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Volumn 90, Issue 10, 2015, Pages 934-950

2015 Clinical trials update in sickle cell anemia

Author keywords

[No Author keywords available]

Indexed keywords

ANTISICKLING AGENT; HEMOGLOBIN F; HEMOGLOBIN S; OXYGEN;

EID: 84942104961     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.24116     Document Type: Article
Times cited : (33)

References (170)
  • 1
    • 74049123836 scopus 로고    scopus 로고
    • Definitions of the phenotypic manifestations of sickle cell disease
    • Ballas SK, Lieff, S, Benjamin LJ, et al. Definitions of the phenotypic manifestations of sickle cell disease. Am J Hematol 2010; 85:6-13.
    • (2010) Am J Hematol , vol.85 , pp. 6-13
    • Ballas, S.K.1    Lieff, S.2    Benjamin, L.J.3
  • 2
    • 84907016412 scopus 로고    scopus 로고
    • Management of sickle cell disease: Summary of the 2014 evidence-based report by expert panel members
    • Yawn BP, Buchanan, GR, Afenyi-Annan AN, et al. Management of sickle cell disease: Summary of the 2014 evidence-based report by expert panel members. JAMA 2014; 312:1033-1048.
    • (2014) JAMA , vol.312 , pp. 1033-1048
    • Yawn, B.P.1    Buchanan, G.R.2    Afenyi-Annan, A.N.3
  • 3
    • 84929917431 scopus 로고    scopus 로고
    • [French guidelines for the management of adult sickle cell disease: 2015 update]
    • 5S3-5S84
    • Habibi A, Arlet, JB, Stankovic K, et al. [French guidelines for the management of adult sickle cell disease: 2015 update]. Rev Med Intern 2015; 36:5S3-5S84.
    • (2015) Rev Med Intern , vol.36
    • Habibi, A.1    Arlet, J.B.2    Stankovic, K.3
  • 4
    • 84921418905 scopus 로고    scopus 로고
    • Health-related quality of life in children with sickle cell anemia: Impact of blood transfusion therapy
    • Beverung LM, Strouse, JJ, Hulbert ML, et al. Health-related quality of life in children with sickle cell anemia: Impact of blood transfusion therapy. Am J Hematol 2015; 90:139-143.
    • (2015) Am J Hematol , vol.90 , pp. 139-143
    • Beverung, L.M.1    Strouse, J.J.2    Hulbert, M.L.3
  • 5
    • 84942170631 scopus 로고    scopus 로고
    • Last accessed on July 28, 2015
    • http://www.nih.gov/news/health/nov2014/nhlbi-0000.htm. Last accessed on July 28, 2015.
  • 6
    • 84899721999 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: Indications and management recommendations from an international expert panel
    • Angelucci E, Matthes-Martin, S, Baronciani D, et al. Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: Indications and management recommendations from an international expert panel. Haematologica 2014; 99:811-820.
    • (2014) Haematologica , vol.99 , pp. 811-820
    • Angelucci, E.1    Matthes-Martin, S.2    Baronciani, D.3
  • 7
    • 80051562984 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation for sickle cell disease: The time is now
    • Hsieh MM, Fitzhugh CD, Tisdale JF. Allogeneic hematopoietic stem cell transplantation for sickle cell disease: The time is now. Blood 2011; 118:1197-1207.
    • (2011) Blood , vol.118 , pp. 1197-1207
    • Hsieh, M.M.1    Fitzhugh, C.D.2    Tisdale, J.F.3
  • 8
    • 0018199125 scopus 로고
    • Requirements for therapeutic inhibition of sickle hemoglobin gelation
    • Sunshine HR, Hofrichter J, Eaton WA. Requirements for therapeutic inhibition of sickle hemoglobin gelation. Nature 1978; 275:238-240.
    • (1978) Nature , vol.275 , pp. 238-240
    • Sunshine, H.R.1    Hofrichter, J.2    Eaton, W.A.3
  • 9
    • 0023572225 scopus 로고
    • Hemoglobin S gelation and sickle cell disease
    • Eaton WA, Hofrichter J. Hemoglobin S gelation and sickle cell disease. Blood 1987; 70:1245-1266.
    • (1987) Blood , vol.70 , pp. 1245-1266
    • Eaton, W.A.1    Hofrichter, J.2
  • 10
    • 0025276708 scopus 로고
    • Sickle cell hemoglobin polymerization
    • Eaton WA, Hofrichter J. Sickle cell hemoglobin polymerization. Adv Prot Chem 1990; 40:63-279.
    • (1990) Adv Prot Chem , vol.40 , pp. 63-279
    • Eaton, W.A.1    Hofrichter, J.2
  • 11
    • 0029008481 scopus 로고
    • The biophysics of sickle cell hydroxyurea therapy
    • Eaton WA, Hofrichter J. The biophysics of sickle cell hydroxyurea therapy. Science 1995; 268:1142-1143.
    • (1995) Science , vol.268 , pp. 1142-1143
    • Eaton, W.A.1    Hofrichter, J.2
  • 12
    • 84942104887 scopus 로고    scopus 로고
    • A phase I trial of zileuton in sickle cell disease
    • Quarmyne M-O Rayes, O, Gonsalves CS, et al. A phase I trial of zileuton in sickle cell disease. Blood 2013; 122:993-993.
    • (2013) Blood , vol.122 , pp. 993-993
    • Quarmyne, M.-O.1    Rayes, O.2    Gonsalves, C.S.3
  • 13
    • 84879350342 scopus 로고    scopus 로고
    • Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson
    • Field JJ Lin, G, Okam MM, et al. Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson. Blood 2013; 121:3329-3334.
    • (2013) Blood , vol.121 , pp. 3329-3334
    • Field, J.J.1    Lin, G.2    Okam, M.M.3
  • 14
    • 84922031978 scopus 로고    scopus 로고
    • Topical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: A phase 1 dose-finding safety and tolerability trial
    • Minniti CP, Gorbach, AM, Xu D, et al. Topical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: A phase 1 dose-finding safety and tolerability trial. Lancet Haematol 2014; 1:e95-e103.
    • (2014) Lancet Haematol , vol.1 , pp. e95-e103
    • Minniti, C.P.1    Gorbach, A.M.2    Xu, D.3
  • 15
    • 84902827324 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled phase II study of the efficacy and safety of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease
    • Reid ME, El Beshlawy, A, Inati A, et al. A double-blind, placebo-controlled phase II study of the efficacy and safety of 2, 2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease. Am J Hematol 2014; 89:709-713.
    • (2014) Am J Hematol , vol.89 , pp. 709-713
    • Reid, M.E.1    El Beshlawy, A.2    Inati, A.3
  • 16
    • 84883807945 scopus 로고    scopus 로고
    • A pilot study of eptifibatide for treatment of acute pain episodes in sickle cell disease
    • Desai PC, Brittain, JE, Jones SK, et al. A pilot study of eptifibatide for treatment of acute pain episodes in sickle cell disease. Thromb Res 2013; 132:341-345.
    • (2013) Thromb Res , vol.132 , pp. 341-345
    • Desai, P.C.1    Brittain, J.E.2    Jones, S.K.3
  • 17
    • 84890613955 scopus 로고    scopus 로고
    • Intravenous magnesium sulfate for vaso-occlusive episodes in sickle cell disease
    • Goldman RD, Mounstephen, W, Kirby-Allen M, et al. Intravenous magnesium sulfate for vaso-occlusive episodes in sickle cell disease. Pediatrics 2013; 132:E1634-E1641.
    • (2013) Pediatrics , vol.132 , pp. E1634-E1641
    • Goldman, R.D.1    Mounstephen, W.2    Kirby-Allen, M.3
  • 18
    • 84928279234 scopus 로고    scopus 로고
    • The delay time in sickle cell disease after 40 years: A paradigm assessed
    • Ferrone FA. The delay time in sickle cell disease after 40 years: A paradigm assessed. Am J Hematol 2015; 438-445.
    • (2015) Am J Hematol , pp. 438-445
    • Ferrone, F.A.1
  • 19
    • 0025770390 scopus 로고
    • Pain in sickle-cell disease - Rates and risk-factors
    • Platt OS, Thorington, BD, Brambilla DJ, et al. Pain in sickle-cell disease - Rates and risk-factors. N Engl J Med 1991; 325:11-16.
    • (1991) N Engl J Med , vol.325 , pp. 11-16
    • Platt, O.S.1    Thorington, B.D.2    Brambilla, D.J.3
  • 20
    • 0028291736 scopus 로고
    • Mortality in sickle-cell disease - Life expectancy and risk-factors for early death
    • Platt OS, Brambilla, DJ, Rosse WF, et al. Mortality in sickle-cell disease - Life expectancy and risk-factors for early death. N Engl J Med 1994; 330:1639-1644.
    • (1994) N Engl J Med , vol.330 , pp. 1639-1644
    • Platt, O.S.1    Brambilla, D.J.2    Rosse, W.F.3
  • 21
    • 84878197791 scopus 로고    scopus 로고
    • Genetic studies of fetal hemoglobin in the Arab-Indian haplotype sickle cell-β0 thalassemia
    • Alsultan A, Ngo, D, Bae H, et al. Genetic studies of fetal hemoglobin in the Arab-Indian haplotype sickle cell-β0 thalassemia. Am J Hematol 2013; 88:531-532.
