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Volumn 14, Issue 9, 2015, Pages 2090-2102

CDK1-mediated SIRT3 activation enhances mitochondrial function and tumor radioresistance

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B1; CYCLIN DEPENDENT KINASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PROTEIN; SERINE; SIRTUIN 3; THREONINE; CDK1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE;

EID: 84942082375     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-15-0017     Document Type: Article
Times cited : (82)

References (53)
  • 1
    • 0029878679 scopus 로고    scopus 로고
    • The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer
    • Recht A, Come SE, Henderson IC, Gelman RS, Silver B, Hayes DF, et al. The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer. N Engl J Med 1996;334:1356-61.
    • (1996) N Engl J Med , vol.334 , pp. 1356-1361
    • Recht, A.1    Come, S.E.2    Henderson, I.C.3    Gelman, R.S.4    Silver, B.5    Hayes, D.F.6
  • 2
    • 77952298828 scopus 로고    scopus 로고
    • Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer
    • Auperin A, Le Pechoux C, Rolland E, Curran WJ, Furuse K, Fournel P, et al. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol 2010;28:2181-90.
    • (2010) J Clin Oncol , vol.28 , pp. 2181-2190
    • Auperin, A.1    Le Pechoux, C.2    Rolland, E.3    Curran, W.J.4    Furuse, K.5    Fournel, P.6
  • 3
    • 77954600968 scopus 로고    scopus 로고
    • Critical impact of radiotherapy protocol compliance and quality in the treatment of advanced head and neck cancer: Results from TROG 02.02
    • Peters LJ, O'Sullivan B, Giralt J, Fitzgerald TJ, Trotti A, Bernier J, et al. Critical impact of radiotherapy protocol compliance and quality in the treatment of advanced head and neck cancer: results from TROG 02.02. J Clin Oncol 2010;28:2996-3001.
    • (2010) J Clin Oncol , vol.28 , pp. 2996-3001
    • Peters, L.J.1    O'Sullivan, B.2    Giralt, J.3    Fitzgerald, T.J.4    Trotti, A.5    Bernier, J.6
  • 4
    • 3242686392 scopus 로고    scopus 로고
    • Sensitization of breast cancer cells to radiation by trastuzumab
    • Liang K, Lu Y, Jin W, Ang KK, Milas L, Fan Z. Sensitization of breast cancer cells to radiation by trastuzumab. Mol Cancer Ther 2003;2:1113-20.
    • (2003) Mol Cancer Ther , vol.2 , pp. 1113-1120
    • Liang, K.1    Lu, Y.2    Jin, W.3    Ang, K.K.4    Milas, L.5    Fan, Z.6
  • 5
    • 62549131134 scopus 로고    scopus 로고
    • Radiation resistance of breast cancer stem cells: Understanding the clinical framework
    • Debeb BG, Xu W, Woodward WA. Radiation resistance of breast cancer stem cells: understanding the clinical framework. J Mammary Gland Biol Neoplasia 2009;14:11-7.
    • (2009) J Mammary Gland Biol Neoplasia , vol.14 , pp. 11-17
    • Debeb, B.G.1    Xu, W.2    Woodward, W.A.3
  • 6
    • 73249143536 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
    • Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010;11:21-8.
    • (2010) Lancet Oncol , vol.11 , pp. 21-28
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3    Cohen, R.B.4    Jones, C.U.5    Sur, R.K.6
  • 7
    • 33846327627 scopus 로고    scopus 로고
    • Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells
    • Ahmed KM, Dong S, Fan M, Li JJ. Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells. Mol Cancer Res 2006;4:945-55.
    • (2006) Mol Cancer Res , vol.4 , pp. 945-955
    • Ahmed, K.M.1    Dong, S.2    Fan, M.3    Li, J.J.4
  • 8
    • 0037379216 scopus 로고    scopus 로고
    • Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses
    • Guo G, Yan-Sanders Y, Lyn-Cook BD, Wang T, Tamae D, Ogi J, et al. Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Mol Cell Biol 2003;23:2362-78.
    • (2003) Mol Cell Biol , vol.23 , pp. 2362-2378
    • Guo, G.1    Yan-Sanders, Y.2    Lyn-Cook, B.D.3    Wang, T.4    Tamae, D.5    Ogi, J.6
  • 9
    • 79951823580 scopus 로고    scopus 로고
    • Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells
    • Gupta S, Koru-Sengul T, Arnold SM, Devi GR, Mohiuddin M, Ahmed MM. Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells. Mol Cancer Ther 2011;10:292-302.
