Reduction of Acute Inflammatory Effects of Fumed Silica Nanoparticles in the Lung by Adjusting Silanol Display through Calcination and Metal Doping

ACS Nano

Volumn 9, Issue 9, 2015, Pages 9357-9372

  Sun, Bingbing ^a   Pokhrel, Suman ^b   Dunphy, Darren R ^c   Zhang, Haiyuan ^e   Ji, Zhaoxia ^a   Wang, Xiang ^a   Wang, Meiying ^a   Liao, Yu Pei ^a   Chang, Chong Hyun ^a   Dong, Juyao ^a   Li, Ruibin ^b   Mädler, Lutz ^b   Brinker, C Jeffrey ^c,d,f   Nel, André E ^a   Xia, Tian ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BREMEN   (Germany)

^c MSC01 1070   (United States)

^d UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^e CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^f SANDIA NATIONAL LABORATORIES   (United States)

Author keywords

doping; fumed silica; IL 1 ; lung inflammation; NLRP3 inflammasome; silanol groups

Indexed keywords

ALUMINUM; BIOLOGICAL ORGANS; CALCINATION; CHEMICAL ACTIVATION; DOPING (ADDITIVES); DRUG PRODUCTS; FLAME SPRAYING; FOOD PRODUCTS; HAZARDS; MACROPHAGES; METAL NANOPARTICLES; PATHOLOGY; SPRAY PYROLYSIS;

FOOD AND DRUG ADMINISTRATION; FUMED SILICA NANOPARTICLES; FUMED SILICAS; HYDROXYL RADICAL GENERATION; INFLAMMASOME; LUNG INFLAMMATION; REACTIVE OXYGEN SPECIES; SILANOL GROUPS;

SILICA;

CALCIUM; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; SILANE DERIVATIVE; SILANOL; SILICON DIOXIDE;

CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; FOOD AND DRUG ADMINISTRATION; HUMAN; LIVER CIRRHOSIS; LUNG; METABOLISM; PATHOLOGY; PNEUMONIA; STRUCTURE ACTIVITY RELATION; UNITED STATES;

CALCIUM; CELL LINE; HUMANS; LIVER CIRRHOSIS; LUNG; NANOPARTICLES; PNEUMONIA; REACTIVE OXYGEN SPECIES; SILANES; SILICON DIOXIDE; STRUCTURE-ACTIVITY RELATIONSHIP; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 84942274911     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.5b03443     Document Type: Article

References (61)

