A profile of volatile organic compounds in breath discriminates COPD patients from controls

Respiratory Medicine

Volumn 104, Issue 4, 2010, Pages 557-563

  Van Berkel, J J B N ^a   Dallinga, J W ^a   Moller G M ^b   Godschalk, R W L ^a   Moonen, E J ^a   Wouters, E F M ^b,c   Van Schooten, F J ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Centre for Integrated Rehabilitation Organ Failure (CIRO)   (Netherlands)

Author keywords

Breath; COPD; Diagnosis; Exhaled air; GC MS; VOC

Indexed keywords

VOLATILE ORGANIC COMPOUND; BIOLOGICAL MARKER; CORTICOSTEROID;

ADULT; ARTICLE; BREATH ANALYSIS; CHEMICAL ANALYSIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; AGED; CASE CONTROL STUDY; EXHALATION; MASS FRAGMENTOGRAPHY; METABOLISM; MIDDLE AGED; OXIDATIVE STRESS; PHYSIOLOGY; PROCEDURES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; VALIDATION STUDY;

ADRENAL CORTEX HORMONES; AGED; BIOLOGICAL MARKERS; BREATH TESTS; CASE-CONTROL STUDIES; EXHALATION; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MIDDLE AGED; OXIDATIVE STRESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SENSITIVITY AND SPECIFICITY; VOLATILE ORGANIC COMPOUNDS;

EID: 77649180011     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2009.10.018     Document Type: Article

References (17)

1. Mannino D.M., and Buist A.S. Global burden of COPD: risk factors, prevalence, and future trends. Lancet 370 9589 (2007 Sep 1) 765-773
2. Rutten-van Molken M.P., Postma M.J., Joore M.A., Van Genugten M.L., Leidl R., and Jager J.C. Current and future medical costs of asthma and chronic obstructive pulmonary disease in The Netherlands. Respir Med 93 11 (1999 Nov) 779-787
3. Kharitonov S.A., and Barnes P.J. Exhaled markers of pulmonary disease. Am J Respir Crit Care Med 163 7 (2001 Jun) 1693-1722
4. Kharitonov S.A., and Barnes P.J. Exhaled markers of inflammation. Curr Opin Allergy Clin Immunol 1 3 (2001 Jun) 217-224
5. Yamaya M., Sekizawa K., Ishizuka S., Monma M., and Sasaki H. Exhaled carbon monoxide levels during treatment of acute asthma. Eur Respir J 13 4 (1999 Apr) 757-760
6. Montuschi P., Kharitonov S.A., and Barnes P.J. Exhaled carbon monoxide and nitric oxide in COPD. Chest 120 2 (2001 Aug) 496-501
7. Horvath I., MacNee W., Kelly F.J., Dekhuijzen P.N., Phillips M., Doring G., et al. "Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases", summary of the ERS Research Seminar in Budapest, Hungary, September, 1999. Eur Respir J 18 2 (2001 Aug) 420-430
8. Paredi P., Kharitonov S.A., Leak D., Ward S., Cramer D., and Barnes P.J. Exhaled ethane, a marker of lipid peroxidation, is elevated in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 162 2 Pt 1 (2000 Aug) 369-373
9. Pauling L., Robinson A.B., Teranishi R., and Cary P. Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proc Natl Acad Sci U S A 68 10 (1971 Oct) 2374-2376
10. Phillips M., Gleeson K., Hughes J.M., Greenberg J., Cataneo R.N., Baker L., et al. Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet 353 9168 (1999 Jun 5) 1930-1933
11. Phillips M., Cataneo R.N., Condos R., Ring Erickson G.A., Greenberg J., La Bombardi V., et al. Volatile biomarkers of pulmonary tuberculosis in the breath. Tuberculosis (Edinb) 87 1 (2007 Jan) 44-52
12. Phillips M., Altorki N., Austin J.H., Cameron R.B., Cataneo R.N., Greenberg J., et al. Prediction of lung cancer using volatile biomarkers in breath. Cancer Biomark 3 2 (2007) 95-109
13. Van Berkel J.J., Dallinga J.W., Moller G.M., Godschalk R.W., Moonen E., Wouters E.F., et al. Development of accurate classification method based on the analysis of volatile organic compounds from human exhaled air. J Chromatogr B Analyt Technol Biomed Life Sci 861 1 (2008 Jan 1) 101-107
14. Stein S.E., and Scott D.R. Optimization and testing of mass-spectral library search algorithms for compound identification. J Am Soc Mass Spectrom 5 9 (1994 Sep) 859-866
15. Guyon I., Weston J., Barnhill S., and Vapnik V. Gene selection for cancer classification using support vector machines. Mach Learn 46 1-3 (2002) 389-422
16. Platt J.C. Fast training of support vector machines using sequential minimal optimization (1998), MIT Press
17. Miekisch W., Schubert J.K., and Noeldge-Schomburg G.F. Diagnostic potential of breath analysis - focus on volatile organic compounds. Clin Chim Acta 347 1-2 (2004 Sep) 25-39