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Volumn 124, Issue 5, 1998, Pages 917-929

The anticonvulsant actions of σ receptor ligands in the Mg2+-free model of epileptiform activity in rat hippocampal slices

Author keywords

Anticonvulsant activity; Hippocampal slice; N methyl D aspartate (NMDA) receptor; Voltage activated Ca2+ channel; receptor

Indexed keywords

CARAMIPHEN; DEXTROMETHORPHAN; DEXTRORPHAN; IFENPRODIL; LOPERAMIDE; OPIPRAMOL; PENTOXYVERINE; ROPIZINE; SIGMA OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND;

EID: 0031839120     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701902     Document Type: Article
Times cited : (31)

References (65)
  • 1
    • 0022003694 scopus 로고
    • Kainic acid and penicillin: Differential effects on excitatory and inhibitory interactions in the CAI region of the hippocampal slice
    • AITKEN, P.G. (1985). Kainic acid and penicillin: Differential effects on excitatory and inhibitory interactions in the CAI region of the hippocampal slice. Brain Res., 325, 261-269.
    • (1985) Brain Res. , vol.325 , pp. 261-269
    • Aitken, P.G.1
  • 2
    • 0026795379 scopus 로고
    • Modification of GABA-mediated inhibition by various injectable anesthetics
    • ALBERTSON, T.E., WALBY, W.F. & JOY, R.M. (1992). Modification of GABA-mediated inhibition by various injectable anesthetics. Anesthesiology, 77, 488-499.
    • (1992) Anesthesiology , vol.77 , pp. 488-499
    • Albertson, T.E.1    Walby, W.F.2    Joy, R.M.3
  • 3
    • 0020001035 scopus 로고
    • Feed-forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro
    • ALGER, B.E. & NICOLL, R.A (1982). Feed-forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro. J. Physiol., 328, 105-23.
    • (1982) J. Physiol. , vol.328 , pp. 105-123
    • Alger, B.E.1    Nicoll, R.A.2
  • 4
    • 0023096401 scopus 로고
    • The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptic form bursting in the rat hippocampal slice
    • ANDERSON, W.W., SWARTZWELDER, H.S. & WILSON, W.A (1987). The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptic form bursting in the rat hippocampal slice. J. Neurophysiol., 57, 1-21.
    • (1987) J. Neurophysiol. , vol.57 , pp. 1-21
    • Anderson, W.W.1    Swartzwelder, H.S.2    Wilson, W.A.3
  • 5
    • 0025951580 scopus 로고
    • Non-opioid antitussives inhibit endogenous glutamate release from rabbit hippocampal slices
    • ANNELS, S.J., ELLIS, Y. & DAVIES, J.A. (1991). Non-opioid antitussives inhibit endogenous glutamate release from rabbit hippocampal slices. Brain Res., 564, 341-343.
    • (1991) Brain Res. , vol.564 , pp. 341-343
    • Annels, S.J.1    Ellis, Y.2    Davies, J.A.3
  • 6
    • 0025048216 scopus 로고
    • Effects of non-opioid antitussives on epileptiform activity and NMDA responses in hippocampal and olfactory cortex slices
    • APLAND, J.P. & BRAITMAN, D.J. (1990). Effects of non-opioid antitussives on epileptiform activity and NMDA responses in hippocampal and olfactory cortex slices. Brain Res., 529, 277-285.
    • (1990) Brain Res. , vol.529 , pp. 277-285
    • Apland, J.P.1    Braitman, D.J.2
  • 7
    • 0028987704 scopus 로고
    • Anticonvulsant effects of memantine and MK-801 in guinea pig hippocampal slices
    • APLAND, J.P. &. CANN, F.J. (1995). Anticonvulsant effects of memantine and MK-801 in guinea pig hippocampal slices. Brain Res. Bull., 37, 311-316.
    • (1995) Brain Res. Bull. , vol.37 , pp. 311-316
    • Apland, J.P.1    Cann, F.J.2
  • 8
    • 0024512047 scopus 로고
    • Neocortical epileptogenesis in vitro: Studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands
    • ARAM, J.A., MARTIN, D., TOMCZYK, M., ZEMAN, S., MILLAR, J., POHLER, G. & LODGE, D. (1989). Neocortical epileptogenesis in vitro: Studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands. J. Pharmacol. Exp. Ther., 248, 320-328.
