메뉴 건너뛰기




Volumn 85, Issue 3, 2014, Pages 222-228

L-Arginine and vascular diseases: Lights and pitfalls!

Author keywords

L arginine; NO; Vascular diseases

Indexed keywords

ARGINASE; ARGININE; ARGININE DECARBOXYLASE; NITRIC OXIDE SYNTHASE;

EID: 84942235814     PISSN: 03924203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (67)
  • 1
    • 49949087968 scopus 로고    scopus 로고
    • New indications and controversies in arginine therapy
    • Coman D, Yaplito-Lee J, Boneh A. New indications and controversies in arginine therapy. Clin Nutr. 2008;27:489-96.
    • (2008) Clin Nutr , vol.27 , pp. 489-496
    • Coman, D.1    Yaplito-Lee, J.2    Boneh, A.3
  • 3
    • 34249706763 scopus 로고    scopus 로고
    • The L-arginine paradox: Importance of the L-arginine/asymmetrical dimethylarginine ratio
    • Bode-Boger SM, Scalera F, Ignarro LJ. The L-arginine paradox: Importance of the L-arginine/asymmetrical dimethylarginine ratio. Pharmacol Ther. 2007;114:295-306.
    • (2007) Pharmacol Ther , vol.114 , pp. 295-306
    • Bode-Boger, S.M.1    Scalera, F.2    Ignarro, L.J.3
  • 4
    • 0025361955 scopus 로고
    • Nitrogen metabolism and ornithine cycle function
    • Meijer AJ, Lamers WH, Chamuleau RA. Nitrogen metabolism and ornithine cycle function. Physiol Rev. 1990;70:701-48.
    • (1990) Physiol Rev , vol.70 , pp. 701-748
    • Meijer, A.J.1    Lamers, W.H.2    Chamuleau, R.A.3
  • 5
    • 0031731634 scopus 로고    scopus 로고
    • L-arginine-induced vasodilation in healthy humans: Pharmacokinetic-pharmacodynamic relationship
    • Bode-Boger SM, Boger RH, Galland A, Tsikas D, Frolich JC. L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol. 1998;46:489-97.
    • (1998) Br J Clin Pharmacol , vol.46 , pp. 489-497
    • Bode-Boger, S.M.1    Boger, R.H.2    Galland, A.3    Tsikas, D.4    Frolich, J.C.5
  • 6
    • 0022450919 scopus 로고
    • Recent advances in the biochemistry of polyamines in eukaryotes
    • Pegg AE. Recent advances in the biochemistry of polyamines in eukaryotes. Biochem J. 1986;234:249-62.
    • (1986) Biochem J , vol.234 , pp. 249-262
    • Pegg, A.E.1
  • 8
    • 0023912670 scopus 로고
    • Vascular endothelial cells synthesize nitric oxide from L-arginine
    • Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988;333:664-6
    • (1988) Nature , vol.333 , pp. 664-666
    • Palmer, R.M.1    Ashton, D.S.2    Moncada, S.3
  • 9
    • 0023814833 scopus 로고
    • Arginine is a physiological precursor of endothelium-derived nitric oxide
    • Schmidt HH, Nau H, Wittfoht W, et al. Arginine is a physiological precursor of endothelium-derived nitric oxide. Eur J Pharmacol. 1988;154:213-6
    • (1988) Eur J Pharmacol , vol.154 , pp. 213-216
    • Schmidt, H.H.1    Nau, H.2    Wittfoht, W.3
  • 10
    • 0037417983 scopus 로고    scopus 로고
    • Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress
    • de Nigris F, Lerman LO, Ignarro SW, et al. Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress. Proc Natl Acad Sci U S A. 2003;100:1420-5
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1420-1425
    • de Nigris, F.1    Lerman, L.O.2    Ignarro, S.W.3
  • 11
    • 2942567667 scopus 로고    scopus 로고
    • Longterm combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice
    • Napoli C, Williams-Ignarro S, De Nigris F, et al. Longterm combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice. Proc Natl Acad Sci U S A. 2004;101:8797-802.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8797-8802
    • Napoli, C.1    Williams-Ignarro, S.2    De Nigris, F.3
  • 12
    • 26444617205 scopus 로고    scopus 로고
