-
1
-
-
65349107082
-
KRAS mutations in non-small cell lung cancer
-
G.J. Riely, J. Marks, W. Pao KRAS mutations in non-small cell lung cancer Proc Am Thorac Soc 6 2009 201 205
-
(2009)
Proc Am Thorac Soc
, vol.6
, pp. 201-205
-
-
Riely, G.J.1
Marks, J.2
Pao, W.3
-
2
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
J.L. Bos Ras oncogenes in human cancer: a review Cancer Res 49 1989 4682 4689
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
3
-
-
0036894746
-
BRAF and RAS mutations in human lung cancer and melanoma
-
M.S. Brose, P. Volpe, M. Feldman BRAF and RAS mutations in human lung cancer and melanoma Cancer Res 62 2002 6997 7000
-
(2002)
Cancer Res
, vol.62
, pp. 6997-7000
-
-
Brose, M.S.1
Volpe, P.2
Feldman, M.3
-
4
-
-
0023619575
-
A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants
-
M. Trahey, F. McCormick A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants Science 238 1987 542 545
-
(1987)
Science
, vol.238
, pp. 542-545
-
-
Trahey, M.1
McCormick, F.2
-
5
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
H. Shigematsu, L. Lin, T. Takahashi Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers J Natl Cancer Inst 97 2005 339 346
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
-
6
-
-
10844231985
-
Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
-
T. Kosaka, Y. Yatabe, H. Endoh Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications Cancer Res 64 2004 8919 8923
-
(2004)
Cancer Res
, vol.64
, pp. 8919-8923
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
-
7
-
-
23844490782
-
Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
-
M. Taron, Y. Ichinose, R. Rosell Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas Clin Cancer Res 11 2005 5878 5885
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5878-5885
-
-
Taron, M.1
Ichinose, Y.2
Rosell, R.3
-
8
-
-
77956805993
-
KRAS gene mutations in lung cancer: Particulars established and issues unresolved
-
K. Okudela, T. Woo, H. Kitamura KRAS gene mutations in lung cancer: particulars established and issues unresolved Pathol Int 60 2010 651 660
-
(2010)
Pathol Int
, vol.60
, pp. 651-660
-
-
Okudela, K.1
Woo, T.2
Kitamura, H.3
-
9
-
-
78149249388
-
Personalized medicine in non-small-cell lung cancer: Is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy?
-
P.J. Roberts, T.E. Stinchcombe, C.J. Der Personalized medicine in non-small-cell lung cancer: is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy? J Clin Oncol 28 2010 4769 4777
-
(2010)
J Clin Oncol
, vol.28
, pp. 4769-4777
-
-
Roberts, P.J.1
Stinchcombe, T.E.2
Der, C.J.3
-
10
-
-
84863273943
-
Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability
-
K.L. Thu, E.A. Vucic, R. Chari Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability PLoS ONE 7 2012 e33003
-
(2012)
PLoS ONE
, vol.7
, pp. 33003
-
-
Thu, K.L.1
Vucic, E.A.2
Chari, R.3
-
11
-
-
77955096407
-
KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: A meta-analysis of 22 studies
-
C. Mao, L.X. Qiu, R.Y. Liao KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: a meta-analysis of 22 studies Lung Cancer 69 2010 272 278
-
(2010)
Lung Cancer
, vol.69
, pp. 272-278
-
-
Mao, C.1
Qiu, L.X.2
Liao, R.Y.3
-
12
-
-
20444480258
-
TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: Distinct patterns in never, former, and current smokers
-
F. Le Calvez, A. Mukeria, J.D. Hunt TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers Cancer Res 65 2005 5076 5083
-
(2005)
Cancer Res
, vol.65
, pp. 5076-5083
-
-
Le Calvez, F.1
Mukeria, A.2
Hunt, J.D.3
-
13
-
-
53249145767
-
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
-
G.J. Riely, M.G. Kris, D. Rosenbaum Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma Clin Cancer Res 14 2008 5731 5734
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5731-5734
-
-
Riely, G.J.1
Kris, M.G.2
Rosenbaum, D.3
-
14
-
-
0032975370
-
