Exhaled volatile organic compounds predict exacerbations of childhood asthma in a 1-year prospective study

European Respiratory Journal

Volumn 42, Issue 1, 2013, Pages 98-106

  Robroeks, Charlotte M ^a   Van Berkel, Joep J ^b   Jöbsis, Quirijn ^a   Van Schooten, Frederik Jan ^b   Dallinga, Jan W ^b   Wouters, Emiel F ^a   Dompeling, Edward ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

VOLATILE ORGANIC COMPOUND;

ADOLESCENT; ARTICLE; ASTHMA; BREATH ANALYSIS; CHILD; CHILD HEALTH; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; DISEASE EXACERBATION; EXHALED NITRIC OXIDE FRACTION; EXPIRED AIR; FEMALE; FORCED EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GAS CHROMATOGRAPHY; HUMAN; MALE; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RELIABILITY; RESPIRATORY TRACT PARAMETERS; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; TIME OF FLIGHT MASS SPECTROMETRY;

ASTHMA; BREATH TESTS; CHILD; EXHALATION; FEMALE; FORCED EXPIRATORY VOLUME; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INFLAMMATION; LONGITUDINAL STUDIES; MALE; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME FACTORS; VOLATILE ORGANIC COMPOUNDS;

EID: 84880147278     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00010712     Document Type: Article

References (35)