    • (1989) J. Pharmacol. Exp. Ther. , vol.248 , pp. 320-328
    • Aram, J.A.1    Martin, D.2    Tomczyk, M.3    Zeman, S.4    Millar, J.5    Pohler, G.6    Lodge, D.7
  • 9
    • 0025354225 scopus 로고
    • Biphasic action of dextrorphan on penicillin induced bursting in rat hippocampal slice
    • ARYANPUR, J., COLE, A.E., ECCLES, C.U. & FISHER, R.S. (1990). Biphasic action of dextrorphan on penicillin induced bursting in rat hippocampal slice. Brain Res., 519, 65-72.
    • (1990) Brain Res. , vol.519 , pp. 65-72
    • Aryanpur, J.1    Cole, A.E.2    Eccles, C.U.3    Fisher, R.S.4
  • 11
    • 0024477885 scopus 로고
    • Specific suppression of pentylenetetrazol-induced epileptiform discharges in CA3 neurons (hippocampal slice, guinea pig) by the organic calcium antagonists flunarizine and verapamil
    • BINGMANN, D. & SPECKMANN, F.-J. (1989). Specific suppression of pentylenetetrazol-induced epileptiform discharges in CA3 neurons (hippocampal slice, guinea pig) by the organic calcium antagonists flunarizine and verapamil. Exp. Brain Res., 74, 239-248.
    • (1989) Exp. Brain Res. , vol.74 , pp. 239-248
    • Bingmann, D.1    Speckmann, F.-J.2
  • 12
    • 0028809829 scopus 로고
    • 2+ channels in rat and mouse cultured hippocampal pyramidal neurones
    • 2+ channels in rat and mouse cultured hippocampal pyramidal neurones. Br. J. Pharmacol., 116, 2801-2810.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2801-2810
    • Church, J.1    Fletcher, E.J.2
  • 13
    • 0024371068 scopus 로고
    • Electrophysiological properties of rat CA1 pyramidal neurones in vitro modified by changes in extracellular bicarbonate
    • CHURCH, J. & MCLENNAN, H. (1989). Electrophysiological properties of rat CA1 pyramidal neurones in vitro modified by changes in extracellular bicarbonate. J Physiol., 415, 85-108.
    • (1989) J Physiol. , vol.415 , pp. 85-108
    • Church, J.1    Mclennan, H.2
  • 14
    • 0028331841 scopus 로고
    • Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons
    • CHURCH, J., FLETCHER, E.J., ABDEL-HAMID, K. & MACDONALD, J.F. (1994a). Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons. Mol. Pharmacol., 45, 747-757.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 747-757
    • Church, J.1    Fletcher, E.J.2    Abdel-Hamid, K.3    Macdonald, J.F.4
  • 15
    • 0028003653 scopus 로고
    • 2+ channels in rat and mouse cultured hippocampal pyramidal neurones: Comparison with N-methyl-D-aspartate receptor antagonist actions
    • 2+ channels in rat and mouse cultured hippocampal pyramidal neurones: Comparison with N-methyl-D-aspartate receptor antagonist actions. Br. J. Pharmacol., 113, 499-507.
    • (1994) Br. J. Pharmacol. , vol.113 , pp. 499-507
    • Church, J.1    Fletcher, E.-J.2    Baxter, K.3    Macdonald, J.F.4
  • 16
    • 0024364830 scopus 로고
    • Antitussive agents as N-methylaspartate antagonists: Further studies
    • CHURCH, J., JONES, M.G., DAVIES, S.N. & LODGE, D. (1989). Antitussive agents as N-methylaspartate antagonists: Further studies. Can. J. Physiol. Pharmacol., 67, 561-567.
    • (1989) Can. J. Physiol. Pharmacol. , vol.67 , pp. 561-567
    • Church, J.1    Jones, M.G.2    Davies, S.N.3    Lodge, D.4
  • 17
    • 0025254330 scopus 로고
    • Anticonvulsant actions of phencyclidine receptor ligands: Correlation with N-methylaspartate antagonism in vivo
    • CHURCH, J. & LODGE, D. (1990). Anticonvulsant actions of phencyclidine receptor ligands: Correlation with N-methylaspartate antagonism in vivo. Gen. Pharmacol., 21, 165-170.
