-
1
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
0037158692
-
Metastasis genes: A progression puzzle
-
Bernards R, Weinberg RA. Metastasis genes: a progression puzzle. Nature 2002;418:823.
-
(2002)
Nature
, vol.418
, pp. 823
-
-
Bernards, R.1
Weinberg, R.A.2
-
3
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004;10:789-99.
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
5
-
-
0024473604
-
G1 events and regulation of cell proliferation
-
Pardee AB. G1 events and regulation of cell proliferation. Science 1989;246:603-8.
-
(1989)
Science
, vol.246
, pp. 603-608
-
-
Pardee, A.B.1
-
6
-
-
0021958679
-
Autocrine growth factors and cancer
-
Sporn MB, Roberts AB. Autocrine growth factors and cancer. Nature 1985;313:745-7.
-
(1985)
Nature
, vol.313
, pp. 745-747
-
-
Sporn, M.B.1
Roberts, A.B.2
-
7
-
-
0026399678
-
Effects of transforming growth factor-β, transforming growth factor-α, and other growth factors on renal proximal tubule cells
-
Humes HD, Beals TF, Cieslinski DA, Sanchez IO, Page TP. Effects of transforming growth factor-β, transforming growth factor-α, and other growth factors on renal proximal tubule cells. Lab Invest 1991;64:538-45.
-
(1991)
Lab Invest
, vol.64
, pp. 538-545
-
-
Humes, H.D.1
Beals, T.F.2
Cieslinski, D.A.3
Sanchez, I.O.4
Page, T.P.5
-
8
-
-
0024851629
-
Expression of transforming growth factor α in normal human adult kidney and enhanced expression of transforming growth factors α and β1 in renal cell carcinoma
-
Gomella LG, Sargent ER, Wade TP, Anglard P, Linehan WM, Kasid A. Expression of transforming growth factor α in normal human adult kidney and enhanced expression of transforming growth factors α and β1 in renal cell carcinoma. Cancer Res 1989;49:6972-5.
-
(1989)
Cancer Res
, vol.49
, pp. 6972-6975
-
-
Gomella, L.G.1
Sargent, E.R.2
Wade, T.P.3
Anglard, P.4
Linehan, W.M.5
Kasid, A.6
-
9
-
-
0035852630
-
Role of transforming growth factor-α in von Hippel-Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
-
de Paulsen N, Brychzy A, Fournier MC, et al. Role of transforming growth factor-α in von Hippel-Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Nail Acad Sci U S A 2001;98:1387-92.
-
(2001)
Proc Nail Acad Sci U S A
, vol.98
, pp. 1387-1392
-
-
De Paulsen, N.1
Brychzy, A.2
Fournier, M.C.3
-
10
-
-
0031964099
-
Transforming growth factor α is a target for the von Hippel-Lindau tumor suppressor
-
Knebelmann B, Ananth S, Cohen HT, Sukhatme VP. Transforming growth factor α is a target for the von Hippel-Lindau tumor suppressor. Cancer Res 1998;58: 226-31.
-
(1998)
Cancer Res
, vol.58
, pp. 226-231
-
-
Knebelmann, B.1
Ananth, S.2
Cohen, H.T.3
Sukhatme, V.P.4
-
11
-
-
0026752792
-
Growth regulation of human renal carcinoma cells: Role of transforming growth factor α
-
Atlas I, Mendelsohn J, Baselga J, Fair WR, Masui H, Kumar R. Growth regulation of human renal carcinoma cells: role of transforming growth factor α. Cancer Res 1992;52:3335-9.
-
(1992)
Cancer Res
, vol.52
, pp. 3335-3339
-
-
Atlas, I.1
Mendelsohn, J.2
Baselga, J.3
Fair, W.R.4
Masui, H.5
Kumar, R.6
-
12
-
-
0024328825
-
Expression of transforming growth factor α and epidermal growth factor receptor messenger RNA in neoplastic and nonneoplastic human kidney tissue
-
Mydlo JH, Michaeli J, Cordon-Cardo C, Goldenberg AS, Heston WD, Fair WR. Expression of transforming growth factor α and epidermal growth factor receptor messenger RNA in neoplastic and nonneoplastic human kidney tissue. Cancer Res 1989;49:3407-11.
-
(1989)
Cancer Res
, vol.49
, pp. 3407-3411
-
-
Mydlo, J.H.1
Michaeli, J.2
Cordon-Cardo, C.3
Goldenberg, A.S.4
Heston, W.D.5
Fair, W.R.6
-
13
-
-
0025323946
-
Modulation of pro-epidermal growth factor, protransforming growth factor α and epidermal growth factor receptor gene expression in human renal carcinomas
-
Petrides PE, Bock S, Bovens J, Hofmann R, Jakse G. Modulation of pro-epidermal growth factor, protransforming growth factor α and epidermal growth factor receptor gene expression in human renal carcinomas. Cancer Res 1990;50:3934-9.
