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Volumn 47, Issue , 2015, Pages

MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LUCIFERASE; MICRORNA 155; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; MICRORNA; MIRN155 MICRORNA, HUMAN; SOCS1 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING; TUMOR NECROSIS FACTOR;

EID: 84942087816     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2015.21     Document Type: Article
Times cited : (95)

References (50)
  • 3
    • 84874028273 scopus 로고    scopus 로고
    • Intestinal stromal cells in mucosal immunity and homeostasis
    • Owens BM, Simmons A. Intestinal stromal cells in mucosal immunity and homeostasis. Mucosal Immunol 2013;6:225-234.
    • (2013) Mucosal Immunol , vol.6 , pp. 225-234
    • Owens, B.M.1    Simmons, A.2
  • 4
    • 84870439805 scopus 로고    scopus 로고
    • The role of stromal cells in the persistence of chronic inflammation
    • Naylor AJ, Filer A, Buckley CD. The role of stromal cells in the persistence of chronic inflammation. Clin Exp Immunol 2013;171:30-35.
    • (2013) Clin Exp Immunol , vol.171 , pp. 30-35
    • Naylor, A.J.1    Filer, A.2    Buckley, C.D.3
  • 5
    • 84861866572 scopus 로고    scopus 로고
    • The mechanics of miRNA-mediated gene silencing: A look under the hood of miRISC
    • Fabian MR, Sonenberg N. The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat Struct Mol Biol 2012;19:586-593.
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 586-593
    • Fabian, M.R.1    Sonenberg, N.2
  • 6
    • 84856273084 scopus 로고    scopus 로고
    • Regulation of signalling by microRNAs
    • Avraham R, Yarden Y. Regulation of signalling by microRNAs. Biochem Soc Trans 2012;40:26-30.
    • (2012) Biochem Soc Trans , vol.40 , pp. 26-30
    • Avraham, R.1    Yarden, Y.2
  • 7
    • 24344494340 scopus 로고    scopus 로고
    • How microRNAs control cell division, differentiation and death
    • Miska EA. How microRNAs control cell division, differentiation and death. Curr Opin Genet Dev 2005;15:563-568.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 563-568
    • Miska, E.A.1
  • 8
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller M. Non-coding RNAs in human disease. Nat Rev Genet 2011;12:861-874.
    • (2011) Nat Rev Genet , vol.12 , pp. 861-874
    • Esteller, M.1
  • 9
    • 84867731967 scopus 로고    scopus 로고
    • MicroRNAs in inflammatory bowel disease - Pathogenesis, diagnostics and therapeutics
    • Coskun M, Bjerrum JT, Seidelin JB, Nielsen OH. MicroRNAs in inflammatory bowel disease - pathogenesis, diagnostics and therapeutics. World J Gastroenterol 2012;18:4629-4634.
    • (2012) World J Gastroenterol , vol.18 , pp. 4629-4634
    • Coskun, M.1    Bjerrum, J.T.2    Seidelin, J.B.3    Nielsen, O.H.4
  • 10
    • 84857506097 scopus 로고    scopus 로고
    • MicroRNAs in autoimmunity and inflammatory bowel disease: Crucial regulators in immune response
    • Iborra M, Bernuzzi F, Invernizzi P, Danese S. MicroRNAs in autoimmunity and inflammatory bowel disease: crucial regulators in immune response. Autoimmun Rev 2012;11:305-314.
    • (2012) Autoimmun Rev , vol.11 , pp. 305-314
    • Iborra, M.1    Bernuzzi, F.2    Invernizzi, P.3    Danese, S.4
  • 11
    • 83555161689 scopus 로고    scopus 로고
    • MicroRNAs in inflammatory bowel disease
    • Pekow JR, Kwon JH. MicroRNAs in inflammatory bowel disease. Inflamm Bowel Dis 2012;18:187-193.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 187-193
    • Pekow, J.R.1    Kwon, J.H.2
  • 12
    • 84875788209 scopus 로고    scopus 로고
    • miR-155: An ancient regulator of the immune system
    • Vigorito E, Kohlhaas S, Lu D, Leyland R. miR-155: an ancient regulator of the immune system. Immunol Rev 2013;253:146-157.
