Microglia induce neurotoxic IL-17+ γδ T cells dependent on TLR2, TLR4, and TLR9 activation

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Derkow, Katja ^a   Krüger, Christina ^a   Dembny, Paul ^a   Lehnardt, Seija ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 23; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; IL1B PROTEIN, MOUSE; IL23A PROTEIN, MOUSE; INTERLEUKIN 23P19; LECTIN; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; MYD88 PROTEIN, MOUSE; T LYMPHOCYTE ANTIGEN; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE; TLR7 PROTEIN, MOUSE; TLR9 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL INTERACTION; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GAMMA DELTA T LYMPHOCYTE; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; IN VITRO STUDY; LIGAND BINDING; LYMPHOCYTE ACTIVATION; MALE; MICROGLIA; MOUSE; NERVE CELL; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; SUPERNATANT; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVATION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PATHOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TH17 CELL;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELLS, CULTURED; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME ACTIVATION; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-23 SUBUNIT P19; LECTINS, C-TYPE; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; MYELOID DIFFERENTIATION FACTOR 88; NEURONS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC; TH17 CELLS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9;

EID: 84942437107     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135898     Document Type: Article

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