Two virus-induced MicroRNAs known only from teleost fishes are orthologues of MicroRNAs involved in cell cycle control in Humans

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Schyth, Brian Dall ^a   Bela Ong, Dennis Berbulla ^a,b   Jalali, Seyed Amir Hossein ^c   Kristensen, Lasse Bøgelund Juel ^a,b   Einer Jensen, Katja ^d   Pedersen, Finn Skou ^b   Lorenzen, Niels ^b  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c ISFAHAN UNIVERSITY OF TECHNOLOGY   (Iran)

^d QIAGEN AAR   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 191; MICRORNA 425; MICRORNA 462; MICRORNA 731; UNCLASSIFIED DRUG; FISH PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CONTROLLED STUDY; FISH GENETICS; GENE CLUSTER; GENE LOCUS; GENE SEQUENCE; GENETIC CONSERVATION; HUMAN; HUMAN CELL; NONHUMAN; ONCORHYNCHUS MYKISS; ORTHOLOGY; PROMOTER REGION; RNA ANALYSIS; SYNTENY; UPREGULATION; VIRAL HEMORRHAGIC SEPTICEMIA VIRUS; VIRUS VIRULENCE; ANIMAL; CELL CULTURE; CELL CYCLE CHECKPOINT; CLASSIFICATION; CYTOLOGY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; HOST PATHOGEN INTERACTION; LIVER; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NOVIRHABDOVIRUS; NUCLEOTIDE SEQUENCE; PHYLOGENY; PHYSIOLOGY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; VIROLOGY;

ANIMALS; BASE SEQUENCE; CELL CYCLE CHECKPOINTS; CELLS, CULTURED; EVOLUTION, MOLECULAR; FISH PROTEINS; GENE EXPRESSION PROFILING; HOST-PATHOGEN INTERACTIONS; HUMANS; LIVER; MICRORNAS; MOLECULAR SEQUENCE DATA; NOVIRHABDOVIRUS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCORHYNCHUS MYKISS; PHYLOGENY; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, NUCLEIC ACID; UP-REGULATION;

EID: 84941670998     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132434     Document Type: Article

References (103)

1. Bartel DP (2009) MicroRNAs: Target recognition and regulatory functions. Cell 136(2):215-233. doi: 10.1016/j.cell.2009.01.002 PMID: 19167326
2. Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, et al. (2004) MicroRNA genes are transcribed by RNA polymerase II. EMBOJ. 23(20):4051-60. PMID: 15372072
3. Swaminathan G, Martin-Garcia J, Navas-Martin S (2013) RNA viruses and microRNAs: challenging discoveries for the 21st century. Physiol Genomics 45(22):1035-48. doi: 10.1152/physiolgenomics. 00112.2013 PMID: 24046280
4. Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75(5):843-854. PMID: 8252621
5. Griffiths-Jones S(2010) miRBase: microRNA sequences and annotation. In: Baxevanis AD, editor. Current protocols in bioinformatics. John Wiley and Sons, Chapter 12, Unit 12.9, 1-10.
6. Kozomara A, Griffiths-Jones S (2011) miRBase: integrating microRNA annotation and deep-sequencing data. Nucl Acids Res 39(Database issue): D152-D157. doi: 10.1093/nar/gkq1027 PMID: 21037258
7. Friedman RC, Fahr KKH, Burge CB, Bartel DP (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19(1):92-105. doi: 10.1101/gr.082701.108 PMID: 18955434
8. Curtale G, Citarella F, Carissimi C, Goldoni M, Carucci N, Fulci V, et al. (2010) An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes. Blood 115(2):265-273. doi: 10.1182/blood-2009-06-225987 PMID: 19965651
9. Inui M, Martello G, Piccolo S. MicroRNA control of signal transduction. (2010) Nat Rev Mol Cell Biol 11(4):252-63. doi: 10.1038/nrm2868 PMID: 20216554
10. Stefani G, Slack FJ. Small non-coding RNAs in animal development. (2008) Nat Rev Mol Cell Biol 9 (3):219-30. doi: 10.1038/nrm2347 PMID: 18270516
11. Bushati N, Cohen SM (2007) microRNAfunctions. Annu. Rev. Cell Dev. Biol 23:175-205. PMID: 17506695
12. Ambros V (2004) The functions of animal microRNAs. Nature 431(2006):350-5.
13. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281-97. PMID: 14744438
14. He L, Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5 (7):522-31. PMID: 15211354
15. Fender A. and Pfeffer S (2013) MicroRNAs as Key Players in Host-Virus Interactions, in MicroRNAs in Medicine (ed Lawrie C. H.), John Wiley & Sons, Inc., Hoboken, NJ, USA.