    • (2013) Am J Hematol , vol.88 , pp. 531-532
    • Alsultan, A.1    Ngo, D.2    Bae, H.3
  • 22
    • 84919701590 scopus 로고    scopus 로고
    • Genetic variants at HbF-modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania
    • Mtatiro SN, Makani, J, Mmbando B, et al. Genetic variants at HbF-modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania. Am J Hematol 2015; 90:E1-E4.
    • (2015) Am J Hematol , vol.90 , pp. E1-E4
    • Mtatiro, S.N.1    Makani, J.2    Mmbando, B.3
  • 23
    • 84884706653 scopus 로고    scopus 로고
    • Genetic modulation of HbF in Brazilians with HbSC disease and sickle cell anemia
    • Barbosa CG, Aleluia, ACM, Pacheco APAS, et al. Genetic modulation of HbF in Brazilians with HbSC disease and sickle cell anemia. Am J Hematol 2013; 88:923-924.
    • (2013) Am J Hematol , vol.88 , pp. 923-924
    • Barbosa, C.G.1    Aleluia, A.C.M.2    Pacheco, A.P.A.S.3
  • 24
    • 84879327608 scopus 로고    scopus 로고
    • Genetic modifiers of sickle cell anemia in the BABY HUG cohort: Influence on laboratory and clinical phenotypes
    • Sheehan VA, Luo Z, Flanagan JM, et al. Genetic modifiers of sickle cell anemia in the BABY HUG cohort: Influence on laboratory and clinical phenotypes. Am J Hematol 2013; 88:571-576.
    • (2013) Am J Hematol , vol.88 , pp. 571-576
    • Sheehan, V.A.1    Luo, Z.2    Flanagan, J.M.3
  • 25
    • 79960147525 scopus 로고    scopus 로고
    • Fetal hemoglobin in sickle cell anemia
    • Akinsheye I, Alsultan A, Solovieff N, et al. Fetal hemoglobin in sickle cell anemia. Blood 2011; 118:19-27.
    • (2011) Blood , vol.118 , pp. 19-27
    • Akinsheye, I.1    Alsultan, A.2    Solovieff, N.3
  • 26
    • 0021286875 scopus 로고
    • Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia
    • Platt OS, Orkin SH, Dover G, et al. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest 1984; 74:652-656.
    • (1984) J Clin Invest , vol.74 , pp. 652-656
    • Platt, O.S.1    Orkin, S.H.2    Dover, G.3
  • 27
    • 0029025475 scopus 로고
    • Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia
    • Charache S, Terrin ML, Moore RD, et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med 1995; 332:1317-1322.
    • (1995) N Engl J Med , vol.332 , pp. 1317-1322
    • Charache, S.1    Terrin, M.L.2    Moore, R.D.3
  • 28
    • 77953057530 scopus 로고    scopus 로고
    • The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up
    • Steinberg MH, McCarthy, WF, Castro O, et al. The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. Am J Hematol 2010; 85:403-408.
    • (2010) Am J Hematol , vol.85 , pp. 403-408
    • Steinberg, M.H.1    McCarthy, W.F.2    Castro, O.3
  • 29
    • 84919464653 scopus 로고    scopus 로고
    • Update on the use of hydroxyurea therapy in sickle cell disease
    • Wong TE, Brandow AM, Lim W, et al. Update on the use of hydroxyurea therapy in sickle cell disease. Blood 2014; 124:3850-3857.
    • (2014) Blood , vol.124 , pp. 3850-3857
    • Wong, T.E.1    Brandow, A.M.2    Lim, W.3
  • 30
    • 13044277572 scopus 로고    scopus 로고
    • Safety of hydroxyurea in children with sickle cell anemia: Results of the HUG-KIDS study, a phase I/II trial
    • Kinney TR, Helms, RW, O'Branski EE, et al. Safety of hydroxyurea in children with sickle cell anemia: Results of the HUG-KIDS study, a phase I/II trial. Blood 1999; 94:1550-1554.
    • (1999) Blood , vol.94 , pp. 1550-1554
    • Kinney, T.R.1    Helms, R.W.2    O'Branski, E.E.3
  • 31
    • 84869803950 scopus 로고    scopus 로고
    • Impact of hydroxyurea on clinical events in the BABY HUG trial
    • Thornburg CD, Files, BA, Luo Z, et al. Impact of hydroxyurea on clinical events in the BABY HUG trial. Blood 2012; 120:4304-4310.
    • (2012) Blood , vol.120 , pp. 4304-4310
    • Thornburg, C.D.1    Files, B.A.2    Luo, Z.3
  • 32
    • 79955909191 scopus 로고    scopus 로고
    • Hydroxycarbamide in very young children with sickle-cell anaemia: A multicentre, randomised, controlled trial (BABY HUG)
    • Wang WC, Ware, RE, Miller ST, et al. Hydroxycarbamide in very young children with sickle-cell anaemia: A multicentre, randomised, controlled trial (BABY HUG). Lancet 2011; 377:1663-1672.
    • (2011) Lancet , vol.377 , pp. 1663-1672
    • Wang, W.C.1    Ware, R.E.2    Miller, S.T.3
  • 33
    • 0036189575 scopus 로고    scopus 로고
    • Effect of hydroxyurea on growth in children with sickle cell anemia: Results of the HUG-KIDS Study
    • Wang WC, Helms, RW, Lynn HS, et al. Effect of hydroxyurea on growth in children with sickle cell anemia: Results of the HUG-KIDS Study. J Pediatr 2002; 140:225-229.
    • (2002) J Pediatr , vol.140 , pp. 225-229
    • Wang, W.C.1    Helms, R.W.2    Lynn, H.S.3
  • 34
    • 84872972122 scopus 로고    scopus 로고
    • Hydroxyurea treatment decreases glomerular hyperfiltration in children with sickle cell anemia
    • Aygun B, Mortier NA, Smeltzer MP, et al. Hydroxyurea treatment decreases glomerular hyperfiltration in children with sickle cell anemia. Am J Hematol 2013; 88:116-119.
    • (2013) Am J Hematol , vol.88 , pp. 116-119
    • Aygun, B.1    Mortier, N.A.2    Smeltzer, M.P.3
  • 35
    • 84907218716 scopus 로고    scopus 로고
    • Hydroxyurea and growth in young children with sickle cell disease
    • Rana S, Houston, PE, Wang WC, et al. Hydroxyurea and growth in young children with sickle cell disease. Pediatrics 2014; 134:465-472.
    • (2014) Pediatrics , vol.134 , pp. 465-472
    • Rana, S.1    Houston, P.E.2    Wang, W.C.3
  • 36
    • 84928718664 scopus 로고    scopus 로고
    • Proportion of adults with sickle cell anemia and pain crises receiving hydroxyurea
    • Stettler N, McKiernan CM, Melin CQ, et al. Proportion of adults with sickle cell anemia and pain crises receiving hydroxyurea. JAMA 2015; 313:1671-1672.
    • (2015) JAMA , vol.313 , pp. 1671-1672
    • Stettler, N.1    McKiernan, C.M.2    Melin, C.Q.3
  • 37
    • 36849065265 scopus 로고    scopus 로고
    • Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia
    • Hankins JS, Wynn, LW, Brugnara C, et al. Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia. Br J Haematol 2008; 140:80-85.
    • (2008) Br J Haematol , vol.140 , pp. 80-85
    • Hankins, J.S.1    Wynn, L.W.2    Brugnara, C.3
  • 38
    • 79951982532 scopus 로고    scopus 로고
    • The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: Results of the multi-centre CHAMPS trial
    • Wang WF, Brugnara, C, Snyder C, et al. The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: Results of the multi-centre CHAMPS trial. Br J Haematol 2011; 152:771-776.
    • (2011) Br J Haematol , vol.152 , pp. 771-776
    • Wang, W.F.1    Brugnara, C.2    Snyder, C.3
  • 39
    • 0141701988 scopus 로고    scopus 로고
    • Hydroxyurea downregulates endothelin-1 gene expression and upregulates ICAM-1 gene expression in cultured human endothelial cells
    • Brun M, Bourdoulous S, Couraud PO, et al. Hydroxyurea downregulates endothelin-1 gene expression and upregulates ICAM-1 gene expression in cultured human endothelial cells. Pharmacogenomics J 2003; 3:215-226.
    • (2003) Pharmacogenomics J , vol.3 , pp. 215-226
    • Brun, M.1    Bourdoulous, S.2    Couraud, P.O.3
  • 40
    • 77957204379 scopus 로고    scopus 로고
    • Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu/BCAM protein phosphorylation
    • Bartolucci P, Chaar V, Picot J, et al. Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu/BCAM protein phosphorylation. Blood 2010; 116:2152-2159.
    • (2010) Blood , vol.116 , pp. 2152-2159
    • Bartolucci, P.1    Chaar, V.2    Picot, J.3
  • 41
    • 45949101942 scopus 로고    scopus 로고
    • Montelukast inhibition of resting and GM-CSF-stimulated eosinophil adhesion to VCAM-1 under flow conditions appears independent of cysLT(1)R antagonism
    • Robinson AJ, Kashanin DF, O'Dowd F, et al. Montelukast inhibition of resting and GM-CSF-stimulated eosinophil adhesion to VCAM-1 under flow conditions appears independent of cysLT(1)R antagonism. J Leukoc Biol 2008; 83:1522-1529.