    • (1990) Gen. Pharmacol. , vol.21 , pp. 165-170
    • Church, J.1    Lodge, D.2
  • 18
    • 0024522478 scopus 로고
    • Selective depression of N-methyl-D-aspartate-mediated responses by dextrorphan in the hippocampal slice in rat
    • COLE, A.E., ECCLES, C.U., ARYANPUR, J.J. & FISHER, R.S. (1989). Selective depression of N-methyl-D-aspartate-mediated responses by dextrorphan in the hippocampal slice in rat. Neuropharmacology, 28, 249-254.
    • (1989) Neuropharmacology , vol.28 , pp. 249-254
    • Cole, A.E.1    Eccles, C.U.2    Aryanpur, J.J.3    Fisher, R.S.4
  • 19
    • 0027409977 scopus 로고
    • Flunarizine inhibits both calcium-dependent and -independent release of glutamate from synaptosomes and cultured neurones
    • COUSIN, M.A., NICHOLLS, D.G. & POCOCK, J.M. (1993). Flunarizine inhibits both calcium-dependent and -independent release of glutamate from synaptosomes and cultured neurones. Brain Res., 606, 227-236.
    • (1993) Brain Res. , vol.606 , pp. 227-236
    • Cousin, M.A.1    Nicholls, D.G.2    Pocock, J.M.3
  • 20
    • 0029670738 scopus 로고    scopus 로고
    • Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: Quantal fluctuation affects subsequent release
    • DEBANNE, D., GUERINEAU, N.C., GÄHWILER, B.H. & THOMPSON, S.M. (1996). Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release. J. Physiol., 491, 163-176.
    • (1996) J. Physiol. , vol.491 , pp. 163-176
    • Debanne, D.1    Guerineau, N.C.2    Gähwiler, B.H.3    Thompson, S.M.4
  • 21
    • 0025161651 scopus 로고
    • Anticonvulsant properties of some calcium antagonists on sound-induced seizures in genetically epilepsy prone rats
    • DESARRO, G., DESARRO, A., FEDERICO, F. & MELDRUM, B.S. (1990). Anticonvulsant properties of some calcium antagonists on sound-induced seizures in genetically epilepsy prone rats. Gen. Pharmacol., 21, 769-778.
    • (1990) Gen. Pharmacol. , vol.21 , pp. 769-778
    • Desarro, G.1    Desarro, A.2    Federico, F.3    Meldrum, B.S.4
  • 22
    • 0026539882 scopus 로고
    • Calcium channel blocking agents and potassium-stimulated release of glutamate from cerebellar slices
    • DICKIE, B.G.M. & DAVIES, J.A. (1992). Calcium channel blocking agents and potassium-stimulated release of glutamate from cerebellar slices. Eur. J. Phamacol., 229, 97-99.
    • (1992) Eur. J. Phamacol. , vol.229 , pp. 97-99
    • Dickie, B.G.M.1    Davies, J.A.2
  • 23
    • 0022923910 scopus 로고
    • Involvement of N-methyl-D-aspartate receptors in epileptiform bursting in the rat hippocampal slice
    • DINGLEDINE, R., HYNES, M.A. & KING, G.L. (1986). Involvement of N-methyl-D-aspartate receptors in epileptiform bursting in the rat hippocampal slice. J. Physiol., 380, 175-189.
    • (1986) J. Physiol. , vol.380 , pp. 175-189
    • Dingledine, R.1    Hynes, M.A.2    King, G.L.3
  • 24
    • 0022272328 scopus 로고
    • Adenosine increases synaptic facilitation in the in vitro rat hippocampus: Evidence for a presynaptic site of action
    • DUNWIDDIE, T.V. & HAAS, H.L. (1985). Adenosine increases synaptic facilitation in the in vitro rat hippocampus: Evidence for a presynaptic site of action. J. Physiol., 369, 365-377.
    • (1985) J. Physiol. , vol.369 , pp. 365-377
    • Dunwiddie, T.V.1    Haas, H.L.2
  • 25
    • 0028067325 scopus 로고
    • The effects of sigma ligands on the release of glutamate from rat striatal slices
    • ELLIS, Y. & DAVIES, J.A. (1994). The effects of sigma ligands on the release of glutamate from rat striatal slices. Naunyn-Schmiedeherg's Arch. Pharmacol., 350, 143-148.