    • (2013) Immunol Rev , vol.253 , pp. 146-157
    • Vigorito, E.1    Kohlhaas, S.2    Lu, D.3    Leyland, R.4
  • 13
    • 84885386910 scopus 로고    scopus 로고
    • Regulation of the MIR155 host gene in physiological and pathological processes
    • Elton TS, Selemon H, Elton SM, Parinandi NL. Regulation of the MIR155 host gene in physiological and pathological processes. Gene 2013;532:1-12.
    • (2013) Gene , vol.532 , pp. 1-12
    • Elton, T.S.1    Selemon, H.2    Elton, S.M.3    Parinandi, N.L.4
  • 14
    • 77951579490 scopus 로고    scopus 로고
    • Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis
    • Takagi T, Naito Y, Mizushima K, Hirata I, Yagi N, Tomatsuri N et al. Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis. J Gastroenterol Hepatol 2010;25(Suppl 1):S129-S133.
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. S129-S133
    • Takagi, T.1    Naito, Y.2    Mizushima, K.3    Hirata, I.4    Yagi, N.5    Tomatsuri, N.6
  • 15
    • 55249119513 scopus 로고    scopus 로고
    • MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha
    • Wu F, Zikusoka M, Trindade A, Dassopoulos T, Harris ML, Bayless TM et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology 2008;135:1624-1635.
    • (2008) Gastroenterology , vol.135 , pp. 1624-1635
    • Wu, F.1    Zikusoka, M.2    Trindade, A.3    Dassopoulos, T.4    Harris, M.L.5    Bayless, T.M.6
  • 16
    • 84898720556 scopus 로고    scopus 로고
    • MicroRNA-155 is involved in the pathogenesis of ulcerative colitis by targeting FOXO3a
    • Min M, Peng L, Yang Y, Guo M, Wang W, Sun G. MicroRNA-155 is involved in the pathogenesis of ulcerative colitis by targeting FOXO3a. Inflamm Bowel Dis 2014;20:652-659.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 652-659
    • Min, M.1    Peng, L.2    Yang, Y.3    Guo, M.4    Wang, W.5    Sun, G.6
  • 17
    • 78049340862 scopus 로고    scopus 로고
    • Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease
    • Fasseu M, Treton X, Guichard C, Pedruzzi E, Cazals-Hatem D, Richard C et al. Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS ONE 2010;5:e13160.
    • (2010) PLoS ONE , vol.5 , pp. e13160
    • Fasseu, M.1    Treton, X.2    Guichard, C.3    Pedruzzi, E.4    Cazals-Hatem, D.5    Richard, C.6
  • 18
    • 73949148671 scopus 로고    scopus 로고
    • Comparison of several activity indices for the evaluation of endoscopic activity in UC: Inter- and intraobserver consistency
    • Osada T, Ohkusa T, Yokoyama T, Shibuya T, Sakamoto N, Beppu K et al. Comparison of several activity indices for the evaluation of endoscopic activity in UC: inter- and intraobserver consistency. Inflamm Bowel Dis 2010;16:192-197.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 192-197
    • Osada, T.1    Ohkusa, T.2    Yokoyama, T.3    Shibuya, T.4    Sakamoto, N.5    Beppu, K.6
  • 20
    • 0033049460 scopus 로고    scopus 로고
    • Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-p3
    • McKaig BC, Makh SS, Hawkey CJ, Podolsky DK, Mahida YR. Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-p3. Am J Physiol 1999;276:1087-1093.
    • (1999) Am J Physiol , vol.276 , pp. 1087-1093
    • McKaig, B.C.1    Makh, S.S.2    Hawkey, C.J.3    Podolsky, D.K.4    Mahida, Y.R.5
  • 21
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2-AACT method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2-AACT method. Methods 2001;25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 22
    • 66649106333 scopus 로고    scopus 로고
    • Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures
    • Di Sabatino A, Jackson CL, Pickard KM, Buckley M, Rovedatti L, Leakey NA et al. Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures. Gut 2009;58:777-789.
