Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine in patients with arteriogenic and non-arteriogenic erectile dysfunction

International Journal of Andrology

Volumn 35, Issue 5, 2012, Pages 660-667

  Paroni, R ^a   Barassi, A ^a   Ciociola, F ^b   Dozio, E ^a   Finati, E ^a   Fermo, I ^d   Ghilardi, F ^a   Colpi, G M ^b   Corsi, M M ^a,c   Melzi d'Eril, G V ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN PAOLO HOSPITAL   (Italy)

^c IRCCS POLICLINICO SAN DONATO   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Arteriogenic erectile dysfunction; Asymmetric dimethylarginin; Non arteriogenic erectile dysfunction; Symmetric dimethylarginine

Indexed keywords

6 N,N' DIMETHYLARGININE; ARGININE; N(G),N(G) DIMETHYLARGININE;

ADULT; AMINO ACID BLOOD LEVEL; ARTERIOGENIC ERECTILE DYSFUNCTION; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ERECTILE DYSFUNCTION; HUMAN; INTERNATIONAL INDEX OF ERECTILE FUNCTION; MAJOR CLINICAL STUDY; MALE; NON ARTERIOGENIC ERECTILE DYSFUNCTION; PRIORITY JOURNAL;

ADULT; ARGININE; ERECTILE DYSFUNCTION; HUMANS; IMPOTENCE, VASCULOGENIC; MALE; MIDDLE AGED;

EID: 84866148959     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2012.01272.x     Document Type: Article

References (50)

