Postprandial endotoxemia linked with chylomicrons and lipopolysaccharides handling in obese versus lean men: A lipid dose-effect trial

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 9, 2015, Pages 3427-3435

  Vors, Cécile ^a,c   Pineau, Gaëlle ^b,d   Drai, Jocelyne ^e   Meugnier, Emmanuelle ^a   Pesenti, Sandra ^b   Laville, Martine ^a,c   Laugerette, Fabienne ^a,b   Malpuech Brugère, Corinne ^f,g   Vidal, Hubert ^a,b   Michalski, Marie Caroline ^a,b,c  

^a UNIVERSITÉ DE LYON   (France)

^b CarMeN   (France)

^c Univ Lyon   (France)

^d Univ Lyon   (France)

^e CENTRE HOSPITALIER LYON SUD   (France)

^f UNIVERSITÉ CLERMONT AUVERGNE   (France)

^g INRA and University of Auvergne   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CHYLOMICRON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE BINDING PROTEIN; ACUTE PHASE PROTEIN; CARRIER PROTEIN; FAT INTAKE; GLUCOSE BLOOD LEVEL; INSULIN; LIPOPOLYSACCHARIDE-BINDING PROTEIN; MEMBRANE PROTEIN;

ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; FAT INTAKE; GENE EXPRESSION; HUMAN; INTERLEUKIN 6 GENE; LIPID BLOOD LEVEL; MALE; OBESITY; POSTPRANDIAL ENDOTOXEMIA; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; BLOOD; CROSSOVER PROCEDURE; DOSE RESPONSE; GLUCOSE BLOOD LEVEL; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ACUTE-PHASE PROTEINS; ADULT; BLOOD GLUCOSE; BODY MASS INDEX; CARRIER PROTEINS; CHYLOMICRONS; CROSS-OVER STUDIES; DIETARY FATS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; HUMANS; INSULIN; LIPOPOLYSACCHARIDES; MALE; MEMBRANE GLYCOPROTEINS; OBESITY; POSTPRANDIAL PERIOD;

EID: 84941710982     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-2518     Document Type: Article

References (40)

