메뉴 건너뛰기




Volumn 45, Issue 11, 2015, Pages 999-1008

Metabolism and plasma pharmacokinetics of isoorientin, a natural active ingredient, in Sprague-Dawley male rats after oral and intravenous administration

Author keywords

Isoorientin; metabolism; pharmacokinetics

Indexed keywords

DRUG METABOLITE; ISOORIENTIN; LUTEOLIN;

EID: 84942251402     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2015.1028513     Document Type: Article
Times cited : (12)

References (28)
  • 1
    • 84867803897 scopus 로고    scopus 로고
    • Isoorientin reverts TNF-A-induced insulin resistance in adipocytes activating the insulin signaling pathway
    • Alonso-Castro AJ, Zapata-Bustos R, Gómez-Espinoza G, Salazar-Olivo LA. (2012). Isoorientin reverts TNF-A-induced insulin resistance in adipocytes activating the insulin signaling pathway. Endocrinology. 153: 5222-30.
    • (2012) Endocrinology , vol.153 , pp. 5222-5230
    • Alonso-Castro, A.J.1    Zapata-Bustos, R.2    Gómez-Espinoza, G.3    Salazar-Olivo, L.A.4
  • 2
    • 1642268315 scopus 로고    scopus 로고
    • A proposed nomenclature system for the cytosolic sulfotransferase (sult) superfamily
    • Blanchard RL, Freimuth RR, Buck J, et al. (2004) A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily. Pharmacogenetics. 14: 199-211.
    • (2004) Pharmacogenetics , vol.14 , pp. 199-211
    • Blanchard, R.L.1    Freimuth, R.R.2    Buck, J.3
  • 3
    • 84873270397 scopus 로고    scopus 로고
    • Flavonoids profiles, antioxidant, acetylcholinesterase inhibition activities of extract from Dryoathyrium boryanum (Willd.) Ching
    • Cao J, Xia X, Dai X, et al. (2013). Flavonoids profiles, antioxidant, acetylcholinesterase inhibition activities of extract from Dryoathyrium boryanum (Willd.) Ching. Food Chem Toxicol. 55: 121-8.
    • (2013) Food Chem Toxicol , vol.55 , pp. 121-128
    • Cao, J.1    Xia, X.2    Dai, X.3
  • 4
    • 79952851325 scopus 로고    scopus 로고
    • Role of catechol-o-methyltransferase in the disposition of luteolin in rats
    • Chen ZJ, Chen M, Pan H, et al. (2011). Role of catechol-O-methyltransferase in the disposition of luteolin in rats. Drug Metab Dispos. 39: 667-74.
    • (2011) Drug Metab Dispos , vol.39 , pp. 667-674
    • Chen, Z.J.1    Chen, M.2    Pan, H.3
  • 5
    • 84871012167 scopus 로고    scopus 로고
    • Chemical constituents from gentianopsis barbata var sinensis ma (gentianaceae
    • Cui ZH, Li Y, Wang ZW, et al. (2013). Chemical constituents from Gentianopsis barbata var. sinensis Ma (Gentianaceae). Biochem Sys Ecol. 47: 101-3.
    • (2013) Biochem Sys Ecol , vol.47 , pp. 101-103
    • Cui, Z.H.1    Li, Y.2    Wang, Z.W.3
  • 6
    • 0032866430 scopus 로고    scopus 로고
    • Catechin is present as metabolites in human plasma after consumption of red wine
    • Donovan JL, Bell JR, Kasim-Karakas S, et al. (1999). Catechin is present as metabolites in human plasma after consumption of red wine. J Nutr. 129: 1662-8.
    • (1999) J Nutr , vol.129 , pp. 1662-1668
    • Donovan, J.L.1    Bell, J.R.2    Kasim-Karakas, S.3
  • 7
    • 84919958104 scopus 로고    scopus 로고
    • Chemical characterization and antiinflammatory activity of luteolin glycosides isolated from lemongrass
    • Francisco V, Figueirinha A, Costa G, et al. (2014). Chemical characterization and antiinflammatory activity of luteolin glycosides isolated from lemongrass. J Func Foods. 10: 436-43.
    • (2014) J Func Foods , vol.10 , pp. 436-443
    • Francisco, V.1    Figueirinha, A.2    Costa, G.3
  • 8
    • 0034950281 scopus 로고    scopus 로고
    • Induction of udpglucuronosyltransferase ugt1a1 by the flavonoid chrysin in caco-2cells-potential role in carcinogen bioinactivation
    • Galijatovic A, Otake Y, Walle UK, Walle T. (2001). Induction of UDPglucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2cells-potential role in carcinogen bioinactivation. Pharm Res. 18: 374-9.
    • (2001) Pharm Res , vol.18 , pp. 374-379
    • Galijatovic, A.1    Otake, Y.2    Walle, U.K.3    Walle, T.4
  • 11
    • 1642539168 scopus 로고    scopus 로고
    • Metabolism of apigenin by rat liver phase i and phase II enzymes and by isolated perfused rat liver
