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Volumn 173, Issue 1, 2004, Pages 682-694

γδ T cells enhance the expression of experimental autoimmune encephalomyelitis by promoting antigen presentation and IL-12 production

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD11B ANTIGEN; CD19 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 12; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 2942718822     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.1.682     Document Type: Article
Times cited : (63)

References (56)
  • 1
    • 0028840828 scopus 로고
    • Experimental autoimmune encephalomyelitis in rodents as a model of demyelinating diseases
    • Swanborg, R. H. 1995. Experimental autoimmune encephalomyelitis in rodents as a model of demyelinating diseases. Clin. Immunol. Immunopathol. 77:4.
    • (1995) Clin. Immunol. Immunopathol. , vol.77 , pp. 4
    • Swanborg, R.H.1
  • 2
    • 0000179231 scopus 로고    scopus 로고
    • Demyelinating diseases
    • R. L. Davis and D. M. Robertson, eds. Williams & Wilkins, Baltimore
    • Raine, C. S. 1997. Demyelinating diseases. In Textbook of Neuropathology, 3rd Ed. R. L. Davis and D. M. Robertson, eds. Williams & Wilkins, Baltimore, p. 243.
    • (1997) Textbook of Neuropathology, 3rd Ed. , pp. 243
    • Raine, C.S.1
  • 3
    • 0011366949 scopus 로고
    • The isolation from bovine spinal cord of homogenous protein with encephalitogenic activity
    • Einstein, E. R., D. M. Robertson, J. M. DiCarpio, and W. Moore. 1962. The isolation from bovine spinal cord of homogenous protein with encephalitogenic activity. J. Neurochem. 9:353.
    • (1962) J. Neurochem. , vol.9 , pp. 353
    • Einstein, E.R.1    Robertson, D.M.2    DiCarpio, J.M.3    Moore, W.4
  • 4
    • 0019997219 scopus 로고
    • Chronic experimental allergic encephalomyelitis induced in rabbits with bovine white matter proteolipid apoprotein
    • Willims, R. M., M. B. Lees, F. Cambi, and W. B. Macklin. 1982. Chronic experimental allergic encephalomyelitis induced in rabbits with bovine white matter proteolipid apoprotein. J. Neuropathol. Exp. Neurol. 41:508.
    • (1982) J. Neuropathol. Exp. Neurol. , vol.41 , pp. 508
    • Willims, R.M.1    Lees, M.B.2    Cambi, F.3    Macklin, W.B.4
  • 5
    • 0029038922 scopus 로고
    • A myelin oligodendrocyte glycoprotein induces typical chronic experimental autoimmune encephalomyelitis in H2-b mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells
    • Mendel, I., N. Kerlero de Rosobo, and A. Ben-Nun. 1995. A myelin oligodendrocyte glycoprotein induces typical chronic experimental autoimmune encephalomyelitis in H2-b mice: fine specificity and T cell receptor Vβ expression of encephalitogenic T cells. Eur. J. Immunol. 25:1951.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1951
    • Mendel, I.1    Kerlero De Rosobo, N.2    Ben-Nun, A.3
  • 6
    • 0021328623 scopus 로고
    • Adoptive transfer of myelin basic protein-sensitized T cells produce chronic relapsing demyelinating disease in mice
    • Mokhtarian, F., D. E. McFarlin, and C. S. Raine. 1984. Adoptive transfer of myelin basic protein-sensitized T cells produce chronic relapsing demyelinating disease in mice. Nature 309:336.
    • (1984) Nature , vol.309 , pp. 336
    • Mokhtarian, F.1    McFarlin, D.E.2    Raine, C.S.3
  • 7
    • 0025246367 scopus 로고
    • The T lymphocyte in experimental allergic encephalomyelitis
    • Zamvil, S. S., and L. Steinman. 1992. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8:579.
    • (1992) Annu. Rev. Immunol. , vol.8 , pp. 579
    • Zamvil, S.S.1    Steinman, L.2
  • 8
    • 0021186832 scopus 로고
    • Experimental allergic encephalomyelitis: Successful treatment in vivo with monoclonal antibody that recognizes T helper cells
    • Brostoff, S. W., and D. W. Manson. 1984. Experimental allergic encephalomyelitis: successful treatment in vivo with monoclonal antibody that recognizes T helper cells. J. Immunol. 133:1938.
    • (1984) J. Immunol. , vol.133 , pp. 1938
    • Brostoff, S.W.1    Manson, D.W.2
  • 9
    • 0035801475 scopus 로고    scopus 로고
    • Myelin-specific CD8 T cells in pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis
    • Steinman, L. 2001. Myelin-specific CD8 T cells in pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. J. Exp. Med. 194:F27.