    • (2011) Mol Cancer Ther , vol.10 , pp. 292-302
    • Gupta, S.1    Koru-Sengul, T.2    Arnold, S.M.3    Devi, G.R.4    Mohiuddin, M.5    Ahmed, M.M.6
  • 10
    • 78751554067 scopus 로고    scopus 로고
    • Signals from the nucleus: Activation of NF-kappaB by cytosolic ATM in the DNA damage response
    • Hadian K, Krappmann D. Signals from the nucleus: activation of NF-kappaB by cytosolic ATM in the DNA damage response. Sci Signal 2011;4:pe2.
    • (2011) Sci Signal , vol.4 , pp. pe2
    • Hadian, K.1    Krappmann, D.2
  • 11
    • 58349107292 scopus 로고    scopus 로고
    • NF-kappaB-mediated HER2 overexpression in radiation-adaptive resistance
    • Cao N, Li S, Wang Z, Ahmed KM, Degnan ME, Fan M, et al. NF-kappaB-mediated HER2 overexpression in radiation-adaptive resistance. Radiat Res 2009;171:9-21.
    • (2009) Radiat Res , vol.171 , pp. 9-21
    • Cao, N.1    Li, S.2    Wang, Z.3    Ahmed, K.M.4    Degnan, M.E.5    Fan, M.6
  • 12
    • 51049101093 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation
    • Wang Z, Cao N, Nantajit D, Fan M, Liu Y, Li JJ. Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation. J Biol Chem 2008;283:21011-23.
    • (2008) J Biol Chem , vol.283 , pp. 21011-21023
    • Wang, Z.1    Cao, N.2    Nantajit, D.3    Fan, M.4    Liu, Y.5    Li, J.J.6
  • 14
    • 84865421953 scopus 로고    scopus 로고
    • Mitochondrial sirtuins: Regulators of protein acylation and metabolism
    • He W, Newman JC, Wang MZ, Ho L, Verdin E. Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends Endocrinol Metab 2012;23:467-76.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 467-476
    • He, W.1    Newman, J.C.2    Wang, M.Z.3    Ho, L.4    Verdin, E.5
  • 16
    • 42449128019 scopus 로고    scopus 로고
    • Where in the cell is SIRT3?-functional localization of an NAD+-dependent protein deacetylase
    • Hallows WC, Albaugh BN, Denu JM. Where in the cell is SIRT3?-functional localization of an NAD+-dependent protein deacetylase. Biochem J 2008;411:e11-3.
    • (2008) Biochem J , vol.411 , pp. e11-e13
    • Hallows, W.C.1    Albaugh, B.N.2    Denu, J.M.3
  • 19
    • 78651468707 scopus 로고    scopus 로고
    • Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
    • Hallows WC, Yu W, Smith BC, Devries MK, Ellinger JJ, Someya S, et al. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell 2011;41:139-49.
    • (2011) Mol Cell , vol.41 , pp. 139-149
    • Hallows, W.C.1    Yu, W.2    Smith, B.C.3    Devries, M.K.4    Ellinger, J.J.5    Someya, S.6
  • 20
    • 77950806433 scopus 로고    scopus 로고
    • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    • Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 2010;464:121-5.
    • (2010) Nature , vol.464 , pp. 121-125
    • Hirschey, M.D.1    Shimazu, T.2    Goetzman, E.3    Jing, E.4    Schwer, B.5    Lombard, D.B.6
  • 21
    • 84859951790 scopus 로고    scopus 로고
    • SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
    • Yu W, Dittenhafer-Reed KE, Denu JM. SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J Biol Chem 2012;287:14078-86.
    • (2012) J Biol Chem , vol.287 , pp. 14078-14086
    • Yu, W.1    Dittenhafer-Reed, K.E.2    Denu, J.M.3
  • 22
    • 78649328799 scopus 로고    scopus 로고
    • Sirtuin regulation of mitochondria: Energy production, apoptosis, and signaling
    • Verdin E, Hirschey MD, Finley LW, Haigis MC. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci 2010;35:669-75.
    • (2010) Trends Biochem Sci , vol.35 , pp. 669-675
    • Verdin, E.1    Hirschey, M.D.2    Finley, L.W.3    Haigis, M.C.4
  • 23
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009;460:587-91.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 24
    • 34247271282 scopus 로고    scopus 로고
    • SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
    • Scher MB, Vaquero A, Reinberg D. SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev 2007;21:920-8.
    • (2007) Genes Dev , vol.21 , pp. 920-928
    • Scher, M.B.1    Vaquero, A.2    Reinberg, D.3
  • 26
    • 84861589885 scopus 로고    scopus 로고
    • Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
    • Fernandez-Marcos PJ, Jeninga EH, Canto C, Harach T, de Boer VC, Andreux P, et al. Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep 2012;2:425.
