-
1
-
-
34748835882
-
Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer
-
Arima T, Enokida H, Kubo H, Kagara I, Matsuda R, Toki K, Nishimura H, Chiyomaru T, Tatarano S, Idesako T, Nishiyama K, Nakagawa M (2007) Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer. Cancer Sci 98: 1720-1726.
-
(2007)
Cancer Sci
, vol.98
, pp. 1720-1726
-
-
Arima, T.1
Enokida, H.2
Kubo, H.3
Kagara, I.4
Matsuda, R.5
Toki, K.6
Nishimura, H.7
Chiyomaru, T.8
Tatarano, S.9
Idesako, T.10
Nishiyama, K.11
Nakagawa, M.12
-
2
-
-
11244261160
-
ADAMs: Key components in EGFR signalling and development
-
Blobel CP (2005) ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 6: 32-43.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 32-43
-
-
Blobel, C.P.1
-
3
-
-
0037416187
-
TACE is required for the activation of the EGFR by TGF-alpha in tumors
-
Borrell-Pages M, Rojo F, Albanell J, Baselga J, Arribas J (2003) TACE is required for the activation of the EGFR by TGF-alpha in tumors. EMBO J 22: 1114-1124.
-
(2003)
EMBO J
, vol.22
, pp. 1114-1124
-
-
Borrell-Pages, M.1
Rojo, F.2
Albanell, J.3
Baselga, J.4
Arribas, J.5
-
4
-
-
70350536784
-
Selective use of ADAM10 and ADAM17 in activation of Notch 1 signaling
-
Bozhulak EC, Weinmaster G (2009) Selective use of ADAM10 and ADAM17 in activation of Notch 1 signaling. Mol Cell Biol 29: 5679-5695.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5679-5695
-
-
Bozhulak, E.C.1
Weinmaster, G.2
-
5
-
-
84867072867
-
Targeted therapy for triple-negative breast cancer: Where are we
-
Duffy MJ, McGowan PM, Crown J (2012) Targeted therapy for triple-negative breast cancer: where are we? Int J Cancer 131: 2471-2477.
-
(2012)
Int J Cancer
, vol.131
, pp. 2471-2477
-
-
Duffy, M.J.1
McGowan, P.M.2
Crown, J.3
-
7
-
-
0037391956
-
The ADAMs family of proteins: From basic studies to potential clinical applications
-
Duffy MJ, Lynn DJ, Lloyd AT, O'Shea CM (2003) The ADAMs family of proteins: from basic studies to potential clinical applications. Thromb Haemostat 89: 622-631.
-
(2003)
Thromb Haemostat
, vol.89
, pp. 622-631
-
-
Duffy, M.J.1
Lynn, D.J.2
Lloyd, A.T.3
O'Shea, C.M.4
-
8
-
-
84907086521
-
ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer
-
Feldinger K, Generali D, Kramer-Marek G, Gijsen M, Ng TB, Wong JH, Strina C, Cappelletti M, Andreis D, Li JL, Bridges E, Turley H, Leek R, Roxanis I, Capala J, Murphy G, Harris AL, Kong A (2014) ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer. Oncotarget 5: 6633-6646.
-
(2014)
Oncotarget
, vol.5
, pp. 6633-6646
-
-
Feldinger, K.1
Generali, D.2
Kramer-Marek, G.3
Gijsen, M.4
Ng, T.B.5
Wong, J.H.6
Strina, C.7
Cappelletti, M.8
Andreis, D.9
Li, J.L.10
Bridges, E.11
Turley, H.12
Leek, R.13
Roxanis, I.14
Capala, J.15
Murphy, G.16
Harris, A.L.17
Kong, A.18
-
9
-
-
33748037366
-
Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17
-
Franovic A, Robert I, Smith K, Kurban G, Pause A, Gunaratnam L, Lee S (2006) Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Cancer Res 66: 8083-8090.
-
(2006)
Cancer Res
, vol.66
, pp. 8083-8090
-
-
Franovic, A.1
Robert, I.2
Smith, K.3
Kurban, G.4
Pause, A.5
Gunaratnam, L.6
Lee, S.7
-
10
-
-
77955730220
-
Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma
-
Gaida MM, Haag N, Günther F, Tschaharganeh DF, Schirmacher P, Friess H, Giese NA, Schmidt J, Wente MN (2010) Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma. Int J Mol Med 26: 281-288.
