Erratum: Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia (PLoS ONE (2014) 9, 7 (e101301) DOI:10.1371/journal.pone.0101301);Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Wun, Ted ^a,b   Styles, Lori ^c   DeCastro, Laura ^d   Telen, Marilyn J ^d   Kuypers, Frans ^c   Cheung, Anthony ^a   Kramer, William ^e   Flanner, Henry ^f   Rhee, Seungshin ^g   Magnani, John L ^f   Thackray, Helen ^f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA NORTHERN CALIFORNIA HEALTH CARE SYSTEM   (United States)

^c CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e Kramer Consulting LLC   (United States)

^f GlycoMimetics   (United States)

^g RHO INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BIOLOGICAL MARKER; CD11B ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOPROTEIN; INTERCELLULAR ADHESION MOLECULE; LACTATE DEHYDROGENASE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PADGEM PROTEIN; RIVIPANSEL; THROMBIN ANTITHROMBIN COMPLEX; THROMBOPLASTIN; UNCLASSIFIED DRUG; GLYCOLIPID; GMI-1070;

ADULT; ANEMIA; ARTHRALGIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLOOD CLOTTING; BLOOD FLOW VELOCITY; BLOOD VESSEL OCCLUSION; CELL ACTIVATION; CLINICAL ARTICLE; COUGHING; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG SAFETY; DRUG TOLERABILITY; DRUG URINE LEVEL; ENDOTHELIUM CELL; ERYTHROCYTE; FEMALE; HEADACHE; HUMAN; HUMAN CELL; HYPOKALEMIA; INJECTION SITE PAIN; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE ACTIVATION; LEUKOCYTE COUNT; LEUKOCYTOSIS; LOADING DRUG DOSE; MALE; OROPHARYNX PAIN; PHASE 1 CLINICAL TRIAL; PRURITUS; SICKLE CELL ANEMIA; SIDE EFFECT; SINGLE DRUG DOSE; VOMITING; ANEMIA, SICKLE CELL; BLOOD; CLINICAL TRIAL; COMPLICATION; DRUG EFFECTS; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADMINISTRATION, INTRAVENOUS; ADULT; ANEMIA, SICKLE CELL; BLOOD FLOW VELOCITY; E-SELECTIN; FEMALE; GLYCOLIPIDS; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84903794779     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111690     Document Type: Erratum

References (48)