    • (2001) J. Exp. Med. , vol.194
    • Steinman, L.1
  • 10
    • 0032729174 scopus 로고    scopus 로고
    • B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide
    • Lyons, J. A., M. San, M. P. Happ, and A. H. Cross. 1999. B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide. Eur. J. Immunol. 29:3432.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 3432
    • Lyons, J.A.1    San, M.2    Happ, M.P.3    Cross, A.H.4
  • 11
    • 0030712367 scopus 로고    scopus 로고
    • Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells
    • Zhang, B., T. Yamamura, T. Kondo, M. Fujiwara, and T. Tabira. 1997. Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J. Exp. Med. 186:1677.
    • (1997) J. Exp. Med. , vol.186 , pp. 1677
    • Zhang, B.1    Yamamura, T.2    Kondo, T.3    Fujiwara, M.4    Tabira, T.5
  • 12
    • 0029901881 scopus 로고
    • A pathoganic role for γδ T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse
    • Rajan, A. J., Y.-L. Gao, C. S. Raine, and C. F. Brosnan. 1995. A pathoganic role for γδ T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse. J. Immunol. 157:941.
    • (1995) J. Immunol. , vol.157 , pp. 941
    • Rajan, A.J.1    Gao, Y.-L.2    Raine, C.S.3    Brosnan, C.F.4
  • 13
    • 0032736525 scopus 로고    scopus 로고
    • Decreased severity of myelin oligodendrocyte glycoprotein peptide 33-35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR δ chain gene
    • Spahn, T. W., S. Issazadah, A. I. Salvin, and H. L. Weiner. 1999. Decreased severity of myelin oligodendrocyte glycoprotein peptide 33-35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR δ chain gene. Eur. J. Immunol. 29:4060.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 4060
    • Spahn, T.W.1    Issazadah, S.2    Salvin, A.I.3    Weiner, H.L.4
  • 18
    • 0031881034 scopus 로고    scopus 로고
    • Role of γδ T lymphocytes in immune response in humans and mice
    • Salerno, A., and F. Dieli. 1998. Role of γδ T lymphocytes in immune response in humans and mice. Crit. Rev. Immunol. 18:327.
    • (1998) Crit. Rev. Immunol. , vol.18 , pp. 327
    • Salerno, A.1    Dieli, F.2
  • 19
    • 0029864606 scopus 로고    scopus 로고
    • γ/δ and other unconventional T lymphocytes: What do they see and what do they do?
    • Kaufmann, S. H. 1996. γ/δ and other unconventional T lymphocytes: what do they see and what do they do? Proc. Natl. Acad. Sci. USA 93:2272.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2272
    • Kaufmann, S.H.1
  • 21
    • 0031831629 scopus 로고    scopus 로고
    • Crucial role of TCRγ chain junctional region in prenyl pyrophosphate antigen recognition by γδ T cells
    • Bukowski, J. K., C. T. Morita, H. Band, and M. B. Brenner. 1998. Crucial role of TCRγ chain junctional region in prenyl pyrophosphate antigen recognition by γδ T cells. J. Immunol. 161:286.
    • (1998) J. Immunol. , vol.161 , pp. 286
    • Bukowski, J.K.1    Morita, C.T.2    Band, H.3    Brenner, M.B.4
  • 23
    • 0030467957 scopus 로고    scopus 로고
    • Thymic and extrathymic T cell development
    • Leclercq, G., and J. Plum. 1996. Thymic and extrathymic T cell development. Leukemia 10:1853.
    • (1996) Leukemia , vol.10 , pp. 1853
    • Leclercq, G.1    Plum, J.2
  • 24
    • 0028113359 scopus 로고
    • Recognition and destruction of virus-infected cells by human γδ CTL
    • Bukowski, J. K., C. T. Morita, and M. B. Brenner. 1994. Recognition and destruction of virus-infected cells by human γδ CTL. J. Immunol. 153:5133.
    • (1994) J. Immunol. , vol.153 , pp. 5133
    • Bukowski, J.K.1    Morita, C.T.2    Brenner, M.B.3
  • 25
    • 0031446766 scopus 로고    scopus 로고
    • γδ cells regulate autoimmunity
    • Hayday, A., and L. Geng. 1997. γδ cells regulate autoimmunity. Curr. Opin. Immunol. 9:884.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 884
    • Hayday, A.1    Geng, L.2
  • 26
    • 0030589323 scopus 로고    scopus 로고
    • Propagation and regulation of systemic autoimmunity by γδ T cells
    • Peng, S. L., M. P. Madaio, A. C. Hayday, and J. Craft. 1996. Propagation and regulation of systemic autoimmunity by γδ T cells. J. Immunol. 157:5689.
