Breathprints of model murine bacterial lung infections are linked with immune response

European Respiratory Journal

Volumn 45, Issue 1, 2015, Pages 181-190

  Bean, Heather D ^a   Jiménez Díaz, Jaime ^b   Zhu, Jiangjiang ^b   Hill, Jane E ^a  

^a DARTMOUTH COLLEGE   (United States)

^b School of Engineering University of Vermont ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; LACTATE DEHYDROGENASE; VOLATILE AGENT; VOLATILE ORGANIC COMPOUND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CELL; BACTERIAL INFECTION; BREATH ANALYSIS; CELL LYSATE; CONTROLLED STUDY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DISEASE MODEL; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; EXPLORATORY RESEARCH; IMMUNE RESPONSE; LEUKOCYTE COUNT; LUNG INFECTION; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PREDICTION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SECONDARY ELECTROSPRAY IONISATION MASS SPECTROMETRY BREATHPRINT; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; ANIMAL; BACTERIAL PNEUMONIA; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CHEMISTRY; DISCRIMINANT ANALYSIS; IMMUNOLOGY; LEAST SQUARE ANALYSIS; LUNG; LUNG DISEASES; METABOLISM; MICROBIOLOGY; NEUTROPHIL;

ANIMALS; BACTERIAL INFECTIONS; BREATH TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISCRIMINANT ANALYSIS; DISEASE MODELS, ANIMAL; L-LACTATE DEHYDROGENASE; LEAST-SQUARES ANALYSIS; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED C57BL; NEUTROPHILS; PNEUMONIA, BACTERIAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VOLATILE ORGANIC COMPOUNDS;

EID: 84920591709     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00015814     Document Type: Article

References (31)

1. Broza YY, Haick H. Nanomaterial-based sensors for detection of disease by volatile organic compounds. Nanomedicine 2013; 8: 785-806.
2. Bijland LR, Bomers MK, Smulders YM. Smelling the diagnosis: a review on the use of scent in diagnosing disease. Neth J Med 2013; 71: 300-307.
3. Boots AW, van Berkel JJBN, Dallinga JW, et al. The versatile use of exhaled volatile organic compounds in human health and disease. J Breath Res 2012; 6: 027108.
4. Dummer J, Storer M, Swanney M, et al. Analysis of biogenic volatile organic compounds in human health and disease. Trends Anal Chem 2011; 30: 960-967.
5. Pleil JD, Stiegel MA. Evolution of environmental exposure science: using breath-borne biomarkers for "discovery" of the human exposome. Anal Chem 2013; 85: 9984-9990.
6. Amann A, Corradi M, Mazzone P, et al. Lung cancer biomarkers in exhaled breath. Expert Rev Mol Diagn 2011; 11: 207-217.
7. Haick H, Broza YY, Mochalski P, et al. Assessment, origin, and implementation of breath volatile cancer markers. Chem Soc Rev 2014; 43: 1423-1449.
8. Buszewski B, Grzywinski D, Ligor T, et al. Detection of volatile organic compounds as biomarkers in breath analysis by different analytical techniques. Bioanalysis 2013; 5: 2287-2306.
9. Phillips M, Herrera J, Krishnan S, et al. Variation in volatile organic compounds in the breath of normal humans. J Chrom B 1999; 729: 75-88.
10. Bean HD, Zhu J, Hill JE. Characterizing bacterial volatiles using secondary electrospray ionization mass spectrometry (SESI-MS). J Vis Exp 2011; 52: 2664.
11. Zhu J, Jiménez-Díaz J, Bean HD, et al. Robust detection of P. aeruginosa and S. aureus acute lung infections by secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting: from initial infection to clearance. J Breath Res 2013; 7: 037106.
12. Zhu J, Bean HD, Jiménez-Díaz J, et al. Secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting of multiple bacterial lung pathogens, a mouse model study. J Appl Physiol 2013; 114: 1544-1549.
13. Zhu J, Bean HD, Kuo YM, et al. Fast detection of volatile organic compounds from bacterial cultures by SESI-MS. J Clin Microbiol 2010; 48: 4426-4431.
14. Zhu J, Bean HD, Wargo MJ, et al. Detecting bacterial lung infections: in vivo evaluation of in vitro volatile fingerprints. J Breath Res 2013; 7: 016003.
15. Allard JB, Rinaldi L, Wargo MJ, et al. Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products. Eur J Immunol 2009; 39: 776-788.
16. Wold S, Sjöström M, Eriksson L. PLS-regression: a basic tool of chemometrics. Chemometrics Intellig Lab Syst 2001; 58: 109-130.
17. Jun CH, Sang-Ho L, Hae-Sang P, et al. Use of partial least squares regression for variable selection and quality prediction. In: International Conference on Computers & Industrial Engineering. New York, IEEE, 2009; pp. 1302-1307.
18. Kohavi R. A study of cross-validation and bootstrap for accuracy estimation and model selection. In: Proceedings of the 14th International Joint Conference on Artificial Intelligence -volume 2. Montreal, Morgan Kaufmann Publishers Inc., 1995; pp. 1137-1143.
19. Cross LJM, Matthay MA. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin 2011; 27: 355-377.
20. Proudfoot AG, Hind M, Griffiths MJ. Biomarkers of acute lung injury: worth their salt?. BMC Med 2011; 9: 132.
21. Sagel SD, Chmiel JF, Konstan MW. Sputum biomarkers of inflammation in cystic fibrosis lung disease. Proc Am Thorac Soc 2007; 4: 406-417.
22. Liang Y, Yeligar SM, Brown LA. Exhaled breath condensate: a promising source for biomarkers of lung disease. ScientificWorldJournal 2012; 2012: 217518.
23. Centers for Disease Controland Prevention. Epidemiology and prevention of vaccine-preventable diseases. 12th Edn. Washington, Public Health Foundation, 2012.
24. Siegel JD, Rhinehart E, Jackson M, et al. 2007 guideline for isolation precautions: preventing transmission of infectious agents in health care settings. Am J Infect Control 2007; 35: S65-S164.
25. Walzl G, Ronacher K, Hanekom W, et al. Immunological biomarkers of tuberculosis. Nat Rev Immunol 2011; 11: 343-354.
26. Gideon HP, Flynn JL. Latent tuberculosis: what the host "sees"? Immunol Res 2011; 50: 202-212.
27. Gibbs K, Holzman IR. Endotracheal tube: friend or foe? Bacteria, the endotracheal tube, and the impact of colonization and infection. Semin Perinatol 2012; 36: 454-461.
28. Mandalakas AM, van Wyk S, Kirchner HL, et al. Detecting tuberculosis infection in HIV-infected children: a study of diagnostic accuracy, confounding and interaction. Pediatr Infect Dis J 2013; 32: E111-E118.
29. Bhargava M, Wendt CH. Biomarkers in acute lung injury. Transl Res 2012; 159: 205-217.
30. Robroeks CM, van Berkel JJ, Jobsis Q, et al. Exhaled volatile organic compounds predict exacerbations of childhood asthma in a 1-year prospective study. Eur Respir J 2013; 42: 98-106.
31. Kash JC, Walters KA, Davis AS, et al. Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses. MBio 2011; 2: e00172-11.