16. Staedel C, Darfeuille F (2013) MicroRNAs and bacterial infection. Cell Microbiol. (9:):1496-507. doi: 10.1111/cmi.12159 PMID: 23795564
17. Zhang Y, Li YK (2013) MicroRNAs in the regulation of immune response against infections. J Zhejiang Univ Sci B. 14(1):1-7. doi: 10.1631/jzus.B1200292 PMID: 23303626
18. Zhuo Y, Gao G, Shi JA, Zhou X, Wang X (2013) miRNAs: biogenesis, origin and evolution, functions on virus-host interaction. Cell Physiol Biochem 32(3):499-510. doi: 10.1159/000354455 PMID: 24008513
19. Eulalio A, Schulte L, Vogel J (2012) The mammalian microRNA response to bacterial infections. RNA Biol. 9(6):742-50. doi: 10.4161/rna.20018 PMID: 22664920
20. Skalsky RL, Cullen BR (2010) Viruses, microRNAs, and host interactions. Annu Rev Microbiol. 64:123-41. doi: 10.1146/annurev.micro.112408.134243 PMID: 20477536
21. Ghosh Z, Mallick B, Chakrabarti J (2009) Cellularversus viral microRNAs in host-virus interaction. Nucleic Acids Res 37:1035-1048. doi: 10.1093/nar/gkn1004 PMID: 19095692
22. Gottwein E, Cullen BR (2008) Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 3:375-387 doi: 10.1016/j.chom.2008.05.002 PMID: 18541214
23. Wu H, Neilson JR, Kumar P, Manocha M, Shankar P, Sharp PA, et al. (2007) miRNA Profiling of Naïve, Effector and Memory CD8T Cells. PLoS ONE 2(10):e1020. PMID: 17925868
24. Sisk JM, Witwer KW, Tarwater PM, Clements JE (2013) SIV replication is directly downregulated by fourantiviral miRNAs. Retrovirology 10:95. doi: 10.1186/1742-4690-10-95 PMID: 23988154
25. Cheng JC, Yeh YJ, Tseng CP, Hsu SD, Chang YL, Sakamoto N, et al. (2012) Let-7b is a novel regulator of hepatitis C virus replication. Cell Mol Life Sci 69(15):2621-33. doi: 10.1007/s00018-012-0940-6 PMID: 22391672
26. Russo A, Potenza N (2011) Antiviral effects of human microRNAs and conservation of their target sites. FEBS Lett 585(16):2551-5. doi: 10.1016/j.febslet.2011.07.015 PMID: 21784072
27. Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J, et al. (2007) Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity 27(1):123-34. PMID: 17613256
28. Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, Chisari FV, et al. (2007) Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 449:919-922
29. Lecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, Himber C, et al. (2005) A cellular microRNA mediates antiviral defense in human cells. Science 308(5721):557-60. PMID: 15845854
30. Gao L, Guo XK, Wang L, Zhang Q, Li N, Chen XX, et al. (2013) MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by targeting PRRSV receptor CD163. J Virol 87(15):8808-12. doi: 10.1128/JVI.00718-13 PMID: 23740977
31. Terrier O, Textoris J, Carron C, Marcel V, Bourdon JC, Rosa-Calatrava M (2013) Host microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses reveal an unanticipated antiviral activity for miR-146a. J Gen Virol 94(Pt5):985-95. doi: 10.1099/vir.0.049528-0 PMID: 23343627
32. Zhang J, Li S, Yan Q, Chen X, Yang Y, Liu X, et al. (2013) Interferon-p induced microRNA-129-5p down-regulates HPV-18 E6and E7 viral gene expression by targeting SP1 in cervical cancer cells. PLoS One 8(12):e81366. doi: 10.1371/journal.pone.0081366 PMID: 24358111
33. Smith JL, Grey FE, Uhrlaub JL, Nikolich-Zugich J, Hirsch AJ (2012) Induction of the cellular micro-RNA, Hs-154, by West Nile virus contributes to virus-mediated apoptosis through repression of antia-poptoticfactors. J Virol 86(9):5278-87. doi: 10.1128/JVI.06883-11 PMID: 22345437
34. Umbach JL, Cullen BR (2009) The role of RNAi and microRNAs in animal virus replication and antiviral immunity. Genes Dev 23(10):1151-64. doi: 10.1101/gad.1793309 PMID: 19451215
35. Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P (2005) Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 309(5740):1577-81. PMID: 16141076
36. Xu J, Zhang R, Shen Y, Liu G, Lu X, Wu C-I (2014) The evolution of evolvability in microRNA target sites in vertebrates. Genome Res 23(11):1810-1816.