1. Platt OS (1994) Easing the suffering caused by sickle cell disease. N Engl J Med 330: 783-784.
2. Rees DC, Williams TN, Gladwin MT (2010) Sickle-cell disease. Lancet 376: 2018-2031.
3. Hebbel RP (1991) Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology. Blood 77: 214-237.
4. Hebbel RP, Boogaerts MA, Eaton JW, Steinberg MH (1980) Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity. N Engl J Med 302: 992-995. (Pubitemid 10125408)
5. Hebbel RP, Boogaerts MA, Koresawa S, Jacob HS, Eaton JW, et al. (1980) Erytrocyte adherence to endothelium as a determinant of vasocclusive severity in sickle cell disease. Trans Assoc Am Physicians 93: 94-99.
6. Zennadi R, De Castro L, Eyler C, Xu K, Ko M, et al. (2008) Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors. Transfus Clin Biol 15: 23-28.
7. Zennadi R, Moeller BJ, Whalen EJ, Batchvarova M, Xu K, et al. (2007) Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. Blood 110: 2708-2717. (Pubitemid 47523194)
8. Brittain HA, Eckman JR, Swerlick RA, Howard RJ, Wick TM (1993) Thrombospondin from activated platelets promotes sickle erythrocyte adherence to human microvascular endothelium under physiologic flow: a potential role for platelet activation in sickle cell vaso-occlusion. Blood 81: 2137-2143. (Pubitemid 23106730)
9. Swerlick RA, Eckman JR, Kumar A, Jeitler M, Wick TM (1993) Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium. Blood 82: 1891-1899. (Pubitemid 23278781)
10. Walmet PS, Eckman JR, Wick TM (2003) Inflammatory mediators promote strong sickle cell adherence to endothelium under venular flow conditions. Am J Hematol 73: 215-224. (Pubitemid 36898876)
11. Parise LV, Telen MJ (2003) Erythrocyte adhesion in sickle cell disease. Curr Hematol Rep 2: 102-108.
12. Embury SH, Matsui NM, Ramanujam S, Mayadas TN, Noguchi CT, et al. (2004) The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo. Blood 104: 3378-3385. (Pubitemid 39507162)
13. Johnson C, Telen MJ (2008) Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease. Haematologica 93: 481-485.
14. Turhan A, Weiss LA, Mohandas N, Coller BS, Frenette PS (2002) Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci U S A 99: 3047-3051. (Pubitemid 34240583)
15. Frenette PS (2004) Sickle cell vasoocclusion: heterotypic, multicellular aggregations driven by leukocyte adhesion. Microcirculation 11: 167-177.
16. Frenette PS (2002) Sickle cell vaso-occlusion: multistep and multicellular paradigm. Curr Opin Hematol 9: 101-106.
17. Lum AFH, Wun T, Staunton D, Simon SI (2004) Inflammatory potential of neutrophils detected in sickle cell disease. American Journal of Hematology 76: 126-133. (Pubitemid 38702555)
18. Wun T, Cordoba M, Rangaswami A, Cheung AW, Paglieroni T (2002) Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease. Clin Lab Haematol 24: 81-88. (Pubitemid 35013546)
19. Okpala I (2004) The intriguing contribution of white blood cells to sickle cell disease - a red cell disorder. Blood Rev 18: 65-73.
20. Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, et al. (1994) Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med 330: 1639-1644.
21. Vichinsky EP, Styles LA, Colangelo LH, Wright EC, Castro O, et al. (1997) Acute chest syndrome in sickle cell disease: clinical presentation and course. Cooperative Study of Sickle Cell Disease. Blood 89: 1787-1792. (Pubitemid 27097475)
22. Canalli AA, Franco-Penteado CF, Saad ST, Conran N, Costa FF (2008) Increased adhesive properties of neutrophils in sickle cell disease may be reversed by pharmacological nitric oxide donation. Haematologica 93: 605-609.
23. Benkerrou M, Delarche C, Brahimi L, Fay M, Vilmer E, et al. (2002) Hydroxyurea corrects the dysregulated L-selectin expression and increased H(2)O(2) production of polymorphonuclear neutrophils from patients with sickle cell anemia. Blood 99: 2297-2303. (Pubitemid 34525412)
24. Charache S, Dover GJ, Moore RD, Eckert S, Ballas SK, et al. (1992) Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia. Blood 79: 2555-2565.
25. Charache S (1997) Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults. Semin Hematol 34: 15-21.
26. Charache S, Terrin ML, Moore RD, Dover GJ, Barton FB, et al. (1995) Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med 332: 1317-1322.
