The role of stromal cells in the persistence of chronic inflammation

Clinical and Experimental Immunology

Volumn 171, Issue 1, 2013, Pages 30-35

  Naylor, A J ^a   Filer, A ^a   Buckley, C D ^a  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Chronic; Fibroblast; Inflammation; Persistence; Stromal

Indexed keywords

CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; INTERFERON;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL INTERACTION; CELL MIGRATION; CELL STRUCTURE; CELL SURVIVAL; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; IMMUNE RESPONSE; LEUKOCYTE; NONHUMAN; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; T LYMPHOCYTE;

ANIMALS; CHRONIC DISEASE; FIBROBLASTS; HUMANS; INFLAMMATION; LEUKOCYTES; MICE; STROMAL CELLS;

EID: 84870439805     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04634.x     Document Type: Article

References (54)

1. Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006; 6:392-401.
2. Filer A, Pitzalis C, Buckley CD. Targeting the stromal microenvironment in chronic inflammation. Curr Opin Pharmacol 2006; 6:393-400.
3. Pilling D, Fan T, Huang D, Kaul B, Gomer RH. Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages and fibroblasts. PLoS ONE 2009; 10:e7475.
4. Buckley CD. Why does chronic inflammatory joint disease persist? Clin Med 2003; 3:361-6.
5. Pilling D, Akbar AN, Girdlestone J etal. Interferon-beta mediates stromal cell rescue of T cells from apoptosis. Eur J Immunol 1999; 29:1041-50.
6. Buckley CD, Amft N, Bradfield PF etal. Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium. J Immunol 2000; 165:3423-9.
7. Filer A, Parsonage G, Smith E etal. Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheum 2006; 54:2096-108.
8. Parsonage G, Falciani F, Burman A etal. Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns. Thromb Haemost 2003; 90:688-97.
9. Bradfield PF, Amft N, Vernon-Wilson E etal. Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue. Arthritis Rheum 2003; 48:2472-82.
10. Lally F, Smith E, Filer A etal. A novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium. Arthritis Rheum 2005; 52:3460-9.
11. Muller-Ladner U, Gay S. MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction? Ann Rheum Dis 2002; 61:957-9.
12. Takayanagi H, Iizuka H, Juji T etal. Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum 2000; 43:259-69.
13. Pap T, Gay S. Fibroblasts and fibroblast-like synoviocytes. In: Firestein G, Budd R, Harris E, McInnes I, Ruddy S, Sergent J, eds. Kelly's Textbook of Rheumatology, 8th edn. Philadelphia: Saunders Elsevir, 2009:201-15.
14. Muller-Ladner U, Kriegsmann J, Franklin BN etal. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 1996; 149:1607-15.
15. Tolboom TC, van der Helm-Van Mil AH, Nelissen RG, Breedveld FC, Toes RE, Huizinga TW. Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis. Arthritis Rheum 2005; 52:1999-2002.
16. Lefèvre S, Knedla A, Tennie C etal. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 2009; 15:1414-20.
17. Wallach-Dayan SB, Golan-Gerstl R, Breuer R. Evasion of myofibroblasts from immune surveillance: a mechanism for tissue fibrosis. Proc Natl Acad Sci USA 2007; 104:20460-5.
18. Schafer M, Werner S. Cancer as an over-healing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol 2008; 9:628-38.
19. Barsky SH, Green WR, Grotendorst GR, Liotta LA. Desmoplastic breast carcinoma as a source of human myofibroblasts. Am J Pathol 1984; 115:329-33.
20. Karnoub AE, Dash AB, Vo AP etal. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007; 449:557-63.
21. Orimo PB, Gupta DC, Sgroi F etal. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005; 121:335-48.
22. Kraman M, Bambrough PJ, Arnold JN etal. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-α. Science 2010; 350:827-30.
23. Haniffa MA, Collin MP, Buckley CD, Dazzi F. Mesenchymal stem cells: the fibroblasts' new clothes? Haematologica 2009; 94:258-63.
24. Salem HK, Thiemermann C. Mesenchymal stromal cells: current understanding and clinical status. Stem Cells 2010; 28:585-96.