37. Ason B, Darnell DK, Wittbrodt B, Berezikov E, Kloosterman WP, Wittbrodt J, et al. (2006) Differences invertebrate microRNA expression. Proc Natl Acad Sci U SA 103(39):14385-14389. PMID: 16983084
38. Nelson JS (2006) Fishes of the world. 4thedition. John Wiley and Sons, Inc. New York. 601 pp.
39. ICTV(2012) Virus Taxonomy: 2011 Release. International Committee on Taxonomy of Viruses. 1-16-2013.http://ictvonline.org/virusTaxonomy.asp?version=2011
40. Jorgensen PEV(1974) A study of viral diseases in Danish rainbow trout, their diagnosis and control. Thesis 1-101. Commissioned byA/SCarl Fr. Mortensen.
41. Einer-Jensen K, Harmache A, Biacchesi S, Bremont M, Stegmann A, Lorenzen N (2014) High virulence differences among phylogenetically distinct isolates of the fish rhabdovirus viral hemorrhagic septicaemia virus are not explained by variability of the surface glycoprotein G or the non-virion protein Nv. J Gen Virol 95(Pt2):307-16. doi: 10.1099/vir.0.057448-0 PMID: 24189623
42. USDA-APHIS (2008a) Federal order to prevent spread of VHSV. http://www.aphis.usda.gov/animal health/animal dis spec/aquaculture/downloads/vhs fed order amended.pdf. US Department of Agriculture-Animal and Plant Health Inspection Service.
43. USDA-APHIS (2008b) Regulated species susceptible to VHSV by the USDA. http://www.aphis.usda. gov/animal health/animal dis spec/aquaculture/downloads/vhs regulated spp.pdf. US Department of Agriculture-Animal and Plant Health Inspection Service.
44. Isshiki T, Nishizawa T, Kobayashi T, Nagano T, Miyazaki T (2001) An outbreak of VHSV (viral hemorrhagic septicemia virus) infection in farmed Japanese flounder Paralichthys olivaceus in Japan. Dis Aquat Organ 47, 87-99. PMID: 11775799
45. Smail DA (1999) Viral haemorrhagic septicaemia. In Fish Diseases and Disorders: Viral, Bacterial and Fungal Infections, vol. 3, pp. 123-146. Edited by Woo P. T. K., Bruno D. W. CAB International.
46. Ross K, McCarthy U, Huntly PJ, Wood BP, Stuart D, Rough EI, et al. (1995) An outbreak of viral haemorrhagic septicaemia (VHS) in turbot (Scophthahus maximus) in Scotland. Bull Eur Assoc Fish Pathol 14: 213-214.
47. Olesen NJ (1998) Sanitation of viral haemorrhagic septicaemia (VHS). Journal of Applied Ichthyology, 14(3-4), 173-177.
48. Lorenzen N., Lorenzen E., Einer-Jensen K., LaPatra S.E. DNA vaccines as a tool for analysing the protective immune response against rhabdoviruses in rainbow trout. Fish & Shellfish Immunology (2002) 12:439-453.
49. Schyth BD, Lorenzen N, Pedersen FS (2007) A high throughput in vivo model for testing delivery and antiviral effects of siRNAs in vertebrates. Mol Ther 15(7):1366-1372. PMID: 17505484
50. Sharov AA, Dudekula DB, Ko MS (2005) A web-based tool for principal component and significance analysis of microarray data. Bioinformatics 21(10):2548-2549. PMID: 15734774
51. Flicek P, Amode MR, Barrell D, Beal K, Brent S, Carvalho-Silva D, et al. (2012) Ensembl2012. Nucl Acids Res 40(D1): D84-D90.