    • (2008) J Leukoc Biol , vol.83 , pp. 1522-1529
    • Robinson, A.J.1    Kashanin, D.F.2    O'Dowd, F.3
  • 42
    • 84867800608 scopus 로고    scopus 로고
    • Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis
    • Bartolucci P, Brugnara, C, Teixeira-Pinto A, et al. Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis. Blood 2012; 120:3136-3141.
    • (2012) Blood , vol.120 , pp. 3136-3141
    • Bartolucci, P.1    Brugnara, C.2    Teixeira-Pinto, A.3
  • 43
    • 84929303433 scopus 로고    scopus 로고
    • Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea
    • Rakotoson MG, Di Liberto G, Audureau E, et al. Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea. Orphanet J Rare Dis 2015; 10:57
    • (2015) Orphanet J Rare Dis , vol.10 , pp. 57
    • Rakotoson, M.G.1    Di Liberto, G.2    Audureau, E.3
  • 44
    • 84886287023 scopus 로고    scopus 로고
    • A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease
    • Kutlar A, Reid ME, Inati A, et al. A dose-escalation phase IIa study of 2, 2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease. Am J Hematol 2013; 88:E255-E260.
    • (2013) Am J Hematol , vol.88 , pp. E255-E260
    • Kutlar, A.1    Reid, M.E.2    Inati, A.3
  • 45
    • 57849083996 scopus 로고    scopus 로고
    • Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A
    • Sankaran VG, Menne TF, Xu J, et al. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science 2008; 322:1839-1842.
    • (2008) Science , vol.322 , pp. 1839-1842
    • Sankaran, V.G.1    Menne, T.F.2    Xu, J.3
  • 46
    • 84885620722 scopus 로고    scopus 로고
    • An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level
    • Bauer DE, Kamran SC, Lessard S, et al. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science 2013; 342:253-257.
    • (2013) Science , vol.342 , pp. 253-257
    • Bauer, D.E.1    Kamran, S.C.2    Lessard, S.3
  • 47
    • 0034927094 scopus 로고    scopus 로고
    • Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures
    • Marianna P, Kollia P, Akel S, et al. Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures. Haematologica 2001; 86:700-705.
    • (2001) Haematologica , vol.86 , pp. 700-705
    • Marianna, P.1    Kollia, P.2    Akel, S.3
  • 48
    • 0019119824 scopus 로고
    • A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis
    • Rosa RM, Bierer BE, Thomas R, et al. A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. N Engl J Med 1980; 303:1138-1143.
    • (1980) N Engl J Med , vol.303 , pp. 1138-1143
    • Rosa, R.M.1    Bierer, B.E.2    Thomas, R.3
  • 49
    • 12844273669 scopus 로고    scopus 로고
    • Ion transport pathology in the mechanism of sickle cell dehydration
    • Lew VL, Bookchin RM. Ion transport pathology in the mechanism of sickle cell dehydration. Physiol Rev 2005; 85:179-200.
    • (2005) Physiol Rev , vol.85 , pp. 179-200
    • Lew, V.L.1    Bookchin, R.M.2
  • 50
    • 0022549289 scopus 로고
    • Regulation of erythrocyte cation and water content in sickle cell anemia
    • Brugnara C, Bunn HF, Tosteson DC. Regulation of erythrocyte cation and water content in sickle cell anemia. Science 1986; 232:388-390.
    • (1986) Science , vol.232 , pp. 388-390
    • Brugnara, C.1    Bunn, H.F.2    Tosteson, D.C.3
  • 51
    • 0029045228 scopus 로고
    • KCl cotransport activity in light versus dense transferrin receptor-positive sickle reticulocytes
    • Franco RS, Palascak M, Thompson H, et al. KCl cotransport activity in light versus dense transferrin receptor-positive sickle reticulocytes. J Clin Invest 1995; 95:2573-2580.
    • (1995) J Clin Invest , vol.95 , pp. 2573-2580
    • Franco, R.S.1    Palascak, M.2    Thompson, H.3
  • 52
    • 0029966766 scopus 로고    scopus 로고
    • Dehydration of transferrin receptor-positive sickle reticulocytes during continuous or cyclic deoxygenation: Role of KCl cotransport and extracellular calcium
    • Franco RS, Palascak, M, Thompson H, et al. Dehydration of transferrin receptor-positive sickle reticulocytes during continuous or cyclic deoxygenation: Role of KCl cotransport and extracellular calcium. Blood 1996; 88:4359-4365.
    • (1996) Blood , vol.88 , pp. 4359-4365
    • Franco, R.S.1    Palascak, M.2    Thompson, H.3
  • 53
    • 19444374693 scopus 로고    scopus 로고
    • Multiple isoforms of the KC1 cotransporter are expressed in sickle and normal erythroid cells
    • Crable SC, Hammond SM, Papes R, et al. Multiple isoforms of the KC1 cotransporter are expressed in sickle and normal erythroid cells. Exp Hematol 2005; 33:624-631.
    • (2005) Exp Hematol , vol.33 , pp. 624-631
    • Crable, S.C.1    Hammond, S.M.2    Papes, R.3
  • 54
    • 0024379876 scopus 로고
    • Acid pH induces formation of dense cells in sickle erythrocytes
    • Brugnara C, Van Ha T, Tosteson DC. Acid pH induces formation of dense cells in sickle erythrocytes. Blood 1989; 74:487-495.
    • (1989) Blood , vol.74 , pp. 487-495
    • Brugnara, C.1    Van Ha, T.2    Tosteson, D.C.3
  • 55
    • 0027275040 scopus 로고
    • Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives
    • Brugnara C, De Franceschi L, Alper SL. Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J Clin Invest 1993; 92:520-526.
    • (1993) J Clin Invest , vol.92 , pp. 520-526
    • Brugnara, C.1    De Franceschi, L.2    Alper, S.L.3
  • 56
    • 0027359209 scopus 로고
    • Effects of deoxygenation on active and passive Ca2+ transport and on the cytoplasmic Ca2+ levels of sickle cell anemia red cells
    • Etzion Z, Tiffert T, Bookchin RM, et al. Effects of deoxygenation on active and passive Ca2+ transport and on the cytoplasmic Ca2+ levels of sickle cell anemia red cells. J Clin Invest 1993; 92:2489-2498.
    • (1993) J Clin Invest , vol.92 , pp. 2489-2498
    • Etzion, Z.1    Tiffert, T.2    Bookchin, R.M.3
  • 57
    • 0030947532 scopus 로고    scopus 로고
    • Stochastic nature and red cell population distribution of the sickling-induced Ca2+ permeability
    • Lew VL, Ortiz OE, Bookchin RM. Stochastic nature and red cell population distribution of the sickling-induced Ca2+ permeability. J Clin Invest 1997; 99:2727-2735.
    • (1997) J Clin Invest , vol.99 , pp. 2727-2735
    • Lew, V.L.1    Ortiz, O.E.2    Bookchin, R.M.3
  • 58
    • 11144237183 scopus 로고    scopus 로고
    • Distribution of dehydration rates generated by maximal Gardos-channel activation in normal and sickle red blood cells
    • Lew VL, Tiffert, T, Etzion Z, et al. Distribution of dehydration rates generated by maximal Gardos-channel activation in normal and sickle red blood cells. Blood 2005; 105:361-367.
    • (2005) Blood , vol.105 , pp. 361-367
    • Lew, V.L.1    Tiffert, T.2    Etzion, Z.3
  • 59
    • 0036093379 scopus 로고    scopus 로고
    • Modulation of gardos channel activity by cytokines in sickle erythrocytes
    • Rivera A, Jarolim P, Brugnara C. Modulation of gardos channel activity by cytokines in sickle erythrocytes. Blood 2002; 99:357-363.
    • (2002) Blood , vol.99 , pp. 357-363
    • Rivera, A.1    Jarolim, P.2    Brugnara, C.3
  • 60
    • 77649297696 scopus 로고    scopus 로고
    • Hypoxia activates a Ca(2+)-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes
    • Vandorpe DH, Xu C, Shmukler BE, et al. Hypoxia activates a Ca(2+)-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One 2010; 5. e8732.
    • (2010) PLoS One , vol.5 , pp. e8732
    • Vandorpe, D.H.1    Xu, C.2    Shmukler, B.E.3
  • 61
    • 0023879884 scopus 로고
    • Deoxygenation-induced cation fluxes in sickle cells: Relationship between net potassium efflux and net sodium influx
    • Joiner CH, Dew A, Ge DL. Deoxygenation-induced cation fluxes in sickle cells: Relationship between net potassium efflux and net sodium influx. Blood Cells 1988; 13:339-358.
    • (1988) Blood Cells , vol.13 , pp. 339-358
    • Joiner, C.H.1    Dew, A.2    Ge, D.L.3
  • 62
    • 0005961348 scopus 로고    scopus 로고
    • Dipyridamole inhibits in vitro deoxygenation-induced cation fluxes in sickle red blood cells at the membrane concentration achievable in blood
    • Joiner CH, Claussen W, Yasin Z, et al. Dipyridamole inhibits in vitro deoxygenation-induced cation fluxes in sickle red blood cells at the membrane concentration achievable in blood. Blood 1997; 90:125.