-
(1990)
Cancer Res
, vol.50
, pp. 3934-3939
-
-
Petrides, P.E.1
Bock, S.2
Bovens, J.3
Hofmann, R.4
Jakse, G.5
-
14
-
-
0242581718
-
Hypoxia inducible factor activates the transforming growth factor-{α}/epidermal growth factor receptor growth stimulatory pathway in VHL-/- renal cell carcinoma cells
-
Gunaratnam L, Morley M, Franovic A, et al. Hypoxia inducible factor activates the transforming growth factor-{α}/epidermal growth factor receptor growth stimulatory pathway in VHL-/- renal cell carcinoma cells. J Biol Chem 2003;278:44966-74.
-
(2003)
J Biol Chem
, vol.278
, pp. 44966-44974
-
-
Gunaratnam, L.1
Morley, M.2
Franovic, A.3
-
15
-
-
20444485232
-
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer
-
Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer Res 2005;65:5221-30.
-
(2005)
Cancer Res
, vol.65
, pp. 5221-5230
-
-
Smith, K.1
Gunaratnam, L.2
Morley, M.3
Franovic, A.4
Mekhail, K.5
Lee, S.6
-
16
-
-
0032515018
-
An essential role for ectodomain shedding in mammalian development
-
Peschon JJ, Slack JL, Reddy P, et al. An essential role for ectodomain shedding in mammalian development Science 1998;282:1281-4.
-
(1998)
Science
, vol.282
, pp. 1281-1284
-
-
Peschon, J.J.1
Slack, J.L.2
Reddy, P.3
-
17
-
-
0037066757
-
Tumor necrosis factor-α converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability
-
Sunnarborg SW, Hinkle CL, Stevenson M, et al. Tumor necrosis factor-α converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem 2002;277:12838-45.
-
(2002)
J Biol Chem
, vol.277
, pp. 12838-12845
-
-
Sunnarborg, S.W.1
Hinkle, C.L.2
Stevenson, M.3
-
18
-
-
0037416187
-
TACE is required for the activation of the EGFR by TGF-α in tumors
-
Borrell-Pages M, Rojo F, Albanell J, Baselga J, Arribas J. TACE is required for the activation of the EGFR by TGF-α in tumors. EMBO J 2003;22:1114-24.
-
(2003)
EMBO J
, vol.22
, pp. 1114-1124
-
-
Borrell-Pages, M.1
Rojo, F.2
Albanell, J.3
Baselga, J.4
Arribas, J.5
-
19
-
-
0034611607
-
Defective cleavage of membrane bound TGF leads to enhanced activation of the EGF receptor in malignant cells
-
Yang H, Jiang D, Li W, Liang J, Gentry LE, Brattain MG. Defective cleavage of membrane bound TGF leads to enhanced activation of the EGF receptor in malignant cells. Oncogene 2000;19:1901-14.
-
(2000)
Oncogene
, vol.19
, pp. 1901-1914
-
-
Yang, H.1
Jiang, D.2
Li, W.3
Liang, J.4
Gentry, L.E.5
Brattain, M.G.6
-
20
-
-
0037224740
-
The ADAMs family of metalloproteases: Multidomain proteins with multiple functions
-
Seals DF, Courtneidge SA. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 2003;17:7-30.
-
(2003)
Genes Dev
, vol.17
, pp. 7-30
-
-
Seals, D.F.1
Courtneidge, S.A.2
-
22
-
-
0035986907
-
TACE inhibition: A new approach to treating inflammation
-
Doggrell SA. TACE inhibition: a new approach to treating inflammation. Expert Opin Investig Drugs 2002; 11:1003-6.
-
(2002)
Expert Opin Investig Drugs
, vol.11
, pp. 1003-1006
-
-
Doggrell, S.A.1
-
23
-
-
0141816747
-
Tumor necrosis factor α-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells
-
Shao MX, Ueki IF, Nadel JA. Tumor necrosis factor α-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A 2003;100:11618-23.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 11618-11623
-
-
Shao, M.X.1
Ueki, I.F.2
Nadel, J.A.3
-
24
-
-
0035847050
-
Role of exon 2-encoded β-domain of the von Hippel-Lindau tumor suppressor protein
-
Bonicalzi M-E, Groulx I, de Paulsen N, Lee S. Role of exon 2-encoded β-domain of the von Hippel-Lindau tumor suppressor protein. J Biol Chem 2001; 276:1407-16.