    • (1994) Naunyn-Schmiedeherg's Arch. Pharmacol. , vol.350 , pp. 143-148
    • Ellis, Y.1    Davies, J.A.2
  • 26
    • 0028824880 scopus 로고
    • Blockade by sigma site ligands of N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurones
    • FLETCHER, E.J., CHURCH, J., ABDEL-HAMID, K. & MACDONALD, J.F. (1995). Blockade by sigma site ligands of N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurones. Br. J. Pharmacol., 116, 2791-2800.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2791-2800
    • Fletcher, E.J.1    Church, J.2    Abdel-Hamid, K.3    Macdonald, J.F.4
  • 27
    • 0024319188 scopus 로고
    • Efflux of rubidium in rat cortical synaptosomes is blocked by sigma and dextromethorphan binding site ligands
    • FLETCHER, E.J., DREW, C., LODGE, D. & O'SHAUGHNESSY, C.T. (1989). Efflux of rubidium in rat cortical synaptosomes is blocked by sigma and dextromethorphan binding site ligands. Neuropharmacology, 28, 661-666.
    • (1989) Neuropharmacology , vol.28 , pp. 661-666
    • Fletcher, E.J.1    Drew, C.2    Lodge, D.3    O'Shaughnessy, C.T.4
  • 29
    • 0021087104 scopus 로고
    • Effects of acidic amino acid antagonists on paired-pulse potentiation at the lateral perforant path
    • HARRIS, E.W. & COTMAN, C.W. (1983). Effects of acidic amino acid antagonists on paired-pulse potentiation at the lateral perforant path. Exp. Brain. Res., 52, 455-460.
    • (1983) Exp. Brain. Res. , vol.52 , pp. 455-460
    • Harris, E.W.1    Cotman, C.W.2
  • 31
    • 0025805826 scopus 로고
    • The effect of ω-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro
    • HORNE, A.L. & KEMP, J.A. (1991). The effect of ω-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro. Br. J. Pharmacol., 103, 1733-1739.
    • (1991) Br. J. Pharmacol. , vol.103 , pp. 1733-1739
    • Horne, A.L.1    Kemp, J.A.2
  • 32
    • 0028970471 scopus 로고
    • 2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil
    • 2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil. Brain Res., 695, 88-91.
    • (1995) Brain Res. , vol.695 , pp. 88-91
    • Ishibashi, H.1    Yatani, A.2    Akaike, N.3
  • 33
    • 0027184979 scopus 로고
    • Adenosine, L-AP4, and baclofen modulation of paired-pulse potentiation in the dentate gyrus: Interstimulus interval-dependent pharmacology
    • KAHLE, J.S. & COTMAN, C.W. (1993). Adenosine, L-AP4, and baclofen modulation of paired-pulse potentiation in the dentate gyrus: Interstimulus interval-dependent pharmacology. Exp. Brain Res., 94, 97-104.
    • (1993) Exp. Brain Res. , vol.94 , pp. 97-104
    • Kahle, J.S.1    Cotman, C.W.2
  • 34
    • 0030450983 scopus 로고    scopus 로고
    • A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones
    • KEW, J.N.C., TRUBE, G. & KEMP, J.A. (1996). A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones. J. Physiol., 497, 761-772.
    • (1996) J. Physiol. , vol.497 , pp. 761-772
    • Kew, J.N.C.1    Trube, G.2    Kemp, J.A.3
  • 35
    • 0024451351 scopus 로고
    • High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents
    • KLEIN, M. & MUSACCHIO, J.M. (1989). High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents. J. Pharmacol. Exp. Ther., 251, 207-215.
    • (1989) J. Pharmacol. Exp. Ther. , vol.251 , pp. 207-215
    • Klein, M.1    Musacchio, J.M.2
  • 36
    • 0026711067 scopus 로고
    • High-affinity dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine
    • KLEIN, M. & MUSACCHIO, J.M. (1992). High-affinity dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine. J. Pharmacol. Exp. Ther., 260, 990-999.