    • (1997) Blood , vol.90 , pp. 125
    • Joiner, C.H.1    Claussen, W.2    Yasin, Z.3
  • 63
    • 0030964677 scopus 로고    scopus 로고
    • Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease
    • De Franceschi L, Bachir D, Galacteros F, et al. Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease. J Clin Invest 1997; 100:1847-1852.
    • (1997) J Clin Invest , vol.100 , pp. 1847-1852
    • De Franceschi, L.1    Bachir, D.2    Galacteros, F.3
  • 64
    • 0034011397 scopus 로고    scopus 로고
    • Oral magnesium pidolate: Effects of long-term administration in patients with sickle cell disease
    • De Franceschi L, Bachir, D, Galacteros F, et al. Oral magnesium pidolate: Effects of long-term administration in patients with sickle cell disease. Br J Haematol 2000; 108:248-289.
    • (2000) Br J Haematol , vol.108 , pp. 248-289
    • De Franceschi, L.1    Bachir, D.2    Galacteros, F.3
  • 65
    • 0022507283 scopus 로고
    • A collaborative, double-blind randomized study of cetiedil citrate in sickle cell crisis
    • Benjamin LJ, Berkowitz, LR, Orringer E, et al. A collaborative, double-blind randomized study of cetiedil citrate in sickle cell crisis. Blood 1986; 67:1442-1447.
    • (1986) Blood , vol.67 , pp. 1442-1447
    • Benjamin, L.J.1    Berkowitz, L.R.2    Orringer, E.3
  • 66
    • 26444480407 scopus 로고    scopus 로고
    • Efficacy and safety of the Gardos channel inhibitor, ICA-17043, in patients with sickle cell anemia
    • Ataga KI, DeCastro LM, Swerdlow P, et al. Efficacy and safety of the Gardos channel inhibitor, ICA-17043, in patients with sickle cell anemia. Blood 2004; 104:33.
    • (2004) Blood , vol.104 , pp. 33
    • Ataga, K.I.1    DeCastro, L.M.2    Swerdlow, P.3
  • 67
    • 0029865706 scopus 로고    scopus 로고
    • Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease
    • Brugnara C, Gee B, Armsby CC, et al. Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest 1996; 97:1227-1234.
    • (1996) J Clin Invest , vol.97 , pp. 1227-1234
    • Brugnara, C.1    Gee, B.2    Armsby, C.C.3
  • 68
    • 79952594455 scopus 로고    scopus 로고
    • Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: A phase III randomized, placebo-controlled, double-blind study of the Gardos channel blocker senicapoc (ICA-17043)
    • Ataga KI, Reid M, Ballas SK, et al. Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: A phase III randomized, placebo-controlled, double-blind study of the Gardos channel blocker senicapoc (ICA-17043). Br J Haematol 2011; 153:92-104.
    • (2011) Br J Haematol , vol.153 , pp. 92-104
    • Ataga, K.I.1    Reid, M.2    Ballas, S.K.3
  • 69
    • 34548713036 scopus 로고    scopus 로고
    • Reduced sickle erythrocyte dehydration in vivo by endothelin-1 receptor antagonists
    • Rivera A. Reduced sickle erythrocyte dehydration in vivo by endothelin-1 receptor antagonists. Am J Physiol Cell Physiol 2007; 293:C960-966.
    • (2007) Am J Physiol Cell Physiol , vol.293 , pp. C960-C966
    • Rivera, A.1
  • 70
    • 0027930702 scopus 로고
    • Improvement of sickle cell anemia by iron-limited erythropoiesis
    • Castro O, Pollen WN, Finke H, et al. Improvement of sickle cell anemia by iron-limited erythropoiesis. Am J Hematol 1994; 47:74-81.
    • (1994) Am J Hematol , vol.47 , pp. 74-81
    • Castro, O.1    Pollen, W.N.2    Finke, H.3
  • 71
    • 0034162841 scopus 로고    scopus 로고
    • Prevention of sickle cell crises with multiple phlebotomies
    • Boucher N, Manigne P, Kanfer A, et al. Prevention of sickle cell crises with multiple phlebotomies. Arch Pediatr 2000; 7:249-255.
    • (2000) Arch Pediatr , vol.7 , pp. 249-255
    • Boucher, N.1    Manigne, P.2    Kanfer, A.3
  • 73
    • 0017169577 scopus 로고
    • Hematologic and clinical responses in patients with sickle cell anemia after chronic extracorporeal red cell carbamylation
    • Deiderich DA, Trueworthy RC, Gill P, et al. Hematologic and clinical responses in patients with sickle cell anemia after chronic extracorporeal red cell carbamylation. J Clin Invest 1976; 58:642-653.
    • (1976) J Clin Invest , vol.58 , pp. 642-653
    • Deiderich, D.A.1    Trueworthy, R.C.2    Gill, P.3
  • 74
    • 0022569505 scopus 로고    scopus 로고
    • Effect of BW12C on oxygen affinity of haemoglobin in sickle-cell disease
    • Keidan AJ, White RD, Huehns ER, et al. Effect of BW12C on oxygen affinity of haemoglobin in sickle-cell disease. Lancet 327:831-834.
    • Lancet , vol.327 , pp. 831-834
    • Keidan, A.J.1    White, R.D.2    Huehns, E.R.3
  • 75
    • 85004854945 scopus 로고
    • A clinical-study of the safety, pharmacokinetics, and pharmacodynamics of intravenous infusions of 12C79 in sickle-cell disease patients not in crisis
    • Orringer E, Huffman J, Guaspari L, et al. A clinical-study of the safety, pharmacokinetics, and pharmacodynamics of intravenous infusions of 12C79 in sickle-cell disease patients not in crisis. Clin Res 1991; 39:238-238.
    • (1991) Clin Res , vol.39 , pp. 238-238
    • Orringer, E.1    Huffman, J.2    Guaspari, L.3
  • 76
    • 0025855331 scopus 로고
    • Vanillin, a potential agent for the treatment of sickle cell anemia
    • Abraham D, Mehanna A, Wireko F, et al. Vanillin, a potential agent for the treatment of sickle cell anemia. Blood 1991; 77:1334-1341.
    • (1991) Blood , vol.77 , pp. 1334-1341
    • Abraham, D.1    Mehanna, A.2    Wireko, F.3
  • 77
    • 23244444304 scopus 로고    scopus 로고
    • In vivo action of Vanillin on delay time determined by magnetic relaxation
    • Garcia AF, Cabal C, Losada J, et al. In vivo action of Vanillin on delay time determined by magnetic relaxation. Hemoglobin 2005; 29:181-187.
    • (2005) Hemoglobin , vol.29 , pp. 181-187
    • Garcia, A.F.1    Cabal, C.2    Losada, J.3
  • 78
    • 84900002774 scopus 로고    scopus 로고
    • Effects of o-vanillin on K+ transport of red blood cells from patients with sickle cell disease
    • Hannemann A, Cytlak UMC, Gbotosho OT, et al. Effects of o-vanillin on K+ transport of red blood cells from patients with sickle cell disease. Blood Cells Mol Dis 2014; 53:21-26.
    • (2014) Blood Cells Mol Dis , vol.53 , pp. 21-26
    • Hannemann, A.1    Cytlak, U.M.C.2    Gbotosho, O.T.3
  • 79
    • 80955136792 scopus 로고    scopus 로고
    • Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin
    • Abdulmalik O, Ghatge MS, Musayev FN, et al. Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Acta Crystallogr Sect D Biol Crystallogr 2011; 67:920-928.
    • (2011) Acta Crystallogr Sect D Biol Crystallogr , vol.67 , pp. 920-928
    • Abdulmalik, O.1    Ghatge, M.S.2    Musayev, F.N.3
  • 80
    • 73949087363 scopus 로고    scopus 로고
    • Sickle cell disease and stroke
    • Verduzco LA, Nathan DG. Sickle cell disease and stroke. Blood 2009; 114:5117-5125.
    • (2009) Blood , vol.114 , pp. 5117-5125
    • Verduzco, L.A.1    Nathan, D.G.2
  • 81
    • 0029895837 scopus 로고    scopus 로고
    • Tucaresol increases oxygen affinity and reduces haemolysis in subjects with sickle cell anaemia
    • Arya R, Rolan PE, Wootton R, et al. Tucaresol increases oxygen affinity and reduces haemolysis in subjects with sickle cell anaemia. Br J Haematol 1996; 93:817-821.
    • (1996) Br J Haematol , vol.93 , pp. 817-821
    • Arya, R.1    Rolan, P.E.2    Wootton, R.3
  • 82
    • 14144255089 scopus 로고    scopus 로고
    • 5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells
    • Abdulmalik O, Safo MK, Chen QK, et al. 5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. Br J Haematol 2005; 128:552-561.
    • (2005) Br J Haematol , vol.128 , pp. 552-561
    • Abdulmalik, O.1    Safo, M.K.2    Chen, Q.K.3
  • 83
    • 84907877340 scopus 로고    scopus 로고
    • Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease
    • Hannemann A, Cytlak UM, Rees DC, et al. Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease. J Physiol Lond 2014; 592:4039-4049.
