Non-alcoholic steatohepatitis: A non-invasive diagnosis by analysis of exhaled breath

Journal of Hepatology

Volumn 58, Issue 3, 2013, Pages 543-548

  Verdam, Froukje J ^a,b   Dallinga, Jan W ^a   Driessen, Ann ^c   Jonge, Charlotte De ^a,b   Moonen, Edwin J C ^a   Van Berkel, Joep B N ^a   Luijk, Jakobus ^a   Bouvy, Nicole D ^a   Buurman, Wim A ^a   Rensen, Sander S ^a   Greve, Jan Willem M ^b   Schooten, Frederik Jan Van ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b Sittard Geleen Heerlen   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Exhaled air; Liver biopsy; NAFLD; NASH; Obesity; Volatile organic compounds

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; VOLATILE ORGANIC COMPOUND;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; EXPIRED AIR; FEMALE; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER HISTOLOGY; LIVER SURGERY; MALE; MASS FRAGMENTOGRAPHY; NON INVASIVE MEASUREMENT; NONALCOHOLIC FATTY LIVER; PILOT STUDY; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC;

ADULT; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BREATH TESTS; FATTY LIVER; FEMALE; HUMANS; LIVER; MALE; MIDDLE AGED; VOLATILE ORGANIC COMPOUNDS;

EID: 84874104955     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.10.030     Document Type: Article

References (42)