-
(2001)
J Biol Chem
, vol.276
, pp. 1407-1416
-
-
Bonicalzi, M.-E.1
Groulx, I.2
De Paulsen, N.3
Lee, S.4
-
25
-
-
0032211360
-
Von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids
-
Lieubeau-Teillet B, Rak J, Jothy S, Iliopoulos O, Kaelin W, Kerbel RS. von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids. Cancer Res 1998;58:4957-62.
-
(1998)
Cancer Res
, vol.58
, pp. 4957-4962
-
-
Lieubeau-Teillet, B.1
Rak, J.2
Jothy, S.3
Iliopoulos, O.4
Kaelin, W.5
Kerbel, R.S.6
-
26
-
-
0029090338
-
Tumour suppression by the human von Hippel-Lindau gene product
-
Iliopoulos O, Kibel A, Gray S, Kaelin WG, Jr. Tumour suppression by the human von Hippel-Lindau gene product. Nat Med 1995;1:822-6.
-
(1995)
Nat Med
, vol.1
, pp. 822-826
-
-
Iliopoulos, O.1
Kibel, A.2
Gray, S.3
Kaelin Jr., W.G.4
-
27
-
-
0028887421
-
Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer
-
Linehan WM, Lerman MI, Zbar B. Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer. JAMA 1995;273:564-70.
-
(1995)
JAMA
, vol.273
, pp. 564-570
-
-
Linehan, W.M.1
Lerman, M.I.2
Zbar, B.3
-
28
-
-
7144256497
-
Functions of the von Hippel-Lindau tumour suppressor protein
-
Kaelin WG, Jr., Iliopoulos O, Lonergan KM, Ohh M. Functions of the von Hippel-Lindau tumour suppressor protein. J Intern Med 1998;243:535-9.
-
(1998)
J Intern Med
, vol.243
, pp. 535-539
-
-
Kaelin Jr., W.G.1
Iliopoulos, O.2
Lonergan, K.M.3
Ohh, M.4
-
29
-
-
0032477788
-
The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
-
Pause A, Lee S, Lonergan KM, Klausner RD. The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proc Natl Acad Sci U S A 1998;95:993-8.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 993-998
-
-
Pause, A.1
Lee, S.2
Lonergan, K.M.3
Klausner, R.D.4
-
30
-
-
32944464205
-
Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis
-
Kurban G, Hudon V, Duplan E, Ohh M, Pause A. Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res 2006;66:1313-9.
-
(2006)
Cancer Res
, vol.66
, pp. 1313-1319
-
-
Kurban, G.1
Hudon, V.2
Duplan, E.3
Ohh, M.4
Pause, A.5
-
31
-
-
0032085240
-
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
-
Ohh M, Yauch RL, Lonergan KM, et al. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell 1998;1:959-68.
-
(1998)
Mol Cell
, vol.1
, pp. 959-968
-
-
Ohh, M.1
Yauch, R.L.2
Lonergan, K.M.3
-
32
-
-
0036133646
-
Tumor necrosis factor-[α] converting enzyme
-
Black RA. Tumor necrosis factor-[α] converting enzyme. Int J Biochem Cell Biol 2002;34:1-5.
-
(2002)
Int J Biochem Cell Biol
, vol.34
, pp. 1-5
-
-
Black, R.A.1
-
33
-
-
2642569570
-
Role of tumor-associated macrophages in renal cell carcinoma
-
Ikemoto S, Yoshida N, Narita K, et al. Role of tumor-associated macrophages in renal cell carcinoma. Oncol Rep 2003;10:1843-9.
-
(2003)
Oncol Rep
, vol.10
, pp. 1843-1849
-
-
Ikemoto, S.1
Yoshida, N.2
Narita, K.3
-
34
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-64.
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
35
-
-
0036674501
-
Dissemination and growth of cancer cells in metastatic sites
-
Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002;2:563-72.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 563-572
-
-
Chambers, A.F.1
Groom, A.C.2
MacDonald, I.C.3
-
36
-
-
0023624729
-
Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-[α] and epidermal growth factor
-
Barrandon Y, Green H. Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-[α] and epidermal growth factor. Cell 1987;50:1131-7.
-
(1987)
Cell
, vol.50
, pp. 1131-1137
-
-
Barrandon, Y.1
Green, H.2
-
37
-
-
0035945359
-
Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration
-
Maheshwari G, Wiley HS, Lauffenburger DA. Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration. J Cell Biol 2001;155:1123-8.
