Dissociation of hedonic reaction to reward and incentive motivation in an animal model of the negative symptoms of schizophrenia

Neuropsychopharmacology

Volumn 37, Issue 7, 2012, Pages 1699-1707

  Ward, Ryan D ^a   Simpson, Eleanor H ^a,b   Richards, Vanessa L ^a   Deo, Gita ^c   Taylor, Kathleen ^a,c   Glendinning, John I ^a,c   Kandel, Eric R ^a,d,e   Balsam, Peter D ^a,c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c Barnard College of Columbia University   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e NONE   (United States)

Author keywords

D2 receptor overexpression; hedonia; incentive motivation; mouse models; operant; schizophrenia

Indexed keywords

DOPAMINE 2 RECEPTOR; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMOTION; FACIAL EXPRESSION; HEDONIA; LICKING; MOTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REWARD; SCHIZOPHRENIA;

ANIMALS; BEHAVIOR, ANIMAL; CALORIC RESTRICTION; DISEASE MODELS, ANIMAL; MICE; MICE, TRANSGENIC; MOTIVATION; RECEPTORS, DOPAMINE D2; REWARD; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SUCROSE;

EID: 84861196612     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2012.15     Document Type: Article

References (47)

1. Abi-Dargham A, Rodenhiser J, Printz D, Zea-Ponce Y, Gil R, Kegeles LS et al (2000). Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proc Natl Acad Sci USA 97: 8104-8109. (Pubitemid 30460780)
2. Barch DM, Dowd EC (2010). Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions. Schizophrenia Bull 36: 919-934.
3. Baum WM (1974). On two types of deviations from the matching law: bias and undermatching. J Exp Anal Behav 22: 231-242.
4. Berridge KC (1996). Food reward: brain substrates of liking and wanting. Neurosci Biobehav Rev 20: 1-25. (Pubitemid 126682107)
5. Berridge KC (2000). Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns. Neurosci Biobehav Rev 24: 173-198. (Pubitemid 30100443)
6. Berridge KC (2009). Liking'' and ''wanting'' food rewards: brain substrates and roles in eating disorders. Physiol Behav 97: 537-550.
7. Berridge KC, Robinson TE (1998). What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Rev 28: 309-369. (Pubitemid 29012677)
8. Berridge KC, Robinson TE (2003). Parsing reward. Trends Neurosci 26: 507-513. (Pubitemid 37025790)
9. Berridge KC, Robinson TE, Aldridge JW (2009). Dissecting components of reward: ''liking'', ''wanting'', and learning. Curr Opin Pharmacol 9: 65-73.
10. Berridge KC, Venier IL, Robinson TE (1989). Taste reactivity analysis of 6-hydroxydopamine-induced aphagia: implications for arousal and anhedonia hypotheses of dopamine function. Behav Neurosci 103: 36-45. (Pubitemid 19058642)
11. Cagniard B, Murphy NP (2009). Taste reactivity and its modulation by morphine and methamphetamine in C57BL/6 and DBA/2 mice. Physiol Behav 96: 412-420.
12. Catania AC (1966). Concurrent operants. In: Honig WK (eds). Operant Behavior: Areas of Research and Application. Prentice Hall: NJ, pp 213-270.
13. Cohen AS, Minor KS (2010). Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies. Schizophr Bull 36: 143-150.
14. Cousins MS, Salamone JD (1994). Nucleus accumbens dopamine depletions in rats affect relative response allocation in a novel cost/benefit procedure. Pharmacol Biochem Behav 49: 85-91. (Pubitemid 24297261)
15. Davis KL, Kahn RS, Ko G, Davidson M (1991). Dopamine in schizophrenia: a review and reconceptualization. Am J Psychiat 148: 1474-1486.
16. Drew MR, Simpson EH, Kellendonk C, Herzberg WG, Lipatova O, Fairhurst S et al (2007). Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing. J Neurosci 27: 7731-7739. (Pubitemid 47093816)
17. Farrar AM, Segovia KN, Randall PA, Nunes EJ, Collins LE, Stopper CM et al (2010). Nucleus accumbens and effort-related functions: behavioral and neural markers of the interaction between adenosine A2A and dopamine D2 receptors. Neuroscience 166: 1056-1067.
18. Gard DE, Kring AM, Gard MG, Horan WP, Green MF (2007). Anhedonia in schizophrenia: distinctions between anticipatory and consummatory pleasure. Schizophr Res 93: 253-260. (Pubitemid 46817952)
19. Glendinning JI, Gresack J, Spector AC (2002). A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function. Chem Senses 27: 461-474. (Pubitemid 34693006)
20. Gold JM, Waltz JA, Prentice KJ, Morris SE, Heerey EA (2008). Reward processing in schizophrenia: a deficit in the representation of value. Schizophr Bull 34: 835-847.
21. Grill HJ, Norgren R (1978). The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats. Brain Res 143: 263-279.
22. Gruber AJ, Calhoon GG, Shusterman I, Schoenbaum G, Roesch MR, O'Donnell P (2010). More is less: a disinhibited prefrontal cortex impairs cognitive flexibility. J Neurosci 30: 17102-17110.
