ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer

Oncotarget

Volumn 5, Issue 16, 2014, Pages 6633-6646

  Feldinger, Katharina ^a   Generali, Daniele ^b   Kramer Marek, Gabriela ^c,g   Gijsen, Merel ^a   Ng, Tzi Bun ^d   Wong, Jack Ho ^d   Strina, Carla ^b   Cappelletti, Mariarosa ^b   Andreis, Daniele ^b   Li, Ji Liang ^a   Bridges, Esther ^a   Turley, Helen ^a   Leek, Russell ^a   Roxanis, Ioannis ^e   Capala, Jacek ^c   Murphy, Gillian ^f   Harris, Adrian L ^a   Kong, Anthony ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CREMONA HOSPITAL   (Italy)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^e NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^f CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^g INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

ADAM10; HER2; Resistance; Survival; Trastuzumab

Indexed keywords

ADAM10 ENDOPEPTIDASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MESSENGER RNA; PROTEIN KINASE B; TRASTUZUMAB; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; ERBB2 PROTEIN, HUMAN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; SECRETASE;

ADAM10 GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL LINE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CANCER SURVIVAL; CELL VIABILITY; COHORT ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LOADING DRUG DOSE; MONOTHERAPY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECURRENCE FREE SURVIVAL; UPREGULATION; ANIMAL; BIOSYNTHESIS; BREAST NEOPLASMS; CELL PROLIFERATION; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; ENZYMOLOGY; FEMALE; GENE SILENCING; GENETICS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MEMBRANE PROTEINS; MICE; RECEPTOR, ERBB-2; TRASTUZUMAB; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84907086521     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1955     Document Type: Article

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