1. Global Initiative for Asthma. Pocket guide for asthma management and prevention in children 5 years and younger. www.ginasthma.org/local/uploads/ files/GINA-Under5-Pocket-20091-1.pdf Date last accessed: May 13, 2013. Date last updated: May 2009.
2. Gustafsson PM, Watson L, Davis KJ, et al. Poor asthma control in children: evidence from epidemiological surveys and implications for clinical practice. Int J Clin Pract 2006; 60: 321-334. (Pubitemid 43337613)
3. Hammer SC, Robroeks CM, van Rij C, et al. Actual asthma control in a paediatric outpatient clinic population: do patients perceive their actual level of control? Pediatr Allergy Immunol 2008; 19: 626-633.
4. Rabe KF, Adachi M, Lai CK, et al. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol 2004; 114: 40-47. (Pubitemid 39022491)
5. O'Connell EJ. Optimizing inhaled corticosteroid therapy in children with chronic asthma. Pediatr Pulmonol 2005; 39: 74-83. (Pubitemid 39628608)
6. van Gent R, van Essen-Zandvliet LE, Rovers MM, et al. Poor perception of dyspnoea in children with undiagnosed asthma. Eur Respir J 2007; 30: 887-891. (Pubitemid 351194791)
7. Kharitonov SA, Barnes PJ. Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers 2002; 7: 1-32. (Pubitemid 34097607)
8. Kips JC, Kharitonov SA, Barnes PJ. Noninvasive assessment of airway inflammation in asthma. Eur Respir Monogr 2003; 13: 164-179.
9. Zacharasiewicz A, Wilson N, Lex C, et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med 2005; 171: 1077-1082. (Pubitemid 40663717)
10. PijnenburgMW, de Jongste JC. Exhaled nitric oxide in childhood asthma: a review. Clin Exp Allergy 2008; 38: 246-249.
11. Rahman I, Kelly F. Biomarkers in breath condensate: a promising new non-invasive technique in free radical research. Free Radic Res 2003; 37: 1253-1266. (Pubitemid 37441709)
12. Kinnula VL. Production and degradation of oxygen metabolites during inflammatory states in the human lung. Curr Drug Targets Inflamm Allergy 2005; 4: 465-470. (Pubitemid 41052411)
13. Dallinga JW, Robroeks CMHHT, Van Berkel JJ, et al. Analysis of volatile organic compounds in exhaled breath as a diagnostic tool for asthma in children. Clin Exp Allergy 2010; 40: 68-76.
14. Dragonieri S, Schot R, Mertens BJ, et al. An electronic nose in the discrimination of patients with asthma and controls. J Allergy Clin Immunol 2007; 120: 856-862. (Pubitemid 47542280)
15. De Jongste JC, Vrijlandt EJLE. Astma monitoring bij kinderen. [Asthma monitoring in children.] http://professionals.gsk.nl/content/dam/Health/nl-NL/ HCP-Home/therapiegebieden/Respiratoir-en-Allergie/Abstract%20- %20Astma%20monitoring%20E-health.pdf Date last accessed: May 13, 2013. Date last updated: 2008.
16. Robroeks CM, van Berkel JJ, Dallinga JW, et al. Metabolomics of volatile organic compounds in cystic fibrosis patients and controls. Pediatr Res 2010; 68: 75-80.
17. Van Berkel JJ, Dallinga JW, Moller GM, et al. Development of accurate classification method based on the analysis of volatile organic compounds from human exhaled air. J Chromatogr B Analyt Technol Biomed Life Sci 2008; 861: 101-107. (Pubitemid 350298064)
18. Reddel HK, Taylor DR, Bateman ED, et al. An Official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009; 180: 59-99.
19. Quanjer PH, Tammeling GJ, Cotes JE, et al. Symbols, abbreviations and units. Working Part Standardization of Lung Function Tests, European Community for Steel and Coal. Eur Respir J 1993; 6: Suppl. 16, S85-S100.
20. Stein SE, Scott DR. Optimization and Testing of Mass-Spectral Library Search Algorithms for Compound Identification. J Am Soc Mass Spectr 1994; 5: 859-866.
21. Penn DJ, Oberzaucher E, Grammer K, et al. Individual and gender fingerprints in human body odour. J R Soc Interface 2007; 4: 331-340. (Pubitemid 46513063)
22. Guyon I, Weston J, Barnhill S, et al. Gene selection for cancer classification using support vector machines. Machine Learning 2002; 46: 389-422. (Pubitemid 34129977)
23. Frank E, Hall M, Trigg L, et al. Data mining in bioinformatics using Weka. Bioinformatics 2004; 20: 2479-2481. (Pubitemid 39429925)
24. Platt JC. Fast training of support vectormachines using sequential minimal optimization. Cambridge, MIT Press, 1998.
25. Ibrahim B, Basanta M, Cadden P, et al. Non-invasive phenotyping using exhaled volatile organic compounds in asthma. Thorax 2011; 66: 804-809.
26. Fritsch M, Uxa S, Horak F Jr, et al. Exhaled nitric oxide in the management of childhood asthma: a prospective 6-months study. Pediatr Pulmonol 2006; 41: 855-862. (Pubitemid 44300181)
27. Pijnenburg MW, Hofhuis W, Hop WC, et al. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax 2005; 60: 215-218. (Pubitemid 40380280)
28. Silvestri M, Sabatini F, Spallarossa D, et al. Exhaled nitric oxide levels in non-allergic and allergic mono-or polysensitised children with asthma. Thorax 2001; 56: 857-862. (Pubitemid 32999833)
29. Steyerberg EW, Bleeker SE, Moll HA, et al. Internal and external validation of predictive models: a simulation study of bias and precision in small samples. J Clin Epidemiol 2003; 56: 441-447. (Pubitemid 36694096)
30. Sanchez JM, Sacks RD. Development of a multibed sorption trap, comprehensive two-dimensional gas chromatography, and time-of-flight mass spectrometry system for the analysis of volatile organic compounds in human breath. Anal Chem 2006; 78: 3046-3054. (Pubitemid 43726124)
31. Ashley DL, Bonin MA, Hamar B, et al. Using the blood concentration of 2,5-dimethylfuran as a marker for smoking. Int Arch Occup Environ Health 1996; 68: 183-187. (Pubitemid 26079737)
32. Corradi M, Pignatti P, Manini P, et al. Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation. Eur Respir J 2004; 24: 1011-1017. (Pubitemid 39642294)
33. Lex C, Zacharasiewicz A, Payne DN, et al. Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study. Respir Res 2006; 7: 63.
34. Paredi P, Kharitonov SA, Leak D, et al. Exhaled ethane, a marker of lipid peroxidation, is elevated in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000; 162: 369-373. (Pubitemid 30647168)
35. PhillipsM,Herrera J,KrishnanS, et al.Variation in volatile organic compounds in the breath of normal humans.J Chromatogr B Biomed Sci Appl 1999; 729: 75-88. (Pubitemid 29264111)