메뉴 건너뛰기




Volumn 98, Issue 2, 2007, Pages 392-396

Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial

Author keywords

Genetic disease; Heparin; Pain; Sickle cell anemia; Tinzaparin

Indexed keywords

LOW MOLECULAR WEIGHT HEPARIN; MORPHINE; PLACEBO; TINZAPARIN;

EID: 34547863870     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH06-12-0718     Document Type: Article
Times cited : (107)

References (46)
  • 1
    • 33646472892 scopus 로고    scopus 로고
    • Pathophysiologically based drug treatment of sickle cell disease
    • Steinberg MH. Pathophysiologically based drug treatment of sickle cell disease. Trends Pharmacol Sci 2006; 27: 204-210.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 204-210
    • Steinberg, M.H.1
  • 2
    • 0013078733 scopus 로고
    • Sickle cell disease
    • Hoffman R, Benz EJ Jr, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, eds, 2nd ed. New York, Churchill Livingston
    • Embury SH. Sickle cell disease. In: Hoffman R, Benz EJ Jr, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, eds. Hematology, Principles and Practice. 2nd ed. New York, Churchill Livingston 1995: 611-648.
    • (1995) Hematology, Principles and Practice , pp. 611-648
    • Embury, S.H.1
  • 3
    • 33745315219 scopus 로고    scopus 로고
    • Pharmacodynamic effects of low molecular weight heparin tinzaparin in obese subjects following subcutaneous administration of 75 IU/kg on plasma tissue factor pathway inhibitor and nitric oxide
    • Mousa SA, Johansen K. Pharmacodynamic effects of low molecular weight heparin tinzaparin in obese subjects following subcutaneous administration of 75 IU/kg on plasma tissue factor pathway inhibitor and nitric oxide. Int Angiol 2005; 24: 40-42.
    • (2005) Int Angiol , vol.24 , pp. 40-42
    • Mousa, S.A.1    Johansen, K.2
  • 4
    • 27744567927 scopus 로고    scopus 로고
    • Elevation of plasma von Willebrand factor and tumor necrosis factor-a in obese subjects and their reduction by the low molecular weight heparin tinzaparin
    • Mousa SA. Elevation of plasma von Willebrand factor and tumor necrosis factor-a in obese subjects and their reduction by the low molecular weight heparin tinzaparin. Int Angiol 2005; 24: 278-281.
    • (2005) Int Angiol , vol.24 , pp. 278-281
    • Mousa, S.A.1
  • 5
    • 3042832804 scopus 로고    scopus 로고
    • Low-molecular-weight heparins in thrombosis and cancer: Emerging links
    • Mousa SA. Low-molecular-weight heparins in thrombosis and cancer: emerging links. Cardiovasc Drug Rev 2004; 22: 121-134.
    • (2004) Cardiovasc Drug Rev , vol.22 , pp. 121-134
    • Mousa, S.A.1
  • 6
    • 26444566779 scopus 로고    scopus 로고
    • Differential metastasis inhibition by clinically relevant levels of heparins-correlation with selectin inhibition, not anti-thrombotic activity
    • Stevenson JL, Choi SH, Varki A. Differential metastasis inhibition by clinically relevant levels of heparins-correlation with selectin inhibition, not anti-thrombotic activity. Clin Cancer Res 2005; 11: 7003-7011.
    • (2005) Clin Cancer Res , vol.11 , pp. 7003-7011
    • Stevenson, J.L.1    Choi, S.H.2    Varki, A.3
  • 7
    • 22144448238 scopus 로고    scopus 로고
    • Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: A systematic review. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study
    • Wu O, Robertson L, Langhorne P, et al. Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: a systematic review. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study. Thromb Haemost 2005; 94: 17-25.
    • (2005) Thromb Haemost , vol.94 , pp. 17-25
    • Wu, O.1    Robertson, L.2    Langhorne, P.3
  • 8
    • 33845622107 scopus 로고    scopus 로고
    • A comparative study of pain measurement scales in acute bum patients
    • Jaywant S, Pai A. A comparative study of pain measurement scales in acute bum patients. Ind J Occup Ther 2003; 35: 13.