1. Scribd, Inc. Fumed Silica Market; http://www.scribd.com/doc/37849468/Fumed-Silica-Market#scribd (accessed July 21, 2015).
2. Leung, C. C.; Yu, I. T. S.; Chen, W. Silicosis Lancet 2012, 379, 2008-2018 10.1016/S0140-6736(12)60235-9
3. Maynard, A. D. Old Materials, New Challenges? Nat. Nanotechnol. 2014, 9, 658-659 10.1038/nnano.2014.196
4. Sandberg, W.; Lag, M.; Holme, J.; Friede, B.; Gualtieri, M.; Kruszewski, M.; Schwarze, P.; Skuland, T.; Refsnes, M. Comparison of Non-Crystalline Silica Nanoparticles in IL-1beta Release from Macrophages Part. Fibre Toxicol. 2012, 9, 32 10.1186/1743-8977-9-32
5. Zhang, H.; Dunphy, D. R.; Jiang, X.; Meng, H.; Sun, B.; Tarn, D.; Xue, M.; Wang, X.; Lin, S.; Ji, Z. et al. Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic J. Am. Chem. Soc. 2012, 134, 15790-15804 10.1021/ja304907c
6. Arts, J. H.; Muijser, H.; Duistermaat, E.; Junker, K.; Kuper, C. F. Five-Day Inhalation Toxicity Study of Three Types of Synthetic Amorphous Silicas in Wistar Rats and Post-Exposure Evaluations for up to 3 Months Food Chem. Toxicol. 2007, 45, 1856-67 10.1016/j.fct.2007.04.001
7. Irfan, A.; Cauchi, M.; Edmands, W.; Gooderham, N. J.; Njuguna, J.; Zhu, H. Assessment of Temporal Dose-Toxicity Relationship of Fumed Silica Nanoparticle in Human Lung A549 Ccells by Conventional Cytotoxicity and (1)H-NMR-Based Extracellular Metabonomic Assays Toxicol. Sci. 2014, 138, 354-64 10.1093/toxsci/kfu009
8. Gerloff, K.; Albrecht, C.; Boots, A. W.; Förster, I.; Schins, R. P. F. Cytotoxicity and Oxidative DNA Damage by Nanoparticles in Human Intestinal Caco-2 Cells Nanotoxicology 2009, 3, 355-364 10.3109/17435390903276933
9. van der Zande, M.; Vandebriel, R.; Groot, M.; Kramer, E.; Herrera Rivera, Z.; Rasmussen, K.; Ossenkoppele, J.; Tromp, P.; Gremmer, E.; Peters, R. et al. Sub-Chronic Toxicity Study in Rats Orally Exposed to Nanostructured Silica Part. Fibre Toxicol. 2014, 11, 8 10.1186/1743-8977-11-8
10. Nel, A.; Xia, T.; Meng, H.; Wang, X.; Lin, S.; Ji, Z.; Zhang, H. Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening Acc. Chem. Res. 2013, 46, 607-621 10.1021/ar300022h
11. Sun, B.; Li, R.; Wang, X.; Xia, T. Predictive Toxicological Paradigm and High Throughput Approach for Toxicity Screening of Engineered Nanomaterials Int. J. Biomed. Nanosci. Nanotechnol. 2013, 3, 4-18 10.1504/IJBNN.2013.054506
12. Nash, T.; Allison, A. C.; Harington, J. S. Physico-Chemical Properties of Silica in Relation to its Toxicity Nature 1966, 210, 259-261 10.1038/210259a0
13. Marks, J. The Neutralization of Silica Toxicity in vitro Occup. Environ. Med. 1957, 14, 81-4 10.1136/oem.14.2.81
14. Slowing, I. I.; Wu, C.-W.; Vivero-Escoto, J. L.; Lin, V. S. Y. Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells Small 2009, 5, 57-62 10.1002/smll.200800926
15. Lin, Y.-S.; Haynes, C. L. Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity J. Am. Chem. Soc. 2010, 132, 4834-4842 10.1021/ja910846q
16. Sato, Y.; Kamo, S.; Takahashi, T.; Suzuki, Y. Mechanism of Free Radical-Induced Hemolysis of Human Erythrocytes: Hemolysis by Water-Soluble Radical Initiator Biochemistry 1995, 34, 8940-8949 10.1021/bi00028a002
17. Marar, T. Amelioration of Glucose Induced Hemolysis of Human Erythrocytes by Vitamin E Chem.-Biol. Interact. 2011, 193, 149-53 10.1016/j.cbi.2011.06.004