    • (1992) J. Pharmacol. Exp. Ther. , vol.260 , pp. 990-999
    • Klein, M.1    Musacchio, J.M.2
  • 37
    • 0024311591 scopus 로고
    • Evaluation of dextromethorphan and carbetapentane as anticonvulsants and N-methyl-D-aspartic acid antagonists in mice
    • LEANDER, J.D. (1989). Evaluation of dextromethorphan and carbetapentane as anticonvulsants and N-methyl-D-aspartic acid antagonists in mice. Epilepsy Res., 4, 28-33.
    • (1989) Epilepsy Res. , vol.4 , pp. 28-33
    • Leander, J.D.1
  • 38
    • 0023951078 scopus 로고
    • Anticonvulsant effects of phencyclidine-like drugs: Relation to N-methyl-D-aspartic acid antagonism
    • LEANDER, J.D., RATHBUN, R.C. & ZIMMERMAN, D.M. (1988). Anticonvulsant effects of phencyclidine-like drugs: Relation to N-methyl-D-aspartic acid antagonism. Brain Res., 454, 368-372.
    • (1988) Brain Res. , vol.454 , pp. 368-372
    • Leander, J.D.1    Rathbun, R.C.2    Zimmerman, D.M.3
  • 39
    • 0029957401 scopus 로고    scopus 로고
    • Effects of glutamate application on the rhythm of low magnesium-induced epileptiform activity in hippocampal slices of guinea-pigs
    • LÜCKE, A., KÖHLING, R. & SPECKMANN, E.-J. (1996). Effects of glutamate application on the rhythm of low magnesium-induced epileptiform activity in hippocampal slices of guinea-pigs. Eur. J. Neurosci., 8, 2137-2148.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 2137-2148
    • Lücke, A.1    Köhling, R.2    Speckmann, E.-J.3
  • 40
    • 0025964149 scopus 로고
    • 3H]D-aspartate release and neuronal calcium influx by verapamil, diltiazem and dextromethorphan: Evidence for non-L/non-N voltage-sensitive calcium channels
    • 3H]D-aspartate release and neuronal calcium influx by verapamil, diltiazem and dextromethorphan: Evidence for non-L/non-N voltage-sensitive calcium channels. Eur. J. Pharmacol., 192, 9-17.
    • (1991) Eur. J. Pharmacol. , vol.192 , pp. 9-17
    • Mangano, T.J.1    Patel, J.2    Salama, A.I.3    Keith, R.A.4
  • 41
    • 0028244495 scopus 로고
    • The actions of L-687,384, a σ receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons
    • MCLARNON, J., SAWYER, D. & CHURCH, J. (1994). The actions of L-687,384, a σ receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons. Neurosci. Lett., 174, 181-184.
    • (1994) Neurosci. Lett. , vol.174 , pp. 181-184
    • Mclarnon, J.1    Sawyer, D.2    Church, J.3
  • 42
    • 0023149047 scopus 로고
    • Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices
    • MODY, I., LAMBERT, J.D.C. & HEINEMANN, U. (1987). Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices. J. Neurophysiol., 57, 869-888.
    • (1987) J. Neurophysiol. , vol.57 , pp. 869-888
    • Mody, I.1    Lambert, J.D.C.2    Heinemann, U.3
  • 43
    • 0025215471 scopus 로고
    • The antiseizure activity of dihydropyridine calcium channel antagonists in the conscious rat
    • MORÓN, M.A., STEVENS, C.W. & YAKSH, T.L. (1990). The antiseizure activity of dihydropyridine calcium channel antagonists in the conscious rat. J. Pharmacol. Exp. Ther., 252, 1150-1155.
    • (1990) J. Pharmacol. Exp. Ther. , vol.252 , pp. 1150-1155
    • Morón, M.A.1    Stevens, C.W.2    Yaksh, T.L.3
  • 44
    • 0023775221 scopus 로고
    • High affinity dextromethorphan binding sites in guinea pig brain: Further characterization and allosteric interactions
    • MUSACCHIO, J.M., KLEIN, M. & SANTIAGO, L.J. (1988). High affinity dextromethorphan binding sites in guinea pig brain: Further characterization and allosteric interactions. J. Pharmacol. Exp. Ther., 247, 424-431.
    • (1988) J. Pharmacol. Exp. Ther. , vol.247 , pp. 424-431
    • Musacchio, J.M.1    Klein, M.2    Santiago, L.J.3
  • 45
    • 0027254655 scopus 로고
    • Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons
    • NETZER, R., PFLIMLIN, P. & TRUBE, G. (1993). Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons. Eur. J. Pharmacol., 238, 209-216.
