메뉴 건너뛰기




Volumn 159, Issue 6, 2001, Pages 2239-2248

Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; HOMEODOMAIN PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG;

EID: 0035190672     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63074-X     Document Type: Article
Times cited : (198)

References (39)
  • 1
    • 0032792276 scopus 로고    scopus 로고
    • Medullary adenocarcinoma of the colon: Clinicopathologic study of 11 cases
    • J.Jessuru, M. Romero-Guadarrama, J.C. Manivel,Medullary adenocarcinoma of the colon: clinicopathologic study of 11 cases, Hum Pathol, 30 (1999), pp. 843-848
    • (1999) Hum Pathol , vol.30 , pp. 834-848
    • Jessurun, J.1    Romero-Guadarrama, M.2    Manivel, J.C.3
  • 3
    • 0031240675 scopus 로고    scopus 로고
    • Anaplastic carcinoma of the colon: Clinicopathologic study of eight cases of a poorly recognized lesion
    • C.V. Reyes, M.T. Siddiqui, Anaplastic carcinoma of the colon: clinicopathologic study of eight cases of a poorly recognized lesion,Ann Diag Pathol, 1 (1997), pp. 19-25
    • (1997) Ann Diag Pathol , vol.1 , pp. 19-25
    • Reyes, C.V.1    Siddiqui, M.T.2
  • 4
    • 0030741318 scopus 로고    scopus 로고
    • Improved prognosis of solid-type poorly differentiated colorectal adenocarcinoma: A clinicopathological and immunohistochemical study
    • Y. Sugao, T. Yao, C. Kubo, M. Tsuneyosh, Improved prognosis of solid-type poorly differentiated colorectal adenocarcinoma: a clinicopathological and immunohistochemical study, Histopathology, 31 (1997), pp. 123-133
    • (1997) Histopathology , vol.31 , pp. 123-133
    • Sugao, Y.1    Yao, T.2    Kubo, C.3    Tsuneyoshi, M.4
  • 6
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • E.R Fearon, B. Vogelstein, A genetic model for colorectal tumorigenesis,Cell, 61 (1990), pp. 759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 7
    • 0001912290 scopus 로고    scopus 로고
    • Molecular biology of gastrointestinal cancers
    • Edited by VT DeVita Jr, S Hellman, SA Rosenberg. Philadelphia, Lippincott, William, and Wilkins
    • E.R. FearonMolecular biology of gastrointestinal cancers, VT DeVita Jr, S Hellman, Rosenberg SA (Eds.), Cancer: Principles and Practice of Oncology (ed 6), Lippincott, William, and Wilkins, Philadelphia (2001), pp. 1037-1051
    • (2001) Cancer: Principles and Practice of Oncology, ed. 6 , pp. 1037-1051
    • Fearon, E.R.1
  • 8
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • K.W. Kinzler, B .Vogelstein, Lessons from hereditary colorectal cancer, Cell, 87 (1996), pp. 159-170
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 9
    • 0029089259 scopus 로고
    • Hereditary nonpolyposis colorectal cancer: The syndrome, the genes, and historical perspectives
    • G. Marra, C.R. Boland, Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives, J Natl Cancer Inst, 87 (1995), pp. 1114-1125
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1114-1125
    • Marra, G.1    Boland, C.R.2
  • 11
    • 0030465095 scopus 로고    scopus 로고
    • Microsatellite instability is associated with the histological features of the tumor in nonfamilial colorectal cancer
    • M. Risio, G. Reato, P.F. di Celle, M. Fizzotti, F.P. Rossini, R. Foa, Microsatellite instability is associated with the histological features of the tumor in nonfamilial colorectal cancer, Cancer Res, 56 (1996), pp. 5470-5474
    • (1996) Cancer Res , vol.56 , pp. 5470-5474
    • Risio, M.1    Reato, G.2    Di Celle, P.F.3    Fizzotti, M.4    Rossini, F.P.5    Foa, R.6
  • 12
    • 0033021439 scopus 로고    scopus 로고
    • High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability
    • R.Dolcetti, A. Viel, C.glioni, A. Russo, M. Guidoboni, E. Capozzi, N. Vecchiato, E. Macri, M. Fornasarig, M. Boiocchi, High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability, Am J Pathol, 154 (1999), pp. 1805-1813