    • (1996) J. Immunol. , vol.157 , pp. 5689
    • Peng, S.L.1    Madaio, M.P.2    Hayday, A.C.3    Craft, J.4
  • 29
    • 0031569452 scopus 로고    scopus 로고
    • γδ T lymphocytes regulate the induction and maintenance of oral tolerance
    • Ke, Y., K. Pearce, J. P. Lake, H. K. Ziegler, and J. Kapp. 1997. γδ T lymphocytes regulate the induction and maintenance of oral tolerance. J. Immunol. 158:3610.
    • (1997) J. Immunol. , vol.158 , pp. 3610
    • Ke, Y.1    Pearce, K.2    Lake, J.P.3    Ziegler, H.K.4    Kapp, J.5
  • 30
    • 0030442650 scopus 로고    scopus 로고
    • γδ T cells from tolerized αβ T cell receptor (TCR)-deficient mice inhibit contact sensitivity-effector T cells in vivo and their interferon-γ production in vitro
    • Szczepanik, M., L. R. Anderson, H. Ushio, W. Ptak, M. J. Owen, A. C. Hayday, and P. W. Askenase. 1996. γδ T cells from tolerized αβ T cell receptor (TCR)-deficient mice inhibit contact sensitivity-effector T cells in vivo and their interferon-γ production in vitro. J. Exp. Med. 184:2129.
    • (1996) J. Exp. Med. , vol.184 , pp. 2129
    • Szczepanik, M.1    Anderson, L.R.2    Ushio, H.3    Ptak, W.4    Owen, M.J.5    Hayday, A.C.6    Askenase, P.W.7
  • 31
    • 0028986903 scopus 로고
    • γδ T cells in normal spleen assist immunized αβ T cells in adoptive cell transfer of contact sensitivity: Effect of Bordetella pertussis, cyclophosphamide, and antibodies to determinants of suppressor cells
    • Askenase, P. W., M. Szczepanik, M. Ptak, V. Paliwal, and W. Ptak. 1995. γδ T cells in normal spleen assist immunized αβ T cells in adoptive cell transfer of contact sensitivity: effect of Bordetella pertussis, cyclophosphamide, and antibodies to determinants of suppressor cells. J. Immunol. 154:3644.
    • (1995) J. Immunol. , vol.154 , pp. 3644
    • Askenase, P.W.1    Szczepanik, M.2    Ptak, M.3    Paliwal, V.4    Ptak, W.5
  • 32
    • 0027504459 scopus 로고
    • Crosstalk between α/β T cells and γ/δ cells in vivo: Activation of α/β T cell response after γ/δ T cell modulation with the monoclonal antibody GL3
    • Kaufmann, S. H. E., C. Blum, and S. Yamamoto. 1993. Crosstalk between α/β T cells and γ/δ cells in vivo: activation of α/β T cell response after γ/δ T cell modulation with the monoclonal antibody GL3. Proc. Natl. Acad. Sci. USA 90:9620.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9620
    • Kaufmann, S.H.E.1    Blum, C.2    Yamamoto, S.3
  • 33
    • 0032519462 scopus 로고    scopus 로고
    • Primary γδ cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation
    • Wen, L., D. F. Barber, W. Pao, F. S. Wong, M. Owen, and A. Hayday. 1998. Primary γδ cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation. J. Immunol. 160:1965.
    • (1998) J. Immunol. , vol.160 , pp. 1965
    • Wen, L.1    Barber, D.F.2    Pao, W.3    Wong, F.S.4    Owen, M.5    Hayday, A.6
  • 34
    • 0031027035 scopus 로고    scopus 로고
    • Sentinel function of broadly reactive human γδ T cells
    • De Libero, G. 1997. Sentinel function of broadly reactive human γδ T cells. Immunol. Today 18:22.
    • (1997) Immunol. Today , vol.18 , pp. 22
    • De Libero, G.1
  • 35
    • 0034176189 scopus 로고    scopus 로고
    • Inhibitory MHC class I receptors on γδ T cells in tumor immunity and autoimmunity
    • Fisch, P., A. Moris, H.-G. Rammensee, and R. Handgretinger. 2000. Inhibitory MHC class I receptors on γδ T cells in tumor immunity and autoimmunity. Immunol. Today 21:187.
