Novel Potent and Selective Acetylcholinesterase Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease: Synthesis, Pharmacological Evaluation, and Molecular Modeling of Amino-Alkyl-Substituted Fluoro-Chalcones Derivatives

Chemical Biology and Drug Design

Volumn 86, Issue 4, 2015, Pages 517-522

  Liu, Hao Ran ^a   Zhou, Chao ^a   Fan, Hao Qun ^a   Tang, Jing Jing ^a   Liu, Lin Bo ^a   Gao, Xiao Hui ^b   Wang, Qiu An ^a   Liu, Wu Kun ^a  

^a HUNAN UNIVERSITY   (China)

^b HUNAN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

AChE inhibitors; chalcone; fluorine; molecular modeling; selectivity

Indexed keywords

1 (2 FLUOROPHENYL) 3 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 1 (3 FLUOROPHENYL) 3 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 1 (4 FLUOROPHENYL) 3 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (2 (DIMETHYLAMINO)ETHOXY)PHENYL] 3 (2 FLUOROPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (DIETHYLAMINO)ETHOXY]PHENYL] 3 (2 FLUOROPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (DIETHYLAMINO)ETHOXY]PHENYL] 3 (3 FLUOROPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (DIETHYLAMINO)ETHOXY]PHENYL] 3 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (DIMETHYLAMINO)ETHOXY]PHENYL] 3 (3 FLUOROPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (DIMETHYLAMINO)ETHOXY]PHENYL] 3 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 (2 FLUOROPHENYL) 1 [4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL]PROP 2 EN 1 ONE; 3 (2 FLUOROPHENYL) 1 [4 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL]PROP 2 EN 1 ONE; 3 (3 FLUOROPHENYL) 1 [4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL]PROP 2 EN 1 ONE; 3 (3 FLUOROPHENYL) 1 [4 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL]PROP 2 EN 1 ONE; 3 (4 FLUOROPHENYL) 1 [4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL]PROP 2 EN 1 ONE; 3 (4 FLUOROPHENYL) 1 [4 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL]PROP 2 EN 1 ONE; ACETYLCHOLINESTERASE; ALKYL GROUP; CHALCONE DERIVATIVE; CHOLINESTERASE INHIBITOR; FLUORO CHALCONE DERIVATIVE; RIVASTIGMINE; UNCLASSIFIED DRUG; FLUORINATED HYDROCARBON;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IC50; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; SUBSTITUTION REACTION; ANIMAL; CHEMISTRY; ENZYMOLOGY; HUMAN;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; CHALCONES; CHOLINESTERASE INHIBITORS; HUMANS; HYDROCARBONS, FLUORINATED; MOLECULAR DOCKING SIMULATION;

EID: 84942552452     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12514     Document Type: Article

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