    • (1999) Am J Pathol , vol.154 , pp. 1805-1813
    • Dolcetti, R.1    Viel, A.2    Doglioni, C.3    Russo, A.4    Guidoboni, M.5    Capozzi, E.6    Vecchiato, N.7    Macri, E.8    Fornasarig, M.9    Boiocchi, M.10
  • 13
    • 0031907144 scopus 로고    scopus 로고
    • Microsatellite instability in sporadic carcinomas of the proximal colon: Association with diploid DNA content, negative protein expression of p53, and distinct histomorphologic features
    • S. Forster, H.P. Sattler, M. Hack, K. Romanakis, V. Rohde, G. Seitz, B. Wullich, Microsatellite instability in sporadic carcinomas of the proximal colon: association with diploid DNA content, negative protein expression of p53, and distinct histomorphologic features, Surgery, 123 (1998), pp. 13-18
    • (1998) Surgery , vol.123 , pp. 13-18
    • Forster, S.1    Sattler, H.P.2    Hack, M.3    Romanakis, K.4    Rohde, V.5    Seitz, G.6    Wullich, B.7
  • 15
    • 0028276666 scopus 로고
    • Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
    • H. Kim, J. Jen, B. Vogelstein, S.R. Hamilton, Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences, Am J Pathol, 145 (1994), pp. 148-156
    • (1994) Am J Pathol , vol.145 , pp. 148-156
    • Kim, H.1    Jen, J.2    Vogelstein, B.3    Hamilton, S.R.4
  • 16
    • 0035132202 scopus 로고    scopus 로고
    • Histopathological identification of colon cancer with microsatellite instability
    • J. Alexander, T. Watanabe, T.T. Wu, A. Rashid, S. Li, S.R. Hamilton, Histopathological identification of colon cancer with microsatellite instability, Am J Pathol, 158 (2001), pp. 527-535
    • (2001) Am J Pathol , vol.158 , pp. 527-535
    • Alexander, J.1    Watanabe, T.2    Wu, T.T.3    Rashid, A.4    Li, S.5    Hamilton, S.R.6
  • 17
    • 0033564467 scopus 로고    scopus 로고
    • Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice
    • Y. Tamai, R. Nakajima, T. Ishikawa, K. Takaku, M.F. Seldin, M.M. Taketo, Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice, Cancer Res, 59 (1999), pp. 2965-2970
    • (1999) Cancer Res , vol.59 , pp. 2965-2970
    • Tamai, Y.1    Nakajima, R.2    Ishikawa, T.3    Takaku, K.4    Seldin, M.F.5    Taketo, M.M.6
  • 18
  • 19
    • 0033594940 scopus 로고    scopus 로고
    • Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice
    • F. Beck, K. Chawengsaksophak, P. Waring, R.J. Playford, J.B. Furness, Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice, Proc Natl Acad Sci USA, 96 (1999), pp. 7318-7323
    • (1999) Proc Nad Acad Sci USA , vol.96 , pp. 7318-7323
    • Beck, F.1    Chawengsaksophak, K.2    Waring, P.3    Playford, R.J.4    Furness, J.B.5
  • 20
    • 0029156944 scopus 로고
    • Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma
    • F. Beck, K. Chawengsaksophak, P. Waring, R.J. Playford, J.B. Furness, Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice, Proc Natl Acad Sci USA, 96 (1999), pp. 7318-7323
    • (1995) Am J Pathol , vol.147 , pp. 586-592
    • Ee, H.C.1    Erler, T.2    Bhathal, P.S.3    Young, G.P.4    James, R.J.5
  • 21
    • 0032950713 scopus 로고    scopus 로고
    • Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas
    • H.C.Ee, T. Erler, P.S. Bhathal, G.P. Young, R.J. James, Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma, Am J Pathol, 147 (1995), pp. 586-592
    • (1999) Br J Cancer , vol.79 , pp. 440-444
    • Yagi, O.K.1    Akiyama, Y.2    Yuasa, Y.3
  • 23
    • 0342503644 scopus 로고    scopus 로고
    • CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling
    • C. Wicking, L.A. Simms, T. Evans, M. Walsh, K. Chawengsaksophak, F. Beck, G. Chenevix-Trench, J. Young, J Jass, B. Leggett, B. Wainwright, CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer, Oncogene, 17 (1998), pp. 657-659
    • (1999) Oncogene , vol.18 , pp. 5010-5014