-
(2001)
J Cell Biol
, vol.155
, pp. 1123-1128
-
-
Maheshwari, G.1
Wiley, H.S.2
Lauffenburger, D.A.3
-
38
-
-
13544262491
-
Hole of TGF[α] stimulation of the ERK, PI3 kinase and PLC[γ] pathways in ovarian cancer growth and migration
-
Sewell JM, Smyth JF, Langdon SP. Hole of TGF[α] stimulation of the ERK, PI3 kinase and PLC[γ] pathways in ovarian cancer growth and migration. Exp Cell Res 2005;304:305-16.
-
(2005)
Exp Cell Res
, vol.304
, pp. 305-316
-
-
Sewell, J.M.1
Smyth, J.F.2
Langdon, S.P.3
-
39
-
-
27644450912
-
Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin
-
Lamszus K, Brockmann MA, Eckerich C, et al. Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin. Clin Cancer Res 2005;11:4934-40.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4934-4940
-
-
Lamszus, K.1
Brockmann, M.A.2
Eckerich, C.3
-
40
-
-
3042554386
-
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation
-
Nagano O, Murakami D, Hartmann D, et al. Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation. J Cell Biol 2004;165:893-902.
-
(2004)
J Cell Biol
, vol.165
, pp. 893-902
-
-
Nagano, O.1
Murakami, D.2
Hartmann, D.3
-
41
-
-
0032847152
-
Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule
-
Beer S, Oleszewski M, Gutwein P, Geiger C, Altevogt P. Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule. J Cell Sci 1999;112: 2667-75.
-
(1999)
J Cell Sci
, vol.112
, pp. 2667-2675
-
-
Beer, S.1
Oleszewski, M.2
Gutwein, P.3
Geiger, C.4
Altevogt, P.5
-
42
-
-
26244444813
-
Selective modulation of integrin-mediated cell migration by distinct ADAM family members
-
Huang J, Bridges LC, White JM. Selective modulation of integrin-mediated cell migration by distinct ADAM family members. Mol Biol Cell 2005;16:4982-91.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 4982-4991
-
-
Huang, J.1
Bridges, L.C.2
White, J.M.3
-
43
-
-
2542423590
-
Integrin {α}5{β}1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells
-
Bax DV, Messent AJ, Tart J, et al. Integrin {α}5{β}1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells. J Biol Chem 2004;279:22377-86.
-
(2004)
J Biol Chem
, vol.279
, pp. 22377-22386
-
-
Bax, D.V.1
Messent, A.J.2
Tart, J.3
-
44
-
-
0033772308
-
FAK integrates growth-factor and integral signals to promote cell migration
-
Sieg DJ, Hauck CR, Ilic D, et al. FAK integrates growth-factor and integral signals to promote cell migration. Nat Cell Biol 2000;2:249-56.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 249-256
-
-
Sieg, D.J.1
Hauck, C.R.2
Ilic, D.3
-
45
-
-
12444251187
-
Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma
-
Motzer RJ, Amato R, Todd M, et al. Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma. Invest New Drugs 2003;21:99-101.
-
(2003)
Invest New Drugs
, vol.21
, pp. 99-101
-
-
Motzer, R.J.1
Amato, R.2
Todd, M.3
-
46
-
-
0345714775
-
Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma
-
Drucker B, Bacik J, Ginsberg M, et al. Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma. Invest New Drugs 2003;21:341-50.
-
(2003)
Invest New Drugs
, vol.21
, pp. 341-350
-
-
Drucker, B.1
Bacik, J.2
Ginsberg, M.3
-
47
-
-
0034089164
-
Requirement for the von Hippel-Lindau tumor suppressor gene for functional epidermal growth factor receptor blockade by monoclonal antibody C225 in renal cell carcinoma
-
Perera AD, Kleymenova EV, Walker CL. Requirement for the von Hippel-Lindau tumor suppressor gene for functional epidermal growth factor receptor blockade by monoclonal antibody C225 in renal cell carcinoma. Clin Cancer Res 2000;6:1518-23.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1518-1523
-
-
Perera, A.D.1
Kleymenova, E.V.2
Walker, C.L.3
-
48
-
-
4143058243
-
Epidermal growth factor receptor and epidermal growth factor receptor therapies in renal cell carcinoma: Do we need a better mouse trap?
-
Dancey JE. Epidermal growth factor receptor and epidermal growth factor receptor therapies in renal cell carcinoma: do we need a better mouse trap? J Clin Oncol 2004;22:2975-7.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2975-2977
-
-
Dancey, J.E.1
|