52. Ganassin RC, Bols NC(1998) Development from the rainbow trout spleen of a cell line, RTS11, in the monocyte/macrophage lineage. Fish Shellfish Immunol 8:457-476.
53. Lee LEJ, Clemons JH, Bechtel DG, Caldwell S, Han KB, Pasitschniak-Arts M, et al. (1993) Development and characterization of a rainbow trout liver cell line expressing cytochrome P450-dependent monooxygenase activity. Cell Biol Toxicol 9: 279-294. PMID: 8299006
54. Scherer WF, Syverton JT, Gey GO (1953) Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix. J Exp Med 97:695-710. PMID: 13052828
55. Rio D, Clark S, Tjian R (1985) A mammalian host-vector system that regulates expression and amplification of transfected genes by temperature induction. Science 227: 23-28. PMID: 2981116
56. Goujon M, McWilliam H, Li W, Valentin F, Squizzato S, Paern J, et al. (2010)Anewbioinformatics analysis tools framework at EMBL-EBI. Nucl Acids Res 38 Suppl:W695-9.
57. Ulitsky I, Shkumatava A, Jan CH, Bell GW, Sive H, Bartel DP (2012) Extensive alternative polyadeny-lation during zebrafish development. Genome Res 22(10):2054-2066. doi: 10.1101/gr.139733.112 PMID: 22722342
58. Kloosterman WP, Steiner FA, Berezikov E, deBruijn E, van de Belt J, Verheul M, et al. (2006) Cloning and expression of new microRNAs from zebrafish. Nucl Acids Res 34(9):2558-2569. PMID: 16698962
59. Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, et al. (2005) The developmental miRNA profiles of zebrafish as determined by small RNA cloning. Genes Dev 19(11):1288-1293. PMID: 15937218
60. Li SC, Chan WC, Ho MR, Tsai KW, Hu LY, Lai CH, et al. (2010) Discovery and characterization of medaka miRNA genes by next generation sequencing platform. BMC Genomics 11(Suppl 4):S8. doi: 10.1186/1471-2164-11-S4-S8 PMID: 21143817
61. Andreassen R, Worren MM, H0yheim B(2013) Discovery and characterization of miRNA genes in Atlantic salmon (Salmosalar) by use of a deep sequencing approach. BMC Genomics. 14:482. doi: 10.1186/1471-2164-14-482 PMID: 23865519
62. Xu Z, Chen J, Li X, Ge J, Pan J, Xu X (2013) Identification and characterization of microRNAs in channel catfish (Ictalurus punctatus) by using Solexa sequencing technology. PLoS ONE 8(1):e54174. doi: 10.1371/journal.pone.0054174 PMID: 23342099
63. Daly C, Reich NC(1993) Double-stranded RNA activates novel factors that bind to the interferon-stim-ulated response element. Mol Cell Biol 13(6):3756-3764. PMID: 8388546
64. Porter AC, Chernajovsky Y, Dale TC, Gilbert CS, Stark GR, Kerr IM (1988) Interferon response element of the human gene 6-16. EMBO J 7(1):85-92. PMID: 3359997
65. Reich N, Evans B, Levy D, Fahey D, Knight E, Darnell JE (1987) Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci USA 84(18):6394-6398. PMID: 3476954
66. Castro R, Martin SA, Bird S, Lamas J, Secombes CJ (2008) Characterisation of gamma-interferon responsive promoters in fish. Mol Immunol 45(12):3454-3462. doi: 10.1016/j.molimm.2008.03.015 PMID: 18457879
67. Shintani S, Terzic J, Sato A, Saraga-Babic M, O'hUigin C, Tichy H, et al. (2000) Do lampreys have lymphocytes? The Spi evidence. Proc Natl Acad Sci USA 97(13):7417-7422. PMID: 10840049
68. DeKoter RP, Walsh JC, Singh H (1998) PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBOJ 17(15):4456-68. PMID: 9687512
69. Rust K, Bingle L, Mariencheck W, Persson A, Crouch EC (1996) Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids. Am J Respir Cell Mol Biol 14(2):121-130. PMID: 8630261
70. Netterwald J, Yang S, Wang W, Ghanny S, Cody M, Soteropoulos P, et al. (2005) Two Gamma Inter-feron-Activated Site-Like Elements in the Human Cytomegalovirus Major Immediate-Early Promoter/Enhancer Are Important for Viral Replication. J Virol 79(8):5035-5046. PMID: 15795289
71. Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon-gamma: an overview of signals, mechanisms and functions. J Leuk Biol 75(2):163-189.