Prognostic significance of K-ras codon 12 mutations in patients with resected stage i and II non-small-cell lung cancer
-
S.L. Graziano, G.P. Gamble, N.B. Newman Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer J Clin Oncol 17 1999 668 675
-
(1999)
J Clin Oncol
, vol.17
, pp. 668-675
-
-
Graziano, S.L.1
Gamble, G.P.2
Newman, N.B.3
-
15
-
-
9044221762
-
Detection of K-ras mutations in lung carcinomas: Relationship to prognosis
-
P. Keohavong, M.A. DeMichele, A.C. Melacrinos Detection of K-ras mutations in lung carcinomas: relationship to prognosis Clin Cancer Res 2 1996 411 418
-
(1996)
Clin Cancer Res
, vol.2
, pp. 411-418
-
-
Keohavong, P.1
Demichele, M.A.2
Melacrinos, A.C.3
-
16
-
-
16544386625
-
Prognostic factors in resected stage i non-small-cell lung cancer: A multivariate analysis of six molecular markers
-
C. Lu, J.C. Soria, X. Tang Prognostic factors in resected stage I non-small-cell lung cancer: a multivariate analysis of six molecular markers J Clin Oncol 22 2004 4575 4583
-
(2004)
J Clin Oncol
, vol.22
, pp. 4575-4583
-
-
Lu, C.1
Soria, J.C.2
Tang, X.3
-
17
-
-
0025074419
-
K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung
-
R.J. Slebos, R.E. Kibbelaar, O. Dalesio K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung N Engl J Med 323 1990 561 565
-
(1990)
N Engl J Med
, vol.323
, pp. 561-565
-
-
Slebos, R.J.1
Kibbelaar, R.E.2
Dalesio, O.3
-
18
-
-
0030894182
-
K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer
-
Y. Fukuyama, T. Mitsudomi, K. Sugio K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer Br J Cancer 75 1997 1125 1130
-
(1997)
Br J Cancer
, vol.75
, pp. 1125-1130
-
-
Fukuyama, Y.1
Mitsudomi, T.2
Sugio, K.3
-
19
-
-
0031908238
-
Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer
-
C.L. Huang, T. Taki, M. Adachi Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer Int J Oncol 12 1998 553 563
-
(1998)
Int J Oncol
, vol.12
, pp. 553-563
-
-
Huang, C.L.1
Taki, T.2
Adachi, M.3
-
20
-
-
0033535615
-
A novel molecular staging protocol for non-small cell lung cancer
-
M. Miyake, M. Adachi, C. Huang A novel molecular staging protocol for non-small cell lung cancer Oncogene 18 1999 2397 2404
-
(1999)
Oncogene
, vol.18
, pp. 2397-2404
-
-
Miyake, M.1
Adachi, M.2
Huang, C.3
-
21
-
-
0033485503
-
Implications and prognostic value of K-ras mutation for early-stage lung cancer in women
-
H.H. Nelson, D.C. Christiani, E.J. Mark Implications and prognostic value of K-ras mutation for early-stage lung cancer in women J Natl Cancer Inst 91 1999 2032 2038
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 2032-2038
-
-
Nelson, H.H.1
Christiani, D.C.2
Mark, E.J.3
-
22
-
-
19944430434
-
The role of RAS oncogene in survival of patients with lung cancer: A systematic review of the literature with meta-analysis
-
C. Mascaux, N. Iannino, B. Martin The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis Br J Cancer 92 2005 131 139
-
(2005)
Br J Cancer
, vol.92
, pp. 131-139
-
-
Mascaux, C.1
Iannino, N.2
Martin, B.3
-
23
-
-
79952376771
-
Treatment of non-small-cell lung cancer with erlotinib or gefitinib
-
V.D. Cataldo, D.L. Gibbons, R. Pérez-Soler Treatment of non-small-cell lung cancer with erlotinib or gefitinib N Engl J Med 364 2011 947 955
-
(2011)
N Engl J Med
, vol.364
, pp. 947-955
-
-
Cataldo, V.D.1
Gibbons, D.L.2
Pérez-Soler, R.3
-
24
-
-
79960702788
-
Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS)
-
M. Fukuoka, Y.L. Wu, S. Thongprasert Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS) J Clin Oncol 29 2011 2866 2874
-
(2011)
J Clin Oncol
, vol.29
, pp. 2866-2874
-
-
Fukuoka, M.1
Wu, Y.L.2
Thongprasert, S.3
-
25
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
T.S. Mok, Y.L. Wu, S. Thongprasert Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma N Engl J Med 361 2009 947 957
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
26
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