    • L-Citrulline and l-arginine supplementation retards the progression of highcholesterol- diet-induced atherosclerosis in rabbits
    • Hayashi T, Juliet PA, Matsui-Hirai H, et al. l-Citrulline and l-arginine supplementation retards the progression of highcholesterol- diet-induced atherosclerosis in rabbits. Proc Natl Acad Sci U S A. 2005;102:13681-6.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 13681-13686
    • Hayashi, T.1    Juliet, P.A.2    Matsui-Hirai, H.3
  • 13
    • 28944452822 scopus 로고    scopus 로고
    • L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease
    • Yin WH, Chen JW, Tsai C, Chiang MC, Young MS, Lin SJ.L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease. Clin Nutr. 2005;24:988-97
    • (2005) Clin Nutr , vol.24 , pp. 988-997
    • Yin, W.H.1    Chen, J.W.2    Tsai, C.3    Chiang, M.C.4    Young, M.S.5    Lin, S.J.6
  • 14
    • 0343306727 scopus 로고    scopus 로고
    • Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris
    • Ceremuzyński L, Chamiec T, Herbaczyńska-Cedro K. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol. 1997;80:331-3.
    • (1997) Am J Cardiol , vol.80 , pp. 331-333
    • Ceremuzyński, L.1    Chamiec, T.2    Herbaczyńska-Cedro, K.3
  • 15
    • 0035344551 scopus 로고    scopus 로고
    • Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients
    • Piatti PM, Monti LD, Valsecchi G, et al. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 2001;24:875-80.
    • (2001) Diabetes Care , vol.24 , pp. 875-880
    • Piatti, P.M.1    Monti, L.D.2    Valsecchi, G.3
  • 16
    • 0037216677 scopus 로고    scopus 로고
    • ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: Effects of L-arginine and B vitamins
    • Sydow K, Schwedhelm E, Arakawa N, et al. ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins. Cardiovasc Res. 2003;57:244-52.
    • (2003) Cardiovasc Res , vol.57 , pp. 244-252
    • Sydow, K.1    Schwedhelm, E.2    Arakawa, N.3
  • 18
    • 0030027672 scopus 로고    scopus 로고
    • L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study
    • Bode-Boger SM, Boger RH, Alfke H, et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation. 1996;93:85-90.
    • (1996) Circulation , vol.93 , pp. 85-90
    • Bode-Boger, S.M.1    Boger, R.H.2    Alfke, H.3
  • 19
    • 0342991848 scopus 로고    scopus 로고
    • Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease
    • Boger RH, Bode-Boger SM, Thiele W, Creutzig A, Alexander K, Frolich JC. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol. 1998;32:1336-44.
    • (1998) J Am Coll Cardiol , vol.32 , pp. 1336-1344
    • Boger, R.H.1    Bode-Boger, S.M.2    Thiele, W.3    Creutzig, A.4    Alexander, K.5    Frolich, J.C.6
  • 20
    • 0034014593 scopus 로고    scopus 로고
    • Nutritional therapy for peripheral arterial disease: A double-blind, placebo- controlled, randomized trial of HeartBar
    • Maxwell AJ, Anderson BE, Cooke JP. Nutritional therapy for peripheral arterial disease: a double-blind, placebo- controlled, randomized trial of HeartBar. Vasc Med. 2000;5:11-9.
    • (2000) Vasc Med , vol.5 , pp. 11-19
    • Maxwell, A.J.1    Anderson, B.E.2    Cooke, J.P.3
  • 22
  • 23
    • 0033922798 scopus 로고    scopus 로고
    • Endothelial dysfunction in hypercholesterolemia is reversed by a nutritional product designed to enhance nitric oxide activity
    • Maxwell AJ, Anderson B, Zapien MP, Cooke JP. Endothelial dysfunction in hypercholesterolemia is reversed by a nutritional product designed to enhance nitric oxide activity. Cardiovasc Drugs Ther. 2000;14:309-16.