    • Da Costa, L.T.1    He, T.C.2    Yu, J.3    Sparks, A.B.4    Morin, P.J.5    Polyak, K.6    Laken, S.7    Vogelstein, B.8    Kinzler, K.W.9
  • 24
    • 0029865340 scopus 로고    scopus 로고
    • Rapid identification of patient specimens with microsatellite DNA markers
    • L.T. da Costa, T.C. He, J. Yu, A.B. Sparks, P.J. Morin, K. Polyak, S. Laken, B. Vogelstein, K.W. Kinzler, CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling, Oncogene, 18 (1999), pp. 5010-5014
    • (1996) Mod Pathol , vol.9 , pp. 183-188
    • Kessis, T.D.1    Silberman, M.A.2    Sherman, M.3    Hedrick, L.4    Cho, K.R.5
  • 25
    • 0025293818 scopus 로고
    • Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products
    • T.D. Kessis, M.A. Silberman, M. Sherman, L. Hedrick, K.R. Cho, Rapid identification of patient specimens with microsatellite DNA markers, Mod Pathol, 9 (1996), pp. 183-188
    • (1990) Oncogene , vol.5 , pp. 1037-1043
    • Suzuki, Y.1    Orita, M.2    Shiraishi, M.3    Hayashi, K.4    Sekiya, T.5
  • 28
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • M.F. Kane, M. Loda, G.M. Gaida, J. Lipman, R. Mishra, H. Goldman, J.M. Jessup, R. Kolodner, Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines, Cancer Res, 57 (1997), pp. 808-811
    • (1997) Cancer Res , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3    Lipman, J.4    Mishra, R.5    Goldman, H.6    Jessup, J.M.7    Kolodner, R.8
  • 29
    • 0033846517 scopus 로고    scopus 로고
    • Immunohistochemical detection of mismatch repair gene proteins as a useful tool for the identification of colorectal carcinoma with the mutator phenotype
    • P. Chaves, C. Cruz, P. Lage, I. Claro, M. Cravo, C.N. Leitao, J. Soares, Immunohistochemical detection of mismatch repair gene proteins as a useful tool for the identification of colorectal carcinoma with the mutator phenotype, J Pathol, 191 (2000), pp. 355-360
    • (2000) J Pathol , vol.191 , pp. 355-360
    • Chaves, P.1    Cruz, C.2    Lage, P.3    Claro, I.4    Cravo, M.5    Leitao, C.N.6    Soares, J.7
  • 30
    • 0032521433 scopus 로고    scopus 로고
    • Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer
    • A.B. Sparks, P.J. Morin, B. Vogelstein, K.W. Kinzler, Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer, Cancer Res, 58 (1998), pp. 1130-1134
    • (1998) Cancer Res , vol.58 , pp. 1130-1134
    • Sparks, A.B.1    Morin, P.J.2    Vogelstein, B.3    Kinzler, K.W.4
  • 31
  • 32
    • 0028987249 scopus 로고
    • Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
    • S. Munemitsu, I. Albert, B. Souza, P. Polakis,Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein, Proc Natl Acad Sci USA, 92 (1995), pp. 3046-3050
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3046-3050
    • Munemitsu, S.1    Albert, I.2    Souza, B.3    Polakis, P.4
  • 33
    • 0033948526 scopus 로고    scopus 로고
    • Sequence variants of the axin gene in breast, colon, and other cancers: An analysis of mutations that interfere with GSK3 binding
    • M.T. Webster, M. Rozycka, E. Sara, E. Davis, M. Smalley, N. Young, T.C. Dale, R. Wooster,Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding, Genes Chromosom Cancer, 28 (2000), pp. 443-453
    • (2000) Genes Chromosom Cancer , vol.28 , pp. 443-453
    • Webster, M.T.1    Rozycka, M.2    Sara, E.3    Davis, E.4    Smalley, M.5    Young, N.6    Dale, T.C.7    Wooster, R.8
  • 36
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Y. Ionov, M.A. Peinado, S. Malkhosyan, D. Shibata, M. Perucho, Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis,Nature, 363 (1993), pp. 558-561
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 37
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • S.N.Thibodeau, G. Bren, D. Schaid, Microsatellite instability in cancer of the proximal colon, Science, 260 (1993), pp. 816-819
    • (1993) Science , vol.260 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.