Pharmacokinetic and excretion study of three secoiridoid glycosides and three flavonoid glycosides in rat by LC-MS/MS after oral administration of the Swertia pseudochinensis extract

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 967, Issue , 2014, Pages 75-83

  Sheng, Ning ^a   Zhi, Xuran ^a   Yuan, Lin ^a   Zhang, Zhiyong ^a   Jia, Peipei ^a   Zhang, Xiaoxu ^a   Zhang, Lantong ^a   Wang, Xinguo ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Excretion study; Flavonoid glycoside; LC MS MS; Pharmacokinetics; Secoiridoid glycoside; Swertia pseudochinensis extract

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; ION SOURCES; LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; PHYSIOLOGY; RATE CONSTANTS; CHROMATOGRAPHY; DRUG PRODUCTS; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; RATS; SOLVENT EXTRACTION; SUGARS;

EXCRETION STUDY; FLAVONOID GLYCOSIDES; LC-MS/MS; SECOIRIDOID GLYCOSIDES; SWERTIA PSEUDOCHINENSIS EXTRACT;

SUGARS; EXTRACTION;

FLAVONOID GLYCOSIDE; FORMIC ACID; GENTIOPICRIN; GLYCOSIDE; ISOORIENTIN; ISOVITEXIN; MANGIFERIN; METHANOL; PLANT EXTRACT; SECOIRIDOID; SECOIRIDOID GLYCOSIDE; SULFAMETHALAZOLE; SWEROSIDE; SWERTIA PSEUDOCHINENSIS EXTRACT; SWERTIAMARIN; UNCLASSIFIED DRUG; FLAVONOID; IRIDOID;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EXCRETION; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SWERTIA; SWERTIA PSEUDOCHINENSIS; TANDEM MASS SPECTROMETRY; AREA UNDER THE CURVE; BILE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; ELIMINATION HALF-LIFE; ELIMINATION RATE CONSTANT; ELUTION; FECES; FLOW RATE; ION TRAP MASS SPECTROMETRY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; PLASMA; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; URINE; VALIDATION PROCESS; ANIMAL; BLOOD; CHEMISTRY; ORAL DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL;

RATTUS; SWERTIA;

ADMINISTRATION, ORAL; ANIMALS; BILE; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FECES; FLAVONOIDS; IRIDOID GLYCOSIDES; LINEAR MODELS; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SWERTIA; TANDEM MASS SPECTROMETRY;

EID: 84905278741     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.07.010     Document Type: Article

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