Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 37, 2015, Pages E5160-E5168

  Paradis, Justine S ^a   Ly, Stevenson ^a,b   Blondel Tepaz, Élodie ^a   Galan, Jacob A ^a,b,d   Beautrait, Alexandre ^a   Scott, Mark G H ^c   Enslen, Hervé ^c   Marullo, Stefano ^c   Roux, Philippe P ^a,b   Bouvier, Michel ^a,b  

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c INSTITUT COCHIN   (France)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cell signaling; G protein coupled receptor; Internalization; MAPK; arrestin

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; BETA ARRESTIN 2; CHEMOKINE RECEPTOR CXCR4; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROSTAGLANDIN F RECEPTOR; PROSTAGLANDIN RECEPTOR; SERINE; THREONINE; UNCLASSIFIED DRUG; VASOPRESSIN; VASOPRESSIN TYPE 2; ARRB2 PROTEIN, HUMAN; ARRB2 PROTEIN, MOUSE; BETA ARRESTIN; LIGAND; MAPK1 PROTEIN, HUMAN; PEPTIDE; PROSTAGLANDIN F2ALPHA RECEPTOR; PROTEIN BINDING; RETINA S ANTIGEN;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REDUCTION; REGULATORY MECHANISM; SECOND MESSENGER; SIGNAL TRANSDUCTION; STEADY STATE; AMINO ACID SEQUENCE; ANIMAL; BOVINE; CELL MEMBRANE; CHEMISTRY; CYTOPLASM; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ARRESTINS; BETA-ARRESTIN 2; BETA-ARRESTINS; CATTLE; CELL MEMBRANE; CYTOPLASM; ENZYME ACTIVATION; FIBROBLASTS; HEK293 CELLS; HELA CELLS; HUMANS; LIGANDS; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PROSTAGLANDIN; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84941712466     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1508836112     Document Type: Article

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