P63 supports aerobic respiration through hexokinase II

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 37, 2015, Pages 11577-11582

  Viticchiè, Guiditta ^a   Agostini, Massimiliano ^a,b   Lena, Anna Maria ^a   Mancini, Mara ^a,b   Zhou, Huiqing ^c   Zolla, Lello ^d   Dinsdale, David ^b   Saintigny, Gaelle ^e   Melino, Gerry ^a,b   Candi, Eleonora ^a,f  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d UNIVERSITY OF TUSCIA   (Italy)

^e Chanel Parfumes Beauté   (France)

^f LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

Author keywords

HK2; Keratinocytes; Mitochondria; Oxidative metabolism; P63

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE TRIPHOSPHATE; HEXOKINASE; HEXOKINASE II; PROTEIN P63; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL; HYDROGEN PEROXIDE; OXYGEN; PROTEIN P53; TP53 PROTEIN, HUMAN; TP63 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

AEROBIC METABOLISM; ARTICLE; CANCER CELL; CELL ADHESION; CELL CYCLE; CELL ENERGY; CELL METABOLISM; CELL RESPIRATION; CELLULAR DISTRIBUTION; EPITHELIUM CELL; GENETIC TRANSFECTION; GLUCOSE UTILIZATION; HUMAN; HUMAN CELL; KERATINOCYTE; MITOCHONDRIAL MEMBRANE; NEWBORN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; WESTERN BLOTTING; 3T3 CELL LINE; ANIMAL; CELL PROLIFERATION; CELL SEPARATION; CHEMISTRY; CYTOLOGY; ELECTRON MICROSCOPY; FLOW CYTOMETRY; GENE SILENCING; GLYCOLYSIS; METABOLISM; MITOCHONDRION; MOUSE; NEOPLASM; PHENOTYPE;

ANIMALS; CELL PROLIFERATION; CELL SEPARATION; FLOW CYTOMETRY; GENE SILENCING; GLYCOLYSIS; HEXOKINASE; HUMANS; HYDROGEN PEROXIDE; KERATINOCYTES; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; NEOPLASMS; NIH 3T3 CELLS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN; OXYGEN CONSUMPTION; PHENOTYPE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84941696058     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1508871112     Document Type: Article

References (49)