T. Mitsudomi, S. Morita, Y. Yatabe Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial Lancet Oncol 11 2010 121 128
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
27
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
M. Maemondo, A. Inoue, K. Kobayashi Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR N Engl J Med 362 2010 2380 2388
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
28
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
-
R. Rosell, E. Carcereny, R. Gervais Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial Lancet Oncol 13 2012 239 246
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
29
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
C. Zhou, Y.L. Wu, G. Chen Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study Lancet Oncol 12 2011 735 742
-
(2011)
Lancet Oncol
, vol.12
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
30
-
-
84861167686
-
Pharmacogenetics of EGFR in lung cancer: Perspectives and clinical applications
-
C. Mayo, J. Bertran-Alamillo, M.A. Molina-Vila Pharmacogenetics of EGFR in lung cancer: perspectives and clinical applications Pharmacogenomics 13 2012 789 802
-
(2012)
Pharmacogenomics
, vol.13
, pp. 789-802
-
-
Mayo, C.1
Bertran-Alamillo, J.2
Molina-Vila, M.A.3
-
31
-
-
52749099497
-
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
-
H. Linardou, I.J. Dahabreh, D. Kanaloupiti Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer Lancet Oncol 9 2008 962 972
-
(2008)
Lancet Oncol
, vol.9
, pp. 962-972
-
-
Linardou, H.1
Dahabreh, I.J.2
Kanaloupiti, D.3
-
32
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
C.S. Karapetis, S. Khambata-Ford, D.J. Jonker K-ras mutations and benefit from cetuximab in advanced colorectal cancer N Engl J Med 359 2008 1757 1765
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
33
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
A. Lièvre, J.B. Bachet, V. Boige KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab J Clin Oncol 26 2008 374 379
-
(2008)
J Clin Oncol
, vol.26
, pp. 374-379
-
-
Lièvre, A.1
Bachet, J.B.2
Boige, V.3
-
34
-
-
33646238486
-
Effects of smoking on the pharmacokinetics of erlotinib
-
M. Hamilton, J.L. Wolf, J. Rusk Effects of smoking on the pharmacokinetics of erlotinib Clin Cancer Res 12 2006 2166 2171
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2166-2171
-
-
Hamilton, M.1
Wolf, J.L.2
Rusk, J.3
-
35
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
-
F. Cappuzzo, T. Ciuleanu, L. Stelmakh Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study Lancet Oncol 11 2010 521 529
-
(2010)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
-
36
-
-
70349477817
-
A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
-
abstract LBA8002
-
V.A. Miller, P. O'Connor, C. Soh A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC) J Clin Oncol 27 2009 abstract LBA8002
-
(2009)
J Clin Oncol
, vol.27
-
-
Miller, V.A.1
O'Connor, P.2
Soh, C.3
-
37
-
-
56249109644
-
Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
-
E.S. Kim, V. Hirsh, T. Mok Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial Lancet 372 2008 1809 1818
-
(2008)
Lancet
, vol.372
, pp. 1809-1818
-
-
Kim, E.S.1
Hirsh, V.2
Mok, T.3
-
38
-
-
20544455590
-
Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer
-
T. Winton, R. Livingston, D. Johnson Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer N Engl J Med 352 2005 2589 2597
-
(2005)
N Engl J Med
, vol.352
, pp. 2589-2597
-
-
Winton, T.1
Livingston, R.2
Johnson, D.3
-
39
-
-
84870841811
-
Prognostic and predictive effects of KRAS mutation subtype in completely resected non-small cell lung cancer (NSCLC): A LACE-bio study
-
abstr 7007
-
F.A. Shepherd, A. Bourredjem, E. Brambilla Prognostic and predictive effects of KRAS mutation subtype in completely resected non-small cell lung cancer (NSCLC): A LACE-bio study J Clin Oncol 30 suppl 2012 abstr 7007