1. Achan V, Broadhead M, Malaki M, Whitley G, Leiper J, MacAllister R & Vallance P. (2003) Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol 23, 1455-1459.
2. Aktoz T, Aktoz M, Tatli{dotless} E, Kaplan M, Turan FN, Barutcu A, Atakan IH, Demir M & Altun A. (2010) Assessment of the relationship between asymmetric dimethylarginine and severity of erectile dysfunction and coronary artery disease. Int Urol Nephrol 42, 873-879.
3. Aversa A, Bruzziches R & Spera G. (2005) Diagnosing erectile dysfunction: the penile dynamic colour duplex ultrasound revisited. Int J Androl 28(Suppl 2), 61-63.
4. Baylis C. (2006) Arginine, arginine analogs and nitric oxide production in chronic kidney disease. Nat Clin Pract Nephrol 2, 209-220.
5. Barassi A, Colpi GM, Piediferro G, Dogliotti G, Melzi d'Eril GV & Corsi MM. (2009) Oxidative stress and antioxidant status in patients with erectile dysfunction. J Sex Med 6, 2820-2825.
6. Barassi A, Pezzilli R, Morselli-Labate AM, Porreca W, Piediferro G, Ciociola F, Colpi G & Melzi d'Eril GV. (2010) Evaluation of microalbuminuria in patients with erectile dysfunction. J Sex Med 7, 1224-1228.
7. Benet AE & Melman A. (1995) The epidemiology of erectile dysfunction. Urol Clin North Am 22, 699-709.
8. Blackwell S, O'Reilly DS & Talwar D. (2007) Biological variation of asymmetric dimethylarginine and related arginine metabolites and analytical performance goals for their measurement in human plasma. Eur J Clin Invest 37, 364-371.
9. Bode-Böger SM, Scalera F, Kielstein JT, Martens-Lobenhoffer J, Breithardt G, Fobker M & Reinecke H. (2006) Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease. J Am Soc Nephrol 17, 1128-1134.
10. Bögerk RH, Maask R, Schulzek F & Schwedhelmk E. (2009) Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality-an update on patient populations with a wide range of cardiovascular risk. Pharmacol Res 60, 481-487.
11. Burchardt M, Burchardt T, Anastasiadis AG, Kiss AJ, Shabsigh A, de La Taille A, Pawar RV, Baer L & Shabsigh R. (2001) Erectile dysfunction is a marker for cardiovascular complications and psychological functioning in men with hypertension. Int J Impot Res 13, 276-281.
12. Carrier S, Hricak H, Lee S, Baba K, Morgan DM, Nunes L, Rosa GY, Phillips TL & Lue TF. (1995) Radiation-induced decrease in nitric oxide synthase-containing nerves in the rat penis. Radiology 195, 95-99.
13. Chen J, Wollman Y, Chernichovsky T, Iaina A, Sofer M & Matzkin H. (1999) Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. BJU Int 83, 269-273.
14. Closs EI, Basha FZ, Habermeier A & Förstermann U. (1997) Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B. Nitric Oxide 1, 65-73.
15. Cooke JP. (2004) Asymmetrical dimethylarginine: the Uber marker? Circulation 109, 1813-1818.
16. Cormio L, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F & Carrieri G. (2011) Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology 77, 119-122.
17. De Angelis L, Marfella MA, Siniscalchi M, Marino L, Nappo F, Giugliano F, De Lucia D & Giugliano D. (2001) Erectile and endothelial dysfunction in type II diabetes: a possible link. Diabetologia 44, 1155-1160.
18. Elesber AA, Solomon H, Lennon RJ, Mathew V, Prasad A, Pumper G, Nelson RE, McConnell JP, Lerman LO & Lerman A. (2006) Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis. Eur Heart J 27, 824-831.
19. Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA, Araujo AB & McKinlay JB. (2000) Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Prev Med 30, 328-338.
20. Fraser CG & Petersen PH. (1999) Analytical performance characteristics should be judged against objective quality specifications. Clin Chem 45, 321-323.
21. Garban H, Vernet D, Freedman A, Rajfer J & Gonzalez-Cadavid NF. (1995) Effect of aging on nitric oxide mediated penile erection in rats. Amer J Physiol 268, H467-475.
22. Hashimoto M, Kozaki K, Eto M, Akishita M, Ako J, Iijima K, Kim S, Toba K, Yoshizumi M & Ouchi Y. (2000) Association of coronary risk factors and endothelium-dependent flow-mediated dilatation of the brachial artery. Hypertens Res 23, 233-238.
23. Ioakeimidis N, Vlachopoulos C, Rokkas K, Aggelis A, Terentes-Printzios D, Samentzas A, Alexopoulos N & Stefanadis C. (2011) Relationship of asymmetric dimethylarginine with penile Doppler ultrasound parameters in men with vasculogenic erectile dysfunction. Eur Urol 59, 948-955.
24. Kendirci M, Trost L, Sikka S & Hellstrom WJ. (2007) The effect of vascular risk factors on penile vascular status in men with erectile dysfunction. J Urol 178, 2516-2520.