    • Gradolatto A, Canivenc-Lavier MC, Basly JP, et al. (2004). Metabolism of apigenin by rat liver phase I and phase II enzymes and by isolated perfused rat liver. Drug Metab Dispos. 32: 58-65.
    • (2004) Drug Metab Dispos , vol.32 , pp. 58-65
    • Gradolatto, A.1    Canivenc-Lavier, M.C.2    Basly, J.P.3
  • 12
    • 0036849077 scopus 로고    scopus 로고
    • The biochemistry and medicinal significance of the flavonoids
    • Havsteen BH. (2002). The biochemistry and medicinal significance of the flavonoids. Pharmacol Ther. 96: 67-202.
    • (2002) Pharmacol Ther , vol.96 , pp. 67-202
    • Havsteen, B.H.1
  • 13
    • 0141742373 scopus 로고    scopus 로고
    • Metabolism of flavonoids via enteric recycling: Mechanistic studies of disposition of apigenin in the caco-2 cell culture model
    • Hu M, Chen JN, Lin HM. (2003). Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the caco-2 cell culture model. J Pharmacol Exp Ther. 307: 314-21.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 314-321
    • Hu, M.1    Chen, J.N.2    Lin, H.M.3
  • 14
    • 67650720890 scopus 로고    scopus 로고
    • Screening and structural characterization of a-glucosidase inhibitors from hawthorn leaf flavonoids extract by ultrafiltration LC-DAD-msn and SORI-CID FTICR MS
    • Li H, Song F, Xing J, et al. (2009). Screening and structural characterization of a-glucosidase inhibitors from hawthorn leaf flavonoids extract by ultrafiltration LC-DAD-MSn and SORI-CID FTICR MS. J Am Soc Mass Spectrom. 20: 1496-503.
    • (2009) J Am Soc Mass Spectrom , vol.20 , pp. 1496-1503
    • Li, H.1    Song, F.2    Xing, J.3
  • 15
    • 84874434187 scopus 로고    scopus 로고
    • Chemical, physico-chemical, technological, antibacterial and antioxidant properties of dietary fiber powder obtained from yellow passion fruit (passiflora edulis var flavicarpa) co-products
    • López-Vargas JH, Fernández-López J, Pérez-Álvarez JA, Viuda-Martos M. (2013). Chemical, physico-chemical, technological, antibacterial and antioxidant properties of dietary fiber powder obtained from yellow passion fruit (Passiflora edulis var. flavicarpa) co-products. Food Res Int. 51: 756-63.
    • (2013) Food Res Int , vol.51 , pp. 756-763
    • López-Vargas, J.H.1    Fernández-López, J.2    Pérez-Álvarez, J.A.3    Viuda-Martos, M.4
  • 16
    • 84871200721 scopus 로고    scopus 로고
    • Udp-glucuronosyltransferase 1a1 is the principal enzyme responsible for puerarin metabolism in human
    • Luo CF, Cai B, Hou N, et al. (2012). UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human. Arch Toxicol. 86: 1681-90.
    • (2012) Arch Toxicol , vol.86 , pp. 1681-1690
    • Luo, C.F.1    Cai, B.2    Hou, N.3
  • 17
    • 84905460207 scopus 로고    scopus 로고
    • Flavonoids from neurada procumbens l (neuradaceae) in Egypt
    • Marzouk MM, Hussein SR, Ibrahim LF, et al. (2014). Flavonoids from Neurada procumbens L. (Neuradaceae) in Egypt. Biochem Sys Ecol. 57: 67-8.
    • (2014) Biochem Sys Ecol , vol.57 , pp. 67-68
    • Marzouk, M.M.1    Hussein, S.R.2    Ibrahim, L.F.3
  • 18
    • 78650726548 scopus 로고    scopus 로고
    • Spectroscopic characterization and antiproliferative activity on hepg2 human hepatoblastoma cells of flavonoid c-glycosides from petrorhagia velutina
    • Pacifico S, Scognamiglio M, D'Abrosc B, et al. (2010). Spectroscopic characterization and antiproliferative activity on HepG2 human hepatoblastoma cells of flavonoid C-glycosides from Petrorhagia velutina. J Nat Prod. 73: 1973-8.
    • (2010) J Nat Prod , vol.73 , pp. 1973-1978
    • Pacifico, S.1    Scognamiglio, M.2    D'Abrosc, B.3
  • 19
    • 84905278741 scopus 로고    scopus 로고
    • Pharmacokinetic and excretion study of three secoiridoid glycosides and three flavonoid glycosides in rat by lc-ms/ms after oraladministration of the swertia pseudochinensis extract
    • Sheng N, Zhi X, Yuan L, et al. (2014). Pharmacokinetic and excretion study of three secoiridoid glycosides and three flavonoid glycosides in rat by LC-MS/MS after oraladministration of the Swertia pseudochinensis extract. J Chromatogr B. 967: 75-83.