    • (2000) Immunol. Today , vol.21 , pp. 187
    • Fisch, P.1    Moris, A.2    Rammensee, H.-G.3    Handgretinger, R.4
  • 37
    • 0030016525 scopus 로고    scopus 로고
    • Multiple sclerosis: A protective or a pathogenic role for heat shock protein 60 in the central nervous system
    • Raine, C. S., E. Wu, and C. F. Brosnan. 1996. Multiple sclerosis: a protective or a pathogenic role for heat shock protein 60 in the central nervous system. Lab. Invest. 75:109.
    • (1996) Lab. Invest. , vol.75 , pp. 109
    • Raine, C.S.1    Wu, E.2    Brosnan, C.F.3
  • 38
    • 0028886407 scopus 로고
    • γδ T cell receptor variable region usage during the development of experimental allergic encephalomyelitis
    • Olive, C. 1995. γδ T cell receptor variable region usage during the development of experimental allergic encephalomyelitis. J. Neuroimmunol. 62:1.
    • (1995) J. Neuroimmunol. , vol.62 , pp. 1
    • Olive, C.1
  • 39
    • 0025790237 scopus 로고
    • Peripheral blood γ-δ T cells lyse fresh human brain-derived oligodendrocytes
    • Freedman, M. S., T. C. G. Ruijs, L. K. Selin, and J. P. Antel. 1991. Peripheral blood γ-δ T cells lyse fresh human brain-derived oligodendrocytes, Ann. Neurol. 30:794.
    • (1991) Ann. Neurol. , vol.30 , pp. 794
    • Freedman, M.S.1    Ruijs, T.C.G.2    Selin, L.K.3    Antel, J.P.4
  • 40
    • 2942708652 scopus 로고    scopus 로고
    • The effect of γδ T cell depletion on cytokine gene expression in experimental in experimental allergic encephalomyelitis
    • Rajan, A. J., J. D. Klein, and C. F. Brosnan. 1998. The effect of γδ T cell depletion on cytokine gene expression in experimental in experimental allergic encephalomyelitis. J. Immunol. 160:595.
    • (1998) J. Immunol. , vol.160 , pp. 595
    • Rajan, A.J.1    Klein, J.D.2    Brosnan, C.F.3
  • 41
    • 0034651922 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis on SJL mouse: Effect of γδ T cell depletion on chemokine and chemokine receptor expression in the central nervous system
    • Rajan, A. J., V. C. Asensio, I. L. Campbell, and C. F. Brosnan. 2000. Experimental autoimmune encephalomyelitis on SJL mouse: effect of γδ T cell depletion on chemokine and chemokine receptor expression in the central nervous system. J. Immunol. 164:2120.
    • (2000) J. Immunol. , vol.164 , pp. 2120
    • Rajan, A.J.1    Asensio, V.C.2    Campbell, I.L.3    Brosnan, C.F.4
  • 42
    • 0031891702 scopus 로고    scopus 로고
    • Adoptively transferred EAE in γδ T cell-knockout mice
    • Clark, R. B., and E. G. Lingenheld. 1997. Adoptively transferred EAE in γδ T cell-knockout mice. J. Autoimmun. 11:105.
    • (1997) J. Autoimmun. , vol.11 , pp. 105
    • Clark, R.B.1    Lingenheld, E.G.2
  • 43
    • 0023212939 scopus 로고
    • Response of rat encephalitogenic T lymphocytes lines to synthetic peptides of myelin basic protein
    • Offner, H., G. Hashim, and A. A. Vandernbark. 1987. Response of rat encephalitogenic T lymphocytes lines to synthetic peptides of myelin basic protein. J. Neurosci. Res. 17:344.
    • (1987) J. Neurosci. Res. , vol.17 , pp. 344
    • Offner, H.1    Hashim, G.2    Vandernbark, A.A.3
  • 44
    • 0023571529 scopus 로고
    • Adoptively transferred acute and chronic relapsing autoimmune encephalomyelitis in the PL/J mouse and observations on altered pathology by intercurrent virus infection
    • Cross, A. H., R. McCarron, D. E. McFarlin, and C. S. Raine. 1987. Adoptively transferred acute and chronic relapsing autoimmune encephalomyelitis in the PL/J mouse and observations on altered pathology by intercurrent virus infection. Lab. Invest. 57:499.