-
(2010)
Int J Mol Med
, vol.26
, pp. 281-288
-
-
Gaida, M.M.1
Haag, N.2
Günther, F.3
Tschaharganeh, D.F.4
Schirmacher, P.5
Friess, H.6
Giese, N.A.7
Schmidt, J.8
Wente, M.N.9
-
11
-
-
0036796421
-
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts
-
Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, von Figura K, Saftig P (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet 11: 2615-2624.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 2615-2624
-
-
Hartmann, D.1
De Strooper, B.2
Serneels, L.3
Craessaerts, K.4
Herreman, A.5
Annaert, W.6
Umans, L.7
Lübke, T.8
Lena Illert, A.9
Von Figura, K.10
Saftig, P.11
-
12
-
-
0042237924
-
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
-
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A (2003) The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 102: 1186-1195.
-
(2003)
Blood
, vol.102
, pp. 1186-1195
-
-
Hundhausen, C.1
Misztela, D.2
Berkhout, T.A.3
Broadway, N.4
Saftig, P.5
Reiss, K.6
Hartmann, D.7
Fahrenholz, F.8
Postina, R.9
Matthews, V.10
Kallen, K.J.11
Rose-John, S.12
Ludwig, A.13
-
13
-
-
33846817495
-
Targeting TACE-dependent EGFR ligand shedding in breast cancer
-
Kenny PA, Bissell MJ (2007) Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest 117: 337-345.
-
(2007)
J Clin Invest
, vol.117
, pp. 337-345
-
-
Kenny, P.A.1
Bissell, M.J.2
-
14
-
-
76649128727
-
ADAM10 is upregulated in melanoma metastasis compared with primary melanoma
-
Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, Gutwein P (2010) ADAM10 is upregulated in melanoma metastasis compared with primary melanoma. J Invest Dermatol 130: 763-773.
-
(2010)
J Invest Dermatol
, vol.130
, pp. 763-773
-
-
Lee, S.B.1
Schramme, A.2
Doberstein, K.3
Dummer, R.4
Abdel-Bakky, M.S.5
Keller, S.6
Altevogt, P.7
Oh, S.T.8
Reichrath, J.9
Oxmann, D.10
Pfeilschifter, J.11
Mihic-Probst, D.12
Gutwein, P.13
-
15
-
-
15244349837
-
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules
-
Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, Becherer JD (2005) Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules. Comb Chem High Throughput Screen 8: 161-171.
-
(2005)
Comb Chem High Throughput Screen
, vol.8
, pp. 161-171
-
-
Ludwig, A.1
Hundhausen, C.2
Lambert, M.H.3
Broadway, N.4
Andrews, R.C.5
Bickett, D.M.6
Leesnitzer, M.A.7
Becherer, J.D.8
-
16
-
-
84879833107
-
BreastMark: An integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome
-
Madden SF, Clarke C, Gaule P, Aherne ST, O'Donovan N, Clynes M, Crown J, Gallagher WM (2013) BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome. Breast Cancer Res 15: R52.
-
(2013)
Breast Cancer Res
, vol.15
, pp. R52
-
-
Madden, S.F.1
Clarke, C.2
Gaule, P.3
Aherne, S.T.4
O'Donovan, N.5
Clynes, M.6
Crown, J.7
Gallagher, W.M.8
-
17
-
-
21544467772
-
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and b-catenin translocation
-
Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P (2005a) ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and b-catenin translocation. Proc Natl Acad Sci USA 102: 9182-9187.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9182-9187
-
-
Maretzky, T.1
Reiss, K.2
Ludwig, A.3
Buchholz, J.4
Scholz, F.5
Proksch, E.6
De Strooper, B.7
Hartmann, D.8
Saftig, P.9
-
18
-
-
26444448409
-
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth
-
Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P, Reiss K (2005b) L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth. Mol Cell Biol 25: 9040-9053.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 9040-9053
-
-
Maretzky, T.1
Schulte, M.2
Ludwig, A.3
Rose-John, S.4
Blobel, C.5
Hartmann, D.6
Altevogt, P.7
Saftig, P.8
Reiss, K.9
-
19
-
-
84873805663
-
ADAM-17: A novel therapeutic target for triple negative breast cancer
-
McGowan PM, Mullooly M, Caiazza F, Sukor S, Madden SF, Maguire AA, Pierce A, McDermott EW, Crown J, O'Donovan N, Duffy MJ (2013) ADAM-17: a novel therapeutic target for triple negative breast cancer. Ann Oncol 24: 362-369.
