메뉴 건너뛰기




Volumn 21, Issue 10, 2015, Pages 633-644

Exhaled Molecular Fingerprinting in Diagnosis and Monitoring: Validating Volatile Promises

Author keywords

Breath; Diagnosis; ENose; GC MS; Metabolomics; Volatile organic compounds

Indexed keywords

BIOLOGICAL MARKER; VOLATILE ORGANIC COMPOUND;

EID: 84942520726     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.08.001     Document Type: Review
Times cited : (135)

References (77)
  • 2
    • 84995527915 scopus 로고    scopus 로고
    • A systems medicine clinical platform for understanding and managing non- communicable diseases
    • Cesario A., et al. A systems medicine clinical platform for understanding and managing non- communicable diseases. Curr. Pharm. Des. 2014, 20:5945-5956.
    • (2014) Curr. Pharm. Des. , vol.20 , pp. 5945-5956
    • Cesario, A.1
  • 3
    • 2542465414 scopus 로고    scopus 로고
    • European Respiratory Society
    • European Lung White Book 2015, European Respiratory Society, European Respiratory Society, (http://www.erswhitebook.org).
    • (2015) European Lung White Book
  • 4
    • 84922895251 scopus 로고    scopus 로고
    • Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM Workshop Held in Barcelona on June 12, 2014
    • Agusti A., et al. Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM Workshop Held in Barcelona on June 12, 2014. Am. J. Respir. Crit. Care Med. 2015, 191:391-401.
    • (2015) Am. J. Respir. Crit. Care Med. , vol.191 , pp. 391-401
    • Agusti, A.1
  • 5
    • 84878940718 scopus 로고    scopus 로고
    • Application of 'omics technologies to biomarker discovery in inflammatory lung diseases
    • Wheelock C.E., et al. Application of 'omics technologies to biomarker discovery in inflammatory lung diseases. Eur. Respir. J. 2013, 42:802-825.
    • (2013) Eur. Respir. J. , vol.42 , pp. 802-825
    • Wheelock, C.E.1
  • 6
    • 84923377513 scopus 로고    scopus 로고
    • Exhaled volatile organic compounds discriminate patients with chronic obstructive pulmonary disease from healthy subjects
    • Besa V., et al. Exhaled volatile organic compounds discriminate patients with chronic obstructive pulmonary disease from healthy subjects. Int. J. Chron. Obstruct. Pulmon. Dis. 2015, 10:399-406.
    • (2015) Int. J. Chron. Obstruct. Pulmon. Dis. , vol.10 , pp. 399-406
    • Besa, V.1
  • 7
    • 84920722600 scopus 로고    scopus 로고
    • Breathomics in lung disease
    • van der Schee M.P., et al. Breathomics in lung disease. Chest 2015, 147:224-231.
    • (2015) Chest , vol.147 , pp. 224-231
    • van der Schee, M.P.1
  • 8
    • 84879760975 scopus 로고    scopus 로고
    • Clinical application of volatile organic compound analysis for detecting infectious diseases
    • Sethi S., et al. Clinical application of volatile organic compound analysis for detecting infectious diseases. Clin. Microbiol. Rev. 2013, 26:462-475.
    • (2013) Clin. Microbiol. Rev. , vol.26 , pp. 462-475
    • Sethi, S.1
  • 9
    • 84893862946 scopus 로고    scopus 로고
    • Assessment, origin, and implementation of breath volatile cancer markers
    • Haick H., et al. Assessment, origin, and implementation of breath volatile cancer markers. Chem. Soc. Rev. 2014, 43:1423-1449.
    • (2014) Chem. Soc. Rev. , vol.43 , pp. 1423-1449
    • Haick, H.1
  • 10
    • 84860262022 scopus 로고    scopus 로고
    • Characterization of volatile organic compounds in human leukocyte antigen heterologous expression systems: a cell's 'chemical odor fingerprint'
    • Aksenov A.A., et al. Characterization of volatile organic compounds in human leukocyte antigen heterologous expression systems: a cell's 'chemical odor fingerprint'. Chembiochem 2012, 13:1053-1059.