    • (2003) Ind J Occup Ther , vol.35 , pp. 13
    • Jaywant, S.1    Pai, A.2
  • 9
    • 0029979392 scopus 로고    scopus 로고
    • Disturbance of plasma and platelet thrombospondin levels in sickle cell disease
    • Browne PV, Mosher DF, Steinberg MH, et al. Disturbance of plasma and platelet thrombospondin levels in sickle cell disease. Am J Hematol 1996; 51: 296-301.
    • (1996) Am J Hematol , vol.51 , pp. 296-301
    • Browne, P.V.1    Mosher, D.F.2    Steinberg, M.H.3
  • 10
    • 0022454179 scopus 로고
    • Fragment D-dimer levels: An objective marker of vaso-occlusive crisis and other complications of sickle cell disease
    • Devine DV, Kinney TR, Thomas PF, et al. Fragment D-dimer levels: an objective marker of vaso-occlusive crisis and other complications of sickle cell disease. Blood 1986; 68: 317-319.
    • (1986) Blood , vol.68 , pp. 317-319
    • Devine, D.V.1    Kinney, T.R.2    Thomas, P.F.3
  • 11
    • 0028903653 scopus 로고
    • Changes in coagulation and fibrinolysis in patients with sickle cell disease compared with healthy black controls
    • Hagger D, Wolff S, Owen J, et al. Changes in coagulation and fibrinolysis in patients with sickle cell disease compared with healthy black controls. Blood Coagul Fibrinol 1995; 6: 93-99.
    • (1995) Blood Coagul Fibrinol , vol.6 , pp. 93-99
    • Hagger, D.1    Wolff, S.2    Owen, J.3
  • 12
    • 0032101042 scopus 로고    scopus 로고
    • Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease
    • Key NS, Slungaard A, Dandelet L, et al. Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease. Blood 1998; 91: 4216-4223.
    • (1998) Blood , vol.91 , pp. 4216-4223
    • Key, N.S.1    Slungaard, A.2    Dandelet, L.3
  • 13
    • 0026743902 scopus 로고
    • Plasma factor VII and thrombin-anti-thrombin III levels indicate increased tissue factor activity in sickle cell patients
    • Kurantsin-Mills J, Ofosu FA, Safa TK, et al. Plasma factor VII and thrombin-anti-thrombin III levels indicate increased tissue factor activity in sickle cell patients. Br J Haematol 1992; 81: 539-544.
    • (1992) Br J Haematol , vol.81 , pp. 539-544
    • Kurantsin-Mills, J.1    Ofosu, F.A.2    Safa, T.K.3
  • 14
    • 0028322292 scopus 로고
    • Elevated urinary levels of thromboxane and prostacyclin metabolites in sickle cell disease reflect activated platelets in the circulation
    • Kurantsin-Mills J, Ibe BO, Natta CL, et al. Elevated urinary levels of thromboxane and prostacyclin metabolites in sickle cell disease reflect activated platelets in the circulation. Br J Haematol 1994; 87: 580-585.
    • (1994) Br J Haematol , vol.87 , pp. 580-585
    • Kurantsin-Mills, J.1    Ibe, B.O.2    Natta, C.L.3
  • 15
    • 0029763425 scopus 로고    scopus 로고
    • Abnormalities of coagulation and fibrinolysis in homozygous sickle cell disease
    • Nsiri B, Grith N, Bayoudh F, et al. Abnormalities of coagulation and fibrinolysis in homozygous sickle cell disease. Hematol Cell Ther 1996; 38: 279-284.
    • (1996) Hematol Cell Ther , vol.38 , pp. 279-284
    • Nsiri, B.1    Grith, N.2    Bayoudh, F.3
  • 16
    • 0027957535 scopus 로고
    • Enhanced thrombin generation in children with sickle cell disease
    • Peters M, Plaat BEC, ten Cate H, et al. Enhanced thrombin generation in children with sickle cell disease. Thromb Haemost 1994; 71: 169-172.