18. Wang, X.; Xia, T.; Duch, M.; Ji, Z.; Zhang, H.; Li, R.; Sun, B.; Lin, S.; Meng, H.; Liao, Y.-P. et al. Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury Nano Lett. 2012, 12, 3050-3061 10.1021/nl300895y
19. Sun, B.; Wang, X.; Ji, Z.; Li, R.; Xia, T. NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials Small 2013, 9, 1595-1607 10.1002/smll.201201962
20. Sun, B.; Ji, Z.; Liao, Y.-P.; Wang, M.; Wang, X.; Dong, J.; Chang, C. H.; Li, R.; Zhang, H.; Nel, A. E. et al. Engineering an Effective Immune Adjuvant by Designed Control of Shape and Crystallinity of Aluminum Oxyhydroxide Nanoparticles ACS Nano 2013, 7, 10834-10849 10.1021/nn404211j
21. Xia, T.; Zhao, Y.; Sager, T.; George, S.; Pokhrel, S.; Li, N.; Schoenfeld, D.; Meng, H.; Lin, S.; Wang, X. et al. Decreased Dissolution of ZnO by Iron Doping Yields Nanoparticles with Reduced Toxicity in the Rodent Lung and Zebrafish Embryos ACS Nano 2011, 5, 1223-35 10.1021/nn1028482
22. Zhang, H.; Pokhrel, S.; Ji, Z.; Meng, H.; Wang, X.; Lin, S.; Chang, C. H.; Li, L.; Li, R.; Sun, B. et al. PdO Doping Tunes Band-Gap Energy Levels as Well as Oxidative Stress Responses to a Co3O4 p-Type Semiconductor in Cells and the Lung J. Am. Chem. Soc. 2014, 136, 6406-6420 10.1021/ja501699e
23. George, S.; Pokhrel, S.; Ji, Z.; Henderson, B. L.; Xia, T.; Li, L.; Zink, J. I.; Nel, A. E.; Mädler, L. Role of Fe Doping in Tuning the Band Gap of TiO2 for the Photo-Oxidation-Induced Cytotoxicity Paradigm J. Am. Chem. Soc. 2011, 133, 11270-11278 10.1021/ja202836s
24. Li, R.; Ji, Z.; Chang, C. H.; Dunphy, D. R.; Cai, X.; Meng, H.; Zhang, H.; Sun, B.; Wang, X.; Dong, J. et al. Surface Interactions with Compartmentalized Cellular Phosphates Explain Rare Earth Oxide Nanoparticle Hazard and Provide Opportunities for Safer Design ACS Nano 2014, 8, 1771-1783 10.1021/nn406166n
25. Li, R.; Wang, X.; Ji, Z.; Sun, B.; Zhang, H.; Chang, C. H.; Lin, S.; Meng, H.; Liao, Y.-P.; Wang, M. et al. Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity ACS Nano 2013, 7, 2352-2368 10.1021/nn305567s
26. Xia, T.; Kovochich, M.; Liong, M.; Zink, J. I.; Nel, A. E. Cationic Polystyrene Nanosphere Toxicity Depends on Cell-Specific Endocytic and Mitochondrial Injury Pathways ACS Nano 2008, 2, 85-96 10.1021/nn700256c
27. Joshi, S.; Ghosh, I.; Pokhrel, S.; Mädler, L.; Nau, W. M. Interactions of Amino Acids and Polypeptides with Metal Oxide Nanoparticles Probed by Fluorescent Indicator Adsorption and Displacement ACS Nano 2012, 6, 5668-5679 10.1021/nn301669t
28. Pokhrel, S.; Nel, A. E.; Mädler, L. Custom-Designed Nanomaterial Libraries for Testing Metal Oxide Toxicity Acc. Chem. Res. 2013, 46, 632-641 10.1021/ar300032q
29. Wang, Z.; Pokhrel, S.; Chen, M.; Hunger, M.; Mädler, L.; Huang, J. Palladium-Doped Silica-Alumina Catalysts Obtained from Double-Flame FSP for Chemoselective Hydrogenation of the Model Aromatic Ketone Acetophenone J. Catal. 2013, 302, 10-19 10.1016/j.jcat.2013.02.017
30. Huang, J.; van Vegten, N.; Jiang, Y.; Hunger, M.; Baiker, A. Increasing the Brønsted Acidity of Flame-Derived Silica/Alumina up to Zeolitic Strength Angew. Chem., Int. Ed. 2010, 49, 7776-7781 10.1002/anie.201003391
31. Xia, T.; Kovochich, M.; Liong, M.; Mädler, L.; Gilbert, B.; Shi, H.; Yeh, J. I.; Zink, J. I.; Nel, A. E. Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties ACS Nano 2008, 2, 2121-2134 10.1021/nn800511k