    • (2014) J Physiol Lond , vol.592 , pp. 4039-4049
    • Hannemann, A.1    Cytlak, U.M.2    Rees, D.C.3
  • 84
    • 84978313365 scopus 로고    scopus 로고
    • Phase 1 clinical trial of the candidate anti-sickling agent Aes-103 in adults with sickle cell anemia
    • Lawrence MP, Mendelsohn LG, Saiyed R, et al. Phase 1 clinical trial of the candidate anti-sickling agent Aes-103 in adults with sickle cell anemia. Blood 2013; 122:1009-1009.
    • (2013) Blood , vol.122 , pp. 1009-1009
    • Lawrence, M.P.1    Mendelsohn, L.G.2    Saiyed, R.3
  • 85
    • 84888260688 scopus 로고    scopus 로고
    • MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice
    • Belcher JD, Young M, Chen CS, et al. MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice. Blood 2013; 122:2757-2764.
    • (2013) Blood , vol.122 , pp. 2757-2764
    • Belcher, J.D.1    Young, M.2    Chen, C.S.3
  • 86
    • 0028267842 scopus 로고
    • Adhesion of sickle cells to vascular endothelium is critically dependent on changes in density and shape of the cells
    • Kaul DK, Chen D, Zhan J. Adhesion of sickle cells to vascular endothelium is critically dependent on changes in density and shape of the cells. Blood 1994; 83:3006-3017.
    • (1994) Blood , vol.83 , pp. 3006-3017
    • Kaul, D.K.1    Chen, D.2    Zhan, J.3
  • 87
    • 45049085089 scopus 로고    scopus 로고
    • Sickle red cell adhesion: Many issues and some answers
    • Kaul DK. Sickle red cell adhesion: Many issues and some answers. Transfus Clin Biol 2008; 15:51-55.
    • (2008) Transfus Clin Biol , vol.15 , pp. 51-55
    • Kaul, D.K.1
  • 88
    • 0027484507 scopus 로고
    • Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation
    • Nelson RM, Cecconi O, Roberts WG, et al. Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood 1993; 82:3253-3258.
    • (1993) Blood , vol.82 , pp. 3253-3258
    • Nelson, R.M.1    Cecconi, O.2    Roberts, W.G.3
  • 89
    • 0029671046 scopus 로고    scopus 로고
    • Adhesion through L-selectin requires a threshold hydrodynamic shear
    • Finger EB, Puri KD, Alon R, et al. Adhesion through L-selectin requires a threshold hydrodynamic shear. Nature 1996; 379:266-269.
    • (1996) Nature , vol.379 , pp. 266-269
    • Finger, E.B.1    Puri, K.D.2    Alon, R.3
  • 90
    • 0031045036 scopus 로고    scopus 로고
    • Threshold levels of fluid shear promote leukocyte adhesion through selectins (CD62L,P,E)
    • Lawrence MB, Kansas GS, Kunkel EJ, et al. Threshold levels of fluid shear promote leukocyte adhesion through selectins (CD62L, P, E). J Cell Biol 1997; 136:717-727.
    • (1997) J Cell Biol , vol.136 , pp. 717-727
    • Lawrence, M.B.1    Kansas, G.S.2    Kunkel, E.J.3
  • 91
    • 0037111637 scopus 로고    scopus 로고
    • Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin
    • Matsui NM, Varki A, Embury SH. Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin. Blood 2002; 100:3790-3796.
    • (2002) Blood , vol.100 , pp. 3790-3796
    • Matsui, N.M.1    Varki, A.2    Embury, S.H.3
  • 92
    • 0032519957 scopus 로고    scopus 로고
    • Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents
    • Koenig A, Norgard-Sumnicht K, Linhardt R, et al. Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents. J Clin Invest 1998; 101:877-889.
    • (1998) J Clin Invest , vol.101 , pp. 877-889
    • Koenig, A.1    Norgard-Sumnicht, K.2    Linhardt, R.3
  • 93
    • 84859885815 scopus 로고    scopus 로고
    • A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease
    • Kutlar A, Ataga KI, McMahon L, et al. A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease. Am J Hematol 2012; 87:536-539.
    • (2012) Am J Hematol , vol.87 , pp. 536-539
    • Kutlar, A.1    Ataga, K.I.2    McMahon, L.3
  • 94
    • 34547863870 scopus 로고    scopus 로고
    • Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial
    • Qari MH, Aljaouni SK, Alardawi MS, et al. Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial. Thromb Haemost 2007; 98:392-396.
    • (2007) Thromb Haemost , vol.98 , pp. 392-396
    • Qari, M.H.1    Aljaouni, S.K.2    Alardawi, M.S.3
  • 95
    • 84942103491 scopus 로고    scopus 로고
    • Sevuparin reduces adhesion of both sickle red cells and leukocytes to endothelial cells in vitro and inhibits vaso-occlusion in vivo
    • Batchvarova M, Shan SQ, Zennadi R, et al. Sevuparin reduces adhesion of both sickle red cells and leukocytes to endothelial cells in vitro and inhibits vaso-occlusion in vivo. Blood 2013; 122:2.
    • (2013) Blood , vol.122 , pp. 2
    • Batchvarova, M.1    Shan, S.Q.2    Zennadi, R.3
  • 96
    • 84903794779 scopus 로고    scopus 로고
    • Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia
    • Wun T, Styles L, DeCastro L, et al. Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia. PLos One 2014; 9:12.
    • (2014) PLos One , vol.9 , pp. 12
    • Wun, T.1    Styles, L.2    DeCastro, L.3
  • 97
    • 84942090666 scopus 로고    scopus 로고
    • Effects of GMI 1070, a pan-selectin inhibitor, on pain intensity and opioid utilization in sickle cell disease
    • De Castro LM, Wun T, Lanzkron S, et al. Effects of GMI 1070, a pan-selectin inhibitor, on pain intensity and opioid utilization in sickle cell disease. Blood 2013; 122:775.
    • (2013) Blood , vol.122 , pp. 775
    • De Castro, L.M.1    Wun, T.2    Lanzkron, S.3
  • 98
    • 84905475975 scopus 로고    scopus 로고
    • An analysis of the pediatric sub-group from the phase 2 study of GMI 1070-A novel agent for the vaso-occlusive crisis of sickle cell anemia
    • McCavit TL, Krishnamurti L, Hsu LL, et al. An analysis of the pediatric sub-group from the phase 2 study of GMI 1070-A novel agent for the vaso-occlusive crisis of sickle cell anemia. Blood 2013; 122:2206.
    • (2013) Blood , vol.122 , pp. 2206
    • McCavit, T.L.1    Krishnamurti, L.2    Hsu, L.L.3
  • 99
    • 84897481799 scopus 로고    scopus 로고
    • GMI 1070: Reduction in time to resolution of vaso-occlusive crisis and decreased opioid use in a prospective, randomized, multi-center double blind, adaptive phase 2 study in sickle cell disease
    • abstract
    • Telen MJ, Wun T, McCavit TL, et al. GMI 1070: Reduction in time to resolution of vaso-occlusive crisis and decreased opioid use in a prospective, randomized, multi-center double blind, adaptive phase 2 study in sickle cell disease. Blood 2013; 122:(abstract).
    • (2013) Blood , vol.122
    • Telen, M.J.1    Wun, T.2    McCavit, T.L.3
  • 100
    • 84928492198 scopus 로고    scopus 로고
    • Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use
    • Telen MJ, Wun T, McCavit TL, et al. Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use. Blood 2015; 125:2656-2664.
    • (2015) Blood , vol.125 , pp. 2656-2664
    • Telen, M.J.1    Wun, T.2    McCavit, T.L.3
  • 101
    • 78751507531 scopus 로고    scopus 로고
    • Inhibition of cell adhesion by anti-P-selectin aptamer: A new potential therapeutic agent for sickle cell disease
    • Gutsaeva DR, Parkerson JB, Yerigenahally SD, et al. Inhibition of cell adhesion by anti-P-selectin aptamer: A new potential therapeutic agent for sickle cell disease. Blood 2011; 117:727-735.
    • (2011) Blood , vol.117 , pp. 727-735
    • Gutsaeva, D.R.1    Parkerson, J.B.2    Yerigenahally, S.D.3
  • 102
    • 0035824175 scopus 로고    scopus 로고
    • Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease - A randomized controlled trial
    • Orringer EP, Casella JF, Ataga KI, et al. Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease - A randomized controlled trial. JAMA 2001; 286:2099-2106.
    • (2001) JAMA , vol.286 , pp. 2099-2106
    • Orringer, E.P.1    Casella, J.F.2    Ataga, K.I.3
  • 103
    • 9244235516 scopus 로고    scopus 로고
    • Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: Computer-assisted intravital microscopy study
    • Cheung ATW, Chan MS, Ramanujam S, et al. Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: Computer-assisted intravital microscopy study. J Invest Med 2004; 52:402-406.
    • (2004) J Invest Med , vol.52 , pp. 402-406
    • Cheung, A.T.W.1    Chan, M.S.2    Ramanujam, S.3
  • 104
    • 84871358724 scopus 로고    scopus 로고
    • Effect of propranolol as antiadhesive therapy in sickle cell disease
    • De Castro LM, Zennadi R, Jonassaint JC, et al. Effect of propranolol as antiadhesive therapy in sickle cell disease. Clin Transl Sci 2012; 5:437-444.