    • (2012) Sci Rep , vol.2 , pp. 425
    • Fernandez-Marcos, P.J.1    Jeninga, E.H.2    Canto, C.3    Harach, T.4    De Boer, V.C.5    Andreux, P.6
  • 27
    • 78650248160 scopus 로고    scopus 로고
    • Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
    • Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, etal. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell 2010;40:893-904.
    • (2010) Mol Cell , vol.40 , pp. 893-904
    • Tao, R.1    Coleman, M.C.2    Pennington, J.D.3    Ozden, O.4    Park, S.H.5    Jiang, H.6
  • 28
  • 29
    • 84881076472 scopus 로고    scopus 로고
    • Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress
    • Cheng Y, Ren X, Gowda AS, Shan Y, Zhang L, Yuan YS, et al. Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress. Cell Death Dis 2013;4:e731.
    • (2013) Cell Death Dis , vol.4 , pp. e731
    • Cheng, Y.1    Ren, X.2    Gowda, A.S.3    Shan, Y.4    Zhang, L.5    Yuan, Y.S.6
  • 32
    • 84877994984 scopus 로고    scopus 로고
    • CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress
    • Candas D, Fan M, Nantajit D, Vaughan AT, Murley JS, Woloschak GE, et al. CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress. J Mol Cell Biol 2013;5:166-75.
    • (2013) J Mol Cell Biol , vol.5 , pp. 166-175
    • Candas, D.1    Fan, M.2    Nantajit, D.3    Vaughan, A.T.4    Murley, J.S.5    Woloschak, G.E.6
  • 33
    • 0035910422 scopus 로고    scopus 로고
    • A bipartite substrate recognition motif for cyclin-dependent kinases
    • Takeda DY, Wohlschlegel JA, Dutta A. A bipartite substrate recognition motif for cyclin-dependent kinases. J Biol Chem 2001;276:1993-7.
    • (2001) J Biol Chem , vol.276 , pp. 1993-1997
    • Takeda, D.Y.1    Wohlschlegel, J.A.2    Dutta, A.3
  • 34
    • 79251531097 scopus 로고    scopus 로고
    • Protein acetylation within the cellular response to radiation
    • Averbeck NB, Durante M. Protein acetylation within the cellular response to radiation. J Cell Physiol 2011;226:962-7.
    • (2011) J Cell Physiol , vol.226 , pp. 962-967
    • Averbeck, N.B.1    Durante, M.2
  • 35
    • 36248973110 scopus 로고    scopus 로고
    • NF-kappa B-mediated adaptive resistance to ionizing radiation
    • Ahmed KM, Li JJ. NF-kappa B-mediated adaptive resistance to ionizing radiation. Free Radic Biol Med 2008;44:1-13.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1-13
    • Ahmed, K.M.1    Li, J.J.2
  • 36
    • 79958041601 scopus 로고    scopus 로고
    • The SirT3 divining rod points to oxidative stress
    • Bell EL, Guarente L. The SirT3 divining rod points to oxidative stress. Mol Cell 2011;42:561-8.
    • (2011) Mol Cell , vol.42 , pp. 561-568
    • Bell, E.L.1    Guarente, L.2
  • 38
    • 51449083112 scopus 로고    scopus 로고
    • SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression
    • Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, Mishra M, et al. SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci 2008;4:291-9.
    • (2008) Int J Biol Sci , vol.4 , pp. 291-299
    • Jacobs, K.M.1    Pennington, J.D.2    Bisht, K.S.3    Aykin-Burns, N.4    Kim, H.S.5    Mishra, M.6
  • 39
    • 84902209678 scopus 로고    scopus 로고
    • Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter
    • Satterstrom FK, Haigis MC. Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter. Methods Enzymol 2014;543:141-63.
    • (2014) Methods Enzymol , vol.543 , pp. 141-163
    • Satterstrom, F.K.1    Haigis, M.C.2
  • 40
    • 0035887492 scopus 로고    scopus 로고
    • Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase
    • Bradbury CM, Markovina S, Wei SJ, Rene LM, Zoberi I, Horikoshi N, et al. Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase. Cancer Res 2001;61:7689-96.
    • (2001) Cancer Res , vol.61 , pp. 7689-7696
    • Bradbury, C.M.1    Markovina, S.2    Wei, S.J.3    Rene, L.M.4    Zoberi, I.5    Horikoshi, N.6
  • 42
    • 0034788759 scopus 로고    scopus 로고
    • NF-kappa B signaling pathway as a target for human tumor radiosensitization
    • Jung M, Dritschilo A. NF-kappa B signaling pathway as a target for human tumor radiosensitization. Semin Radiat Oncol 2001;11:346-51.