25. Kielstein JT & Zoccali C. (2005) Asymmetric dimethylarginine: a cardiovascular risk factor and a uremic toxin coming of age? Am J Kidney Dis 46, 186-202.
26. Lugg JA, Rajfer J & Gonzalez-Cedavid NF. (1995) Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology 136, 1495-1501.
27. Maas R, Schwedhelm E, Albsmeier J & Böger RH. (2002) The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function. Vasc Med 7, 213-225.
28. Maas R, Wenske S, Zabel M, Ventura R, Schwedhelm E, Steenpaß A, Klemm H, Noldus J & Boger RH. (2005) Elevation of asymmetrical dimethylarginine (ADMA) and coronary artery disease in men with erectile dysfunction. Eur Urol 48, 1004-1012.
29. Nijveldt RJ, Teerlink T, Siroen MP, van Lambalgen AA, Rauwerda JA & van Leeuwen PA. (2003) The liver is an important organ in the metabolism of asymmetrical dimethylarginine (ADMA). Clin Nutr 22, 17-22.
30. Orozco-Gutiérrez JJ, Castillo-Martínez L, Orea-Tejeda A, Vázquez-Díaz O, Valdespino-Trejo A, Narváez-David R, Keirns-Davis C, Carrasco-Ortiz O, Navarro-Navarro A & Sánchez-Santillán R. (2010) Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction. Cardiol J 17, 612-618.
31. Palm F, Onozato ML, Luo Z & Wilcox CS. (2007) Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 293, H3227-H3245.
32. Palmer RM, Ashton DS & Moncada S. (1988) Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333, 664-666.
33. Paroni R, Fermo I, Fiorina P & Cighetti G. (2005) Determination of asymmetric and symmetric dimethylarginines in plasma of hyperhomocysteinemic subjects. Amino Acids 28, 389-394.
34. Rosen RC, Cappelleri JC, Smith MD, Lipsky J & Peña BM. (1999) Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 11, 319-326.
35. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J & Mishra A. (1997) The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 49, 822-830.
36. Sáenz de Tejada I, Angulo J, Cellek S, González-Cadavid N, Heaton J, Pickard R & Simonsen U. (2004) Physiology of erectile function. J Sex Med 1, 254-265.
37. Schiel R, Franke S, Busch M, Müller A, Fleck C, Müller UA, Braun A & Stein G. (2003) Effect of smoking on risk factors for cardiovascular disease in patients with diabetes mellitus and renal insufficiency. Eur J Med Res 8, 283-291.
38. Sydow K & Münzel T. (2003) ADMA and oxidative stress. Atheroscler Suppl 4, 41-51.
39. Solomon H, Man JW & Jackson G. (2003) Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 89, 251-253.
40. Solomon H, Man JW, Wierzbicki AS & Jackson G. (2003) Relation of erectile dysfunction to angiographic coronary artery disease. Am J Cardiol 91, 230-231.
41. Takiuchi S, Fujii H, Kamide K, Horio T, Nakatani S, Hiuge A, Rakugi H, Ogihara T & Kawano Y. (2004) Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients. Am J Hypertens 17, 802-808.
42. Tostes RC, Carneiro FS, Lee AJ, Giachini FR, Leite R, Osawa Y & Webb RC. (2008) Cigarette smoking and erectile dysfunction: focus on NO bioavailability and ROS generation. J Sex Med 5, 1284-1295.
43. Tsuji H, Ogawa T, Bando N & Sasaoka K. (1986) Purification and properties of 4-aminobenzoate hydroxylase, a new monooxygenase from Agaricus bisporus. J Biol Chem 261, 13203-13209.
44. Ueda S, Kato S, Matsuoka H, Kimoto M, Okuda S, Morimatsu M & Imaizumi T. (2003) Regulation of cytokine-induced nitric oxide synthesis by asymmetric dimethylarginine: role of dimethylarginine dimethylaminohydrolase. Circ Res 92, 226-233.
45. Valkonen VP, Päivä H, Salonen JT, Lakka TA, Lehtimäki T, Laakso J & Laaksonen R. (2001) Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine. Lancet 358, 2127-2128.
46. Vallance P, Leone A, Calver A, Collier J & Moncada S. (1992) Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339, 572-575.
47. Vallance P, Leone A, Calver A, Collier J & Moncada S. (1992) Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol 20(Suppl 12), S60-S62.
48. Welch WJ & Wilcox CS. (1997) Macula densa arginine delivery and uptake in the rat regulates glomerular capillary pressure. Effects of salt intake. J Clin Invest 100, 2235-2242.
49. Widlansky ME, Gokce N, Keaney JF Jr & Vita JA. (2003) The clinical implications of endothelial dysfunction. J Am Coll Cardiol 42, 1149-1160.
50. Wierzbicki AS, Solomon H, Lumb PJ, Lyttle K, Lambert-Hammill M & Jackson G. (2006) Asymmetric dimethyl arginine levels correlate with cardiovascular risk factors in patients with erectile dysfunction. Atherosclerosis 185, 421-425.