72. Darnell JE Jr, Kerr IM, Stark GR(1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264(5164):1415-21. PMID: 8197455
73. Janssens S, Beyaert R (2003) Role of Toll-Like receptors in pathogen recognition. Clin Microbiol Rev 16(4):637-646. PMID: 14557290
74. Hornung V, Rothenfusser S, Britsch S, Krug A, JahrsdörferB, Giese T, et al. (2002) Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 168(9):4531-4537. PMID: 11970999
75. Filipowicz W, Bhattacharyya SN, Sonenberg N (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9(2):102-114. doi: 10.1038/nrg2290 PMID: 18197166
76. Venkatesh B, Lee AP, Ravi V, Maurya AK, Lian MM, Swann JB, et al. (2014) Elephant shark genome provides unique insights into gnathostome evolution. Nature 505(7482):174-179. doi: 10.1038/nature12826 PMID: 24402279
77. Tarver JE, Sperling EA, Nailor A, Heimberg AM, Robinson JM, King BL, et al. (2013) miRNAs: small genes with big potential in metazoan phylogenetics. Mol Biol Evol 30(11):2369-2382. doi: 10.1093/molbev/mst133 PMID: 23913097
78. Sperling EA, Peterson KJ (2009) MicroRNAs and metazoan phylogeny: Big trees from little genes. In Telford MJ, Littlewood DTJ, editors. Animal Evolution: Genomes, Fossils, and Trees, Oxford: Oxford Univ Press, pp 157-210.
79. Berezikov E(2011) Evolution of microRNA diversity and regulation in animals. Nat Rev Genet 12 (12):846-860. doi: 10.1038/nrg3079 PMID: 22094948
80. Ribas L, Roher N, Martinez M, Balasch JC, Donate C, Goetz FW, et al. (2008) Characterisation and expression of the transcription factor PU.1 during LPS-induced inflammation in the rainbowtrout (Oncorhynchusmykiss). Fish Shellfish Immunol 24(1):35-45. PMID: 18083598
81. Anderson MK, Sun X, Miracle AL, Litman GW, Rothenberg EV (2001) Evolution of hematopoiesis: Three members of the PU.1 transcription factor family in a cartilaginous fish, Rajaeglanteria. Proc Natl Acad Sci USA 98:553-558. PMID: 11149949
82. Thoulouze ML, Bouguyon E, Carpentier C, Bremont M (2004) Essential role of the NV protein of Novir-habdovirus for pathogenicity in rainbowtrout. J Virol 78:4098-4107. PMID: 15047826
83. Zou J, Carrington AC, Collet B, Dijkstra JM, Yoshiura Y, Bols N, et al. (2005) Identification and bioac-tivities of IFN-gamma in rainbow trout Oncorhynchus mykiss: the first Th1-type cytokine characterized functionally in fish. J Immunol 175(4):2484-2494. PMID: 16081820
84. Lin J, Cao Q, Zhang J, Li Y, Shen B, Zhao Z, et al. (2013) MicroRNA expression patterns in indeterminate inflammatory bowel disease. Mod Pathol. 26(1):148-54. doi: 10.1038/modpathol.2012.131 PMID: 22899284
85. Paraskevi A, Theodoropoulos G, Papaconstantinou I, Mantzaris G, Nikiteas N, Gazouli M (2012) Circulating MicroRNA in inflammatory bowel disease. J Crohns Colitis. 6(9):900-4. doi: 10.1016/j. crohns.2012.02.006 PMID: 22386737
86. Liu X, Wang Y, Sun Q, Yan J, Huang J, Zhu S, et al. (2012) Identification of microRNA transcriptome involved in human natural killer cell activation. Immunol Lett. 143(2):208-17. PMID: 22701882
87. Ma J, Liu J, Wang Z, Gu X, Fan Y, Zhang W, et al. (2014) NF-kappaB-dependent microRNA-425 upre-gulation promotes gastric cancer cell growth by targeting PTEN upon IL-1 p induction. Mol Cancer. 13:40. doi: 10.1186/1476-4598-13-40 PMID: 24571667