    • (2009) Gut , vol.58 , pp. 777-789
    • Di Sabatino, A.1    Jackson, C.L.2    Pickard, K.M.3    Buckley, M.4    Rovedatti, L.5    Leakey, N.A.6
  • 23
    • 65549121606 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration
    • Brenmoehl J, Miller SN, Hofmann C, Vogl D, Falk W, Schölmerich J et al. Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration. World J Gastroenterol 2009;15:1431-1442.
    • (2009) World J Gastroenterol , vol.15 , pp. 1431-1442
    • Brenmoehl, J.1    Miller, S.N.2    Hofmann, C.3    Vogl, D.4    Falk, W.5    Schölmerich, J.6
  • 24
    • 0036073299 scopus 로고    scopus 로고
    • Differential expression of TGFbeta isoforms by normal and inflammatory bowel disease intestina myofibroblasts
    • McKaig BC, Hughes K, Tighe PJ, Mahida YR. Differential expression of TGFbeta isoforms by normal and inflammatory bowel disease intestina myofibroblasts. Am J Physiol Cell Physiol 2002;282:C172-C182.
    • (2002) Am J Physiol Cell Physiol , vol.282 , pp. C172-C182
    • McKaig, B.C.1    Hughes, K.2    Tighe, P.J.3    Mahida, Y.R.4
  • 25
    • 0030719443 scopus 로고    scopus 로고
    • Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts
    • Bajaj-Elliott M, Breese E, Poulsom R, Fairclough PD, MacDonald TT. Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts. Am J Pathol 1997;151:1469-1476.
    • (1997) Am J Pathol , vol.151 , pp. 1469-1476
    • Bajaj-Elliott, M.1    Breese, E.2    Poulsom, R.3    Fairclough, P.D.4    MacDonald, T.T.5
  • 26
    • 0345237913 scopus 로고    scopus 로고
    • Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofi-broblasts in inflammatory bowel disease
    • McKaig BC, McWilliams D, Watson SA, Mahida YR. Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofi-broblasts in inflammatory bowel disease. Am J Pathol 2003;162:1355-1360.
    • (2003) Am J Pathol , vol.162 , pp. 1355-1360
    • McKaig, B.C.1    McWilliams, D.2    Watson, S.A.3    Mahida, Y.R.4
  • 27
    • 44849121674 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodiumnduced colitis in mice
    • Horino J, Fujimoto M, Terabe F, Serada S, Takahashi T, Soma Y et al. Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodiumnduced colitis in mice. Int Immunol 2008;20:753-762.
    • (2008) Int Immunol , vol.20 , pp. 753-762
    • Horino, J.1    Fujimoto, M.2    Terabe, F.3    Serada, S.4    Takahashi, T.5    Soma, Y.6
  • 28
    • 32044451547 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved
    • Chinen T, Kobayashi T, Ogata H, Takaesu G, Takaki H, Hashimoto M et al. Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology 2006;130:373-388.
    • (2006) Gastroenterology , vol.130 , pp. 373-388
    • Chinen, T.1    Kobayashi, T.2    Ogata, H.3    Takaesu, G.4    Takaki, H.5    Hashimoto, M.6
  • 29
    • 79955554997 scopus 로고    scopus 로고
    • Immune and nonimmune components orchestrate the pathogenesis of inflammatory bowel disease
    • Danese S. Immune and nonimmune components orchestrate the pathogenesis of inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 2011;300:G716-G722.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G716-G722
    • Danese, S.1
  • 30
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 2010;10:111-122.
    • (2010) Nat Rev Immunol , vol.10 , pp. 111-122
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Baltimore, D.4
  • 31
    • 84918810194 scopus 로고    scopus 로고
    • Implication of miRNAs for inflammatory bowel disease treatment: Systematic review
    • Chen WX, Ren LH, Shi RH. Implication of miRNAs for inflammatory bowel disease treatment: Systematic review. World J Gastrointest Pathophysiol 2014;5:63-70.