1. Evert AB, Boucher JL, Cypress M, et al. Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care. 2013;36:3821-3842.
2. Pendyala S, Walker JM, Holt PR. A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology 2012; 142:1100-1101 e1102.
3. Laugerette F, Vors C, Peretti N, Michalski MC. Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation. Biochimie. 2011;93:39-45.
4. Manco M, Putignani L, Bottazzo GF. Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk. Endocr Rev. 2010;31:817-844.
5. Lassenius MI, Pietiläinen KH, Kaartinen K, et al. Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation. Diabetes Care. 2011;34:1809-1815.
6. Pussinen PJ, Havulinna AS, Lehto M, Sundvall J, Salomaa V. Endotoxemia is associated with an increased risk of incident diabetes. Diabetes Care. 2011;34:392-397.
7. Cani PD,AmarJ, IglesiasMA,et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761-1772.
8. Erridge C, Attina T, SpickettCM,Webb DJ.Ahigh-fat meal induces low-grade endotoxemia: Evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr. 2007;86:1286-1292.
9. Laugerette F, Vors C, Geloen A, et al. Emulsified lipids increase endotoxemia: Possible role in early postprandial low-grade inflammation. J Nutr Biochem. 2011;22:53-59.
10. Ghanim H, Abuaysheh S, Sia CL, et al. Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: Implications for insulin resistance. Diabetes Care. 2009;32:2281-2287.
11. Deopurkar R, Ghanim H, Friedman J, et al. Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care. 2010;33:991-997.
12. Ghoshal S, Witta J, Zhong J, de Villiers W, Eckhardt E. Chylomicrons promote intestinal absorption of lipopolysaccharides. J Lipid Res. 2009;50:90-97.
13. Chapman MJ, Ginsberg HN, Amarenco P, et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: Evidence and guidance for management. Eur Heart J. 2011;32:1345-1361.
14. Alipour A, Elte JW, van Zaanen HC, Rietveld AP, Cabezas MC. Postprandial inflammation and endothelial dysfuction. Biochem Soc Trans. 2007;35:466-469.
15. Vors C, Pineau G, Gabert L, et al. Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: A randomized cross over clinical trial. Am J Clin Nutr. 2013;97: 23-36.
16. Laugerette F, Pineau G, Vors C, Michalski MC. Endotoxemia analysis by the Limulus amoebocyte lysate assay in different mammal species used in metabolic studies. J Anal Bioanal Tech. 2015;6:247.
17. Schwander F, Kopf-Bolanz KA, Buri C, et al. A dose-response strategy reveals differences between normal-weight and obese men in their metabolic and inflammatory responses to a high-fat meal. J Nutr. 2014;144:1517-1523.
18. Clemente-Postigo M, Queipo-Ortuño MI, Murri M, et al. Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients. J Lipid Res. 2012;53:973-978.
19. Harte AL, Varma MC, Tripathi G, et al. High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects. Diabetes Care. 2012;35:375-382.
20. Kim KA, Gu W, Lee IA, Joh EH, Kim DH. High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. PloS One. 2012;7:e47713.
21. Wurfel MM, Hailman E, Wright SD. Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein. JExpMed. 1995; 181:1743-1754.
22. Barcia AM, Harris HW. Triglyceride-rich lipoproteins as agents of innate immunity. Clin Infect Dis. 2005;41:S498-S503.
23. Vreugdenhil AC, Rousseau CH, Hartung T, Greve JW, van 't Veer C, Buurman WA. Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons. J Immunol. 2003;170: 1399-1405.
24. Xiang SQ, Cianflone K, Kalant D, Sniderman AD. Differential binding of triglyceride-rich lipoproteins to lipoprotein lipase. J Lipid Res. 1999;40:1655-1663.
25. Wurfel MM, Kunitake ST, Lichenstein H, Kane JP, Wright SD. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J Exp Med. 1994;180:1025-1035.
26. Vergès B, Duvillard L, Lagrost L, et al. Changes in lipoprotein kinetics associated with type 2 diabetes affect the distribution of lipopolysaccharides among lipoproteins. J Clin Endocrinol Metab. 2014;99:E1245-E1253.
27. Blackburn P, Despres JP, Lamarche B, et al. Postprandial variations of plasma inflammatory markers in abdominally obese men. Obesity (Silver Spring). 2006;14:1747-1754.
28. Lundman P, Boquist S, Samnegard A, et al. A high-fat meal is accompanied by increased plasma interleukin-6 concentrations. Nutr Metab Cardiovasc Dis. 2007;17:195-202.
29. Nappo F, Esposito K, Cioffi M, et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: Role of fat and carbohydrate meals. J Am Coll Cardiol. 2002;39:1145-1150.
30. Poppitt SD, Keogh GF, Lithander FE, et al. Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load. Nutrition. 2008;24:322-329.
31. Jiménez-Gómez Y, López-Miranda J, Blanco-Colio LM, et al. Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men. Atherosclerosis. 2009;204:e70-e76.
32. Manning PJ, Sutherland WH, Hendry G, de Jong SA, McGrath M, Williams SM. Changes in circulating postprandial proinflammatory cytokine concentrations in diet-controlled type 2 diabetes and the effect of ingested fat. Diabetes Care. 2004;27:2509-2511.
33. Teng KT, Nagapan G, Cheng HM, Nesaretnam K. Palm olein and olive oil cause a higher increase in postprandial lipemia compared with lard but had no effect on plasma glucose, insulin and adipocytokines. Lipids. 2011;46:381-388.
34. Tholstrup T, Teng KT, RaffM.Dietary cocoa butter or refined olive oil does not alter postprandial hsCRP and IL-6 concentrations in healthy women. Lipids. 2011;46:365-370.
35. Alvarez JA, Higgins PB, Oster RA, Fernandez JR, Darnell BE, Gower BA. Fasting and postprandial markers of inflammation in lean and overweight children.AmJ Clin Nutr. 2009;89:1138-1144.
36. Manning PJ, Sutherland WH, McGrath MM, de Jong SA, Walker RJ, Williams MJ. Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity (Silver Spring). 2008;16:2046-2052.
37. Fogarty CL, Nieminen JK, Peräneva L, et al. High-fat meals induce systemic cytokine release without evidence of endotoxemia-mediated cytokine production from circulating monocytes or myeloid dendritic cells. Acta Diabetologica. 2015;52:315-322.
38. Meneses ME, Camargo A, Perez-Martinez P, et al. Postprandial inflammatory response in adipose tissue of patients with metabolic syndrome after the intake of different dietary models. Mol Nutr Food Res. 2011;55:1759-1770.
39. Moreno-Navarrete JM, Ortega F, Serino M, et al. Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance. Int J Obes (Lond). 2012;36:1442-1449.
40. Laugerette F, Alligier M, Bastard JP, et al. Overfeeding increases postprandial endotoxemia in men: Inflammatory outcome may depend on LPS transporters LBP and sCD14. Mol Nutr Food Res. 2014;58:1513-1518.