1. Blanpain C, Fuchs E (2006) Epidermal stem cells of the skin. Annu Rev Cell Dev Biol 22:339-373.
2. Bickenbach JR, Greer JM, Bundman DS, Rothnagel JA, Roop DR (1995) Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development. J Invest Dermatol 104(3):405-410.
3. Byrne C, Tainsky M, Fuchs E (1994) Programming gene expression in developing epidermis. Development 120(9):2369-2383.
4. Candi E, Schmidt R, Melino G (2005) The cornified envelope: A model of cell death in the skin. Nat Rev Mol Cell Biol 6(4):328-340.
5. Candi E, et al. (2006) Differential roles of p63 isoforms in epidermal development: Selective genetic complementation in p63 null mice. Cell Death Differ 13(6):1037-1047.
6. Koster MI, et al. (2007) p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci USA 104(9):3255-3260.
7. Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR (2004) p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev 18(2):126-131.
8. Truong AB, Kretz M, Ridky TW, Kimmel R, Khavari PA (2006) p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev 20(22):3185-3197.
9. Mills AA, et al. (1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398(6729):708-713.
10. Yang A, et al. (1999) p63 is essential for regenerative proliferation in limb, cranio-facial and epithelial development. Nature 398(6729):714-718.
11. Yang A, Kaghad M, Caput D, McKeon F (2002) On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet 18(2):90-95.
12. Yang A, McKeon F (2000) P63 and P73: P53 mimics, menaces and more. Nat Rev Mol Cell Biol 1(3):199-207.
13. Duijf PH, et al. (2002) Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63. Hum Mol Genet 11(7):799-804.
14. Yang A, et al. (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 2(3): 305-316.
15. Romano RA, et al. (2012) ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development 139(4): 772-782.
16. Senoo M, Pinto F, Crum CP, McKeon F (2007) p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell 129(3):523-536.
17. Su X, et al. (2012) TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metab 16(4):511-525.
18. Berkers CR, Maddocks OD, Cheung EC, Mor I, Vousden KH (2013) Metabolic regulation by p53 family members. Cell Metab 18(5):617-633.
19. Gottlieb E, Vousden KH (2010) p53 regulation of metabolic pathways. Cold Spring Harb Perspect Biol 2(4):a001040.
20. Mathupala SP, Heese C, Pedersen PL (1997) Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J Biol Chem 272(36):22776-22780.
21. Kouwenhoven EN, et al. (2010) Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genet 6(8):e1001065.
22. Kouwenhoven EN, et al. (2015) Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation. EMBO Rep 16(7):863-878.
23. Giacobbe A, et al. (2015) p63 controls cell migration and invasion by transcriptional regulation of MTSS1. Oncogene, 10.1038/onc.2015.230.
24. Rivetti di Val Cervo P, et al. (2012) p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci USA 109(4):1133-1138.
25. Wilson JE (2003) Isozymes of mammalian hexokinase: Structure, subcellular localization and metabolic function. J Exp Biol 206(pt 12):2049-2057.
26. Robey RB, Hay N (2006) Mitochondrial hexokinases, novel mediators of the anti-apoptotic effects of growth factors and Akt. Oncogene 25(34):4683-4696.
27. Gottlob K, et al. (2001) Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 15(11):1406-1418.
28. Majewski N, et al. (2004) Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 16(5):819-830.
29. da-Silva WS, et al. (2004) Mitochondrial bound hexokinase activity as a preventive antioxidant defense: Steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria. J Biol Chem 279(38):39846-39855.
30. d'Adda di Fagagna F (2008) Living on a break: Cellular senescence as a DNA-damage response. Nat Rev Cancer 8(7):512-522.
31. Adams PD (2009) Healing and hurting: Molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell 36(1):2-14.
32. Rufini A, et al. (2012) TAp73 depletion accelerates aging through metabolic dysre-gulation. Genes Dev 26(18):2009-2014.
33. Paris M, Rouleau M, Pucéat M, Aberdam D (2012) Regulation of skin aging and heart development by TAp63. Cell Death Differ 19(2):186-193.
34. Sommer M, et al. (2006) DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle 5(17):2005-2011.
35. Keyes WM, et al. (2005) p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev 19(17):1986-1999.
36. Viticchiè G, et al. (2012) MicroRNA-203 contributes to skin re-epithelialization. Cell Death Dis 3:e435.
37. Candi E, et al. (2007) DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci USA 104(29):11999-12004.
38. Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324(5930):1029-1033.
39. Patra KC, et al. (2013) Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell 24(2): 213-228.
40. Peschiaroli A, et al. (2013) miR-143 regulates hexokinase 2 expression in cancer cells. Oncogene 32(6):797-802.
41. Wang L, et al. (2014) Hexokinase 2-mediated Warburg effect is required for PTEN-and p53-deficiency-driven prostate cancer growth. Cell Reports 8(5):1461-1474.
42. Panasyuk G, et al. (2012) PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nat Commun 3:672.
43. Ramsey MR, et al. (2013) FGFR2 signaling underlies p63 oncogenic function in squa-mous cell carcinoma. J Clin Invest 123(8):3525-3538.
44. Ramsey MR, He L, Forster N, Ory B, Ellisen LW (2011) Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. Cancer Res 71(13):4373-4379.
45. Piccolo S, Enzo E, Montagner M (2013) p63, Sharp1, and HIFs: Master regulators of metastasis in triple-negative breast cancer. Cancer Res 73(16):4978-4981.
46. Montagner M, et al. (2012) SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature 487(7407):380-384.
47. Adorno M, et al. (2009) A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell 137(1):87-98.
48. Wu M, et al. (2007) Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 292(1):C125-C136.
49. Tucci P, et al. (2013) Rapamycin regulates biochemical metabolites. Cell Cycle 12(15): 2454-2467.