    • (1994) Thromb Haemost , vol.71 , pp. 169-172
    • Peters, M.1    Plaat, B.E.C.2    ten Cate, H.3
  • 17
    • 0032080802 scopus 로고    scopus 로고
    • Tissue factor expression by endothelial cells in sickle cell anemia
    • Solovey A, Gui L, Key NS, et al. Tissue factor expression by endothelial cells in sickle cell anemia. J Clin Invest 1998; 101: 1899-1904.
    • (1998) J Clin Invest , vol.101 , pp. 1899-1904
    • Solovey, A.1    Gui, L.2    Key, N.S.3
  • 18
    • 0025366383 scopus 로고
    • Platelet functions in sickle cell disease during steady state
    • Triadou P, Fonty E, Ambrosio AS, et al. Platelet functions in sickle cell disease during steady state. Nouv Rev Fr Hematol 1990; 32: 137-142.
    • (1990) Nouv Rev Fr Hematol , vol.32 , pp. 137-142
    • Triadou, P.1    Fonty, E.2    Ambrosio, A.S.3
  • 19
    • 0025732539 scopus 로고
    • Large-vessel occlusion in sickle cell disease: Pathogenesis, clinical consequences, and therapeutic implications
    • Francis RB. Large-vessel occlusion in sickle cell disease: pathogenesis, clinical consequences, and therapeutic implications. Med Hypotheses 1991; 35: 88-95.
    • (1991) Med Hypotheses , vol.35 , pp. 88-95
    • Francis, R.B.1
  • 21
    • 34547878070 scopus 로고
    • Pathology of sickle cell disease
    • Murphy RC, Shapiro S. Pathology of sickle cell disease. Ann Intern Med 1945; 23: 376.
    • (1945) Ann Intern Med , vol.23 , pp. 376
    • Murphy, R.C.1    Shapiro, S.2
  • 22
    • 0023911253 scopus 로고
    • Brain infarction in sickle cell anemia: Magnetic resonance imaging correlates
    • Pavlakis SG, Bello J, Prohovnik I, et al. Brain infarction in sickle cell anemia: magnetic resonance imaging correlates. Ann Neurol 1988; 23: 125-130.
    • (1988) Ann Neurol , vol.23 , pp. 125-130
    • Pavlakis, S.G.1    Bello, J.2    Prohovnik, I.3
  • 23
    • 0019440273 scopus 로고
    • Sickled erythrocytes accelerate clotting in vitro: An effect of abnormal membrane lipid asymmetry
    • Chiu D, Lubin B, Roelofsen B, et al. Sickled erythrocytes accelerate clotting in vitro: an effect of abnormal membrane lipid asymmetry. Blood 1981; 58: 398-401.
    • (1981) Blood , vol.58 , pp. 398-401
    • Chiu, D.1    Lubin, B.2    Roelofsen, B.3
  • 24
    • 0018885938 scopus 로고
    • Erythrocyte adherence to endothelium in sickle-cell anemia: A possible determinant of disease severity
    • Hebbel RP, Boogaerts MA, Eaton JW, et al. Erythrocyte adherence to endothelium in sickle-cell anemia: a possible determinant of disease severity. N Engl J Med 1980; 302: 992-995.
    • (1980) N Engl J Med , vol.302 , pp. 992-995
    • Hebbel, R.P.1    Boogaerts, M.A.2    Eaton, J.W.3
  • 25
    • 0019454521 scopus 로고
    • Abnormalities in membrane phospholipids organization in sickled erythrocytes
    • Lubin B, Chiu D, Bastacky J, et al. Abnormalities in membrane phospholipids organization in sickled erythrocytes. J Clin Invest 1981; 67: 1643-1649.
    • (1981) J Clin Invest , vol.67 , pp. 1643-1649
    • Lubin, B.1    Chiu, D.2    Bastacky, J.3
  • 26
    • 0026558470 scopus 로고
    • The use of transcranial ultrasonography to predict stroke on sickle cell disease
    • Adams R, McKie V, Nichols F, et al. The use of transcranial ultrasonography to predict stroke on sickle cell disease. N Engl J Med 1992; 326: 605-610.