32. Zhang, H.; Ji, Z.; Xia, T.; Meng, H.; Low-Kam, C.; Liu, R.; Pokhrel, S.; Lin, S.; Wang, X.; Liao, Y.-P. et al. Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation ACS Nano 2012, 6, 4349-4368 10.1021/nn3010087
33. Nel, A. E.; Mädler, L.; Velegol, D.; Xia, T.; Hoek, E. M. V.; Somasundaran, P.; Klaessig, F.; Castranova, V.; Thompson, M. Understanding Biophysicochemical Interactions at the Nano-Bio Interface Nat. Mater. 2009, 8, 543-557 10.1038/nmat2442
34. Matsuda, A.; Kogure, T.; Matsuno, Y.; Katayama, S.; Tsuno, T.; Tohge, N.; Minami, T. Structural-Changes of Sol Gel-Derived TIO2-SIO2 Coatings in an Environment of High-Temperature and High Humidity J. Am. Ceram. Soc. 1993, 76, 2899-2903 10.1111/j.1151-2916.1993.tb04034.x
35. Voigt, A.; Murugavel, R.; Ritter, U.; Roesky, H. W. Infrared and Si-29 NMR Spectroscopic Investigations on Metallasiloxanes Derived from Organosilanetriols J. Organomet. Chem. 1996, 521, 279-286 10.1016/0022-328X(96)06319-X
36. Ji, Z.; Wang, X.; Zhang, H.; Lin, S.; Meng, H.; Sun, B.; George, S.; Xia, T.; Nel, A.; Zink, J. Designed Synthesis of CeO2 Nanorods and Nanowires for Studying Toxicological Effects of High Aspect Ratio Nanomaterials ACS Nano 2012, 6, 5366-5380 10.1021/nn3012114
37. Zhang, H.; Xia, T.; Meng, H.; Xue, M.; George, S.; Ji, Z.; Wang, X.; Liu, R.; Wang, M.; France, B. et al. Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells ACS Nano 2011, 5, 2756-2769 10.1021/nn200328m
38. Bortner, C. D.; Cidlowski, J. A. Caspase Independent/Dependent Regulation of K+, Cell Shrinkage, and Mitochondrial Membrane Potential during Lymphocyte Apoptosis J. Biol. Chem. 1999, 274, 21953-21962 10.1074/jbc.274.31.21953
39. Al-Mehdi, A. B.; Ischiropoulos, H.; Fisher, A. B. Endothelial Cell Oxidant Generation during K(+)-Induced Membrane Depolarization J. Cell. Physiol. 1996, 166, 274-280 10.1002/(SICI)1097-4652(199602)166:2<274::AID-JCP4>3.3.CO;2-X
40. Petrilli, V.; Papin, S.; Dostert, C.; Mayor, A.; Martinon, F.; Tschopp, J. Activation of the NALP3 Inflammasome is Triggered by Low Intracellular Potassium Concentration Cell Death Differ. 2007, 14, 1583-1589 10.1038/sj.cdd.4402195
41. Oberdorster, G.; Oberdorster, E.; Oberdorster, J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles Environ. Health Perspect. 2005, 113, 823-39 10.1289/ehp.7339
42. Taylor, U.; Rehbock, C.; Streich, C.; Rath, D.; Barcikowski, S. Rational design of gold nanoparticle toxicology assays: a question of exposure scenario, dose and experimental setup Nanomedicine 2014, 9, 1971-1989 10.2217/nnm.14.139
43. Lin, S.; Wang, X.; Ji, Z.; Chang, C. H.; Dong, Y.; Meng, H.; Liao, Y.-P.; Wang, M.; Song, T.-B.; Kohan, S. et al. Aspect Ratio Plays a Role in the Hazard Potential of CeO2 Nanoparticles in Mouse Lung and Zebrafish Gastrointestinal Tract ACS Nano 2014, 8, 4450-4464 10.1021/nn5012754
44. Sun, B.; Wang, X.; Ji, Z.; Wang, M.; Liao, Y.-P.; Chang, C. H.; Li, R.; Zhang, H.; Nel, A. E.; Xia, T. NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes Small 2015, 11, 2087-97 10.1002/smll.201402859
45. Choudat, D.; Frisch, C.; Barrat, G.; el Kholti, A.; Conso, F. Occupational Exposure to Amorphous Silica Dust and Pulmonary Function Occup. Environ. Med. 1990, 47, 763-766 10.1136/oem.47.11.763
