Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression

Journal of Neuroscience

Volumn 35, Issue 38, 2015, Pages 13206-13218

  Simkin, Dina ^a   Hattori, Shoai ^a   Ybarra, Natividad ^a,b   Musia, Timothy F ^b   Buss, Eric W ^b   Richter, Hannah ^a   Matthew Oh, M ^a   Nicholson, Daniel A ^b   Disterhoft, John F ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

A type K+ channels; Action potential repolarization; Aging; CA3; Kv4.2 Kv4.3; Pyramidal neurons

Indexed keywords

SHAL POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ACTION POTENTIAL; AGED; AGING; AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; SPIKE WAVE; TOMOGRAPHY; WESTERN BLOTTING; YOUNG ADULT; ANALYSIS OF VARIANCE; ANIMAL; BIOPHYSICS; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; ELECTROSTIMULATION; FISCHER 344 RAT; IN VITRO STUDY; MEMBRANE POTENTIAL; METABOLISM; PHYSIOLOGY; SYNAPTIC POTENTIAL;

AGING; ANALYSIS OF VARIANCE; ANIMALS; BIOPHYSICS; CA3 REGION, HIPPOCAMPAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; IN VITRO TECHNIQUES; MALE; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PYRAMIDAL CELLS; RATS; RATS, INBRED F344; SHAL POTASSIUM CHANNELS; SYNAPTIC POTENTIALS;

EID: 84942155130     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0193-15.2015     Document Type: Article

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