1. P. Angulo Obesity and nonalcoholic fatty liver disease Nutr Rev 65 2007 S57 S63
2. G. Vernon, A. Baranova, and Z.M. Younossi Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults Aliment Pharmacol Ther 34 2011 274 285
3. E.M. Brunt Pathology of fatty liver disease Mod Pathol 20 Suppl 1 2007 S40 S48
4. H. Tilg, and A.R. Moschen Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis Hepatology 52 2010 1836 1846
5. E.M. Brunt, C.G. Janney, A.M. Di Bisceglie, B.A. Neuschwander-Tetri, and B.R. Bacon Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions Am J Gastroenterol 94 1999 2467 2474
6. D.E. Kleiner, E.M. Brunt, M. Van Natta, C. Behling, M.J. Contos, and O.W. Cummings Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 2005 1313 1321
7. A.A. Bravo, S.G. Sheth, and S. Chopra Liver biopsy N Engl J Med 344 2001 495 500
8. F. Piccinino, E. Sagnelli, G. Pasquale, and G. Giusti Complications following percutaneous liver biopsy. A multicentre retrospective study on 68,276 biopsies J Hepatol 2 1986 165 173
9. W.S. Junior, and C.B. Nonino-Borges Clinical predictors of different grades of nonalcoholic fatty liver disease Obes Surg 22 2012 248 252
10. B.A. Neuschwander-Tetri, J.M. Clark, N.M. Bass, M.L. Van Natta, A. Unalp-Arida, and J. Tonascia Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease Hepatology 52 2010 913 924
11. P. Mofrad, M.J. Contos, M. Haque, C. Sargeant, R.A. Fisher, and V.A. Luketic Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values Hepatology 37 2003 1286 1292
12. P. Paredi, S.A. Kharitonov, and P.J. Barnes Analysis of expired air for oxidation products Am J Respir Crit Care Med 166 2002 S31 S37
13. J.W. Dallinga, C.M. Robroeks, J.J. van Berkel, E.J. Moonen, R.W. Godschalk, and Q. Jobsis Volatile organic compounds in exhaled breath as a diagnostic tool for asthma in children Clin Exp Allergy 40 2010 68 76
14. J.J. Van Berkel, J.W. Dallinga, G.M. Moller, R.W. Godschalk, E.J. Moonen, and E.F. Wouters A profile of volatile organic compounds in breath discriminates COPD patients from controls Respir Med 104 2010 557 563
15. G. Millonig, S. Praun, M. Netzer, C. Baumgartner, A. Dornauer, and S. Mueller Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach: a pilot study Biomarkers 15 2010 297 306
16. M. Netzer, G. Millonig, M. Osl, B. Pfeifer, S. Praun, and J. Villinger A new ensemble-based algorithm for identifying breath gas marker candidates in liver disease using ion molecule reaction mass spectrometry Bioinformatics 25 2009 941 947
17. S.F. Solga, A. Alkhuraishe, K. Cope, A. Tabesh, J.M. Clark, and M. Torbenson Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations Biomarkers 11 2006 174 183
18. J.J. Van Berkel, J.W. Dallinga, G.M. Moller, R.W. Godschalk, E. Moonen, and E.F. Wouters Development of accurate classification method based on the analysis of volatile organic compounds from human exhaled air J Chromatogr B Analyt Technol Biomed Life Sci 861 2008 101 107
19. F.J. Verdam, J.W. Greve, S. Roosta, H. van Eijk, N. Bouvy, and W.A. Buurman Small intestinal alterations in severely obese hyperglycemic subjects J Clin Endocrinol Metab 96 2011 E379 E383
20. D.R. Dufour, J.A. Lott, F.S. Nolte, D.R. Gretch, R.S. Koff, and L.B. Seeff Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests Clin chem 46 2000 2027 2049
21. D.S. Pratt, and M.M. Kaplan Evaluation of abnormal liver-enzyme results in asymptomatic patients N Engl J Med 342 2000 1266 1271
22. F.J. Verdam, S.S. Rensen, A. Driessen, J.W. Greve, and W.A. Buurman Novel evidence for chronic exposure to endotoxin in human nonalcoholic steatohepatitis J Clin Gastroenterol 45 2011 149 152
23. X. Bossuyt Clinical performance characteristics of a laboratory test. A practical approach in the autoimmune laboratory Autoimmun Rev 8 2009 543 548
24. B.W. Camp What the clinician really needs to know: questioning the clinical usefulness of sensitivity and specificity in studies of screening tests J Dev Behav Pediatr 27 2006 226 230
25. L.A. Adams, J.F. Lymp, J. St Sauver, S.O. Sanderson, K.D. Lindor, and A. Feldstein The natural history of nonalcoholic fatty liver disease: a population-based cohort study Gastroenterology 129 2005 113 121
26. M. Ekstedt, L.E. Franzen, U.L. Mathiesen, L. Thorelius, M. Holmqvist, and G. Bodemar Long-term follow-up of patients with NAFLD and elevated liver enzymes Hepatology 44 2006 865 873
27. A.E. Feldstein, A. Wieckowska, A.R. Lopez, Y.C. Liu, N.N. Zein, and A.J. McCullough Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study Hepatology 50 2009 1072 1078
28. D. Joka, K. Wahl, S. Moeller, J. Schlue, B. Vaske, and M.J. Bahr Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis Hepatology 55 2012 455 464
29. C.D. Williams, J. Stengel, M.I. Asike, D.M. Torres, J. Shaw, and M. Contreras Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study Gastroenterology 140 2011 124 131
30. R.P. Myers, G. Pomier-Layrargues, R. Kirsch, A. Pollett, A. Duarte-Rojo, and D. Wong Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients Hepatology 55 2012 199 208
31. J. Chen, J.A. Talwalkar, M. Yin, K.J. Glaser, S.O. Sanderson, and R.L. Ehman Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography Radiology 259 2011 749 756
32. C.C. Mottin, M. Moretto, A.V. Padoin, A.M. Swarowsky, M.G. Toneto, and L. Glock The role of ultrasound in the diagnosis of hepatic steatosis in morbidly obese patients Obes Surg 14 2004 635 637
33. S. Strauss, E. Gavish, P. Gottlieb, and L. Katsnelson Interobserver and intraobserver variability in the sonographic assessment of fatty liver AJR Am J Roentgenol 189 2007 W320 W323
34. V. Ratziu, F. Charlotte, A. Heurtier, S. Gombert, P. Giral, and E. Bruckert Sampling variability of liver biopsy in nonalcoholic fatty liver disease Gastroenterology 128 2005 1898 1906
35. J. Arun, N. Jhala, A.J. Lazenby, R. Clements, and G.A. Abrams Influence of liver biopsy heterogeneity and diagnosis of nonalcoholic steatohepatitis in subjects undergoing gastric bypass Obes Surg 17 2007 155 161
36. G.J. Park, E. Wiseman, J. George, P.H. Katelaris, F. Seow, and C. Fung Non-invasive estimation of liver fibrosis in non-alcoholic fatty liver disease using the (13) C-caffeine breath test J Gastroenterol Hepatol 26 2011 1411 1416
37. M. Ligor, T. Ligor, A. Bajtarevic, C. Ager, M. Pienz, and M. Klieber Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry Clin Chem Lab Med 47 2009 550 560
38. S. Seki, T. Kitada, T. Yamada, H. Sakaguchi, K. Nakatani, and K. Wakasa In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases J Hepatol 37 2002 56 62
39. F. Pabst, W. Miekisch, P. Fuchs, S. Kischkel, and J.K. Schubert Monitoring of oxidative and metabolic stress during cardiac surgery by means of breath biomarkers: an observational study J Cardiothorac Surg 2 2007 37
40. E. Lebovics, and J. Rubin Non-alcoholic fatty liver disease (NAFLD): why you should care, when you should worry, what you should do Diabetes Metab Res Rev 27 2011 419 424
41. C.O. Zein, L.M. Yerian, P. Gogate, R. Lopez, J.P. Kirwan, and A.E. Feldstein Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial Hepatology 54 2011 1610 1619
42. R.R. Mummadi, K.S. Kasturi, S. Chennareddygari, and G.K. Sood Effect of bariatric surgery on nonalcoholic fatty liver disease: systematic review and meta-analysis Clin Gastroenterol Hepatol 6 2008 1396 1402