Assessment of temporal dose-toxicity relationship of fumed silica nanoparticle in human lung A549 cells by conventional cytotoxicity and 1H-NMR-based extracellular metabonomic assays

Toxicological Sciences

Volumn 138, Issue 2, 2014, Pages 354-364

  Irfan, Adeel ^a   Cauchi, Michael ^a   Edmands, William ^b   Gooderham, Nigel J ^b   Njuguna, James ^a,c   Zhu, Huijun ^a  

^a CRANFIELD UNIVERSITY   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c ROBERT GORDON UNIVERSITY   (United Kingdom)

Author keywords

A549 cells; Cytotoxicity; Dose effect relationship; Fumed silica nanoparticles

Indexed keywords

FUMED SILICA NANOPARTICLE; GLUCOSE; HISTIDINE; LACTIC ACID; NANOPARTICLE; PHENYLALANINE; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CELL INTERACTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; EXTRACELLULAR METABONOMIC ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGHT SCATTERING; LUNG TOXICITY; MEMBRANE DAMAGE; MITOCHONDRION; MONITORING; PARTICLE SIZE; PROTON NUCLEAR MAGNETIC RESONANCE; SEDIMENTATION; TRANSMISSION ELECTRON MICROSCOPY;

1H-NMR METABONOMICS; A549 CELLS; CYTOTOXICITY; DOSE-EFFECT RELATIONSHIP; FUMED SILICA NANOPARTICLES;

AIR POLLUTANTS; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; CULTURE MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR FLUID; HUMANS; LUNG; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOME; MICROSCOPY, ELECTRON, TRANSMISSION; MULTIVARIATE ANALYSIS; NANOPARTICLES; PARTICLE SIZE; REACTIVE OXYGEN SPECIES; SCATTERING, RADIATION; SILICON DIOXIDE; SURFACE PROPERTIES;

EID: 84896474432     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu009     Document Type: Article

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