    • (2000) Cardiovasc Drugs Ther , vol.14 , pp. 309-316
    • Maxwell, A.J.1    Anderson, B.2    Zapien, M.P.3    Cooke, J.P.4
  • 24
    • 79957557558 scopus 로고    scopus 로고
    • To give or not to give? Lessons from the arginine paradox
    • Dioguardi FS. To give or not to give? Lessons from the arginine paradox. J Nutrigenet Nutrigenomics. 2011;4:90-8.
    • (2011) J Nutrigenet Nutrigenomics , vol.4 , pp. 90-98
    • Dioguardi, F.S.1
  • 25
    • 34447334222 scopus 로고    scopus 로고
    • L-arginine supplementation in peripheral arterial disease: No benefit and possible harm
    • Wilson AM, Harada R, Nair N, Balasubramanian N, Cooke JP. L-arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation. 2007;116:188-95.
    • (2007) Circulation , vol.116 , pp. 188-195
    • Wilson, A.M.1    Harada, R.2    Nair, N.3    Balasubramanian, N.4    Cooke, J.P.5
  • 26
    • 29944434110 scopus 로고    scopus 로고
    • L-arginine therapy in acute myocardial infarction: The Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial
    • Schulman SP, Becker LC, Kass DA, et al. L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA. 2006;295:58-64.
    • (2006) JAMA , vol.295 , pp. 58-64
    • Schulman, S.P.1    Becker, L.C.2    Kass, D.A.3
  • 27
    • 0031452440 scopus 로고    scopus 로고
    • A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the "arginine paradox"
    • McDonald KK, Zharikov S, Block ER, Kilberg MS. A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the "arginine paradox". J Biol Chem. 1997;272:31213-6.
    • (1997) J Biol Chem , vol.272 , pp. 31213-31216
    • McDonald, K.K.1    Zharikov, S.2    Block, E.R.3    Kilberg, M.S.4
  • 28
    • 4744338284 scopus 로고    scopus 로고
    • Arginine and endothelial and vascular health
    • Gornik HL, Creager MA. Arginine and endothelial and vascular health. J Nutr. 2004;134:2880S-2887S.
    • (2004) J Nutr , vol.134 , pp. 2880S-2887S
    • Gornik, H.L.1    Creager, M.A.2
  • 29
    • 0031002483 scopus 로고    scopus 로고
    • Oral L-arginine improves endotheliumdependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease
    • Adams MR, McCredie R, Jessup W, Robinson J, Sullivan D, Celermajer DS. Oral L-arginine improves endotheliumdependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis. 1997;129:261-9.
    • (1997) Atherosclerosis , vol.129 , pp. 261-269
    • Adams, M.R.1    McCredie, R.2    Jessup, W.3    Robinson, J.4    Sullivan, D.5    Celermajer, D.S.6
  • 30
    • 0034625152 scopus 로고    scopus 로고
    • Oral L-arginine in patients with coronary artery disease on medical management
    • Blum A, Hathaway L, Mincemoyer R, et al. Oral L-arginine in patients with coronary artery disease on medical management. Circulation. 2000;101:2160-4.
    • (2000) Circulation , vol.101 , pp. 2160-2164
    • Blum, A.1    Hathaway, L.2    Mincemoyer, R.3
  • 31
    • 0034889663 scopus 로고    scopus 로고
    • Endothelium-dependent vasodilation is independent of the plasma L-arginine/ ADMA ratio in men with stable angina: Lack of effect of oral L-arginine on endothelial function, oxidative stress and exercise performance
    • Walker HA, McGing E, Fisher I, et al. Endothelium-dependent vasodilation is independent of the plasma L-arginine/ ADMA ratio in men with stable angina: lack of effect of oral L-arginine on endothelial function, oxidative stress and exercise performance. J Am Coll Cardiol. 2001;38:499-505.