    • (2014) J Chromatogr B. , vol.967 , pp. 75-83
    • Sheng, N.1    Zhi, X.2    Yuan, L.3
  • 20
    • 70449726820 scopus 로고    scopus 로고
    • Molecular cloning, expression and characterization of a novel mouse sult6 cytosolic sulfotransferase
    • Takahashi S, Sakakibara Y, Mishiro E, et al. (2009). Molecular cloning, expression and characterization of a novel mouse SULT6 cytosolic sulfotransferase. J Biochem. 146: 399-405.
    • (2009) J Biochem , vol.146 , pp. 399-405
    • Takahashi, S.1    Sakakibara, Y.2    Mishiro, E.3
  • 21
    • 0036320939 scopus 로고    scopus 로고
    • Glucuronidation and sulfation of the tea flavonoid ()-epicatechin by the human and rat enzymes
    • Vaidyanathan JB, Walle T. (2002). Glucuronidation and sulfation of the tea flavonoid ()-epicatechin by the human and rat enzymes. Drug Metab Dispos. 30: 897-903.
    • (2002) Drug Metab Dispos , vol.30 , pp. 897-903
    • Vaidyanathan, J.B.1    Walle, T.2
  • 22
    • 0034795649 scopus 로고    scopus 로고
    • Carbon dioxide is the major metabolite of quercetin in humans
    • Walle T, Walle UK, Halushka PV. (2001). Carbon dioxide is the major metabolite of quercetin in humans. J Nutr. 131: 2648-52.
    • (2001) J Nutr , vol.131 , pp. 2648-2652
    • Walle, T.1    Walle, U.K.2    Halushka, P.V.3
  • 23
    • 84865319685 scopus 로고    scopus 로고
    • Screening and quantitative analysis of antioxidants in the fruits of livistona chinensis r br using hplcdad-esi/ms coupled with pre-column dpph assay
    • Yao H, Chen Y, Shi P, et al. (2012). Screening and quantitative analysis of antioxidants in the fruits of Livistona chinensis R. Br using HPLCDAD-ESI/MS coupled with pre-column DPPH assay. Food Chem. 135: 2802-7.
    • (2012) Food Chem , vol.135 , pp. 2802-2807
    • Yao, H.1    Chen, Y.2    Shi, P.3
  • 24
    • 84884415645 scopus 로고    scopus 로고
    • Isoorientin protects brl-3a rat liver cell against hydrogen peroxide-induced apoptosis by inhibiting mitochondrial dysfunction, inactivating mapks, activating akt and scavenging ros and no
    • Yuan L, Ren X, Wu Y, et al. (2013). Isoorientin protects BRL-3A rat liver cell against hydrogen peroxide-induced apoptosis by inhibiting mitochondrial dysfunction, inactivating MAPKs, activating Akt and scavenging ROS and NO. Biomed Aging Pathol. 3: 153-9
    • (2013) Biomed Aging Pathol , vol.3 , pp. 153-159
    • Yuan, L.1    Ren, X.2    Wu, Y.3
  • 25
    • 84867744044 scopus 로고    scopus 로고
    • Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of pi3k/akt signaling pathway in hepg2 cancer cells
    • Yuan L, Wang J, Xiao H, et al. (2012). Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells. Toxicol Appl Pharmacol. 265: 83-92.
    • (2012) Toxicol Appl Pharmacol , vol.265 , pp. 83-92
    • Yuan, L.1    Wang, J.2    Xiao, H.3
  • 26
    • 84871550801 scopus 로고    scopus 로고
    • Mapk signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells
    • Yuan L, Wang J, Xiao H, et al. (2013). MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells. Food Chem Toxicol. 53: 62-8.
    • (2013) Food Chem Toxicol , vol.53 , pp. 62-68
    • Yuan, L.1    Wang, J.2    Xiao, H.3
  • 27
    • 84891534157 scopus 로고    scopus 로고
    • Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ros-related mapk/nf-kb signaling pathway in bv-2 microglia
    • Yuan L, Wu Y, Ren X, et al. (2014). Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-kB signaling pathway in BV-2 microglia. Mol Cell Biochem. 386: 153-65.
    • (2014) Mol Cell Biochem , vol.386 , pp. 153-165
    • Yuan, L.1    Wu, Y.2    Ren, X.3
  • 28
    • 34047271279 scopus 로고    scopus 로고
    • Metabolism of flavone c-glucosides and p-coumaric acid from antioxidant of bamboo leaves (aob) in rats
    • Zhang Y, Tie XW, Bao BL, et al. (2007). Metabolism of flavone C-glucosides and p-coumaric acid from antioxidant of bamboo leaves (AOB) in rats. Br J Nutr. 97: 484-94.
    • (2007) Br J Nutr , vol.97 , pp. 484-494
    • Zhang, Y.1    Tie, X.W.2    Bao, B.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.