Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: A phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapoc (ICA-17043)

British Journal of Haematology

Volumn 153, Issue 1, 2011, Pages 92-104

  Ataga, Kenneth I ^a   Reid, Marvin ^b   Ballas, Samir K ^c   Yasin, Zahida ^d   Bigelow, Carolyn ^e   James, Luther St ^f   Smith, Wally R ^g   Galacteros, Frederic ^h   Kutlar, Abdullah ⁱ   Hull, James H ^a   Stocker, Jonathan W ^j  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF THE WEST INDIES   (Jamaica)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d UNIVERSITY OF CINCINNATI   (United States)

^e UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^f Twin Lakes Family Practice   (United States)

^g VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

^h HENRI MONDOR HOSPITAL   (France)

ⁱ MEDICAL COLLEGE OF GEORGIA   (United States)

^j Icagen Inc   (United States)

more..

Author keywords

Gardos channel; KCa3 1; Red blood cell; Senicapoc; Sickle cell disease

Indexed keywords

HEMOGLOBIN; HYDROXYUREA; PLACEBO; SENICAPOC;

ABDOMINAL PAIN; ACUTE DISEASE; ADOLESCENT; ADULT; AGED; ANEMIA; ARTHRALGIA; ARTICLE; ASTHMA; BACKACHE; BLOOD VESSEL OCCLUSION; BRAIN INFARCTION; CATHETER INFECTION; CEREBELLUM INFARCTION; CONSTIPATION; CONTROLLED STUDY; COUGHING; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FEVER; DRUG HYPERSENSITIVITY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG WITHDRAWAL; ERYTHROCYTE COUNT; ERYTHROCYTE LIFESPAN; FATIGUE; FEMALE; FEVER; HEMATOCRIT; HEMATURIA; HEMOLYSIS; HUMAN; HYPOKALEMIA; MAJOR CLINICAL STUDY; MALE; NAUSEA; PHASE 3 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RETICULOCYTE COUNT; RHINOPHARYNGITIS; SICKLE CELL ANEMIA; SIDE EFFECT; SORE THROAT; THROMBOCYTE COUNT; UPPER RESPIRATORY TRACT INFECTION; URINARY TRACT INFECTION; VOMITING;

ACETAMIDES; ADOLESCENT; ADULT; AGED; ANEMIA, SICKLE CELL; ANTISICKLING AGENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ERYTHROCYTE AGING; FEMALE; HEMATOCRIT; HEMOLYSIS; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MIDDLE AGED; PAIN; TREATMENT OUTCOME; TRITYL COMPOUNDS; YOUNG ADULT;

EID: 79952594455     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08520.x     Document Type: Article

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