    • (2001) Semin Radiat Oncol , vol.11 , pp. 346-351
    • Jung, M.1    Dritschilo, A.2
  • 43
    • 0028141973 scopus 로고
    • Radiation induction of immediate early genes: Effectors of the radiation-stress response
    • Weichselbaum RR, Hallahan D, Fuks Z, Kufe D. Radiation induction of immediate early genes: effectors of the radiation-stress response. Int J Radiat Oncol Biol Phys 1994;30:229-34.
    • (1994) Int J Radiat Oncol Biol Phys , vol.30 , pp. 229-234
    • Weichselbaum, R.R.1    Hallahan, D.2    Fuks, Z.3    Kufe, D.4
  • 45
    • 3042716638 scopus 로고    scopus 로고
    • NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis
    • Biswas DK, Shi Q, Baily S, Strickland I, Ghosh S, Pardee AB, et al. NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci U S A 2004;101:10137-42.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10137-10142
    • Biswas, D.K.1    Shi, Q.2    Baily, S.3    Strickland, I.4    Ghosh, S.5    Pardee, A.B.6
  • 46
    • 0038498102 scopus 로고    scopus 로고
    • NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4
    • Helbig G, Christopherson KW II, Bhat-Nakshatri P, Kumar S, Kishimoto H, Miller KD, et al. NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 2003;278:21631-8.
    • (2003) J Biol Chem , vol.278 , pp. 21631-21638
    • Helbig, G.1    Christopherson, K.W.2    Bhat-Nakshatri, P.3    Kumar, S.4    Kishimoto, H.5    Miller, K.D.6
  • 47
    • 84917677976 scopus 로고    scopus 로고
    • Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells
    • Candas D, Lu CL, Fan M, Chuang FY, Sweeney C, Borowsky AD, et al. Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells. Cancer Res 2014;74:7498-509.
    • (2014) Cancer Res , vol.74 , pp. 7498-7509
    • Candas, D.1    Lu, C.L.2    Fan, M.3    Chuang, F.Y.4    Sweeney, C.5    Borowsky, A.D.6
  • 48
    • 79957979314 scopus 로고    scopus 로고
    • Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS
    • Chen Y, Zhang J, Lin Y, Lei Q, Guan KL, Zhao S, et al. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep 2011;12:534-41.
    • (2011) EMBO Rep , vol.12 , pp. 534-541
    • Chen, Y.1    Zhang, J.2    Lin, Y.3    Lei, Q.4    Guan, K.L.5    Zhao, S.6
  • 49
    • 0018749490 scopus 로고
    • Role of superoxide dismutase in cancer: A review
    • Oberley LW, Buettner GR. Role of superoxide dismutase in cancer: a review. Cancer Res 1979;39:1141-9.
    • (1979) Cancer Res , vol.39 , pp. 1141-1149
    • Oberley, L.W.1    Buettner, G.R.2
  • 50
    • 67649224733 scopus 로고    scopus 로고
    • Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model
    • Liu J, Gu X, Robbins D, Li G, Shi R, McCord JM, et al. Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model. PLoS ONE 2009;4:e5284.
    • (2009) PLoS ONE , vol.4
    • Liu, J.1    Gu, X.2    Robbins, D.3    Li, G.4    Shi, R.5    McCord, J.M.6
  • 51
    • 84863906015 scopus 로고    scopus 로고
    • Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE
    • Indo HP, Inanami O, Koumura T, Suenaga S, Yen HC, Kakinuma S, et al. Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE. Free Radic Res 2012;46:1029-43.
    • (2012) Free Radic Res , vol.46 , pp. 1029-1043
    • Indo, H.P.1    Inanami, O.2    Koumura, T.3    Suenaga, S.4    Yen, H.C.5    Kakinuma, S.6
  • 52
    • 84862558070 scopus 로고    scopus 로고
    • Acquisition of resistance of pancreatic cancer cells to 2-methoxyestradiol is associated with the upregulation of manganese superoxide dismutase
    • Zhou J, Du Y. Acquisition of resistance of pancreatic cancer cells to 2-methoxyestradiol is associated with the upregulation of manganese superoxide dismutase. Mol Cancer Res 2012;10:768-77.
    • (2012) Mol Cancer Res , vol.10 , pp. 768-777
    • Zhou, J.1    Du, Y.2
  • 53
    • 78649521247 scopus 로고    scopus 로고
    • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    • Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010;12:662-7.
    • (2010) Cell Metab , vol.12 , pp. 662-667
    • Qiu, X.1    Brown, K.2    Hirschey, M.D.3    Verdin, E.4    Chen, D.5


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