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Shepherd, F.A.1
Bourredjem, A.2
Brambilla, E.3
-
40
-
-
79955483992
-
The identification of KRAS mutations at codon 12 in plasma DNA is not a prognostic factor in advanced non-small cell lung cancer patients
-
C. Camps, E. Jantus-Lewintre, A. Cabrera The identification of KRAS mutations at codon 12 in plasma DNA is not a prognostic factor in advanced non-small cell lung cancer patients Lung Cancer 72 2011 365 369
-
(2011)
Lung Cancer
, vol.72
, pp. 365-369
-
-
Camps, C.1
Jantus-Lewintre, E.2
Cabrera, A.3
-
41
-
-
77953361374
-
Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status
-
A. Kalikaki, A. Koutsopoulos, D. Hatzidaki Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status Lung Cancer 69 2010 110 115
-
(2010)
Lung Cancer
, vol.69
, pp. 110-115
-
-
Kalikaki, A.1
Koutsopoulos, A.2
Hatzidaki, D.3
-
42
-
-
84863116014
-
Effect of KRAS oncogene substitutions on protein behavior: Implications for signaling and clinical outcome
-
N.T. Ihle, L.A. Byers, E.S. Kim Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome J Natl Cancer Inst 104 2012 228 239
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 228-239
-
-
Ihle, N.T.1
Byers, L.A.2
Kim, E.S.3
-
43
-
-
79957857433
-
The BATTLE trial: Personalizing therapy for lung cancer
-
E.S. Kim, R.S. Herbst, I.I. Wistuba The BATTLE trial: personalizing therapy for lung cancer Cancer Discov 1 2011 44 53
-
(2011)
Cancer Discov
, vol.1
, pp. 44-53
-
-
Kim, E.S.1
Herbst, R.S.2
Wistuba, I.I.3
-
44
-
-
78650372656
-
Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer
-
M.C. Garassino, M. Marabese, P. Rusconi Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer Ann Oncol 22 2011 235 237
-
(2011)
Ann Oncol
, vol.22
, pp. 235-237
-
-
Garassino, M.C.1
Marabese, M.2
Rusconi, P.3
-
45
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
J.A. Engelman, L. Chen, X. Tan Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers Nat Med 14 2008 1351 1356
-
(2008)
Nat Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
-
46
-
-
26644449670
-
The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells
-
Q.B. She, D.B. Solit, Q. Ye The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells Cancer Cell 8 2005 287 297
-
(2005)
Cancer Cell
, vol.8
, pp. 287-297
-
-
She, Q.B.1
Solit, D.B.2
Ye, Q.3
-
47
-
-
27744606737
-
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
-
I.K. Mellinghoff, M.Y. Wang, I. Vivanco Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors N Engl J Med 353 2005 2012 2024
-
(2005)
N Engl J Med
, vol.353
, pp. 2012-2024
-
-
Mellinghoff, I.K.1
Wang, M.Y.2
Vivanco, I.3
-
48
-
-
34547681718
-
The role of phosphoinositide 3-kinase pathway inhibitors in the treatment of lung cancer
-
J.A. Engelman The role of phosphoinositide 3-kinase pathway inhibitors in the treatment of lung cancer Clin Cancer Res 13 2007 s4637 s4640
-
(2007)
Clin Cancer Res
, vol.13
-
-
Engelman, J.A.1
-
49
-
-
33746388176
-
'Oncogenic shock': Explaining oncogene addiction through differential signal attenuation
-
S.V. Sharma, M.A. Fischbach, D.A. Haber 'Oncogenic shock': explaining oncogene addiction through differential signal attenuation Clin Cancer Res 12 2006 4392s 4395s
-
(2006)
Clin Cancer Res
, vol.12
-
-
Sharma, S.V.1
Fischbach, M.A.2
Haber, D.A.3
-
50
-
-
84866182159
-
Phase II double-blind, randomized study of selumetinib (SEL) plus docetaxel (DOC) versus DOC plus placebo as secondline treatment for advanced KRAS mutant non-small cell lung cancer (NSCLC)
-
abstr 7503, ASCO 2012
-
P.A. Janne, A. Tsang Shaw, J. Rodrigues Pereira Phase II double-blind, randomized study of selumetinib (SEL) plus docetaxel (DOC) versus DOC plus placebo as secondline treatment for advanced KRAS mutant non-small cell lung cancer (NSCLC) J Clin Oncol 30 suppl 2012 abstr 7503, ASCO 2012
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Janne, P.A.1