    • (2012) Chembiochem , vol.13 , pp. 1053-1059
    • Aksenov, A.A.1
  • 11
    • 84903783420 scopus 로고    scopus 로고
    • The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva
    • Amann A., et al. The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva. J. Breath Res. 2014, 8:034001.
    • (2014) J. Breath Res. , vol.8 , pp. 034001
    • Amann, A.1
  • 12
    • 84902300192 scopus 로고    scopus 로고
    • Glucose prediction by analysis of exhaled metabolites - a systematic review
    • Leopold J.H., et al. Glucose prediction by analysis of exhaled metabolites - a systematic review. BMC Anesthesiol. 2014, 14:46.
    • (2014) BMC Anesthesiol. , vol.14 , pp. 46
    • Leopold, J.H.1
  • 13
    • 84885750930 scopus 로고    scopus 로고
    • Exhaled breath analysis with electronic nose technology for detection of acute liver failure in rats
    • Wlodzimirow K.A., et al. Exhaled breath analysis with electronic nose technology for detection of acute liver failure in rats. Biosens. Bioelectron. 2014, 53:129-134.
    • (2014) Biosens. Bioelectron. , vol.53 , pp. 129-134
    • Wlodzimirow, K.A.1
  • 14
    • 84861477023 scopus 로고    scopus 로고
    • The versatile use of exhaled volatile organic compounds in human health and disease
    • Boots A.W., et al. The versatile use of exhaled volatile organic compounds in human health and disease. J. Breath Res. 2012, 6:027108.
    • (2012) J. Breath Res. , vol.6 , pp. 027108
    • Boots, A.W.1
  • 15
    • 77649180011 scopus 로고    scopus 로고
    • A profile of volatile organic compounds in breath discriminates COPD patients from controls
    • Van Berkel J.J., et al. A profile of volatile organic compounds in breath discriminates COPD patients from controls. Respir. Med. 2010, 104:557-563.
    • (2010) Respir. Med. , vol.104 , pp. 557-563
    • Van Berkel, J.J.1
  • 16
    • 84874104955 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: a non-invasive diagnosis by analysis of exhaled breath
    • Verdam F.J., et al. Non-alcoholic steatohepatitis: a non-invasive diagnosis by analysis of exhaled breath. J. Hepatol. 2013, 58:543-548.
    • (2013) J. Hepatol. , vol.58 , pp. 543-548
    • Verdam, F.J.1
  • 17
    • 85168648472 scopus 로고    scopus 로고
    • Unique volatolomic signatures of TP53 and KRAS in lung cells
    • Davies M.P., et al. Unique volatolomic signatures of TP53 and KRAS in lung cells. Br. J. Cancer 2014, 111:1213-1221.
    • (2014) Br. J. Cancer , vol.111 , pp. 1213-1221
    • Davies, M.P.1
  • 18
    • 84879520955 scopus 로고    scopus 로고
    • Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions
    • Fens N., et al. Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions. Clin. Exp. Allergy 2013, 43:705-715.
    • (2013) Clin. Exp. Allergy , vol.43 , pp. 705-715
    • Fens, N.1
  • 19
    • 84901640017 scopus 로고    scopus 로고
    • Comparative analyses of volatile organic compounds (VOCs) from patients, tumors and transformed cell lines for the validation of lung cancer-derived breath markers
    • Filipiak W., et al. Comparative analyses of volatile organic compounds (VOCs) from patients, tumors and transformed cell lines for the validation of lung cancer-derived breath markers. J. Breath Res. 2014, 8:027111.