46. Wang, X.; Ji, Z.; Chang, C. H.; Zhang, H.; Wang, M.; Liao, Y.-P.; Lin, S.; Meng, H.; Li, R.; Sun, B. et al. Use of Coated Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and Lung Toxicological Potential Small 2014, 10, 385-398 10.1002/smll.201301597
47. Chizallet, C.; Raybaud, P. Pseudo-Bridging Silanols as Versatile Brønsted Acid Sites of Amorphous Aluminosilicate Surfaces Angew. Chem., Int. Ed. 2009, 48, 2891-2893 10.1002/anie.200804580
48. March, H. N.; Mucci, J. F. Chemical Physics of Free Molecules; Springer: Berlin, 1993.
49. Sahl, R. Defect Related Luminescence in Silicon Dioxide Netowrk: A Review. In Crystalline Silicon - Properties and Uses; Basu, S., Ed.; InTech: Rijeka, Croatia, 2011; pp 135-172.
50. Khavryuchenko, V. D.; Khavryuchenko, O. V.; Lisnyak, V. V. Formation of Pyrogenic Silica: Spectroscopic and Quantum Chemical Insight Crit. Rev. Solid State Mater. Sci. 2011, 36, 47-65 10.1080/10408436.2011.572741
51. Moore, T.; Brady, B.; Martin, L. R. Measurements and Modeling of SiCl4 Combustion in a Low-Pressure H2/O2 Flame Combust. Flame 2006, 146, 407-418 10.1016/j.combustflame.2006.06.003
52. Shekar, S.; Sander, M.; Riehl, R. C.; Smith, A. J.; Braumann, A.; Kraft, M. Modelling the Flame Synthesis of Silica Nanoparticles from Tetraethoxysilane Chem. Eng. Sci. 2012, 70, 54-66 10.1016/j.ces.2011.06.010
53. Wagner, N. J.; Brady, J. F. Shear thickening in colloidal dispersions Phys. Today 2009, 62, 27-32 10.1063/1.3248476
54. Wang, X.; Duch, M. C.; Mansukhani, N.; Ji, Z.; Liao, Y.-P.; Wang, M.; Zhang, H.; Sun, B.; Chang, C. H.; Li, R. et al. Use of a Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials ACS Nano 2015, 9, 3032-3043 10.1021/nn507243w
55. Franchi, L.; Kanneganti, T. D.; Dubyak, G. R.; Nunez, G. Differential Requirement of P2 × 7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria J. Biol. Chem. 2007, 282, 18810-8 10.1074/jbc.M610762200
56. Munoz-Planillo, R.; Kuffa, P.; Martinez-Colon, G.; Smith, B. L.; Rajendiran, T. M.; Nunez, G. K(+) Efflux is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter Immunity 2013, 38, 1142-53 10.1016/j.immuni.2013.05.016
57. Pokhrel, S.; Birkenstock, J.; Schowalter, M.; Rosenauer, A.; Mädler, L. Growth of Ultrafine Single Crystalline WO3 Nanoparticles Using Flame Spray Pyrolysis Cryst. Growth Des. 2010, 10, 632-639 10.1021/cg9010423
58. Ji, Z.; Jin, X.; George, S.; Xia, T.; Meng, H.; Wang, X.; Suarez, E.; Zhang, H.; Hoek, E. M. V.; Godwin, H. et al. Dispersion and Stability Optimization of TiO2 Nanoparticles in Cell Culture Media Environ. Sci. Technol. 2010, 44, 7309-7314 10.1021/es100417s
59. Shvedova, A. A.; Kisin, E.; Murray, A. R.; Johnson, V. J.; Gorelik, O.; Arepalli, S.; Hubbs, A. F.; Mercer, R. R.; Keohavong, P.; Sussman, N. et al. Inhalation vs. Aspiration of Single-Walled Carbon Nanotubes in C57BL/6 Mice: Inflammation, Fibrosis, Oxidative Stress, and Mutagenesis Am. J. Physiol.: Lung Cell. Mol. Physiol. 2008, 295, L552-L565 10.1152/ajplung.90287.2008
60. Hao, M.; Comier, S.; Wang, M.; Lee, J. J.; Nel, A. Diesel Exhaust Particles Exert Acute Effects on Airway Inflammation and Function in Murine Allergen Provocation Models J. Allergy Clin. Immunol. 2003, 112, 905-914 10.1016/j.jaci.2003.07.005
61. Servoss, S. L.; Gonzalez, R.; Varnum, S.; Zangar, R. C. High-Throughput Analysis of Serum Antigens using Sandwich ELISAs on Microarrays Methods Mol. Biol. 2009, 520, 143-50 10.1007/978-1-60327-811-9-10