Reduced sickle erythrocyte dehydration in vivo by endothelin-1 receptor antagonists

American Journal of Physiology - Cell Physiology

Volumn 293, Issue 3, 2007, Pages

  Rivera, Alicia ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cellular dehydration; Gardos channel; Transgenic sickle mice

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); CYTOKINE; CYTOKINE RECEPTOR; ENDOTHELIN 1; ENDOTHELIN 1 RECEPTOR ANTAGONIST; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; GARDOS CHANNEL; HEMOGLOBIN; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DENSITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG TARGETING; ERYTHROCYTE; ERYTHROCYTE VOLUME; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN DETERMINATION; IN VITRO STUDY; IN VIVO STUDY; MEAN CORPUSCULAR VOLUME; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RETICULOCYTE HEMOGLOBIN CONTENT; SICKLE CELL; SICKLE CELL ANEMIA; SICKLE ERYTHROCYTE DEHYDRATION; TRANSGENIC MOUSE;

ANEMIA, SICKLE CELL; ANIMALS; ANTIHYPERTENSIVE AGENTS; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; ERYTHROCYTES, ABNORMAL; MICE; MICE, TRANSGENIC; OLIGOPEPTIDES; PIPERIDINES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RECEPTOR, ENDOTHELIN A; WATER;

MUS; MUS MUSCULUS;

EID: 34548713036     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00530.2006     Document Type: Article

References (37)