    • (2014) J. Breath Res. , vol.8 , pp. 027111
    • Filipiak, W.1
  • 20
    • 84869193541 scopus 로고    scopus 로고
    • Volatile organic compounds of lung cancer and possible biochemical pathways
    • Hakim M., et al. Volatile organic compounds of lung cancer and possible biochemical pathways. Chem. Rev. 2012, 112:5949-5966.
    • (2012) Chem. Rev. , vol.112 , pp. 5949-5966
    • Hakim, M.1
  • 21
    • 66149108824 scopus 로고    scopus 로고
    • Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect
    • Gorham K.A., et al. Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect. Biomarkers 2009, 14:17-25.
    • (2009) Biomarkers , vol.14 , pp. 17-25
    • Gorham, K.A.1
  • 22
    • 84874864097 scopus 로고    scopus 로고
    • Clinical breath analysis: discriminating between human endogenous compounds and exogenous (environmental) chemical confounders
    • Pleil J.D., et al. Clinical breath analysis: discriminating between human endogenous compounds and exogenous (environmental) chemical confounders. J. Breath Res. 2013, 7:017107.
    • (2013) J. Breath Res. , vol.7 , pp. 017107
    • Pleil, J.D.1
  • 23
    • 84878493090 scopus 로고    scopus 로고
    • Volatile metabolites of pathogens: a systematic review
    • Bos L.D., et al. Volatile metabolites of pathogens: a systematic review. PLoS Pathog. 2013, 9:e1003311.
    • (2013) PLoS Pathog. , vol.9 , pp. e1003311
    • Bos, L.D.1
  • 24
    • 34547135710 scopus 로고    scopus 로고
    • Bacterial volatiles: the smell of small organisms
    • Schulz S., Dickschat J.S. Bacterial volatiles: the smell of small organisms. Nat. Prod. Rep. 2007, 24:814-842.
    • (2007) Nat. Prod. Rep. , vol.24 , pp. 814-842
    • Schulz, S.1    Dickschat, J.S.2
  • 25
    • 84901248574 scopus 로고    scopus 로고
    • Breath gas metabolites and bacterial metagenomes from cystic fibrosis airways indicate active pH neutral 2,3-butanedione fermentation
    • Whiteson K.L., et al. Breath gas metabolites and bacterial metagenomes from cystic fibrosis airways indicate active pH neutral 2,3-butanedione fermentation. ISME J. 2014, 8:1247-1258.
    • (2014) ISME J. , vol.8 , pp. 1247-1258
    • Whiteson, K.L.1
  • 26
    • 84899570854 scopus 로고    scopus 로고
    • Current breathomics - a review on data pre-processing techniques and machine learning in metabolomics breath analysis
    • Smolinska A., et al. Current breathomics - a review on data pre-processing techniques and machine learning in metabolomics breath analysis. J. Breath Res. 2014, 8:027105.
    • (2014) J. Breath Res. , vol.8 , pp. 027105
    • Smolinska, A.1
  • 27
    • 84899714967 scopus 로고    scopus 로고
    • Profiling of volatile organic compounds in exhaled breath as a strategy to find early predictive signatures of asthma in children
    • Smolinska A., et al. Profiling of volatile organic compounds in exhaled breath as a strategy to find early predictive signatures of asthma in children. PLoS ONE 2014, 9:e95668.
    • (2014) PLoS ONE , vol.9 , pp. e95668
    • Smolinska, A.1
  • 28
    • 84875552323 scopus 로고    scopus 로고
    • Translational biomarker discovery in clinical metabolomics: an introductory tutorial
    • Xia J., et al. Translational biomarker discovery in clinical metabolomics: an introductory tutorial. Metabolomics 2013, 9:280-299.
    • (2013) Metabolomics , vol.9 , pp. 280-299
    • Xia, J.1
  • 29
    • 84906959071 scopus 로고    scopus 로고
    • Towards standardization in the analysis of breath gas volatiles
    • Herbig J., Beauchamp J. Towards standardization in the analysis of breath gas volatiles. J. Breath Res. 2014, 8:037101.
