Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients

Journal of Lipid Research

Volumn 53, Issue 5, 2012, Pages 973-978

  Clemente Postigo, M ^a   Queipo Ortuno M I ^a,b   Murri, M ^a,b   Boto Ordonez M ^c   Perez Martinez, P ^b,d   Andres Lacueva, C ^c   Cardona, F ^a,b   Tinahones, F J ^a,b  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

Chylomicrons; Insulin resistance; Metabolic endotoxemia; Nutrition; Obesity; Triglycerides

Indexed keywords

C REACTIVE PROTEIN; CHYLOMICRON; ENDOTOXIN; LIPOPOLYSACCHARIDE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD ANALYSIS; CARBOHYDRATE ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; ENDOTOXEMIA; ENZYME ACTIVITY; HUMAN; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LIPID DIET; LIPOGENESIS; MORBID OBESITY; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TOXIN ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; ENDOTOXEMIA; ENDOTOXINS; FATS; HUMANS; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LIPOPOLYSACCHARIDES; OBESITY, MORBID; POSTPRANDIAL PERIOD;

EID: 84860291378     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.P020909     Document Type: Article

References (27)

1. Reaven, G. 2005. All obese individuals are not created equal: insulin resistance is the major determinant of cardiovascular disease in overweight / obese individuals. Diab. Vasc. Dis. Res. 2: 105-112. (Pubitemid 41695168)
2. Barbarroja, N., R. López-Pedrera, M. D. Mayas, E. García-Fuentes, L. Garrido-Sánchez, M. Macías- González, R. El Bekay, A. Vidal-Puig, and F. J. Tinahones. 2010. The obese healthy paradox: is inflammation the answer? Biochem. J. 430: 141-149.
3. Furukawa, S., T. Fujita, M. Shimabukuro, M. Iwaki, Y. Yamada, Y. Nakajima, O. Nakayama, M. Makishima, M. Matsuda, and I. Shimomura. 2004. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114: 1752-1761. (Pubitemid 40385531)
4. Hotamisligil, G. S. 2006. Inflammation and metabolic disorders. Nature. 444: 860-867. (Pubitemid 46024993)
5. van Oostrom, A. J., T. J. Rabelink, C. Verseyden, T. P. Sijmonsma, H. W. Plokker, P. P. De Jaegere and M. Castro-Cabezas. 2004. Activation of leukocytes by postprandial lipemia in healthy volunteers. Atherosclerosis. 177: 175-182. (Pubitemid 39361153)
6. Aljada, A., P. Mohanty, H. Ghanim, T. Abdo, D. Tripathy, A. Chaudhuri, and P. Dandona. 2004. Increase in intranuclear nuclear factor κB and decrease in inhibitor κB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. Am. J. Clin. Nutr. 79: 682-690. (Pubitemid 41103915)
7. Erridge, C., T. Attina, C. M. Spickett, and D. J. Webb. 2007. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am. J. Clin. Nutr. 86: 1286-1292. (Pubitemid 350126229)
8. Cardona, F., I. Tunez, I. Tasset, M. Murri, and F. J. Tinahones. 2008. Similar increase in oxidative stress after fat overload in persons with baseline hypertriglyceridemia with or without the metabolic syndrome. Clin. Biochem. 41: 701-705.
9. Berg, R. D. 1996. The indigenous gastrointestinal microflora. Trends Microbiol. 4: 430-435. (Pubitemid 26373240)
10. Wiedermann, C. J., S. Kiechl, S. Dunzendorfer, P. Schratzberger, G. Egger, F. Oberhollenzer, and J. Willeit. 1999. Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study. J. Am. Coll. Cardiol. 34: 1975-1981. (Pubitemid 30002653)
11. Amar, J., R. Burcelin, J. B. Ruidavets, P. D. Cani, J. Fauvel, M. C. Alessi, B. Chamontin, and J. Ferriéres. 2008. Energy intake is associated with endotoxemia in apparently healthy men. Am. J. Clin. Nutr. 87: 1219-1223. (Pubitemid 351679761)
12. Ravin, H. A., D. Rowley, C. Jenkins, and J. Fine. 1960. On the absorption of bacterial endotoxin from the gastro-intestinal tract of the normal and shocked animal. J. Exp. Med. 112: 783-792.
13. Ghoshal, S., J. Witta, J. Zhong, W. de Villiersa, and E. Eckhardt. 2009. Chylomicrons promote intestinal absorption of lipopolysaccharides. J. Lipid Res. 50: 90-97.
14. Laugerette, F., C. Vors, A. Géloën, M. A. Chauvin, C. Soulage, S. Lambert-Porcheron, N. Peretti, M. Alligier, R. Burcelin, M. Laville, et al. 2011. Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation. J. Nutr. Biochem. 22: 53-59.
15. Vreugdenhil, A. C., C. H. Rousseau, T. Hartung, J. W. Greve, C. van't Veer, and W. A. Buurman. 2003. Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons. J. Immunol. 170: 1399-1405. (Pubitemid 36139507)
16. Ley, R. E., P. J. Turnbaugh, S. Klein, and J. I. Gordon. 2006. Microbial ecology: human gut microbes associated with obesity. Nature. 444: 1022-1023. (Pubitemid 46018512)
17. Turnbaugh, P. J., R. E. Ley, M. A. Mahowald, V. Magrini, E. R. Mardis, and J. I. Gordon. 2006. An obesity associated gut microbiome with increased capacity for energy harvest. Nature. 444: 1027-1031. (Pubitemid 46018515)
18. Cani, P. D., J. Amar, M. A. Iglesias, M. Poggi, C. Knauf, D. Bastelica, A. M. Neyrinck, F. Fava, K. M. Tuohy, C. Chabo, et al. 2007. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 56: 1761-1772. (Pubitemid 47025442)
19. Cardona, F., and F. J. Tinahones. Composition useful for the detection of postprandial hypertriglyceridemia. Spain patent with license number P201030776.
20. Matthews, D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28: 412-419. (Pubitemid 15018832)
21. Brenchley, J. M., D. A. Price, T. W. Schacker, T. E. Asher, G. Silvestri, S. Rao, Z. Kazzaz, E. Bornstein, O. Lambotte, D. Altmann, et al. 2006. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12: 1365-1371. (Pubitemid 44924494)
22. Nádházi, Z., A. Takats, K. Offenmüller, and L. Bertók. 2002. Plasma endotoxin level of healthy donors. Acta Microbiol. Immunol. Hung. 49: 151-157. (Pubitemid 135704973)
23. Cardona, F., I. Tunez, I. Tasset, P. Montilla, E. Collantes, and F. J. Tinahones. 2008. Fat overload aggravates oxidative stress in patients with the metabolic syndrome. Eur. J. Clin. Invest. 38: 510-515. (Pubitemid 351832030)
24. Greaves, D. R., and K. M. Channon. 2002. Inflammation and immune responses in atherosclerosis. Trends Immunol. 23: 535-541. (Pubitemid 35223552)
25. Stoll, L. L., G. M. Denning, and N. L. Weintraub. 2004. Potential role of endotoxin as a proinflammatory mediator of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 24: 2227-2236. (Pubitemid 39658022)
26. Greenberg, A. S., and M. S. Obin. 2006. Obesity and the role of adipose tissue in inflammation and metabolism. Am. J. Clin. Nutr. 83: 461S-465S. (Pubitemid 44713219)
27. Hurley, J. C. 1995. Endotoxemia: methods of detection and clinical correlates. Clin. Microbiol. Rev. 8: 268-292.