Use of a pro-fibrogenic mechanism-based predictive toxicological approach for tiered testing and decision analysis of carbonaceous nanomaterials

ACS Nano

Volumn 9, Issue 3, 2015, Pages 3032-3043

  Wang, Xiang ^a,b   Duch, Matthew C ^c   Mansukhani, Nikhita ^c   Ji, Zhaoxia ^b   Liao, Yu Pei ^a   Wang, Meiying ^a   Zhang, Haiyuan ^b   Sun, Bingbing ^a   Chang, Chong Hyun ^b   Li, Ruibin ^a   Lin, Sijie ^b   Meng, Huan ^a,b   Xia, Tian ^a,b   Hersam, Mark C ^c   Nel, André E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

engineered carbonaceous nanomaterials; graphene; graphene oxide; NLRP3 inflammasome lung fibrosis; SWCNT

Indexed keywords

BINARY ALLOYS; BIOLOGICAL ORGANS; CELL CULTURE; COBALT ALLOYS; GRAPHENE OXIDE; HAZARDS; MAMMALS; MULTIWALLED CARBON NANOTUBES (MWCN); NANOTUBES; PHYSICOCHEMICAL PROPERTIES; SINGLE-WALLED CARBON NANOTUBES (SWCN); SOLS;

BOVINE SERUM ALBUMINS; COLLOIDAL STABILITY; COMPARATIVE ANALYSIS; LUNG FIBROSIS; PULMONARY FIBROSIS; SURFACE REACTIVITY; SWCNT; TRANSFORMING GROWTH FACTORS;

GRAPHENE;

CARBON; GRAPHITE; INTERLEUKIN 1BETA; NANOMATERIAL; OXIDE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; BIOSYNTHESIS; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; ENGINEERING; HUMAN; LUNG FIBROSIS; LYSOSOME; MALE; METABOLISM; MOUSE; TOXICITY TESTING;

ANIMALS; CARBON; CELL LINE; ENGINEERING; GRAPHITE; HUMANS; INTERLEUKIN-1BETA; LYSOSOMES; MALE; MICE; NANOSTRUCTURES; OXIDES; PULMONARY FIBROSIS; TOXICITY TESTS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84925670313     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn507243w     Document Type: Article

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