    • (2014) J. Breath Res. , vol.8 , pp. 037101
    • Herbig, J.1    Beauchamp, J.2
  • 30
    • 84874854806 scopus 로고    scopus 로고
    • Effect of transportation and storage using sorbent tubes of exhaled breath samples on diagnostic accuracy of electronic nose analysis
    • van der Schee M.P., et al. Effect of transportation and storage using sorbent tubes of exhaled breath samples on diagnostic accuracy of electronic nose analysis. J. Breath Res. 2013, 7:016002.
    • (2013) J. Breath Res. , vol.7 , pp. 016002
    • van der Schee, M.P.1
  • 31
    • 84880031607 scopus 로고    scopus 로고
    • Standardised exhaled breath collection for the measurement of exhaled volatile organic compounds by proton transfer reaction mass spectrometry
    • Bikov A., et al. Standardised exhaled breath collection for the measurement of exhaled volatile organic compounds by proton transfer reaction mass spectrometry. BMC Pulm. Med. 2013, 13:43.
    • (2013) BMC Pulm. Med. , vol.13 , pp. 43
    • Bikov, A.1
  • 32
    • 35148827504 scopus 로고    scopus 로고
    • An electronic nose in the discrimination of patients with asthma and controls
    • Dragonieri S., et al. An electronic nose in the discrimination of patients with asthma and controls. J. Allergy Clin. Immunol. 2007, 120:856-862.
    • (2007) J. Allergy Clin. Immunol. , vol.120 , pp. 856-862
    • Dragonieri, S.1
  • 33
    • 34250667846 scopus 로고    scopus 로고
    • Human exhaled air analytics: biomarkers of diseases
    • Buszewski B., et al. Human exhaled air analytics: biomarkers of diseases. Biomed. Chromatogr. 2007, 21:553-566.
    • (2007) Biomed. Chromatogr. , vol.21 , pp. 553-566
    • Buszewski, B.1
  • 34
    • 85016865468 scopus 로고    scopus 로고
    • Advances in electronic-nose technologies for the detection of volatile biomarker metabolites in the human breath
    • Wilson A.D. Advances in electronic-nose technologies for the detection of volatile biomarker metabolites in the human breath. Metabolites 2015, 5:140-163.
    • (2015) Metabolites , vol.5 , pp. 140-163
    • Wilson, A.D.1
  • 35
    • 77949866490 scopus 로고    scopus 로고
    • Automated needle trap heart-cut GC/MS and needle trap comprehensive two-dimensional GC/TOF-MS for breath gas analysis in the clinical environment
    • Mieth M., et al. Automated needle trap heart-cut GC/MS and needle trap comprehensive two-dimensional GC/TOF-MS for breath gas analysis in the clinical environment. Anal. Chem. 2010, 82:2541-2551.
    • (2010) Anal. Chem. , vol.82 , pp. 2541-2551
    • Mieth, M.1
  • 36
    • 80255133261 scopus 로고    scopus 로고
    • Phase-resolved real-time breath analysis during exercise by means of smart processing of PTR-MS data
    • Schwoebel H., et al. Phase-resolved real-time breath analysis during exercise by means of smart processing of PTR-MS data. Anal. Bioanal. Chem. 2011, 401:2079-2091.
    • (2011) Anal. Bioanal. Chem. , vol.401 , pp. 2079-2091
    • Schwoebel, H.1
  • 37
    • 67449147120 scopus 로고    scopus 로고
    • Parameter selection for peak alignment in chromatographic sample profiling: objective quality indicators and use of control samples
    • Peters S., et al. Parameter selection for peak alignment in chromatographic sample profiling: objective quality indicators and use of control samples. Anal. Bioanal. Chem. 2009, 394:1273-1281.