Tsang Shaw, A.2
Rodrigues Pereira, J.3
-
51
-
-
58749097239
-
LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition
-
C.L. Mahoney, B. Choudhury, H. Davies LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition Br J Cancer 100 2009 370 375
-
(2009)
Br J Cancer
, vol.100
, pp. 370-375
-
-
Mahoney, C.L.1
Choudhury, B.2
Davies, H.3
-
52
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
L. Ding, G. Getz, D.A. Wheeler Somatic mutations affect key pathways in lung adenocarcinoma Nature 455 2008 1069 1075
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
-
53
-
-
50249143902
-
Role of LKB1 in lung cancer development
-
L. Makowski, D.N. Hayes Role of LKB1 in lung cancer development Br J Cancer 99 2008 683 688
-
(2008)
Br J Cancer
, vol.99
, pp. 683-688
-
-
Makowski, L.1
Hayes, D.N.2
-
55
-
-
78049418533
-
Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models
-
S. Vicent, R. Chen, L.C. Sayles Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models J Clin Invest 120 2010 3940 3952
-
(2010)
J Clin Invest
, vol.120
, pp. 3940-3952
-
-
Vicent, S.1
Chen, R.2
Sayles, L.C.3
-
56
-
-
5644264889
-
The nuclear factor kappa B subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation
-
J.L. Hanson, N.A. Hawke, D. Kashatus The nuclear factor kappa B subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation Cancer Res 64 2004 7248 7255
-
(2004)
Cancer Res
, vol.64
, pp. 7248-7255
-
-
Hanson, J.L.1
Hawke, N.A.2
Kashatus, D.3
-
57
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-associated cancer
-
E. Pikarsky, R.M. Porat, I. Stein NF-kappaB functions as a tumour promoter in inflammation-associated cancer Nature 431 2004 461 466
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
-
58
-
-
0030882666
-
Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation
-
T.S. Finco, J.K. Westwick, J.L. Norris Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation J Biol Chem 272 1997 24113 24116
-
(1997)
J Biol Chem
, vol.272
, pp. 24113-24116
-
-
Finco, T.S.1
Westwick, J.K.2
Norris, J.L.3
-
59
-
-
34047248402
-
Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB
-
W.C. Huang, T.K. Ju, M.C. Hung Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB Mol Cell 26 2007 75 87
-
(2007)
Mol Cell
, vol.26
, pp. 75-87
-
-
Huang, W.C.1
Ju, T.K.2
Hung, M.C.3
-
60
-
-
43049139541
-
P53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
-
K. Kawauchi, K. Araki, K. Tobiume p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation Nat Cell Biol 10 2008 611 618
-
(2008)
Nat Cell Biol
, vol.10
, pp. 611-618
-
-
Kawauchi, K.1
Araki, K.2
Tobiume, K.3
-
61
-
-
62549161375
-
Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification
-
K. Kawauchi, K. Araki, K. Tobiume Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification Proc Natl Acad Sci U S A 106 2009 3431 3436
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3431-3436
-
-
Kawauchi, K.1
Araki, K.2
Tobiume, K.3
-
62
-
-
70449109147
-
Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma
-
E. Meylan, A.L. Dooley, D.M. Feldser Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma Nature 462 2009 104 107
-
(2009)
Nature
, vol.462
, pp. 104-107
-
-
Meylan, E.1
Dooley, A.L.2
Feldser, D.M.3
-
63
-
-
66149091940
-
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
-
J. Luo, M.J. Emanuele, D. Li A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene Cell 137 2009 835 848
-
(2009)
Cell
, vol.137
, pp. 835-848
-
-
Luo, J.1
Emanuele, M.J.2
Li, D.3
-
64
-
-
70449091786
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
-
D.A. Barbie, P. Tamayo, J.S. Boehm Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 Nature 462 2009 108 112
-
(2009)
Nature
, vol.462
, pp. 108-112
-
-
Barbie, D.A.1
Tamayo, P.2
Boehm, J.S.3
-
65
-
-
84860319361
-
The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer
-