    • (1992) N Engl J Med , vol.326 , pp. 605-610
    • Adams, R.1    McKie, V.2    Nichols, F.3
  • 28
    • 0021164824 scopus 로고
    • A double-blind trial of ticlopidine in sickle cell disease
    • Semple MJ, Al-Hasani SF, Kioy P, et al. A double-blind trial of ticlopidine in sickle cell disease. Thromb Haemost 1984; 51: 303-306.
    • (1984) Thromb Haemost , vol.51 , pp. 303-306
    • Semple, M.J.1    Al-Hasani, S.F.2    Kioy, P.3
  • 29
    • 0021192822 scopus 로고
    • Treatment of sickle cell diseases with aspirin
    • Zago MA, Costa FF, Ismael SJ, et al. Treatment of sickle cell diseases with aspirin. Acta Haematol 1984; 72: 61-64.
    • (1984) Acta Haematol , vol.72 , pp. 61-64
    • Zago, M.A.1    Costa, F.F.2    Ismael, S.J.3
  • 31
    • 0023550545 scopus 로고
    • Membrane-associated sickle hemoglobin: A major determinant of sickle erythrocyte rigidity
    • Evans EA, Mohandas N. Membrane-associated sickle hemoglobin: a major determinant of sickle erythrocyte rigidity. Blood 1987; 70: 1443-1449.
    • (1987) Blood , vol.70 , pp. 1443-1449
    • Evans, E.A.1    Mohandas, N.2
  • 32
    • 0029040383 scopus 로고
    • Sickle cell vaso-occlusive crisis is associated with abnormalities in the ratio of vasoconstrictor to vasodilator prostanoids
    • Setty BN, Chen D, Stuart MJ. Sickle cell vaso-occlusive crisis is associated with abnormalities in the ratio of vasoconstrictor to vasodilator prostanoids. Pediatr Res 1995; 38: 95-102.
    • (1995) Pediatr Res , vol.38 , pp. 95-102
    • Setty, B.N.1    Chen, D.2    Stuart, M.J.3
  • 33
    • 0242552237 scopus 로고    scopus 로고
    • Managing sickle cell disease
    • Claster S, Vichinsky EP. Managing sickle cell disease. Br Med J 2003; 327: 1151-1155.
    • (2003) Br Med J , vol.327 , pp. 1151-1155
    • Claster, S.1    Vichinsky, E.P.2
  • 34
    • 0030895689 scopus 로고    scopus 로고
    • Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea
    • Styles LA, Lubin B, Vichinsky E, et al. Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea. Blood 1997; 89: 2554-2559.
    • (1997) Blood , vol.89 , pp. 2554-2559
    • Styles, L.A.1    Lubin, B.2    Vichinsky, E.3
  • 35
    • 0029861597 scopus 로고    scopus 로고
    • Inhibition of plasma-mediated adherence of sickle erythrocytes to microvascular endothelium by conformationally constrained RGD-containing peptides
    • Kumar A, Eckman JR, Wick TM. Inhibition of plasma-mediated adherence of sickle erythrocytes to microvascular endothelium by conformationally constrained RGD-containing peptides. Am J Hematol 1996; 53: 92-98.
    • (1996) Am J Hematol , vol.53 , pp. 92-98
    • Kumar, A.1    Eckman, J.R.2    Wick, T.M.3
  • 36
    • 0034649782 scopus 로고    scopus 로고
    • Monoclonal anti-bodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor
    • Kaul DK, Tsai HM, Liu XD, et al. Monoclonal anti-bodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. Blood 2000; 95: 365-367.
    • (2000) Blood , vol.95 , pp. 365-367
    • Kaul, D.K.1    Tsai, H.M.2    Liu, X.D.3
  • 37
    • 0034102968 scopus 로고    scopus 로고
    • Nitric oxide attenuates normal and sickle red blood cell adherence to pulmonary endothelium
    • Space SL, Lane PA, Pickett CK, et al. Nitric oxide attenuates normal and sickle red blood cell adherence to pulmonary endothelium. Am J Hematol 2000; 63: 200-204.