    • (2009) Anal. Bioanal. Chem. , vol.394 , pp. 1273-1281
    • Peters, S.1
  • 38
    • 77954772536 scopus 로고    scopus 로고
    • MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data
    • Pluskal T., et al. MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinformatics 2010, 11:395.
    • (2010) BMC Bioinformatics , vol.11 , pp. 395
    • Pluskal, T.1
  • 39
    • 84881658782 scopus 로고    scopus 로고
    • A method of aligning peak lists generated by gas chromatography high-resolution mass spectrometry
    • Wei X., et al. A method of aligning peak lists generated by gas chromatography high-resolution mass spectrometry. Analyst 2013, 138:5453-5460.
    • (2013) Analyst , vol.138 , pp. 5453-5460
    • Wei, X.1
  • 40
    • 84904306550 scopus 로고    scopus 로고
    • Interactive XCMS Online: simplifying advanced metabolomic data processing and subsequent statistical analyses
    • Gowda H., et al. Interactive XCMS Online: simplifying advanced metabolomic data processing and subsequent statistical analyses. Anal. Chem. 2014, 86:6931-6939.
    • (2014) Anal. Chem. , vol.86 , pp. 6931-6939
    • Gowda, H.1
  • 41
    • 33645663178 scopus 로고    scopus 로고
    • Scaling and normalization effects in NMR spectroscopic metabonomic data sets
    • Craig A., et al. Scaling and normalization effects in NMR spectroscopic metabonomic data sets. Anal. Chem. 2006, 78:2262-2267.
    • (2006) Anal. Chem. , vol.78 , pp. 2262-2267
    • Craig, A.1
  • 42
    • 84893425747 scopus 로고    scopus 로고
    • A review of the volatiles from the healthy human body
    • de Lacy Costello B., et al. A review of the volatiles from the healthy human body. J. Breath Res. 2014, 8:014001.
    • (2014) J. Breath Res. , vol.8 , pp. 014001
    • de Lacy Costello, B.1
  • 43
    • 33846240326 scopus 로고    scopus 로고
    • Statistical strategies for avoiding false discoveries in metabolomics and related experiments
    • Broadhurst D.I., Kell D.B. Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2006, 2:171-196.
    • (2006) Metabolomics , vol.2 , pp. 171-196
    • Broadhurst, D.I.1    Kell, D.B.2
  • 44
    • 84929947684 scopus 로고    scopus 로고
    • A tutorial review: metabolomics and partial least squares-discriminant analysis ndash a marriage of convenience or a shotgun wedding
    • Gromski P.S., et al. A tutorial review: metabolomics and partial least squares-discriminant analysis ndash a marriage of convenience or a shotgun wedding. Anal. Chim. Acta 2015, 879:10-23.
    • (2015) Anal. Chim. Acta , vol.879 , pp. 10-23
    • Gromski, P.S.1
  • 45
    • 84884145058 scopus 로고    scopus 로고
    • Profile of volatile organic compounds in exhaled breath changes as a result of gluten-free diet
    • Baranska A., et al. Profile of volatile organic compounds in exhaled breath changes as a result of gluten-free diet. J. Breath Res. 2013, 7:037104.
    • (2013) J. Breath Res. , vol.7 , pp. 037104
    • Baranska, A.1
  • 46
    • 77958090625 scopus 로고    scopus 로고
    • External validity of risk models: use of benchmark values to disentangle a case-mix effect from incorrect coefficients
    • Vergouwe Y., et al. External validity of risk models: use of benchmark values to disentangle a case-mix effect from incorrect coefficients. Am. J. Epidemiol. 2010, 172:971-980.
    • (2010) Am. J. Epidemiol. , vol.172 , pp. 971-980
    • Vergouwe, Y.1
  • 47
    • 84871712516 scopus 로고    scopus 로고
    • The electronic nose in respiratory medicine
    • Montuschi P., et al. The electronic nose in respiratory medicine. Respiration 2013, 85:72-84.