M.S. Kumar, D.C. Hancock, M. Molina-Arcas The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer Cell 149 2012 642 655
-
(2012)
Cell
, vol.149
, pp. 642-655
-
-
Kumar, M.S.1
Hancock, D.C.2
Molina-Arcas, M.3
-
66
-
-
55949136562
-
Roles of the EZH2 histone methyltransferase in cancer epigenetics
-
J.A. Simon, C.A. Lange Roles of the EZH2 histone methyltransferase in cancer epigenetics Mutat Res 647 2008 21 29
-
(2008)
Mutat Res
, vol.647
, pp. 21-29
-
-
Simon, J.A.1
Lange, C.A.2
-
67
-
-
80053365354
-
MRNA expression levels and genetic status of genes involved in the EGFR and NF-kappaB pathways in metastatic non-small-cell lung cancer patients
-
M. Santarpia, I. Magri, M. Sanchez-Ronco mRNA expression levels and genetic status of genes involved in the EGFR and NF-kappaB pathways in metastatic non-small-cell lung cancer patients J Transl Med 9 2011 163
-
(2011)
J Transl Med
, vol.9
, pp. 163
-
-
Santarpia, M.1
Magri, I.2
Sanchez-Ronco, M.3
-
68
-
-
84857998198
-
Enhancer of zeste homolog 2 is a novel prognostic biomarker in nonsmall cell lung cancer
-
Huqun, R. Ishikawa, J. Zhang Enhancer of zeste homolog 2 is a novel prognostic biomarker in nonsmall cell lung cancer Cancer 118 2012 1599 1606
-
(2012)
Cancer
, vol.118
, pp. 1599-1606
-
-
Huqun1
Ishikawa, R.2
Zhang, J.3
-
69
-
-
77749297990
-
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB
-
J. Min, A. Zaslavsky, G. Fedele An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB Nat Med 16 2010 286 294
-
(2010)
Nat Med
, vol.16
, pp. 286-294
-
-
Min, J.1
Zaslavsky, A.2
Fedele, G.3
-
70
-
-
84863252826
-
EZH2 couples pancreatic regeneration to neoplastic progression
-
J. Mallen-St Clair, R. Soydaner-Azeloglu, K.E. Lee EZH2 couples pancreatic regeneration to neoplastic progression Genes Dev 26 2012 439 444
-
(2012)
Genes Dev
, vol.26
, pp. 439-444
-
-
Mallen-St Clair, J.1
Soydaner-Azeloglu, R.2
Lee, K.E.3
-
71
-
-
71549155940
-
Siah proteins: Novel drug targets in the Ras and hypoxia pathways
-
C.M. House, A. Möller, D.D. Bowtell Siah proteins: novel drug targets in the Ras and hypoxia pathways Cancer Res 69 2009 8835 8838
-
(2009)
Cancer Res
, vol.69
, pp. 8835-8838
-
-
House, C.M.1
Möller, A.2
Bowtell, D.D.3
-
72
-
-
56749097004
-
Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth
-
A.U. Ahmed, R.L. Schmidt, C.H. Park Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth J Natl Cancer Inst 100 2008 1606 1629
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 1606-1629
-
-
Ahmed, A.U.1
Schmidt, R.L.2
Park, C.H.3
-
73
-
-
37549018162
-
Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue
-
R.L. Schmidt, C.H. Park, A.U. Ahmed Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue Cancer Res 67 2007 11798 11810
-
(2007)
Cancer Res
, vol.67
, pp. 11798-11810
-
-
Schmidt, R.L.1
Park, C.H.2
Ahmed, A.U.3
-
74
-
-
33845673574
-
Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2
-
R.J. Nadeau, J.L. Toher, X. Yang Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2 J Cell Biochem 100 2007 151 160
-
(2007)
J Cell Biochem
, vol.100
, pp. 151-160
-
-
Nadeau, R.J.1
Toher, J.L.2
Yang, X.3
-
75
-
-
0029978835
-
Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: Progress toward the isolation of a lung cancer TSG
-
M.H. Wei, F. Latif, S. Bader Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG Cancer Res 56 1996 1487 1492
-
(1996)
Cancer Res
, vol.56
, pp. 1487-1492
-
-
Wei, M.H.1
Latif, F.2
Bader, S.3
-
76
-
-
33645741210
-
3p21.3 tumor suppressor gene; H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis
-
J.J. Oh, A. Razfar, I. Delgado 3p21.3 tumor suppressor gene; H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis Cancer Res 66 2006 3419 3427
-
(2006)
Cancer Res
, vol.66
, pp. 3419-3427
-
-
Oh, J.J.1
Razfar, A.2
Delgado, I.3
-
77
-
-
85047688435
-
3p21.3 tumor suppressor cluster: Prospects for translational applications
-
L. Ji, J.D. Minna, J.A. Roth 3p21.3 tumor suppressor cluster: prospects for translational applications Future Oncol 1 2005 79 92