    • (2001) J Am Coll Cardiol , vol.38 , pp. 499-505
    • Walker, H.A.1    McGing, E.2    Fisher, I.3
  • 32
    • 73249118905 scopus 로고    scopus 로고
    • Oral L-arginine supplementation in acute myocardial infarction therapy: A meta-analysis of randomized controlled trials
    • Sun T, Zhou WB, Luo XP, Tang YL, Shi HM. Oral L-arginine supplementation in acute myocardial infarction therapy: a meta-analysis of randomized controlled trials. Clin Cardiol. 2009;32:649-52.
    • (2009) Clin Cardiol , vol.32 , pp. 649-652
    • Sun, T.1    Zhou, W.B.2    Luo, X.P.3    Tang, Y.L.4    Shi, H.M.5
  • 33
    • 20444423645 scopus 로고    scopus 로고
    • Efficacy and safety of oral l-arginine in acute myocardial infarction. Results of the multicenter, randomized, doubleblind, placebo-controlled ARAMI pilot trial
    • Bednarz B, Jaxa-Chamiec T, Maciejewski P, et al. Efficacy and safety of oral l-arginine in acute myocardial infarction. Results of the multicenter, randomized, doubleblind, placebo-controlled ARAMI pilot trial. Kardiol Pol. 2005;62:421-7.
    • (2005) Kardiol Pol , vol.62 , pp. 421-427
    • Bednarz, B.1    Jaxa-Chamiec, T.2    Maciejewski, P.3
  • 36
    • 13844321746 scopus 로고    scopus 로고
    • L-arginine improves the symptoms of strokelike episodes in MELAS
    • Koga Y, Akita Y, Nishioka J, et al. L-arginine improves the symptoms of strokelike episodes in MELAS. Neurology. 2005;64:710-2.
    • (2005) Neurology , vol.64 , pp. 710-712
    • Koga, Y.1    Akita, Y.2    Nishioka, J.3
  • 38
    • 33745648369 scopus 로고    scopus 로고
    • Endothelial dysfunction in MELAS improved by l-arginine supplementation
    • Koga Y, Akita Y, Junko N, et al. Endothelial dysfunction in MELAS improved by l-arginine supplementation. Neurology. 2006;66:1766-9.
    • (2006) Neurology , vol.66 , pp. 1766-1769
    • Koga, Y.1    Akita, Y.2    Junko, N.3
  • 39
    • 38849146382 scopus 로고    scopus 로고
    • Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction
    • Masuda H. Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction. Int J Urol. 2008;15:128-34
    • (2008) Int J Urol , vol.15 , pp. 128-134
    • Masuda, H.1
  • 40
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med. 1992;326:90-4.
    • (1992) N Engl J Med , vol.326 , pp. 90-94
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 42
    • 78650894376 scopus 로고    scopus 로고
    • Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction
    • Cormio L, De Siati M, Lorusso F, et al. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011;77:119-22.
    • (2011) Urology , vol.77 , pp. 119-122
    • Cormio, L.1    De Siati, M.2    Lorusso, F.3
  • 43
    • 85013698298 scopus 로고    scopus 로고
    • Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: A multicenter, randomized, double blind, placebo-controlled clinical trial
    • Akhondzadeh S, Amiri A, Bagheri AH. Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial. Iran J Psychiatry. 2010;5:1-3.
    • (2010) Iran J Psychiatry , vol.5 , pp. 1-3
    • Akhondzadeh, S.1    Amiri, A.2    Bagheri, A.H.3
  • 44
    • 84856280305 scopus 로고    scopus 로고
    • Clinical assessment of a supplement of PycnogenolR and L-arginine in Japanese patients with mild to moderate erectile dysfunction
    • Aoki H, Nagao J, Ueda T, et al. Clinical assessment of a supplement of PycnogenolR and L-arginine in Japanese patients with mild to moderate erectile dysfunction. Phytother Res. 2012;26:204-7.