    • (2013) Respiration , vol.85 , pp. 72-84
    • Montuschi, P.1
  • 48
    • 84901602288 scopus 로고    scopus 로고
    • Detecting cancer by breath volatile organic compound analysis: a review of array-based sensors
    • Queralto N., et al. Detecting cancer by breath volatile organic compound analysis: a review of array-based sensors. J. Breath Res. 2014, 8:027112.
    • (2014) J. Breath Res. , vol.8 , pp. 027112
    • Queralto, N.1
  • 49
    • 84982701505 scopus 로고    scopus 로고
    • Breath analysis as a potential and non-invasive frontier in disease diagnosis: an overview
    • Pereira J., et al. Breath analysis as a potential and non-invasive frontier in disease diagnosis: an overview. Metabolites 2015, 5:3-55.
    • (2015) Metabolites , vol.5 , pp. 3-55
    • Pereira, J.1
  • 50
    • 84898758129 scopus 로고    scopus 로고
    • Breath analysis of ammonia, volatile organic compounds and deuterated water vapor in chronic kidney disease and during dialysis
    • Davies S.J., et al. Breath analysis of ammonia, volatile organic compounds and deuterated water vapor in chronic kidney disease and during dialysis. Bioanalysis 2014, 6:843-857.
    • (2014) Bioanalysis , vol.6 , pp. 843-857
    • Davies, S.J.1
  • 51
    • 84865066944 scopus 로고    scopus 로고
    • The clinical potential of exhaled breath analysis for diabetes mellitus
    • Minh Tdo C., et al. The clinical potential of exhaled breath analysis for diabetes mellitus. Diabetes Res. Clin. Pract. 2012, 97:195-205.
    • (2012) Diabetes Res. Clin. Pract. , vol.97 , pp. 195-205
    • Minh Tdo, C.1
  • 52
    • 84906088673 scopus 로고    scopus 로고
    • Editorial: metabolomic analysis of breath volatile organic compounds - a new scent for inflammatory bowel disease
    • Arasaradnam R.P., et al. Editorial: metabolomic analysis of breath volatile organic compounds - a new scent for inflammatory bowel disease. Aliment. Pharmacol. Ther. 2014, 40:732-733.
    • (2014) Aliment. Pharmacol. Ther. , vol.40 , pp. 732-733
    • Arasaradnam, R.P.1
  • 53
    • 84921435429 scopus 로고    scopus 로고
    • Review article: breath analysis in inflammatory bowel diseases
    • Kurada S., et al. Review article: breath analysis in inflammatory bowel diseases. Aliment. Pharmacol. Ther. 2015, 41:329-341.
    • (2015) Aliment. Pharmacol. Ther. , vol.41 , pp. 329-341
    • Kurada, S.1
  • 54
    • 84905747379 scopus 로고    scopus 로고
    • Metabolomic analysis of breath volatile organic compounds reveals unique breathprints in children with inflammatory bowel disease: a pilot study
    • Patel N., et al. Metabolomic analysis of breath volatile organic compounds reveals unique breathprints in children with inflammatory bowel disease: a pilot study. Aliment. Pharmacol. Ther. 2014, 40:498-507.
    • (2014) Aliment. Pharmacol. Ther. , vol.40 , pp. 498-507
    • Patel, N.1
  • 55
    • 84904338175 scopus 로고    scopus 로고
    • Analysis of exhaled breath for disease detection
    • Amann A., et al. Analysis of exhaled breath for disease detection. Annu. Rev. Anal. Chem. 2014, 7:455-482.
    • (2014) Annu. Rev. Anal. Chem. , vol.7 , pp. 455-482
    • Amann, A.1
  • 56
    • 84861125147 scopus 로고    scopus 로고
    • Breath analysis as a potential diagnostic tool for tuberculosis
    • Kolk A.H., et al. Breath analysis as a potential diagnostic tool for tuberculosis. Int. J. Tuberc. Lung Dis. 2012, 16:777-782.