88. Peng WZ, Ma R, Wang F, Yu J, Liu ZB (2014) Role of miR-191/425 Cluster in Tumorigenesis and Diagnosis of Gastric Cancer. Int J Mol Sci 15(3):4031-4048. doi: 10.3390/ijms15034031 PMID: 24603541
89. Gong BD, Xie Q, Xiang XG, Wang L, Zhao GD, An FM, et al. (2010) Effect of ribavirin and interferon beta on miRNA profile in the hepatitis C virus subgenomic replicon-bearing Huh7 cells. Int J Mol Med 25(6):853-859. PMID: 20428788
90. Di Leva G, Piovan C, Gasparini P, Ngankeu A, Taccioli C, Briskin D, et al. 2013. Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status. PLoS Genet 9(3): e1003311. doi: 10.1371/journal.pgen. 1003311 PMID: 23505378
91. Nagpal N, Ahmad HM, Molparia B, Kulshreshtha R(2013) MicroRNA-191, an estrogen-responsive microRNA, functions as an oncogenic regulator in human breast cancer. Carcinogenesis 34 (8):1889-1899. doi: 10.1093/carcin/bgt107 PMID: 23542418
92. Colamaio M, Borbone E, Russo L, Bianco M, Federico A, Califano D, et al. (2011) miR-191 down-regulation plays a role in thyroid follicular tumors through CDK6 targeting. J Clin Endocrinol Metab 96 (12):E1915-1924. doi: 10.1210/jc.2011-0408 PMID: 21956418
93. Elyakim E, Sitbon E, Faerman A, Tabak S, Montia E, Belanis L, et al. (2010) hsa-miR-191 is a candidate oncogene target for hepatocellular carcinoma therapy. Cancer Res 70(20):8077-8087. doi: 10. 1158/0008-5472.CAN-10-1313 PMID: 20924108
94. He Y, Cui Y, Wang W, Gu J, Guo S, Ma K, et al. (2011) Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma. Neoplasia 13(9):841-853. PMID: 21969817
95. Hu Z, Yu D, Gu QH, Yang Y, Tu K, Zhu J, et al. (2014) miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression. Nat Commun 5:3263. doi: 10.1038/ncomms4263 PMID: 24535612
96. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, et al. (2013) Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest 123(8):3378-3382. doi: 10.1172/JCI67383 PMID: 23867623
97. Lena AM, Mancini M, Rivetti di Val Cervo P, Saintigny G, MahéC, Melino G, et al. (2012) MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation. Biochem Biophys Res Commun 423(3):509-514. doi: 10.1016/j.bbrc.2012.05.153 PMID: 22683624
98. Zhang L, Flygare J, Wong P, Lim B, Lodish HF(2011) miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3and Mxi1. Genes Dev 25(2):119-124. doi: 10.1101/gad.1998711 PMID: 21196494
99. Grinchuk OV, Jenjaroenpun P, Orlov YL, Zhou J, Kuznetsov VA (2010) Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns. Nucleic Acids Res 38(2):534-547. doi: 10.1093/nar/gkp954 PMID: 19906709
100. Shen J, DiCioccio R, Odunsi K, Lele SB, Zhao H (2010) Novel genetic variants in miR-191 gene and familial ovarian cancer. BMC Cancer 10:47. doi: 10.1186/1471-2407-10-47 PMID: 20167074
101. Nagpal N, Kulshreshtha R (2014) miR-191: an emerging player in disease biology. Front Genet. 5:99. doi: 10.3389/fgene.2014.00099 PMID: 24795757
102. Bela-ong DB, Schyth BD, Zou J, Secombes CJ, Lorenzen N (2015) Involvement of two microRNAs in the early immune response to DNA vaccination against a fish virus. Vaccine 33(28): 3215-3222. doi: 10.1016/j.vaccine.2015.04.092 PMID: 25957662
103. Wu S, Liu L, Zohaib A, Lin L, Yuan J, Wang M, et al. (2015) MicroRNA profile analysis of Epithelioma papulosumcyprini cell line before and after SVCV infection. Dev Comp Immunol 48(1):124-8. doi: 10.1016/j.dci.2014.09.012 PMID: 25291211