    • (2012) Phytother Res , vol.26 , pp. 204-207
    • Aoki, H.1    Nagao, J.2    Ueda, T.3
  • 45
    • 79955574239 scopus 로고    scopus 로고
    • Relationship of asymmetric dimethylarginine with penile Doppler ultrasound parameters in men with vasculogenic erectile dysfunction
    • Ioakeimidis N, Vlachopoulos C, Rokkas K, et al. Relationship of asymmetric dimethylarginine with penile Doppler ultrasound parameters in men with vasculogenic erectile dysfunction. Eur Urol. 2011;59:948-55.
    • (2011) Eur Urol , vol.59 , pp. 948-955
    • Ioakeimidis, N.1    Vlachopoulos, C.2    Rokkas, K.3
  • 46
    • 84866148959 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine in patients with arteriogenic and non-arteriogenic erectile dysfunction
    • Paroni R, Barassi A, Ciociola F, et al. Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine in patients with arteriogenic and non-arteriogenic erectile dysfunction. Int J Androl. 2012;35:660-7.
    • (2012) Int J Androl , vol.35 , pp. 660-667
    • Paroni, R.1    Barassi, A.2    Ciociola, F.3
  • 47
    • 0032490711 scopus 로고    scopus 로고
    • Endothelial function in health and disease: New insights into the genesis of cardiovascular disease
    • Quyyumi AA. Endothelial function in health and disease: new insights into the genesis of cardiovascular disease. Am J Med. 1998;105:32S-39S.
    • (1998) Am J Med , vol.105 , pp. 32S-39S
    • Quyyumi, A.A.1
  • 48
    • 0031020629 scopus 로고    scopus 로고
    • Hypertension causes premature aging of endothelial function in humans
    • Taddei S, Virdis A, Mattei P, et al. Hypertension causes premature aging of endothelial function in humans. Hypertension. 1997;29:736-43.
    • (1997) Hypertension , vol.29 , pp. 736-743
    • Taddei, S.1    Virdis, A.2    Mattei, P.3
  • 49
    • 0030006173 scopus 로고    scopus 로고
    • Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans
    • Gerhard M, Roddy MA, Creager SJ, Creager MA.Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension. 1996;27:849-53.
    • (1996) Hypertension , vol.27 , pp. 849-853
    • Gerhard, M.1    Roddy, M.A.2    Creager, S.J.3    Creager, M.A.4
  • 51
    • 0027252930 scopus 로고
    • Effects of age on endothelium- dependent vasodilation of resistance coronary artery by acetylcholine in humans
    • Egashira K, Inou T, Hirooka Y, et al. Effects of age on endothelium- dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation. 1993;88:77- 81.
    • (1993) Circulation , vol.88 , pp. 77-81
    • Egashira, K.1    Inou, T.2    Hirooka, Y.3
  • 52
  • 53
    • 33947716172 scopus 로고    scopus 로고
    • Endothelial function and dysfunction: Testing and clinical relevance
    • Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction: testing and clinical relevance. Circulation. 2007;115:1285-95.
    • (2007) Circulation , vol.115 , pp. 1285-1295
    • Deanfield, J.E.1    Halcox, J.P.2    Rabelink, T.J.3
  • 55
    • 0035195526 scopus 로고    scopus 로고
    • Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease
    • Kuvin JT, Patel AR, Sliney KA, et al. Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease. J Am Coll Cardiol. 2001;38:1843-9.
    • (2001) J Am Coll Cardiol , vol.38 , pp. 1843-1849
    • Kuvin, J.T.1    Patel, A.R.2    Sliney, K.A.3
  • 56
    • 45249109727 scopus 로고    scopus 로고
    • Advanced age is associated with endothelial dysfunction in healthy elderly subjects
    • Yavuz BB, Yavuz B, Sener DD, et al. Advanced age is associated with endothelial dysfunction in healthy elderly subjects. Gerontology. 2008;54:153-6.
    • (2008) Gerontology , vol.54 , pp. 153-156
    • Yavuz, B.B.1    Yavuz, B.2    Sener, D.D.3
  • 57
    • 33845388678 scopus 로고    scopus 로고
    • Effects of L-arginine supplementation on exercise metabolism
    • McConell GK. Effects of L-arginine supplementation on exercise metabolism. Curr Opin Clin Nutr Metab Care. 2007;10:46-51.