    • (2012) Int. J. Tuberc. Lung Dis. , vol.16 , pp. 777-782
    • Kolk, A.H.1
  • 57
    • 84862003214 scopus 로고    scopus 로고
    • Point-of-care breath test for biomarkers of active pulmonary tuberculosis
    • Phillips M., et al. Point-of-care breath test for biomarkers of active pulmonary tuberculosis. Tuberculosis 2012, 92:314-320.
    • (2012) Tuberculosis , vol.92 , pp. 314-320
    • Phillips, M.1
  • 58
    • 67650708042 scopus 로고    scopus 로고
    • The scent of Mycobacterium tuberculosis. Part II. Breath
    • Syhre M., et al. The scent of Mycobacterium tuberculosis. Part II. Breath. Tuberculosis 2009, 89:263-266.
    • (2009) Tuberculosis , vol.89 , pp. 263-266
    • Syhre, M.1
  • 59
    • 82555189254 scopus 로고    scopus 로고
    • Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD
    • Fens N., et al. Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD. Eur. Respir. J. 2011, 38:1301-1309.
    • (2011) Eur. Respir. J. , vol.38 , pp. 1301-1309
    • Fens, N.1
  • 60
    • 80051903043 scopus 로고    scopus 로고
    • Non-invasive phenotyping using exhaled volatile organic compounds in asthma
    • Ibrahim B., et al. Non-invasive phenotyping using exhaled volatile organic compounds in asthma. Thorax 2011, 66:804-809.
    • (2011) Thorax , vol.66 , pp. 804-809
    • Ibrahim, B.1
  • 61
    • 84886266027 scopus 로고    scopus 로고
    • Predicting steroid responsiveness in patients with asthma using exhaled breath profiling
    • van der Schee M.P., et al. Predicting steroid responsiveness in patients with asthma using exhaled breath profiling. Clin. Exp. Allergy 2013, 43:1217-1225.
    • (2013) Clin. Exp. Allergy , vol.43 , pp. 1217-1225
    • van der Schee, M.P.1
  • 62
    • 84880147278 scopus 로고    scopus 로고
    • Exhaled volatile organic compounds predict exacerbations of childhood asthma in a 1-year prospective study
    • Robroeks C.M., et al. Exhaled volatile organic compounds predict exacerbations of childhood asthma in a 1-year prospective study. Eur. Respir. J. 2013, 42:98-106.
    • (2013) Eur. Respir. J. , vol.42 , pp. 98-106
    • Robroeks, C.M.1
  • 63
    • 84923923813 scopus 로고    scopus 로고
    • Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD Statement
    • Collins G.S., et al. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD Statement. Ann. Inter. Med. 2015, 162:55-63.
    • (2015) Ann. Inter. Med. , vol.162 , pp. 55-63
    • Collins, G.S.1
  • 64
    • 84920591709 scopus 로고    scopus 로고
    • Breathprints of model murine bacterial lung infections are linked with immune response
    • Bean H.D., et al. Breathprints of model murine bacterial lung infections are linked with immune response. Eur. Respir. J. 2015, 45:181-190.
    • (2015) Eur. Respir. J. , vol.45 , pp. 181-190
    • Bean, H.D.1
  • 65
    • 84899507110 scopus 로고    scopus 로고
    • Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice
    • Kistler M., et al. Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice. J. Breath Res. 2014, 8:016004.
    • (2014) J. Breath Res. , vol.8 , pp. 016004
    • Kistler, M.1
  • 66
    • 84897112190 scopus 로고    scopus 로고
    • Online breath gas analysis in unrestrained mice by hs-PTR-MS
    • Szymczak W., et al. Online breath gas analysis in unrestrained mice by hs-PTR-MS. Mamm. Genome 2014, 25:129-140.
