Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS

Neuron

Volumn 87, Issue 6, 2015, Pages 1207-1214

  Tran, Helene ^a   Almeida, Sandra ^a   Moore, Jill ^a   Gendron, Tania F ^b   Chalasani, UmaDevi ^a   Lu, Yubing ^a   Du, Xing ^a   Nickerson, Jeffrey A ^a   Petrucelli, Leonard ^b   Weng, Zhiping ^a   Gao, Fen Biao ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

ALS; C9ORF72; DPR; Drosophila; FTD; Ran translation; Repeats; RNA foci

Indexed keywords

DIPEPTIDE REPEAT PROTEIN; MESSENGER RNA; NUCLEAR RNA; POLYADENYLIC ACID; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; C9ORF72 PROTEIN, HUMAN; DIPEPTIDE; DROSOPHILA PROTEIN; PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; CYTOPLASM; DROSOPHILA; EXON; FRONTOTEMPORAL DEMENTIA; GENE EXPRESSION; GLIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; INTRON; NERVE CELL; NEUROTOXICITY; NONHUMAN; OPEN READING FRAME; PATHOGENESIS; PATHOGENICITY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TEMPERATURE; ANIMAL; BIOSYNTHESIS; COMPARATIVE STUDY; DISEASE MODEL; METABOLISM; PATHOLOGY; TRANSGENIC ANIMAL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DIPEPTIDES; DISEASE MODELS, ANIMAL; DROSOPHILA; DROSOPHILA PROTEINS; FRONTOTEMPORAL DEMENTIA; HUMANS; PROTEINS; RNA, NUCLEAR;

EID: 84942122433     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2015.09.015     Document Type: Article

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