    • (1987) Lab. Invest. , vol.57 , pp. 499
    • Cross, A.H.1    McCarron, R.2    McFarlin, D.E.3    Raine, C.S.4
  • 46
    • 0035544358 scopus 로고    scopus 로고
    • γδ T cells express activation markers in the central nervous system of mice with chronic-relapsing experimental autoimmune encephalomyelitis
    • Gao, Y. L., A. J. Rajan, C. S. Raine, and C. F. Brosnan. 2001. γδ T cells express activation markers in the central nervous system of mice with chronic-relapsing experimental autoimmune encephalomyelitis. J. Autoimmun. 17:261.
    • (2001) J. Autoimmun. , vol.17 , pp. 261
    • Gao, Y.L.1    Rajan, A.J.2    Raine, C.S.3    Brosnan, C.F.4
  • 47
    • 0033233286 scopus 로고    scopus 로고
    • Evidence for γδ T cells with a restricted Vγ6 junctional region in the normal mouse central nervous system
    • Szymanska, B., A. J. Rajan, Y. L. Gao, E. Tronczynska, C. F. Brosnan, and K. Selmaj. 1999. Evidence for γδ T cells with a restricted Vγ6 junctional region in the normal mouse central nervous system. J. Neuroimmunol. 100:260.
    • (1999) J. Neuroimmunol. , vol.100 , pp. 260
    • Szymanska, B.1    Rajan, A.J.2    Gao, Y.L.3    Tronczynska, E.4    Brosnan, C.F.5    Selmaj, K.6
  • 49
    • 0030056468 scopus 로고    scopus 로고
    • Models of T cell anergy: Is there a common molecular mechanism?
    • Schwartz, R. H. 1996. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1.
    • (1996) J. Exp. Med. , vol.184 , pp. 1
    • Schwartz, R.H.1
  • 50
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7:CTLA-4 costimulatory pathways in autoimmunity and transplantation
    • Salomon, B., and J. A. Bluestone. 2001. Complexities of CD28/B7:CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19:225.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 225
    • Salomon, B.1    Bluestone, J.A.2
  • 51
    • 0036155874 scopus 로고    scopus 로고
    • CD40L in autoimmunity and mucosally induced tolerance
    • Kweon, M., and H. Kiyono. 2002. CD40L in autoimmunity and mucosally induced tolerance. J. Clin. Invest. 109:171.
    • (2002) J. Clin. Invest. , vol.109 , pp. 171
    • Kweon, M.1    Kiyono, H.2
  • 52
    • 0033458806 scopus 로고    scopus 로고
    • The critical role of IL-12 and the IL-12Rβ2 subunit in the generation of pathogenic autoreactive Th1 cells
    • Shevach, E. M., J. T. Chang, and B. M. Segal. 1999. The critical role of IL-12 and the IL-12Rβ2 subunit in the generation of pathogenic autoreactive Th1 cells. Springer Semin. Immunopathol. 21:249.
    • (1999) Springer Semin. Immunopathol. , vol.21 , pp. 249
    • Shevach, E.M.1    Chang, J.T.2    Segal, B.M.3
  • 54
    • 0034975741 scopus 로고    scopus 로고
    • Two-step activation of T cells, clonal expansion and subsequent Th1 cytokine production, is essential for the development of clinical autoimmune encephalomyelitis
    • Jee, Y., and Y. Matsumoto. 2001. Two-step activation of T cells, clonal expansion and subsequent Th1 cytokine production, is essential for the development of clinical autoimmune encephalomyelitis. Eur. J. Immunol. 31:1800.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1800
    • Jee, Y.1    Matsumoto, Y.2
  • 55
    • 0032528896 scopus 로고    scopus 로고
    • Elevated inteleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy
    • Comabella, M., K. Balashov, S. Issazadeh, D. Smith, H. L. Weiner, and S. J. Khoury. 1998. Elevated inteleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. J. Clin. Invest. 102:671.
    • (1998) J. Clin. Invest. , vol.102 , pp. 671
    • Comabella, M.1    Balashov, K.2    Issazadeh, S.3    Smith, D.4    Weiner, H.L.5    Khoury, S.J.6
  • 56
    • 0033136305 scopus 로고    scopus 로고
    • Decreased IL-12 production underlies the decreased ability of male lymph node cells to induce experimental autoimmune encephalomyelitis
    • Kim, S., and R. R. Voskuhl. 1999. Decreased IL-12 production underlies the decreased ability of male lymph node cells to induce experimental autoimmune encephalomyelitis. J. Immunol. 162:5561.
    • (1999) J. Immunol. , vol.162 , pp. 5561
    • Kim, S.1    Voskuhl, R.R.2


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