1. Ambalavanan N, Bulger A, Murphy-Ullrich J, Oparil S, Chen YF. Endothelin-A receptor blockade prevents and partially reverses neonatal hypoxic pulmonary vascular remodeling. Pediatr Res 57: 631-636, 2005.
2. Bourantas KL, Dalekos GN, Makis A, Chaidos A, Tsiara S, Mavridis A. Acute phase proteins and interleukins in steady state sickle cell disease. Eur J Haematol 61: 49-54, 1998.
3. Briehl RW, Christoph GW. Exponential progress curves and shear in the gelation of hemoglobin S. Prog Clin Biol Res 240: 129-149, 1987.
4. Brugnara C, Gee B, Armsby CC, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS. Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest 97: 1227-1234, 1996.
5. Castro O, Gladwin MT. Pulmonary hypertension in sickle cell disease: mechanisms, diagnosis, and management. Hematol Oncol Clin North Am 19: 881-896, 2005.
6. Corash L. Density dependent red cell separation. In: Red Cell Metabolism. Methods in Haematology, edited by Beutler E. New York: Churchill Livingston, 1986, p. 90.
7. Croizat H, Nagel RL. Circulating cytokines response and the level of erythropoiesis in sickle cell anemia. Am J Hematol 60: 105-115, 1999.
8. De Franceschi L, Beuzard Y, Jouault H, Brugnara C. Modulation of erythrocyte potassium chloride cotransport, potassium content, and density by dietary magnesium intake in transgenic SAD mouse. Blood 88: 2738-2744, 1996.
9. De Franceschi L, Brugnara C, Rouyer-Fessard P, Jouault H, Beuzard Y. Formation of dense erythrocytes in SAD mice exposed to chronic hypoxia: evaluation of different therapeutic regimens and of a combination of oral clotrimazole and magnesium therapies. Blood 94: 4307-4313, 1999.
10. + transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease. J Clin Invest 93: 1670-1676, 1994.
11. Duits AJ, Schnog JB, Lard LR, Saleh AW, Rojer RA. Elevated IL-8 levels during sickle cell crisis. Eur J Haematol 61: 302-305, 1998.
12. Eddahibi S, Raffestin B, Clozel M, Levame M, Adnot S. Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats. Am J Physiol Heart Circ Physiol 268: H828-H835, 1995.
13. Fabry ME, Romero JR, Buchanan ID, Suzuka SM, Stamatoyannopoulos G, Nagel RL, Canessa M. Rapid increase in red blood cell density driven by K:Cl cotransport in a subset of sickle cell anemia reticulocytes and discocytes. Blood 78: 217-225, 1991.
14. Ca channel in deoxygenated sickle cells. Am J Physiol Cell Physiol 273: C1206-C1214, 1997.
15. Finsnes F, Lyberg T, Christensen G, Skjonsberg OH. Effect of endothelin antagonism on the production of cytokines in eosinophilic airway inflammation. Am J Physiol Lung Cell Mol Physiol 280: L659-L665, 2001.
16. 2 levels in sickle cell disease and acute vaso-occlusive sickle crisis. Blood 92: 2551-2555, 1998.
17. Hammerman SI, Kourembanas S, Conca TJ, Tucci M, Brauer M, Farber HW. Endothelin-1 production during the acute chest syndrome in sickle cell disease. Am J Respir Crit Care Med 156: 280-285, 1997.
18. Holtzclaw JD, Jiang M, Yasin Z, Joiner CH, Franco RS. Rehydration of high-density sickle erythrocytes in vitro. Blood 100: 3017-3025, 2002.
19. Kaul DK, Fabry ME, Nagel RL. The pathophysiology of vascular obstruction in the sickle syndromes. Blood Rev 10: 29-44, 1996.
20. Kurantsin-Mills J, Jacobs HM, Lessin LS. Assessment of the hydration state of sickle cells by phthalate ester density distribution. J Lab Clin Med 109: 486-494, 1987.
21. Longenecker GL, Beyers BJ, Mankad VN. Platelet regulatory prostanoids and platelet release products in sickle cell disease. Am J Hematol 40: 12-19, 1992.
22. Miller CL, Mishell RI. Differential regulatory effects of accessory cells on the generation of cell-mediated immune reactions. J Immunol 114: 692-695, 1975.
23. Pearl JM, Wellmann SA, McNamara JL, Lombardi JP, Wagner CJ, Raake JL, Nelson DP. Bosentan prevents hypoxia-reoxygenation-induced pulmonary hypertension and improves pulmonary function. Ann Thorac Surg 68: 1714-1721, 1999.
24. Phelan M, Perrine SP, Brauer M, Faller DV. Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture. J Clin Invest 96: 1145-1151, 1995.
25. Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg MH, Klug PP. Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med 330: 1639-1644, 1994.
26. Platt OS, Thorington BD, Brambilla DJ, Milner PF, Rosse WF, Vichinsky E, Kinney TR. Pain in sickle cell disease. Rates and risk factors. N Engl J Med 325: 11-16, 1991.
27. Rivera A. In vivo regulation of cellular dehydration by endothelin-1 receptor B antagonist in sickle cell mouse model. Blood 102: 934a, 2003.
28. Rivera A, Jarolim P, Brugnara C. Modulation of Gardos channel activity by cytokines in sickle erythrocytes. Blood 99: 357-603, 2002.
29. + channels via endothelin B receptors in CD-1 mouse erythrocytes. Am J Physiol Cell Physiol 277: C746-C754, 1999.
30. Romero JR, Rivera A, Suzuka S, Nagel RL, Fabry ME. Effect of arginine diet for sickle transgenic mice o plasma cytokine levels and the mechanism of reduction of Gardos channel activity. Blood 102: 260a, 2003.
31. Romero JR, Suzuka SM, Nagel RL, Fabry ME. Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity. Blood 99: 1103-1108, 2002.
32. Rybicki AC, Benjamin LJ. Increased levels of endothelin-1 in plasma of sickle cell anemia patients. Blood 92: 2594-2596, 1998.
33. Sabaa N, De Franceschi L, Bonnin P, Malpeli G, Germain S, Vandermeersch S, Mater-Redelsperger M, Scarpa A, Janin A, Levy B, Girot B, Beuzard Y, Leboeuf C, Henri A, Dussaule JC, Tharaux PL. The dual endothelin receptor antagonist bosentan prevents the acute sickle cell-related hypoxic lung and kidney injury in transgenic SAD mice. Blood 108: 687a, 2006.
34. Schwartz RS, Musto S, Fabry ME, Nagel RL. Two distinct pathways mediate the formation of intermediate density cells and hyperdense cells from normal density sickle red blood cells. Blood 92: 4844, 1998.
35. Steinberg MH. Management of sickle cell disease. N Engl J Med 340: 1021-1030, 1999.
36. Stocker JW, De FL, Naughton-Smith GA, Corrocher R, Beuzard Y, Brugnara C. ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood 101: 2412-2418, 2003.
37. Szabo MC, Soo KS, Zlotnik A, Schall TJ. Chemokine class differences in binding to the Duffy antigen-erythrocyte chemokine receptor. J Biol Chem 270: 25348-25351, 1995.