Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 19, 2014, Pages 4749-4753

  Liu, Hao Ran ^a   Huang, Xue Qin ^a   Lou, Ding Hui ^a   Liu, Xian Jun ^a   Liu, Wu Kun ^a   Wang, Qiu An ^a  

^a HUNAN UNIVERSITY   (China)

Author keywords

AChE inhibitory activity; Chalcone; Flavokawain B; Mannich bases; Synthesis

Indexed keywords

CHOLINESTERASE INHIBITOR; FLAVOKAWAIN B DERIVATIVE; MANNICH BASE; PHLOROGLUCINOL; RIVASTIGMINE; UNCLASSIFIED DRUG; ACETYLCHOLINESTERASE; FLAVOKAWAIN B; FLAVONOID;

ARTICLE; BLOOD BRAIN BARRIER; CHOLINESTERASE INHIBITION; CLAISEN CONDENSATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME KINETICS; ENZYME MECHANISM; IC50; IN VIVO STUDY; INFRARED SPECTROSCOPY; LIPOPHILICITY; METHYLATION; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FLAVONOIDS; HUMANS; MANNICH BASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907194879     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.07.087     Document Type: Article

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