    • (2012) Clin Transl Sci , vol.5 , pp. 437-444
    • De Castro, L.M.1    Zennadi, R.2    Jonassaint, J.C.3
  • 105
    • 84904041713 scopus 로고    scopus 로고
    • A multicenter, double-blind, placebo-controlled trial of the PDE9A inhibitor
    • Schwam E, Nicholas T, Chew R, et al. A multicenter, double-blind, placebo-controlled trial of the PDE9A inhibitor. Curr Alzheimer Res 2014; 11:413-421.
    • (2014) Curr Alzheimer Res , vol.11 , pp. 413-421
    • Schwam, E.1    Nicholas, T.2    Chew, R.3
  • 106
    • 84928285050 scopus 로고    scopus 로고
    • Single-dose intravenous gamamglobulin can stabilize neutrophil Mac-1 activation in sickle cell pain crises
    • Manwani D, Chen G, Carullo V, et al. Single-dose intravenous gamamglobulin can stabilize neutrophil Mac-1 activation in sickle cell pain crises. Am J Hematol 2015; 90:381-385.
    • (2015) Am J Hematol , vol.90 , pp. 381-385
    • Manwani, D.1    Chen, G.2    Carullo, V.3
  • 107
    • 84873737324 scopus 로고    scopus 로고
    • A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease
    • Wun T, Soulieres D, Frelinger AL, et al. A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease. J Hematol Oncol 2013; 6:17.
    • (2013) J Hematol Oncol , vol.6 , pp. 17
    • Wun, T.1    Soulieres, D.2    Frelinger, A.L.3
  • 108
    • 0028234283 scopus 로고
    • The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease
    • Castro O, Brambilla DJ, Thorington B, et al. The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease. Blood 1994; 84:643-649.
    • (1994) Blood , vol.84 , pp. 643-649
    • Castro, O.1    Brambilla, D.J.2    Thorington, B.3
  • 109
    • 0032989606 scopus 로고    scopus 로고
    • Silent cerebral infarcts in sickle cell anemia: A risk factor analysis. The Cooperative Study of Sickle Cell Disease
    • Kinney TR, Sleeper LA, Wang WC, et al. Silent cerebral infarcts in sickle cell anemia: A risk factor analysis. The Cooperative Study of Sickle Cell Disease. Pediatrics 1999; 103:640-645.
    • (1999) Pediatrics , vol.103 , pp. 640-645
    • Kinney, T.R.1    Sleeper, L.A.2    Wang, W.C.3
  • 110
    • 84897499880 scopus 로고    scopus 로고
    • Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation
    • Li J, Kim K, Hahm E, et al. Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. J Clin Invest 2014; 124:1483-1496.
    • (2014) J Clin Invest , vol.124 , pp. 1483-1496
    • Li, J.1    Kim, K.2    Hahm, E.3
  • 111
    • 84902189880 scopus 로고    scopus 로고
    • Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression
    • Zhang Y Berka V, Song A, et al. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. J Clin Invest 2014; 124:2750-2761.
    • (2014) J Clin Invest , vol.124 , pp. 2750-2761
    • Zhang, Y.1    Berka, V.2    Song, A.3
  • 112
    • 84897514444 scopus 로고    scopus 로고
    • Not simply misshapen red cells: Multimolecular and cellular events in sickle vaso-occlusion
    • Vercellotti GM, Belcher JD. Not simply misshapen red cells: Multimolecular and cellular events in sickle vaso-occlusion. J Clin Invest 2014; 124:1462-1465.
    • (2014) J Clin Invest , vol.124 , pp. 1462-1465
    • Vercellotti, G.M.1    Belcher, J.D.2
  • 113
    • 2342455050 scopus 로고    scopus 로고
    • Zileuton induces hemoglobin F synthesis in erythroid progenitors: Role of the l-arginine-nitric oxide signaling pathway
    • Haynes J, Baliga BS, Obiako B, et al. Zileuton induces hemoglobin F synthesis in erythroid progenitors: Role of the l-arginine-nitric oxide signaling pathway. Blood 2004; 103:3945-3950.
    • (2004) Blood , vol.103 , pp. 3945-3950
    • Haynes, J.1    Baliga, B.S.2    Obiako, B.3
  • 114
    • 79958007234 scopus 로고    scopus 로고
    • Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
    • Macari ER, Lowrey CH. Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway. Blood 2011; 117:5987-5997.
    • (2011) Blood , vol.117 , pp. 5987-5997
    • Macari, E.R.1    Lowrey, C.H.2
  • 115
    • 84907646540 scopus 로고    scopus 로고
    • Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina
    • Promsote W, Makala L, Li B, et al. Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina. Invest Ophthalmol Vis Sci 2014; 55:5382-5393.
    • (2014) Invest Ophthalmol Vis Sci , vol.55 , pp. 5382-5393
    • Promsote, W.1    Makala, L.2    Li, B.3
  • 116
    • 84868525766 scopus 로고    scopus 로고
    • Atorvastatin reduces serum cholesterol and triglycerides with limited improvement in vascular function in adults with sickle cell anemia
    • Bereal-Williams C, Machado RF, McGowan V, et al. Atorvastatin reduces serum cholesterol and triglycerides with limited improvement in vascular function in adults with sickle cell anemia. Haematologica 2012; 97:1768-1770.
    • (2012) Haematologica , vol.97 , pp. 1768-1770
    • Bereal-Williams, C.1    Machado, R.F.2    McGowan, V.3
  • 117
    • 79955715758 scopus 로고    scopus 로고
    • A pilot study of the short-term use of simvastatin in sickle cell disease: Effects on markers of vascular dysfunction
    • Hoppe C, Kuypers F, Larkin S, et al. A pilot study of the short-term use of simvastatin in sickle cell disease: Effects on markers of vascular dysfunction. Br J Haematol 2011; 153:655-663.
    • (2011) Br J Haematol , vol.153 , pp. 655-663
    • Hoppe, C.1    Kuypers, F.2    Larkin, S.3
  • 118
    • 84936098682 scopus 로고    scopus 로고
    • Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease
    • Kalish BT, Matte A, Andolfo I, et al. Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease. Haematologica 2015; 100:870-880.
    • (2015) Haematologica , vol.100 , pp. 870-880
    • Kalish, B.T.1    Matte, A.2    Andolfo, I.3
  • 119
    • 84908178939 scopus 로고    scopus 로고
    • MEK inhibitors, novel anti-adhesive molecules, reduce sickle red blood cell adhesion in vitro and in vivo, and vasoocclusion in vivo
    • Zennadi R. MEK inhibitors, novel anti-adhesive molecules, reduce sickle red blood cell adhesion in vitro and in vivo, and vasoocclusion in vivo. PLos One 2014; 9:11.
    • (2014) PLos One , vol.9 , pp. 11
    • Zennadi, R.1
  • 120
    • 14044254869 scopus 로고    scopus 로고
    • Impaired vasodilation by red blood cells in sickle cell disease
    • Pawloski JR, Hess DT, Stamler JS. Impaired vasodilation by red blood cells in sickle cell disease. Proc Natl Acad Sci USA 2005; 102:2531-2536.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2531-2536
    • Pawloski, J.R.1    Hess, D.T.2    Stamler, J.S.3
  • 121
    • 0036908599 scopus 로고    scopus 로고
    • Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
    • Reiter CD, Wang XD, Tanus-Santos JE, et al. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 2002; 8:1383-1389.
    • (2002) Nat Med , vol.8 , pp. 1383-1389
    • Reiter, C.D.1    Wang, X.D.2    Tanus-Santos, J.E.3
  • 122
    • 10744233940 scopus 로고    scopus 로고
    • Pulmonary hypertension as a risk factor for death in patients with sickle cell disease
    • Gladwin MT, Sachdev, V, Jison ML, et al. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med 2004; 350:886-895.
    • (2004) N Engl J Med , vol.350 , pp. 886-895
    • Gladwin, M.T.1    Sachdev, V.2    Jison, M.L.3
  • 123
    • 56749163948 scopus 로고    scopus 로고
    • Pulmonary complications of sickle cell disease
    • Gladwin MT, Vichinsky E. Pulmonary complications of sickle cell disease. N Engl J Med 2008; 359:2254-2265.
    • (2008) N Engl J Med , vol.359 , pp. 2254-2265
    • Gladwin, M.T.1    Vichinsky, E.2
  • 124
    • 79960101398 scopus 로고    scopus 로고
    • A hemodynamic study of pulmonary hypertension in sickle cell disease
    • Parent F, Bachir D, Inamo J, et al. A hemodynamic study of pulmonary hypertension in sickle cell disease. N Engl J Med 2011; 365:44-53.
    • (2011) N Engl J Med , vol.365 , pp. 44-53
    • Parent, F.1    Bachir, D.2    Inamo, J.3
  • 125
    • 77955279272 scopus 로고    scopus 로고
    • Pulmonary hypertension and nitric oxide depletion in sickle cell disease
    • Bunn HF, Nathan DG, Dover GJ, et al. Pulmonary hypertension and nitric oxide depletion in sickle cell disease. Blood 2010; 116:687-692.
    • (2010) Blood , vol.116 , pp. 687-692
    • Bunn, H.F.1    Nathan, D.G.2    Dover, G.J.3
  • 126
    • 77956270087 scopus 로고    scopus 로고
    • Pulmonary hypertension and NO in sickle cell
    • Gladwin MT, Barst RJ, Castro OL, et al. Pulmonary hypertension and NO in sickle cell. Blood 2010; 116:852-854.
