IκBζ is a transcriptional key regulator of CCL2/MCP-1

Journal of Immunology

Volumn 190, Issue 9, 2013, Pages 4812-4820

  Hildebrand, Dominic G ^a   Alexander, Eva ^a   HoNrber, Sebastian ^a   Lehle, Simon ^a   Obermayer, Kerstin ^a   Münck, Niels Arne ^b   Rothfuss, Oliver ^a   Frick, Julia Stefanie ^c   Morimatsu, Masami ^d   Schmitz, Ingo ^e,f   Roth, Johannes ^b   Ehrchen, Jan M ^b   Essmann, Frank ^a   Schulze Osthoff, Klaus ^a,g  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d HOKKAIDO UNIVERSITY   (Japan)

^e HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^f Institute for Molecular and Clinical Immunology   (Germany)

^g GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; I KAPPA B; I KAPPA B ZETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LYSINE; MONOCYTE CHEMOTACTIC PROTEIN 1; PEPTIDOGLYCAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CCL2 GENE; CELL INFILTRATION; CELL STIMULATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA SEQUENCE; EMBRYO; FEMALE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE LOCUS; GENE TARGETING; HISTONE METHYLATION; IN VIVO STUDY; MACROPHAGE FUNCTION; MALE; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEUM MACROPHAGE; PERITONITIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELLS, CULTURED; CHEMOKINE CCL2; FEMALE; GENE EXPRESSION; HISTONES; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; NF-KAPPA B; NUCLEAR PROTEINS; PERITONITIS; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC;

EID: 84876786104     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300089     Document Type: Article

References (36)