23. Heerey EA, Gold JM (2007). Patients with schizophrenia demonstrate dissociation between affective experience and motivated behavior. J Abnorm Psychol 116: 268-278. (Pubitemid 46800341)
24. Herrnstein RJ (1961). Relative and absolute strength of response as a function of frequency of reinforcement. J Exp Anal Behav 4: 267-272.
25. Kellendonk C, Simpson EH, Polan HJ, Malleret G, Vronskaya S, Winiger V et al (2006). Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron 49: 603-615. (Pubitemid 43221894)
26. Li YC, Kellendonk C, Simpson EH, Kandel ER, Gao WJ (2011). D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex. Proc Natl Acad Sci USA 108: 12107-12112.
27. Manschreck TC, Boshes RA (2007). The CATIE schizophrenia trial: results, impact, controversy. Harv Rev Psychiatry 15: 245-258. (Pubitemid 47557208)
28. Mazur JE (1987). An adjusting procedure for studying delayed reinforcement. In: Commons ML, Mazur JE, Nevin JA, Rachlin H (eds). Quantitative Analysis of Behavior: The Effect of Delay and Intervening Events on Reinforcement Value, Vol. 5. Erlbaum: Hillsdale, NJ, pp 55-73.
29. Pecina S, Berridge KC (2005). Hedonic hot spot in nucleus accumbens shell: where do u-opioids cause increased hedonic impact of sweetness? J Neurosci 25: 11777-11786. (Pubitemid 43098470)
30. Pecina S, Cagniard B, Berridge KC, Aldridge JW, Zhuang X (2003). Hyperdopaminergic mutant mice have higher ''wanting'' but not ''liking'' for sweet rewards. J Neurosci 23: 9395-9402. (Pubitemid 37323039)
31. Pecina S, Berridge KC, Parker LA (1997). Pimozide does not shift palatability: separation of anhedonia from sensorimotor suppression by taste reactivity. Pharmacol Biochem Behav 58: 801-811. (Pubitemid 27438140)
32. Robinson S, Sandstrom SM, Denenberg VH, Palmiter RD (2005). Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards. Behav Neurosci 119: 5-15. (Pubitemid 40279492)
33. Salamone JD, Correa M (2002). Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine. Behav Brain Res 137: 3-25. (Pubitemid 35346426)
34. Salamone JD, Correa M, Farrar A, Mingote SM (2007). Effortrelated functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology 191: 461-482. (Pubitemid 46355902)
35. Salamone JD, Correa M, Farrar AM, Nunes EJ, Pardo M (2009). Dopamine, behavioral economics, and effort. Front Behav Neurosci 3: 13.
36. Salamone JD, Cousins MS, Maio C, Champion M, Turski T, Kovach J (1996). Different behavioral effects of haloperidol, clozapine and thioridazine in a concurrent lever pressing and feeding procedure. Psychopharmacology 125: 105-112. (Pubitemid 26172087)
37. Salamone JD, Steinpreis RE, McCullough LD, Smith P, Grebel D, Mahan K (1991). Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure. Psychopharmacology 104: 515-521.
38. Simpson EH, Kellendonk C, Ward RD, Richards V, Lipatova O, Fairhurst S et al (2011). Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia. Biol Psychiatry 69: 928-935.
39. Spector AC, Grill HJ, Norgren R (1993). Concentration dependent licking of sucrose and sodium chloride in rats with parabrachial gustatory lesions. Physiol Behav 53: 277-283. (Pubitemid 23048330)
40. Strauss GP, Robinson BM, Waltz JA, Frank MJ, Kasanova Z, Herbener ES et al (2011). Patients with schizophrenia demonstrate inconsistent preference judgments for affective and nonaffective stimuli. Schizophr Bull 37: 1295-1304.
41. Strauss GP, Wilbur RC, Warren KR, August SM, Gold JM (2011). Anticipatory vs. consummatory pleasure: what is the nature of hedonic deficits in schizophrenia? Psychiatry Res 187: 36-41.
42. Treit D, Berridge KC (1990). A comparison of benzodiazepine, serotonin, and dopamine agents in the taste reactivity paradigm. Pharmacol Biochem Behav 37: 451-456.
43. van den Bos R, van der Harst J, Jonkman S, Schilders M, Spruijt B (2006). Rats assess costs and benefits according to an internal standard. Behav Brain Res 171: 350-354. (Pubitemid 43946495)
44. Ward RD, Kellendonk C, Simpson EH, Lipatova O, Drew MR, Fairhurst S et al (2009). Impaired timing precision produced by striatal D2 receptor overexpression is mediated by cognitive and motivational deficits. Behav Neurosci 123: 720-730.
45. Ward RD, Simpson EH, Kandel ER, Balsam PD (2011). Modeling motivational deficits in mouse models of schizophrenia. Behavior analysis as a guide for neuroscience. Behav Processes 87: 149-156.
46. Yin HH, Ostland SB, Balleine BW (2008). Reward guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks. Eur J Neurosci 28: 1437-1448.
47. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ et al (2011). Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477: 172-178.