002/art.22132
    • Liu H, Huang Q, Shi B, et al. Regulation of mcl-1 expression in rheumatoid arthritis synovial macrophages. Arthritis Rheum. 2006; 54: 3174-81. (Pubitemid 44622088)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.10 , pp. 3174-3181
    • Liu, H.1    Huang, Q.2    Shi, B.3    Eksarko, P.4    Temkin, V.5    Pope, R.M.6
  • 49
    • 0033711724 scopus 로고    scopus 로고
    • Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis
    • Barrera P, Blom A, van Lent PL, et al. Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis. Arthritis Rheum. 2000; 43: 1951-9.
    • (2000) Arthritis Rheum. , vol.43 , pp. 1951-1959
    • Barrera, P.1    Blom, A.2    Van Lent, P.L.3
  • 50
    • 58149229634 scopus 로고    scopus 로고
    • A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells
    • Hochweller K, Striegler J, Hammerling GJ, et al. A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur J Immunol. 2008; 38: 2776-83.
    • (2008) Eur J Immunol. , vol.38 , pp. 2776-2783
    • Hochweller, K.1    Striegler, J.2    Hammerling, G.J.3
  • 51
    • 44849120587 scopus 로고    scopus 로고
    • Drug Insight: Tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis
    • DOI 10.1038/ncprheum0797, PII NCPRHEUM0797
    • Moss ML, Sklair-Tavron L, Nudelman R, et al. Tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nat Clin Pract Rheumatol. 2008; 4: 300-9. (Pubitemid 351791441)
    • (2008) Nature Clinical Practice Rheumatology , vol.4 , Issue.6 , pp. 300-309
    • Moss, M.L.1    Sklair-Tavron, L.2    Nudelman, R.3
  • 52
    • 67650904196 scopus 로고    scopus 로고
    • More about masitinib
    • Walker UA. More about masitinib. Arthritis Res Ther. 2009; 11: 120.
    • (2009) Arthritis Res Ther , vol.11 , pp. 120
    • Walker, U.A.1
  • 53
    • 34247874750 scopus 로고    scopus 로고
    • Imatinib for the treatment of rheumatic diseases
    • DOI 10.1038/ncprheum0465, PII NCPRHEUM0465
    • Paniagua RT, Robinson WH. Imatinib for the treatment of rheumatic diseases. Nat Clin Pract Rheumatol. 2007; 3: 190-1. (Pubitemid 46860398)
    • (2007) Nature Clinical Practice Rheumatology , vol.3 , Issue.4 , pp. 190-191
    • Paniagua, R.T.1    Robinson, W.H.2


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