    • (2010) Blood , vol.116 , pp. 852-854
    • Gladwin, M.T.1    Barst, R.J.2    Castro, O.L.3
  • 127
    • 80053620977 scopus 로고    scopus 로고
    • Guilt by association
    • Nathan DG Guilt by association. Blood 2011; 118:3758-3759.
    • (2011) Blood , vol.118 , pp. 3758-3759
    • Nathan, D.G.1
  • 128
    • 0037420269 scopus 로고    scopus 로고
    • Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease
    • Weiner DL, Hibberd PL, Betit P, et al. Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease. JAMA 2003; 289:1136-1142.
    • (2003) JAMA , vol.289 , pp. 1136-1142
    • Weiner, D.L.1    Hibberd, P.L.2    Betit, P.3
  • 129
    • 79952233719 scopus 로고    scopus 로고
    • Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis a randomized controlled trial
    • Gladwin MT, Kato GJ, Weiner D, et al. Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis a randomized controlled trial. JAMA 2011; 305:893-902.
    • (2011) JAMA , vol.305 , pp. 893-902
    • Gladwin, M.T.1    Kato, G.J.2    Weiner, D.3
  • 130
    • 0030669447 scopus 로고    scopus 로고
    • Inhaled nitric oxide in sickle cell disease with acute chest syndrome
    • Atz AM, Wessel DL. Inhaled nitric oxide in sickle cell disease with acute chest syndrome. Anesthesiology 1997; 87:988-990.
    • (1997) Anesthesiology , vol.87 , pp. 988-990
    • Atz, A.M.1    Wessel, D.L.2
  • 131
    • 0032738619 scopus 로고    scopus 로고
    • Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent
    • Sullivan KJ, Goodwin SR, Evangelist J, et al. Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent. Crit Care Med 1999; 27:2563-2568.
    • (1999) Crit Care Med , vol.27 , pp. 2563-2568
    • Sullivan, K.J.1    Goodwin, S.R.2    Evangelist, J.3
  • 132
    • 0035869387 scopus 로고    scopus 로고
    • Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress-mediated vasodilation
    • Belhassen L, Pelle G, Sediame S, et al. Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress-mediated vasodilation. Blood 2001; 97:1584-1589.
    • (2001) Blood , vol.97 , pp. 1584-1589
    • Belhassen, L.1    Pelle, G.2    Sediame, S.3
  • 133
    • 37049023457 scopus 로고    scopus 로고
    • Endothelial-dependent vasodilation is impaired in children with sickle cell disease
    • de Montalembert M, Aggoun Y, Niakate A, et al. Endothelial-dependent vasodilation is impaired in children with sickle cell disease. Haematologica 2007; 92:1709-1710.
    • (2007) Haematologica , vol.92 , pp. 1709-1710
    • de Montalembert, M.1    Aggoun, Y.2    Niakate, A.3
  • 134
    • 79961004549 scopus 로고    scopus 로고
    • Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity
    • Machado RF, Barst RJ, Yovetich NA, et al. Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. Blood 2011; 118:855-864.
    • (2011) Blood , vol.118 , pp. 855-864
    • Machado, R.F.1    Barst, R.J.2    Yovetich, N.A.3
  • 135
    • 84903141313 scopus 로고    scopus 로고
    • Randomized controlled trial of sildenafil for preventing recurrent ischemic priapism in sickle cell disease
    • Burnett AL, Anele UA, Trueheart IN, et al. Randomized controlled trial of sildenafil for preventing recurrent ischemic priapism in sickle cell disease. Am J Med 2014; 127:664-668.
    • (2014) Am J Med , vol.127 , pp. 664-668
    • Burnett, A.L.1    Anele, U.A.2    Trueheart, I.N.3
  • 136
    • 77950820615 scopus 로고    scopus 로고
    • Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: Results of the ASSET studies
    • Barst RJ, Mubarak KK, Machado RF, et al. Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: Results of the ASSET studies. Br J Haematol 2010; 149:426-435.
    • (2010) Br J Haematol , vol.149 , pp. 426-435
    • Barst, R.J.1    Mubarak, K.K.2    Machado, R.F.3
  • 137
    • 84896898737 scopus 로고    scopus 로고
    • Alterations of the arginine metabolome in sickle cell disease: A growing rationale for arginine therapy
    • Morris CR. Alterations of the arginine metabolome in sickle cell disease: A growing rationale for arginine therapy. Hematol/Oncol Clin North Am 2014; 28:301-321.
    • (2014) Hematol/Oncol Clin North Am , vol.28 , pp. 301-321
    • Morris, C.R.1
  • 138
    • 84883621394 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes
    • Morris CR, Kuypers FA, Lavrisha L, et al. A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes. Haematologica 2013; 98:1375-1382.
    • (2013) Haematologica , vol.98 , pp. 1375-1382
    • Morris, C.R.1    Kuypers, F.A.2    Lavrisha, L.3
  • 139
    • 84874439878 scopus 로고    scopus 로고
    • Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins
    • Schaer DJ, Buehler PW, Alayash AI, et al. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood 2013; 121:1276-1284.
    • (2013) Blood , vol.121 , pp. 1276-1284
    • Schaer, D.J.1    Buehler, P.W.2    Alayash, A.I.3
  • 140
    • 84924002582 scopus 로고    scopus 로고
    • Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease
    • Chintagari NR, Nguyen J, Belcher JD, et al. Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease. Blood Cells Mol Dis 2015; 54:302-306.
    • (2015) Blood Cells Mol Dis , vol.54 , pp. 302-306
    • Chintagari, N.R.1    Nguyen, J.2    Belcher, J.D.3
  • 141
    • 84908407148 scopus 로고    scopus 로고
    • Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications
    • Boretti FS, Baek JH, Palmer AF, et al. Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications. Front Physiol 2014; 5:385
    • (2014) Front Physiol , vol.5 , pp. 385
    • Boretti, F.S.1    Baek, J.H.2    Palmer, A.F.3
  • 142
    • 0031156954 scopus 로고    scopus 로고
    • A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study
    • Gonzalez P, Hackney AC, Jones S, et al. A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study. J Invest Med 1997; 45:258-264.
    • (1997) J Invest Med , vol.45 , pp. 258-264
    • Gonzalez, P.1    Hackney, A.C.2    Jones, S.3
  • 143
    • 44249093233 scopus 로고    scopus 로고
    • Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: A meta-analysis
    • Natanson C, Kern SJ, Lurie P, et al. Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: A meta-analysis. JAMA 2008; 299:2304-2312.
    • (2008) JAMA , vol.299 , pp. 2304-2312
    • Natanson, C.1    Kern, S.J.2    Lurie, P.3
  • 144
    • 84942170633 scopus 로고    scopus 로고
    • Last accessed on July 28, 2015
    • http://www.sec.gov/Archives/edgar/data/1420031/000104746915003012/a2223903z10-k.htm. Last accessed on July 28, 2015.
  • 145
    • 84881262533 scopus 로고    scopus 로고
    • β-globin gene transfer to human bone marrow for sickle cell disease
    • Romero Z, Urbinati F, Geiger S, et al. β-globin gene transfer to human bone marrow for sickle cell disease. J Clin Invest 2013; 123:3317-3330.
    • (2013) J Clin Invest , vol.123 , pp. 3317-3330
    • Romero, Z.1    Urbinati, F.2    Geiger, S.3
  • 146
    • 84929047585 scopus 로고    scopus 로고
    • Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34+ cells
    • Urbinati F, Hargrove PW, Geiger S, et al. Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34+ cells. Exp Hematol 2015; 43:346-351.
    • (2015) Exp Hematol , vol.43 , pp. 346-351
    • Urbinati, F.1    Hargrove, P.W.2    Geiger, S.3
  • 147
    • 84928470127 scopus 로고    scopus 로고
    • Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells
    • Hoban MD, Cost GJ, Mendel MC, et al. Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells. Blood 2015; 125:2597-2604.
    • (2015) Blood , vol.125 , pp. 2597-2604
    • Hoban, M.D.1    Cost, G.J.2    Mendel, M.C.3
  • 148
    • 84930613203 scopus 로고    scopus 로고
    • CRISPR, the disruptor
    • Ledford H. CRISPR, the disruptor. Nature 2015; 522:20-24.
    • (2015) Nature , vol.522 , pp. 20-24
    • Ledford, H.1
  • 149
    • 84898444338 scopus 로고    scopus 로고
    • Haematopoietic stem cell transplantation for severe sickle cell disease in childhood: A single centre experience of 50 patients
    • Dedeken L, Le PQ, Azzi N, et al. Haematopoietic stem cell transplantation for severe sickle cell disease in childhood: A single centre experience of 50 patients. Br J Haematol 2014; 165:402-408.
    • (2014) Br J Haematol , vol.165 , pp. 402-408
    • Dedeken, L.1    Le, P.Q.2    Azzi, N.3
  • 150
    • 34948830175 scopus 로고    scopus 로고
    • Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease
    • Bernaudin F, Socie G, Kuentz M, et al. Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease. Blood 2007; 110:2749-2756.
    • (2007) Blood , vol.110 , pp. 2749-2756
    • Bernaudin, F.1    Socie, G.2    Kuentz, M.3
  • 151
    • 84886897873 scopus 로고    scopus 로고
    • Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling. Blood
    • Locatelli F, Kabbara N, Ruggeri A, et al. Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling. Blood 2013; 122:1072-1078.