    • (2014) World J Gastrointest Pathophysiol , vol.5 , pp. 63-70
    • Chen, W.X.1    Ren, L.H.2    Shi, R.H.3
  • 32
    • 84880008053 scopus 로고    scopus 로고
    • Dentification of serum and tissue micro-RNA expression profiles in different stages of inflammatory bowel disease
    • Iborra M, Bernuzzi F, Correale C, Vetrano S, Fiorino G, Beltrán B et al. dentification of serum and tissue micro-RNA expression profiles in different stages of inflammatory bowel disease. Clin Exp Immunol 2013;173:250-258.
    • (2013) Clin Exp Immunol , vol.173 , pp. 250-258
    • Iborra, M.1    Bernuzzi, F.2    Correale, C.3    Vetrano, S.4    Fiorino, G.5    Beltrán, B.6
  • 33
    • 38049030287 scopus 로고    scopus 로고
    • Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
    • Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B et al. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 2007;179:5082-5089.
    • (2007) J Immunol , vol.179 , pp. 5082-5089
    • Tili, E.1    Michaille, J.J.2    Cimino, A.3    Costinean, S.4    Dumitru, C.D.5    Adair, B.6
  • 34
    • 77958495102 scopus 로고    scopus 로고
    • MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    • O'Connell RM, Kahn D, Gibson WS, Round JL, Scholz RL, Chaudhuri AA et al. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity 2010;33:607-619.
    • (2010) Immunity , vol.33 , pp. 607-619
    • O'Connell, R.M.1    Kahn, D.2    Gibson, W.S.3    Round, J.L.4    Scholz, R.L.5    Chaudhuri, A.A.6
  • 35
    • 84908270734 scopus 로고    scopus 로고
    • Mir-155 deficiency protects mice from experimental colitis by reducing Th1/Th17 responses
    • Singh UP, Murphy AE, Enos RT, Shamran HA, Singh NP, Guan H et al. miR-155 deficiency protects mice from experimental colitis by reducing Th1/Th17 responses. Immunology 2014;143:478-489.
    • (2014) Immunology , vol.143 , pp. 478-489
    • Singh, U.P.1    Murphy, A.E.2    Enos, R.T.3    Shamran, H.A.4    Singh, N.P.5    Guan, H.6
  • 36
    • 78651399501 scopus 로고    scopus 로고
    • Upregulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor a production via increased mRNA half-life in alcoholic iver disease
    • Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P et al. Upregulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor a production via increased mRNA half-life in alcoholic iver disease. J Biol Chem 2011;286:1436-1444.
    • (2011) J Biol Chem , vol.286 , pp. 1436-1444
    • Bala, S.1    Marcos, M.2    Kodys, K.3    Csak, T.4    Catalano, D.5    Mandrekar, P.6
  • 37
    • 66149152303 scopus 로고    scopus 로고
    • Quantitive cytokine mRNA expression profiles in the colonic mucosa of patients with steroid naïve ulcerative colitis during active and quiescent disease
    • Matsuda R, Koide T, Tokoro C, Yamamoto T, Godai T, Morohashi T et al. Quantitive cytokine mRNA expression profiles in the colonic mucosa of patients with steroid naïve ulcerative colitis during active and quiescent disease. Inflamm Bowel Dis 2009;15:328-334.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 328-334
    • Matsuda, R.1    Koide, T.2    Tokoro, C.3    Yamamoto, T.4    Godai, T.5    Morohashi, T.6
  • 38
    • 77649242925 scopus 로고    scopus 로고
    • Targeting of SMAD5 inks microRNA-155 to the TGF-beta pathway and lymphomagenesis
    • Rai D, Kim SW, McKeller MR, Dahia PL, Aguiar RC. Targeting of SMAD5 inks microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci USA 2010;107:3111-3116.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3111-3116
    • Rai, D.1    Kim, S.W.2    McKeller, M.R.3    Dahia, P.L.4    Aguiar, R.C.5
  • 39
    • 55849123946 scopus 로고    scopus 로고
    • MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    • Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS et al. MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 2008;28:6773-6784.