25. Romieu-Mourez R, Francois M, Boivin MN, Bouchentouf M, Spaner DE, Galipeau J. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol 2009; 182:7963-73.
26. Waterman RS, Tomchuck SL, Henkle SL, Betancourt AM. A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. PLoS ONE 2010; 5:e10088.
27. Gonzalez MA, Gonzalez-Rey E, Rico L, Buscher D, Delgado M. Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. Arthritis Rheum 2009; 60:1006-19.
28. Schurgers E, Kelchtermans H, Mitera T, Geboes L, Matthys P. Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis. Arthritis Res Ther 2010; 12:R31.
29. Tyndall A, Uccelli A. Multipotent mesenchymal stromal cells for autoimmune diseases: teaching new dogs old tricks. Bone Marrow Transplant 2009; 43:821-8.
30. Dominici M, Le Blanc K, Mueller I etal. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8:315-7.
31. Buckner JH. Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol 2010; 10:849-59.
32. Ley K. Molecular mechanisms of leukocyte recruitment in the inflammatory process. Cardiovasc Res 1996; 32:733-42.
33. Bombara MP, Webb DL, Conrad P etal. Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines. J Leukoc Biol 1993; 54:399-406.
34. Smith RS, Smith TJ, Blieden TM, Phipps RP. Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol 1997; 151:317-22.
35. Bucala R, Ritchlin C, Winchester R, Cerami A. Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts. J Exp Med 1991; 173:569-74.
36. Pablos JL, Amara A, Bouloc A etal. Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin. Am J Pathol 1999; 155:1577-86.
37. Agace WW, Amara A, Roberts AI etal. Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation. Curr Biol 2000; 10:325-8.
38. Buckley CD, Pilling D, Lord JM, Akbar AN, Scheel-Toellner D, Salmon M. Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol 2001; 22:199-204.
39. Amft N, Curnow SJ, Scheel-Toellner D etal. Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome. Arthritis Rheum 2001; 44:2633-41.
40. Manzo A, Paoletti S, Carulli M etal. Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis. Eur J Immunol 2005; 35:1347-59.
41. Hjelmstrom P. Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines. J Leukocyte Biol 2001; 69:331-9.
42. Reilkoff RA, Bucala R, Herzog EL. Fibrocytes: emerging effector cells in chronic inflammation. Nat Rev Immunol 2011; 11:427-35.
43. Mathai SK, Gulati M, Peng X etal. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show and enhanced profibrotic phenotype. Lab Invest 2010; 90:812-23.
44. Chang HY, Chi J-T, Dudoit S etal. Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci USA 2002; 99:12877-82.
45. Parsonage G, Filer AD, Haworth O etal. A stromal address code defined by fibroblasts. Trends Immunol 2005; 26:150-6.
46. Fries KM, Blieden T, Looney RJ etal. Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. Clin Immunol Immunopathol 1994; 72:283-92.
47. Scaife S, Brown R, Kellie S etal. Detection of differentially expressed genes in synovial fibroblasts by restriction fragment differential display. Rheumatology 2004; 43:1346-52.
48. Jüngel A, Ospelt C, Gay S. What can we learn from epigenetics in the year 2009? Curr Opin Rheumatol 2010; 22:284-92.
49. 49 Huber LC, Brock M, Hemmatazad H etal. Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients. Arthritis Rheum 2007; 56:1087-93.
50. Kawabata T, Nishida K, Takasugi K etal. Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis. Arthritis Res Ther 2010; 12:R133.
51. Niederer F, Brentano F, Ospelt C etal. Expression of sirtuins in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2009; 60:S52.
52. Li M, Riddle SR, Frid MG etal. Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. J Immunol 2011; 187:2711-22.
53. Burman A, Haworth O, Hardie DL etal. A chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromised lymphatic return in rheumatoid arthritis. J Immunol 2005; 174:1693-700.
54. Hammerschmidt SI, Ahrendt M, Bode U etal. Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. J Exp Med 2008; 205:2483-90.