1. Soehnlein, O., and L. Lindbom. 2010. Phagocyte partnership during the onset and resolution of inflammation. Nat. Rev. Immunol. 10: 427-439.
2. Luster, A. D. 1998. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338: 436-445. (Pubitemid 28135672)
3. Charo, I. F., and R. M. Ransohoff. 2006. The many roles of chemokines and chemokine receptors in inflammation. N. Engl. J. Med. 354: 610-621. (Pubitemid 43209108)
4. Lu, B., B. J. Rutledge, L. Gu, J. Fiorillo, N. W. Lukacs, S. L. Kunkel, R. North, C. Gerard, and B. J. Rollins. 1998. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J. Exp. Med. 187: 601-608. (Pubitemid 28093362)
5. Takahashi, M., C. Galligan, L. Tessarollo, and T. Yoshimura. 2009. Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A. J. Immunol. 183: 3463-3471.
6. Ajuebor, M. N., R. J. Flower, R. Hannon, M. Christie, K. Bowers, A. Verity, and M. Perretti. 1998. Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. J. Leukoc. Biol. 63: 108-116. (Pubitemid 28070389)
7. Palframan, R. T., S. Jung, G. Cheng, W. Weninger, Y. Luo, M. Dorf, D. R. Littman, B. J. Rollins, H. Zweerink, A. Rot, and U. H. von Andrian. 2001. Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J. Exp. Med. 194: 1361-1373. (Pubitemid 33055053)
8. Daly, C., and B. J. Rollins. 2003. Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies. Microcirculation 10: 247-257. (Pubitemid 39004252)
9. Deshmane, S. L., S. Kremlev, S. Amini, and B. E. Sawaya. 2009. Monocyte chemoattractant protein-1 (MCP-1): an overview. J. Interferon Cytokine Res. 29: 313-326.
10. Gu, L., Y. Okada, S. K. Clinton, C. Gerard, G. K. Sukhova, P. Libby, and B. J. Rollins. 1998. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol. Cell 2: 275-281. (Pubitemid 128373654)
11. Khan, W. I., Y. Motomura, H. Wang, R. T. El-Sharkawy, E. F. Verdu, M. Verma-Gandhu, B. J. Rollins, and S. M. Collins. 2006. Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochro-maffin cells. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G803-G811. (Pubitemid 44772006)
12. Xia, M., and Z. Sui. 2009. Recent developments in CCR2 antagonists. Expert Opin. Ther. Pat. 19: 295-303.
13. Kang, Y. S., J. J. Cha, Y. Y. Hyun, and D. R. Cha. 2011. Novel C-C chemokine receptor 2 antagonists in metabolic disease: a review of recent developments. Expert Opin. Investig. Drugs 20: 745-756.
14. Rollins, B. J., T. Yoshimura, E. J. Leonard, and J. S. Pober. 1990. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemo-attractant, MCP-1/JE. Am. J. Pathol. 136: 1229-1233. (Pubitemid 20210321)
15. Yoshimura, T., N. Yuhki, S. K. Moore, E. Appella, M. I. Lerman, and E. J. Leonard. 1989. Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. FEBS Lett. 244: 487-493. (Pubitemid 19067175)
16. Yadav, A., V. Saini, and S. Arora. 2010. MCP-1: chemoattractant with a role beyond immunity: a review. Clin. Chim. Acta 411: 1570-1579.
17. Wang, Y., G. K. Rangan, B. Goodwin, Y. C. Tay, and D. C. Harris. 2000. Lipopolysaccharide-induced MCP-1 gene expression in rat tubular epithelial cells is nuclear factor-kappaB dependent. Kidney Int. 57: 2011-2022. (Pubitemid 30252293)
18. Ueda, A., Y. Ishigatsubo, T. Okubo, and T. Yoshimura. 1997. Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-kappaB sites and NF-kappaB/Rel subunit specificity. J. Biol. Chem. 272: 31092-31099. (Pubitemid 27527558)
19. Ueda, A., K. Okuda, S. Ohno, A. Shirai, T. Igarashi, K. Matsunaga, J. Fukushima, S. Kawamoto, Y. Ishigatsubo, and T. Okubo. 1994. NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J. Immunol. 153: 2052-2063.
20. Smale, S. T. 2011. Hierarchies of NF-kB target-gene regulation. Nat. Immunol. 12: 689-694.
21. Smale, S. T. 2010. Selective transcription in response to an inflammatory stimulus. Cell 140: 833-844.
22. Hayden, M. S., and S. Ghosh. 2008. Shared principles in NF-kappaB signaling. Cell 132: 344-362.
23. Yamamoto, M., S. Yamazaki, S. Uematsu, S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Kuwata, O. Takeuchi, K. Takeshige, et al. 2004. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein Ikap-paBzeta. Nature 430: 218-222. (Pubitemid 38902431)
24. Yamazaki, S., T. Muta, and K. Takeshige. 2001. A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei. J. Biol. Chem. 276: 27657-27662.
25. Totzke, G., F. Essmann, S. Pohlmann, C. Lindenblatt, R. U. Jänicke, and K. Schulze-Osthoff. 2006. A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. J. Biol. Chem. 281: 12645-12654. (Pubitemid 43855354)
26. Trinh, D. V., N. Zhu, G. Farhang, B. J. Kim, and T. Huxford. 2008. The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA. J. Mol. Biol. 379: 122-135.
27. Kayama, H., V. R. Ramirez-Carrozzi, M. Yamamoto, T. Mizutani, H. Kuwata, H. Iba, M. Matsumoto, K. Honda, S. T. Smale, and K. Takeda. 2008. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and Ikap-paBzeta. J. Biol. Chem. 283: 12468-12477.
28. Shiina, T., A. Konno, T. Oonuma, H. Kitamura, K. Imaoka, N. Takeda, K. Todokoro, and M. Morimatsu. 2004. Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease. J. Biol. Chem. 279: 55493-55498. (Pubitemid 40066550)
29. Meerbrey, K. L., G. Hu, J. D. Kessler, K. Roarty, M. Z. Li, J. E. Fang, J. I. Herschkowitz, A. E. Burrows, A. Ciccia, T. Sun, et al. 2011. The pIN-DUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc. Natl. Acad. Sci. USA 108: 3665-3670.
30. Xu, J. 2005. Preparation, culture, and immortalization of mouse embryonic fibroblasts. Curr. Protoc. Mol. Biol. Chapter 28: Unit 28.1.
31. Ehrchen, J. M., K. Roebrock, D. Foell, N. Nippe, E. von Stebut, J. M. Weiss, N. A. Münck, D. Viemann, G. Varga, C. Müller-Tidow, et al. 2010. Keratinocytes determine Th1 immunity during early experimental leishmaniasis. PLoS Pathog. 6: e1000871.
32. Graupner, V., E. Alexander, T. Overkamp, O. Rothfuss, V. De Laurenzi, B. F. Gillissen, P. T. Daniel, K. Schulze-Osthoff, and F. Essmann. 2011. Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level. Cell Death Differ. 18: 1130-1139.
33. Ghosn, E. E., A. A. Cassado, G. R. Govoni, T. Fukuhara, Y. Yang, D. M. Monack, K. R. Bortoluci, S. R. Almeida, L. A. Herzenberg, and L. A. Herzenberg. 2010. Two physically, functionally, and developmentally distinct peritoneal macrophage subsets. Proc. Natl. Acad. Sci. USA 107: 2568-2573.
34. Kaplanski, G., V. Marin, F. Montero-Julian, A. Mantovani, and C. Farnarier. 2003. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol. 24: 25-29. (Pubitemid 35462110)
35. Gu, L., S. Tseng, R. M. Horner, C. Tam, M. Loda, and B. J. Rollins. 2000. Control of TH2 polarization by the chemokine monocyte chemoattractant pro-tein-1. Nature 404: 407-411. (Pubitemid 30164344)
36. Wolf, M. J., A. Hoos, J. Bauer, S. Boettcher, M. Knust, A. Weber, N. Simonavicius, C. Schneider, M. Lang, M. Stürzl, et al. 2012. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 22: 91-105.