27. Steinberg MH, Lu ZH, Barton FB, Terrin ML, Charache S, et al. (1997) Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea. Multicenter Study of Hydroxyurea. Blood 89: 1078-1088. (Pubitemid 27121303)
28. Saleh AW, Hillen HF, Duits AJ (1999) Levels of endothelial, neutrophil and platelet-specific factors in sickle cell anemia patients during hydroxyurea therapy. Acta Haematol 102: 31-37. (Pubitemid 29417701)
29. Haynes J Jr, Obiako B, Hester RB, Baliga BS, Stevens T (2008) Hydroxyurea attenuates activated neutrophil-mediated sickle erythrocyte membrane phosphatidylserine exposure and adhesion to pulmonary vascular endothelium. Am J Physiol Heart Circ Physiol 294: H379-385.
30. Canalli AA, Franco-Penteado CF, Traina F, Saad ST, Costa FF, et al. (2007) Role for cAMP-protein kinase A signalling in augmented neutrophil adhesion and chemotaxis in sickle cell disease. Eur J Haematol 79: 330-337. (Pubitemid 47390136)
31. Kaul DK, Finnegan E, Barabino GA (2009) Sickle red cell-endothelium interactions. Microcirculation 16: 97-111.
32. Simon SI, Green CE (2005) Molecular mechanics and dynamics of leukocyte recruitment during inflammation. Annu Rev Biomed Eng 7: 151-185. (Pubitemid 41170187)
33. Bullard DC, Kunkel EJ, Kubo H, Hicks MJ, Lorenzo I, et al. (1996) Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in Eselectin and P-selectin double mutant mice. J Exp Med 183: 2329-2336. (Pubitemid 26158923)
34. Frenette PS, Wagner DD (1997) Insights into selectin function from knockout mice. Thromb Haemost 78: 60-64. (Pubitemid 27289216)
35. Hidalgo A, Chang J, Jang JE, Peired AJ, Chiang EY, et al. (2009) Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nat Med 15: 384-391.
36. Berg EL, Robinson MK, Mansson O, Butcher EC, Magnani JL (1991) A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. J Biol Chem 266: 14869-14872. (Pubitemid 21907587)
37. Leppanen A, White SP, Helin J, McEver RP, Cummings RD (2000) Binding of glycosulfopeptides to P-selectin requires stereospecific contributions of individual tyrosine sulfate and sugar residues. J Biol Chem 275: 39569-39578. (Pubitemid 32058983)
38. Chang J, Patton JT, Sarkar A, Ernst B, Magnani JL, et al. (2010) GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood 116: 1779-1786.
39. Cheung AT, Chan MS, Ramanujam S, Rangaswami A, Curl K, et al. (2004) Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: computer-assisted intravital microscopy study. J Investig Med 52: 402-406. (Pubitemid 39552610)
40. Cheung AT, Chen PC, Larkin EC, Duong PL, Ramanujam S, et al. (2002) Microvascular abnormalities in sickle cell disease: a computer-assisted intravital microscopy study. Blood 99: 3999-4005. (Pubitemid 35332040)
41. Cheung AT, Harmatz P, Wun T, Chen PC, Larkin EC, et al. (2001) Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease. Blood 97: 3401-3404.
42. Cheung AT, Miller JW, Craig SM, To PL, Lin X, et al. (2010) Comparison of real-time microvascular abnormalities in pediatric and adult sickle cell anemia patients. Am J Hematol 85: 899-901.
43. Wun T, Paglieroni T, Rangaswami A, Gosselin R, Cheung ATW (1999) Platelet-monocyte aggregates (PMA) in patients with sickle cell disease. Blood 94: 198A-198A.
44. Styles L, Wun T, De Castro LM, Telen MJ, Kramer W, et al. (2010) GMI-1070, a Pan-Selectin Inhibitor: Safety and PK In a Phase 1/2 Study In Adults with Sickle Cell Disease. Blood 116: 685-686.
45. Flanner H, Kramer W, Magnani JL, Thackray H (2009) Single and Multiple Ascending Dose Pharmacokinetics of the Novel Pan Selectin Antagonist GMI-1070 after Intravenous Infusions of 2, 5, 10, 20 and 40 Mg/Kg to Healthy Volunteers. Journal of Clinical Pharmacology 49: 1105-1105.
46. Flanner HH, Kramer WG, Thackray HM, Magani JL (2010) Single Dose Pharmacokinetics of the Novel Pan Selectin Antagonist GMI-1070 after Intravenous Infusions to Adults with Sickle Cell Disease. Journal of Clinical Pharmacology 50: 1081-1081.
47. Cheung AT, Miller JW, Miguelino MG, To WJ, Li J, et al. (2012) Exchange transfusion therapy and its effects on real-time microcirculation in pediatric sickle cell anemia patients: an intravital microscopy study. J Pediatr Hematol Oncol 34: 169-174.
48. Frenette PS, Atweh GF (2007) Sickle cell disease: old discoveries, new concepts, and future promise. J Clin Invest 117: 850-858. (Pubitemid 46556737)