    • (2013) , vol.122 , pp. 1072-1078
    • Locatelli, F.1    Kabbara, N.2    Ruggeri, A.3
  • 152
    • 84942164379 scopus 로고    scopus 로고
    • Survival among children and adults with sickle cell disease in Belgium: Benefit from hydroxyurea treatment
    • Lê PQ, Gulbis, Dedeken L, Dupont S, et al. Survival among children and adults with sickle cell disease in Belgium: Benefit from hydroxyurea treatment. Pediatr Blood Cancer, in press.
    • Pediatr Blood Cancer
    • Lê PQ, G.1    Dedeken, L.2    Dupont, S.3
  • 153
    • 84903625438 scopus 로고    scopus 로고
    • Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype
    • Hsieh MM, Fitzhugh CD, Weitzel RP, et al. Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype. JAMA 2014; 312:48-56.
    • (2014) JAMA , vol.312 , pp. 48-56
    • Hsieh, M.M.1    Fitzhugh, C.D.2    Weitzel, R.P.3
  • 154
    • 84928207399 scopus 로고    scopus 로고
    • Using fludarabine to reduce exposure to alkylating agents in children with sickle cell disease receiving busulfan, cyclophosphamide, and antithymocyte globulin transplant conditioning: Results of a dose de-escalation trial
    • Horan JT, Haight A, Dioguardi JL, et al. Using fludarabine to reduce exposure to alkylating agents in children with sickle cell disease receiving busulfan, cyclophosphamide, and antithymocyte globulin transplant conditioning: Results of a dose de-escalation trial. Biol Blood Marrow Transplant 2015; 21:900-905.
    • (2015) Biol Blood Marrow Transplant , vol.21 , pp. 900-905
    • Horan, J.T.1    Haight, A.2    Dioguardi, J.L.3
  • 155
    • 84868582399 scopus 로고    scopus 로고
    • Sickle cell pain: A critical reappraisal
    • Ballas SK, Gupta K, Adams-Graves P. Sickle cell pain: A critical reappraisal. Blood 2012; 120:3647-3656.
    • (2012) Blood , vol.120 , pp. 3647-3656
    • Ballas, S.K.1    Gupta, K.2    Adams-Graves, P.3
  • 157
    • 84888039064 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox compared with deferoxamine in sickle cell disease: Two-year results including pharmacokinetics and concomitant hydroxyurea
    • Vichinsky E, Torres M, Minniti CP, et al. Efficacy and safety of deferasirox compared with deferoxamine in sickle cell disease: Two-year results including pharmacokinetics and concomitant hydroxyurea. Am J Hematol 2013; 88:1068-1073.
    • (2013) Am J Hematol , vol.88 , pp. 1068-1073
    • Vichinsky, E.1    Torres, M.2    Minniti, C.P.3
  • 158
    • 80051762413 scopus 로고    scopus 로고
    • Increased prevalence of osteonecrosis of the femoral head in children and adolescents with sickle-cell disease
    • Mahadeo KM, Oyeku S, Taragin B, et al. Increased prevalence of osteonecrosis of the femoral head in children and adolescents with sickle-cell disease. Am J Hematol 2011; 86:806-808.
    • (2011) Am J Hematol , vol.86 , pp. 806-808
    • Mahadeo, K.M.1    Oyeku, S.2    Taragin, B.3
  • 159
    • 84856077947 scopus 로고    scopus 로고
    • The natural progression of symptomatic humeral head osteonecrosis in adults with sickle cell disease
    • Poignard A, Flouzat-Lachaniette CH, Amzallag J, et al. The natural progression of symptomatic humeral head osteonecrosis in adults with sickle cell disease. J Bone Joint Surg Am 2012;94:156-162.
    • (2012) J Bone Joint Surg Am , vol.94 , pp. 156-162
    • Poignard, A.1    Flouzat-Lachaniette, C.H.2    Amzallag, J.3
  • 160
    • 84885022675 scopus 로고    scopus 로고
    • Excellent results and minimal complications of total hip arthroplasty in sickle cell hemoglobinopathy at mid-term follow-up using cementless prosthetic components
    • Issa K, Naziri Q, Maheshwari AV, et al. Excellent results and minimal complications of total hip arthroplasty in sickle cell hemoglobinopathy at mid-term follow-up using cementless prosthetic components. J Arthroplast 2013; 28:1693-1698.
    • (2013) J Arthroplast , vol.28 , pp. 1693-1698
    • Issa, K.1    Naziri, Q.2    Maheshwari, A.V.3
  • 161
    • 84923776133 scopus 로고    scopus 로고
    • Sickle cell disease: Renal manifestations and mechanisms
    • Nath KA, Hebbel RP. Sickle cell disease: Renal manifestations and mechanisms. Nat Rev Nephrol 2015; 11:161-171.
    • (2015) Nat Rev Nephrol , vol.11 , pp. 161-171
    • Nath, K.A.1    Hebbel, R.P.2
  • 162
    • 84902134170 scopus 로고    scopus 로고
    • Prevalence and progression of chronic kidney disease in adult patients with sickle cell disease
    • Gosmanova EO, Zaidi S, Wan JY, et al. Prevalence and progression of chronic kidney disease in adult patients with sickle cell disease. J Invest Med 2014; 62:804-807.
    • (2014) J Invest Med , vol.62 , pp. 804-807
    • Gosmanova, E.O.1    Zaidi, S.2    Wan, J.Y.3
  • 163
    • 84886544419 scopus 로고    scopus 로고
    • The prevalence of hypertension and abnormal kidney function in children with sickle cell disease -a cross sectional review
    • Bodas P, Huang A, O'Riordan MA, et al. The prevalence of hypertension and abnormal kidney function in children with sickle cell disease -a cross sectional review. BMC Nephrol 2013; 14:6.
    • (2013) BMC Nephrol , vol.14 , pp. 6
    • Bodas, P.1    Huang, A.2    O'Riordan, M.A.3
  • 164
    • 84901812596 scopus 로고    scopus 로고
    • Hydroxyurea is associated with lower prevalence of albuminuria in adults with sickle cell disease
    • Laurin LP, Nachman PH, Desai PC, et al. Hydroxyurea is associated with lower prevalence of albuminuria in adults with sickle cell disease. Nephrol Dial Transplant 2014; 29:1211-1218.
    • (2014) Nephrol Dial Transplant , vol.29 , pp. 1211-1218
    • Laurin, L.P.1    Nachman, P.H.2    Desai, P.C.3
  • 165
    • 84864806084 scopus 로고    scopus 로고
    • Hemoglobin sickle cell disease complications: A clinical study of 179 cases
    • Lionnet F, Hammoudi N, Stojanovic KS, et al. Hemoglobin sickle cell disease complications: A clinical study of 179 cases. Haematol-Hematol J 2012; 97:1136-1141.
    • (2012) Haematol-Hematol J , vol.97 , pp. 1136-1141
    • Lionnet, F.1    Hammoudi, N.2    Stojanovic, K.S.3
  • 166
    • 84880777479 scopus 로고    scopus 로고
    • Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease
    • Wanek J, Gaynes B, Lim JI, et al. Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease. Am J Hematol 2013; 88:661-664.
    • (2013) Am J Hematol , vol.88 , pp. 661-664
    • Wanek, J.1    Gaynes, B.2    Lim, J.I.3
  • 167
    • 84918805176 scopus 로고    scopus 로고
    • Pneumococcal vaccination rates in children with sickle cell disease
    • Nero AC, Akuete K, Reeves SL, et al. Pneumococcal vaccination rates in children with sickle cell disease. J Public Health Manag Pract 2014; 20:587-590.
    • (2014) J Public Health Manag Pract , vol.20 , pp. 587-590
    • Nero, A.C.1    Akuete, K.2    Reeves, S.L.3
  • 168
    • 84891742904 scopus 로고    scopus 로고
    • Invasive pneumococcal disease among children with and without sickle cell disease in the United States, 1998 to 2009
    • Payne AB, Link-Gelles R, Azonobi I, et al. Invasive pneumococcal disease among children with and without sickle cell disease in the United States, 1998 to 2009. Pediatr Infect Dis J 2013; 32:1308-1312.
    • (2013) Pediatr Infect Dis J , vol.32 , pp. 1308-1312
    • Payne, A.B.1    Link-Gelles, R.2    Azonobi, I.3
  • 169
    • 84896894640 scopus 로고    scopus 로고
    • Ambulatory quality indicators to prevent infection in sickle cell disease
    • Beverung LM, Brousseau D, Hoffmann RG, et al. Ambulatory quality indicators to prevent infection in sickle cell disease. Am J Hematol 2014; 89:256-260.
    • (2014) Am J Hematol , vol.89 , pp. 256-260
    • Beverung, L.M.1    Brousseau, D.2    Hoffmann, R.G.3
  • 170
    • 84903744852 scopus 로고    scopus 로고
    • Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phophorylation
    • Soderblom EJ, Thompson JW, Schwartz EA, et al. Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phophorylation. Clin Proteom 2013; 10:1.
    • (2013) Clin Proteom , vol.10 , pp. 1
    • Soderblom, E.J.1    Thompson, J.W.2    Schwartz, E.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.