-
(2013)
Ann Oncol
, vol.24
, pp. 362-369
-
-
McGowan, P.M.1
Mullooly, M.2
Caiazza, F.3
Sukor, S.4
Madden, S.F.5
Maguire, A.A.6
Pierce, A.7
McDermott, E.W.8
Crown, J.9
O'Donovan, N.10
Duffy, M.J.11
-
20
-
-
34247846314
-
ADAM-17 expression in breast cancer correlates with variables of tumor progression
-
McGowan PM, Ryan BM, Hill AD, McDermott E, O'Higgins N, Duffy MJ (2007) ADAM-17 expression in breast cancer correlates with variables of tumor progression. Clin Cancer Res 13: 2335-2343.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2335-2343
-
-
McGowan, P.M.1
Ryan, B.M.2
Hill, A.D.3
McDermott, E.4
O'Higgins, N.5
Duffy, M.J.6
-
21
-
-
0035969235
-
Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins
-
Mechtersheimer S, Gutwein P, Agmon-Levin N, Stoeck A, Oleszewski M, Riedle S, Postina R, Fahrenholz F, Fogel M, Lemmon V, Altevogt P (2001) Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins. J Cell Biol 155: 661-673.
-
(2001)
J Cell Biol
, vol.155
, pp. 661-673
-
-
Mechtersheimer, S.1
Gutwein, P.2
Agmon-Levin, N.3
Stoeck, A.4
Oleszewski, M.5
Riedle, S.6
Postina, R.7
Fahrenholz, F.8
Fogel, M.9
Lemmon, V.10
Altevogt, P.11
-
23
-
-
33645575688
-
Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10
-
Murai T, Miyauchi T, Yanagida T, Sako Y (2006) Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10. Biochem J 395: 65-71.
-
(2006)
Biochem J
, vol.395
, pp. 65-71
-
-
Murai, T.1
Miyauchi, T.2
Yanagida, T.3
Sako, Y.4
-
24
-
-
56749133149
-
The ADAMs: Signalling scissors in the tumour microenvironment
-
Murphy G (2008) The ADAMs: Signalling scissors in the tumour microenvironment. Nat Rev Cancer 9: 929-941.
-
(2008)
Nat Rev Cancer
, vol.9
, pp. 929-941
-
-
Murphy, G.1
-
25
-
-
15444371289
-
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling
-
Reiss K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann D, Saftig P (2005) ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling. EMBO J 24: 742-752.
-
(2005)
EMBO J
, vol.24
, pp. 742-752
-
-
Reiss, K.1
Maretzky, T.2
Ludwig, A.3
Tousseyn, T.4
De Strooper, B.5
Hartmann, D.6
Saftig, P.7
-
26
-
-
33845729910
-
Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17
-
Sahin U, Blobel CP (2007) Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17. FEBS Lett 581: 41-44.
-
(2007)
FEBS Lett
, vol.581
, pp. 41-44
-
-
Sahin, U.1
Blobel, C.P.2
-
27
-
-
1442358746
-
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
-
Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel CP (2004) Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 164: 769-779.
-
(2004)
J Cell Biol
, vol.164
, pp. 769-779
-
-
Sahin, U.1
Weskamp, G.2
Kelly, K.3
Zhou, H.M.4
Higashiyama, S.5
Peschon, J.6
Hartmann, D.7
Saftig, P.8
Blobel, C.P.9
-
28
-
-
80052499952
-
Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling
-
Solanas G, Cortina C, Servillano M, Batlle E (2011) Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling. Nat Cell Biol 13: 1100-1107.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1100-1107
-
-
Solanas, G.1
Cortina, C.2
Servillano, M.3
Batlle, E.4
-
29
-
-
78751520783
-
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling
-
Weber S, Niessen MT, Prox J, Lüllmann-Rauch R, Schmitz A, Schwanbeck R, Blobel CP, Jorissen E, de Strooper B, Niessen CM, Saftig P (2011) The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development 138: 495-505.
-
(2011)
Development
, vol.138
, pp. 495-505
-
-
Weber, S.1
Niessen, M.T.2
Prox, J.3
Lüllmann-Rauch, R.4
Schmitz, A.5
Schwanbeck, R.6
Blobel, C.P.7
Jorissen, E.8
De Strooper, B.9
Niessen, C.M.10
Saftig, P.11
|