Dual therapeutic effects of c-10068, a dextromethorphan derivative, against post-traumatic nonconvulsive seizures and neuroinflammation in a rat model of penetrating ballistic-like brain injury

Journal of Neurotrauma

Volumn 32, Issue 20, 2015, Pages 1621-1632

  Lu, Xi Chun May ^a   Shear, Deborah A ^a   Graham, Philip B ^b   Bridson, Gary W ^b   Uttamsingh, Vinita ^b   Chen, Zhiyong ^a   Leung, Lai Yee ^a   Tortella, Frank C ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Drug Metabolism and Pharmacokinetics   (United States)

Author keywords

C 10068; dextromethorphan; EEG; neuroinflammation; nonconvulsive seizures; penetrating brain injury

Indexed keywords

ANTICONVULSIVE AGENT; ANTIINFLAMMATORY AGENT; C 10068; DEXTROMETHORPHAN DERIVATIVE; GLIAL FIBRILLARY ACIDIC PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR BLOCKING AGENT; DEXTROMETHORPHAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BALLISTICS; BIOAVAILABILITY; CELL ACTIVATION; CELL FUNCTION; COGNITION; CONTINUOUS INFUSION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; ELECTROENCEPHALOGRAPHY; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INCIDENCE; LIMIT OF QUANTITATION; MALE; MICROGLIA; MORRIS WATER MAZE TEST; MOTOR PERFORMANCE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PENETRATING TRAUMA; RAT; ROTAROD TEST; SEIZURE; TRAUMATIC BRAIN INJURY; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL BEHAVIOR; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; HEAD INJURIES, PENETRATING; IMMUNOLOGY; INFLAMMATION; SEIZURES; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICONVULSANTS; ASTROCYTES; BEHAVIOR, ANIMAL; DEXTROMETHORPHAN; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; EXCITATORY AMINO ACID ANTAGONISTS; HEAD INJURIES, PENETRATING; HIPPOCAMPUS; INFLAMMATION; MALE; MICROGLIA; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES;

EID: 84941593526     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2014.3766     Document Type: Article

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