    • (2014) Mamm. Genome , vol.25 , pp. 129-140
    • Szymczak, W.1
  • 67
    • 84885757481 scopus 로고    scopus 로고
    • Criteria for the use of omics-based predictors in clinical trials
    • McShane L.M., et al. Criteria for the use of omics-based predictors in clinical trials. Nature 2013, 502:317-320.
    • (2013) Nature , vol.502 , pp. 317-320
    • McShane, L.M.1
  • 68
    • 84864813894 scopus 로고    scopus 로고
    • Molecular signatures from omics data: from chaos to consensus
    • Sung J., et al. Molecular signatures from omics data: from chaos to consensus. Biotechnol. J. 2012, 7:946-957.
    • (2012) Biotechnol. J. , vol.7 , pp. 946-957
    • Sung, J.1
  • 69
    • 77649182705 scopus 로고    scopus 로고
    • Unveiling the role of network and systems biology in drug discovery
    • Pujol A., et al. Unveiling the role of network and systems biology in drug discovery. Trends Pharm. Sci. 2010, 31:115-123.
    • (2010) Trends Pharm. Sci. , vol.31 , pp. 115-123
    • Pujol, A.1
  • 70
    • 0242579271 scopus 로고    scopus 로고
    • The standards for reporting of diagnostic accuracy
    • Knottnerus J.A., Tugwell P. The standards for reporting of diagnostic accuracy. J. Clin. Epidemiol. 2003, 56:1029.
    • (2003) J. Clin. Epidemiol. , vol.56 , pp. 1029
    • Knottnerus, J.A.1    Tugwell, P.2
  • 71
    • 70350676329 scopus 로고    scopus 로고
    • Diagnosing lung cancer in exhaled breath using gold nanoparticles
    • Peng G., et al. Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nat. Nanotechnol. 2009, 4:669-673.
    • (2009) Nat. Nanotechnol. , vol.4 , pp. 669-673
    • Peng, G.1
  • 72
    • 79551505136 scopus 로고    scopus 로고
    • Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome
    • Lotvall J., et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J. Allergy Clin. Immunol. 2011, 127:355-360.
    • (2011) J. Allergy Clin. Immunol. , vol.127 , pp. 355-360
    • Lotvall, J.1
  • 73
    • 0037160696 scopus 로고    scopus 로고
    • Evaluation of diagnostic procedures
    • Knottnerus J.A., et al. Evaluation of diagnostic procedures. BMJ 2002, 324:477-480.
    • (2002) BMJ , vol.324 , pp. 477-480
    • Knottnerus, J.A.1
  • 74
    • 84896706516 scopus 로고    scopus 로고
    • Using a web-based application to define the accuracy of diagnostic tests when the gold standard is imperfect
    • Lim C., et al. Using a web-based application to define the accuracy of diagnostic tests when the gold standard is imperfect. PLoS ONE 2013, 8:e79489.
    • (2013) PLoS ONE , vol.8 , pp. e79489
    • Lim, C.1
  • 75
    • 84883374872 scopus 로고    scopus 로고
    • Results of the two incidence screenings in the National Lung Screening Trial
    • Aberle D.R., et al. Results of the two incidence screenings in the National Lung Screening Trial. N. Engl. J. Med. 2013, 369:920-931.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 920-931
    • Aberle, D.R.1
  • 76
    • 79955571240 scopus 로고    scopus 로고
    • Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study
    • Boehme C.C., et al. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet 2011, 377:1495-1505.
    • (2011) Lancet , vol.377 , pp. 1495-1505
    • Boehme, C.C.1
  • 77
    • 84890347130 scopus 로고    scopus 로고
    • Rapid diagnosis of TB using GC-MS and chemometrics
    • Dang N.A., et al. Rapid diagnosis of TB using GC-MS and chemometrics. Bioanalysis 2013, 5:3079-3097.
    • (2013) Bioanalysis , vol.5 , pp. 3079-3097
    • Dang, N.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.