    • (2008) Mol Cell Biol , vol.28 , pp. 6773-6784
    • Kong, W.1    Yang, H.2    He, L.3    Zhao, J.J.4    Coppola, D.5    Dalton, W.S.6
  • 41
    • 44849127680 scopus 로고    scopus 로고
    • Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells
    • Wang J, Yang L, Yang J, Kuropatwinski K, Wang W, Liu XQ et al. Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells. Cancer Res 2008;68:3152-3160.
    • (2008) Cancer Res , vol.68 , pp. 3152-3160
    • Wang, J.1    Yang, L.2    Yang, J.3    Kuropatwinski, K.4    Wang, W.5    Liu, X.Q.6
  • 43
    • 70350054798 scopus 로고    scopus 로고
    • Role of microRNA-155 at early stages of hepatocarcinogenesis induced by cholinedeficient and amino acid-defined diet in C57BL/6 mice
    • Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, Patel T et al. Role of microRNA-155 at early stages of hepatocarcinogenesis induced by cholinedeficient and amino acid-defined diet in C57BL/6 mice. Hepatology 2009;50:1152-1161.
    • (2009) Hepatology , vol.50 , pp. 1152-1161
    • Wang, B.1    Majumder, S.2    Nuovo, G.3    Kutay, H.4    Volinia, S.5    Patel, T.6
  • 44
    • 84867584246 scopus 로고    scopus 로고
    • MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1
    • Yao R, Ma YL, Liang W, Li HH, Ma ZJ, Yu X et al. MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1. PLoS ONE 2012;7:e46082.
    • (2012) PLoS ONE , vol.7 , pp. e46082
    • Yao, R.1    Ma, Y.L.2    Liang, W.3    Li, H.H.4    Ma, Z.J.5    Yu, X.6
  • 45
    • 84876746489 scopus 로고    scopus 로고
    • MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer
    • Dudda JC, Salaun B, Ji Y, Palmer DC, Monnot GC, Merck E. MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity 2013;38:742-753.
    • (2013) Immunity , vol.38 , pp. 742-753
    • Dudda, J.C.1    Salaun, B.2    Ji, Y.3    Palmer, D.C.4    Monnot, G.C.5    Merck, E.6
  • 46
    • 78650658467 scopus 로고    scopus 로고
    • Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1
    • Wang P, Hou J, Lin L, Wang C, Liu X, Li D et al. Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1. J Immunol 2010;185:6226-6233.
    • (2010) J Immunol , vol.185 , pp. 6226-6233
    • Wang, P.1    Hou, J.2    Lin, L.3    Wang, C.4    Liu, X.5    Li, D.6
  • 47
    • 83055176904 scopus 로고    scopus 로고
    • miR-155 modulates microglia-mediated immune response by downregulating SOCS-1 and promoting cytokine and nitric oxide production
    • Cardoso AL, Guedes JR, Pereira de Almeida L, Pedroso de Lima MC. miR-155 modulates microglia-mediated immune response by downregulating SOCS-1 and promoting cytokine and nitric oxide production. Immunology 2012;135:73-88.
    • (2012) Immunology , vol.135 , pp. 73-88
    • Cardoso, A.L.1    Guedes, J.R.2    Pereira De Almeida, L.3    Pedroso De Lima, M.C.4
  • 49
    • 68049135501 scopus 로고    scopus 로고
    • Regulation of cytokine signaling by the SOCS and spred family proteins
    • Yoshimura A. Regulation of Cytokine Signaling by the SOCS and Spred Family Proteins. Keio J Med 2009;58:73-83.
    • (2009) Keio J Med , vol.58 , pp. 73-83
    • Yoshimura, A.1
  • 50
    • 0035910753 scopus 로고    scopus 로고
    • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
    • Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, Hoshino T et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001;193:471-481.
    • (2001) J Exp Med , vol.193 , pp. 471-481
    • Suzuki, A.1    Hanada, T.2    Mitsuyama, K.3    Yoshida, T.4    Kamizono, S.5    Hoshino, T.6


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