-
(2005)
Future Oncol
, vol.1
, pp. 79-92
-
-
Ji, L.1
Minna, J.D.2
Roth, J.A.3
-
78
-
-
77649331985
-
RBM5 as a putative tumor suppressor gene for lung cancer
-
L.C. Sutherland, K. Wang, A.G. Robinson RBM5 as a putative tumor suppressor gene for lung cancer J Thorac Oncol 5 2010 294 298
-
(2010)
J Thorac Oncol
, vol.5
, pp. 294-298
-
-
Sutherland, L.C.1
Wang, K.2
Robinson, A.G.3
-
79
-
-
0033755837
-
LUCA15, a putative tumour suppressor gene encoding an RNA-binding nuclear protein, is down-regulated in ras-transformed rat-1 cells
-
H. Edamatsu, Y. Kaziro, H. Itoh LUCA15, a putative tumour suppressor gene encoding an RNA-binding nuclear protein, is down-regulated in ras-transformed rat-1 cells Genes Cells 5 2000 849 858
-
(2000)
Genes Cells
, vol.5
, pp. 849-858
-
-
Edamatsu, H.1
Kaziro, Y.2
Itoh, H.3
-
80
-
-
84862198466
-
Differential expression of RBM5, EGFR and KRAS mRNA and protein in non-small cell lung cancer tissues
-
H. Liang, J. Zhang, C. Shao Differential expression of RBM5, EGFR and KRAS mRNA and protein in non-small cell lung cancer tissues J Exp Clin Cancer Res 31 2012 36
-
(2012)
J Exp Clin Cancer Res
, vol.31
, pp. 36
-
-
Liang, H.1
Zhang, J.2
Shao, C.3
-
81
-
-
33847622522
-
Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation
-
F. Luppi, A.M. Longo, W.I. de Boer Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation Lung Cancer 56 2007 25 33
-
(2007)
Lung Cancer
, vol.56
, pp. 25-33
-
-
Luppi, F.1
Longo, A.M.2
De Boer, W.I.3
-
82
-
-
84055209996
-
Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer
-
N. Sunaga, H. Imai, K. Shimizu Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer Int J Cancer 130 2012 1733 1744
-
(2012)
Int J Cancer
, vol.130
, pp. 1733-1744
-
-
Sunaga, N.1
Imai, H.2
Shimizu, K.3
-
83
-
-
72949096792
-
Senescence in tumours: Evidence from mice and humans
-
M. Collado, M. Serrano Senescence in tumours: evidence from mice and humans Nat Rev Cancer 10 2010 51 57
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 51-57
-
-
Collado, M.1
Serrano, M.2
-
84
-
-
45849087087
-
Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
-
S. Ansieau, J. Bastid, A. Doreau Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence Cancer Cell 14 2008 79 89
-
(2008)
Cancer Cell
, vol.14
, pp. 79-89
-
-
Ansieau, S.1
Bastid, J.2
Doreau, A.3
-
85
-
-
84863651484
-
Twist1 suppresses senescence programs and thereby accelerates and maintains mutant kras-induced lung tumorigenesis
-
P.T. Tran, E.H. Shroff, T.F. Burns Twist1 suppresses senescence programs and thereby accelerates and maintains mutant kras-induced lung tumorigenesis PLoS Genet 8 2012 e1002650
-
(2012)
PLoS Genet
, vol.8
, pp. 1002650
-
-
Tran, P.T.1
Shroff, E.H.2
Burns, T.F.3
-
86
-
-
53349103292
-
Modelling Myc inhibition as a cancer therapy
-
L. Soucek, J. Whitfield, C.P. Martins Modelling Myc inhibition as a cancer therapy Nature 455 2008 679 683
-
(2008)
Nature
, vol.455
, pp. 679-683
-
-
Soucek, L.1
Whitfield, J.2
Martins, C.P.3
-
87
-
-
65849111219
-
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
-
C. Scholl, S. Fröhling, I.F. Dunn Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells Cell 137 2009 821 834
-
(2009)
Cell
, vol.137
, pp. 821-834
-
-
Scholl, C.1
Fröhling, S.2
Dunn, I.F.3
-
88
-
-
80052187354
-
STK33 kinase activity is nonessential in KRAS-dependent cancer cells
-
C. Babij, Y. Zhang, R.J. Kurzeja STK33 kinase activity is nonessential in KRAS-dependent cancer cells Cancer Res 71 2011 5818 5826
-
(2011)
Cancer Res
, vol.71
, pp. 5818-5826
-
-
Babij, C.1
Zhang, Y.2
Kurzeja, R.J.3
-
89
-
-
77954279920
-
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma
-
M. Puyol, A. Martín, P. Dubus A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma Cancer Cell 18 2010 63 73
-
(2010)
Cancer Cell
, vol.18
, pp. 63-73
-
-
Puyol, M.1
Martín, A.2
Dubus, P.3
|