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 46-51
    • McConell, G.K.1
  • 58
    • 0034651949 scopus 로고    scopus 로고
    • Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: A specific vascular action of insulin
    • Kuboki K, Jiang ZY, Takahara N, et al. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation. 2000;101:676-81.
    • (2000) Circulation , vol.101 , pp. 676-681
    • Kuboki, K.1    Jiang, Z.Y.2    Takahara, N.3
  • 59
    • 0032602366 scopus 로고    scopus 로고
    • L-arginine stimulates NO-dependent vasodilation in healthy humans--effect of somatostatin pretreatment
    • Bode-Boger SM, Boger RH, Loffler M, Tsikas D, Brabant G, Frolich JC. L-arginine stimulates NO-dependent vasodilation in healthy humans--effect of somatostatin pretreatment. J Investig Med. 1999;47:43-50.
    • (1999) J Investig Med , vol.47 , pp. 43-50
    • Bode-Boger, S.M.1    Boger, R.H.2    Loffler, M.3    Tsikas, D.4    Brabant, G.5    Frolich, J.C.6
  • 60
    • 0032954522 scopus 로고    scopus 로고
    • Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive rats and normal rats
    • Susic D, Francischetti A, Frohlich ED. Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive rats and normal rats. Hypertension. 1999;33:451-5.
    • (1999) Hypertension , vol.33 , pp. 451-455
    • Susic, D.1    Francischetti, A.2    Frohlich, E.D.3
  • 62
    • 33846159514 scopus 로고    scopus 로고
    • Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression
    • Gates PE, Boucher ML, Silver AE, Monahan KD, Seals DR. Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression. J Appl Physiol. 2007;102:63-71.
    • (2007) J Appl Physiol , vol.102 , pp. 63-71
    • Gates, P.E.1    Boucher, M.L.2    Silver, A.E.3    Monahan, K.D.4    Seals, D.R.5
  • 63
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-12.
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 64
    • 0023912670 scopus 로고
    • Vascular endothelial cells synthesize nitric oxide from L-arginine
    • Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988;333:664-6.
    • (1988) Nature , vol.333 , pp. 664-666
    • Palmer, R.M.1    Ashton, D.S.2    Moncada, S.3
  • 65
    • 4744338284 scopus 로고    scopus 로고
    • Arginine and endothelial and vascular health
    • Gornik HL, Creager MA. Arginine and endothelial and vascular health. J Nutr. 2004;134:2880S-2887S
    • (2004) J Nutr , vol.134 , pp. 2880S-2887S
    • Gornik, H.L.1    Creager, M.A.2
  • 66
    • 80052628813 scopus 로고    scopus 로고
    • Does L-arginine supplementation play a role in cerebral small vessels disease? Implication in the treatment of leukoaraiosis
    • Calabro RS, Gervasi G, Bramanti P. Does L-arginine supplementation play a role in cerebral small vessels disease? Implication in the treatment of leukoaraiosis. Med Hypotheses. 2011;77:671-3.
    • (2011) Med Hypotheses , vol.77 , pp. 671-673
    • Calabro, R.S.1    Gervasi, G.2    Bramanti, P.3
  • 67
    • 84882785203 scopus 로고    scopus 로고
    • Is high oral dose L-arginine intake effective in leukoaraiosis? Preliminary data, study protocol and expert’s opinion
    • Calabro RS, Gervasi G, Baglieri A, Furnari A, Marino S, Bramanti P. Is high oral dose L-arginine intake effective in leukoaraiosis? Preliminary data, study protocol and expert’s opinion. Curr Aging Sci. 2013 ;6:170-7
    • (2013) Curr Aging Sci , vol.6 , pp. 170-177
    • Calabro, R.S.1    Gervasi, G.2    Baglieri, A.3    Furnari, A.4    Marino, S.5    Bramanti, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.