    • (2000) Am J Hematol , vol.63 , pp. 200-204
    • Space, S.L.1    Lane, P.A.2    Pickett, C.K.3
  • 38
    • 0043204998 scopus 로고    scopus 로고
    • Arginine therapy: A new treatment for pulmonary hypertension in sickle cell disease?
    • Morris CR, Morris SM Jr, Hagar W, et al. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med 2003; 168: 63-69.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 63-69
    • Morris, C.R.1    Morris Jr, S.M.2    Hagar, W.3
  • 39
    • 0030982523 scopus 로고    scopus 로고
    • Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo [see comments]
    • Head CA, Brugnara C, Martinez-Ruiz R, et al. Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo [see comments]. J Clin Invest 1997; 100: 1193-1198.
    • (1997) J Clin Invest , vol.100 , pp. 1193-1198
    • Head, C.A.1    Brugnara, C.2    Martinez-Ruiz, R.3
  • 40
    • 0026338964 scopus 로고
    • Correction of endothelial dysfunction in coronary microcirculation of hypercholesterotlaemic patients by L-arginine
    • Drexler H, Zeiher AM, Meinzer K, et al. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterotlaemic patients by L-arginine. Lancet 1991; 338: 1546-1550.
    • (1991) Lancet , vol.338 , pp. 1546-1550
    • Drexler, H.1    Zeiher, A.M.2    Meinzer, K.3
  • 41
    • 0026459857 scopus 로고
    • L-argi-nine improves endothelium-dependent vasodilatation in hypercholesterolemic humans
    • Creager MA, Gallagher SJ, Girerd XJ, et al. L-argi-nine improves endothelium-dependent vasodilatation in hypercholesterolemic humans. J Clin Invest 1992; 90: 1248-1253.
    • (1992) J Clin Invest , vol.90 , pp. 1248-1253
    • Creager, M.A.1    Gallagher, S.J.2    Girerd, X.J.3
  • 42
    • 0028873392 scopus 로고
    • L-arginine increases exhaled nitric oxide in normal human subjects
    • Kharitonov SA, Lubec G, Lubec B, et al. L-arginine increases exhaled nitric oxide in normal human subjects. Clin Sci (Lond) 1995; 88: 135-139.
    • (1995) Clin Sci (Lond) , vol.88 , pp. 135-139
    • Kharitonov, S.A.1    Lubec, G.2    Lubec, B.3
  • 43
    • 0028293434 scopus 로고
    • Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine
    • Tsao PS, McEvoy LM, Drexler H, et al. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation 1994; 89: 2176-2182.
    • (1994) Circulation , vol.89 , pp. 2176-2182
    • Tsao, P.S.1    McEvoy, L.M.2    Drexler, H.3
  • 44
    • 0037974202 scopus 로고    scopus 로고
    • Pharmacodynamic properties of the low molecular weight heparin, tinzaparin: Effect of molecular weight distribution on plasma tissue factor pathway inhibitor in healthy human subjects
    • Mousa SA. Pharmacodynamic properties of the low molecular weight heparin, tinzaparin: effect of molecular weight distribution on plasma tissue factor pathway inhibitor in healthy human subjects. J Clin Pharmacol 2003; 43: 727-734.
    • (2003) J Clin Pharmacol , vol.43 , pp. 727-734
    • Mousa, S.A.1
  • 45
    • 26444566779 scopus 로고    scopus 로고
    • Differential metastasis inhibition by clinically relevant levels of heparins-correlation with selectin inhibition, not antithrombotic activity
    • Stevenson JL, Choi SH, Varki A. Differential metastasis inhibition by clinically relevant levels of heparins-correlation with selectin inhibition, not antithrombotic activity. Clin Cancer Res 2005; 11: 7003-7011.
    • (2005) Clin Cancer Res , vol.11 , pp. 7003-7011
    • Stevenson, J.L.1    Choi, S.H.2    Varki, A.3
  • 46
    • 0037111637 scopus 로고    scopus 로고
    • Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin
    • Matsui NM, Varki A, Embury SH. Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin. Blood 2002; 100: 3790-3796.
    • (2002) Blood , vol.100 , pp. 3790-3796
    • Matsui, N.M.1    Varki, A.2    Embury, S.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.