    • (1993) Eur. J. Pharmacol. , vol.238 , pp. 209-216
    • Netzer, R.1    Pflimlin, P.2    Trube, G.3
  • 46
    • 0028885626 scopus 로고
    • Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo
    • PARSONS, C.G., QUACK, G., BRESINK, I., BARAN, L., PRZEGALINSKI, E., KOSTOWSKI, W., KRZASCIK, P., HARTMANN, S. & DANYSZ, W. (1995). Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo. Neuropharmacology, 34, 1239-1258.
    • (1995) Neuropharmacology , vol.34 , pp. 1239-1258
    • Parsons, C.G.1    Quack, G.2    Bresink, I.3    Baran, L.4    Przegalinski, E.5    Kostowski, W.6    Krzascik, P.7    Hartmann, S.8    Danysz, W.9
  • 47
    • 0026608540 scopus 로고
    • Low magnesium-induced epileptiform discharges in guinea pig hippocampal slices: Depression by the organic calcium antagonist verapamil
    • POHL, M., STRAUB, H. & SPECKMANN, E.-J. (1992). Low magnesium-induced epileptiform discharges in guinea pig hippocampal slices: Depression by the organic calcium antagonist verapamil. Brain Res., 577, 29-35.
    • (1992) Brain Res. , vol.577 , pp. 29-35
    • Pohl, M.1    Straub, H.2    Speckmann, E.-J.3
  • 48
    • 0030964099 scopus 로고    scopus 로고
    • Either N- or P-type calcium channels mediate GABA release at distinct hippocampal inhibitory synapses
    • PONCER, J.-C., MCKINNEY, R.A., GÄHWILER, B.H. & THOMPSON, S.M. (1997). Either N- or P-type calcium channels mediate GABA release at distinct hippocampal inhibitory synapses. Neuron. 18, 463-472.
    • (1997) Neuron. , vol.18 , pp. 463-472
    • Poncer, J.-C.1    Mckinney, R.A.2    Gähwiler, B.H.3    Thompson, S.M.4
  • 50
    • 0027256639 scopus 로고
    • Different effects of ω-conotoxin GVIA at excitatory and inhibitory synapses in rat CA1 hippocampal neurons
    • POTIER, B., DUTAR, P. & LAMOUR, Y. (1993). Different effects of ω-conotoxin GVIA at excitatory and inhibitory synapses in rat CA1 hippocampal neurons. Brain Res., 616, 236-241.
    • (1993) Brain Res. , vol.616 , pp. 236-241
    • Potier, B.1    Dutar, P.2    Lamour, Y.3
  • 51
    • 0028178539 scopus 로고
    • 2+ channel (VSCC) antagonists ω-Aga-IVA and ω-CTX-MVIIC inhibit spontaneous epileptiform discharges in the rat cortical wedge
    • 2+ channel (VSCC) antagonists ω-Aga-IVA and ω-CTX-MVIIC inhibit spontaneous epileptiform discharges in the rat cortical wedge. Brain Res., 643, 352-356.
    • (1994) Brain Res. , vol.643 , pp. 352-356
    • Robichaud, L.J.1    Wurster, S.2    Boxer, P.A.3
  • 52
    • 0025050694 scopus 로고
    • Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds
    • ROGAWSKI, M.A. & PORTER, R.J. (1990). Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev., 42, 223-286.
    • (1990) Pharmacol. Rev. , vol.42 , pp. 223-286
    • Rogawski, M.A.1    Porter, R.J.2
  • 53
    • 0030425334 scopus 로고    scopus 로고
    • 3H]dextrorphan binding sites in rat brain determined by quantitative autoradiography
    • 3H]dextrorphan binding sites in rat brain determined by quantitative autoradiography. J. Pharmacol. Exp. Ther., 277, 1823-1836.
    • (1996) J. Pharmacol. Exp. Ther. , vol.277 , pp. 1823-1836
    • Roth, J.E.1    Murray, T.F.2    Franklin, P.H.3
  • 54
    • 0025275168 scopus 로고
    • Low magnesium epileptogenesis in the rat hippocampal slice: Electrophysiological and pharmacological features
    • TANCREDI, V., HWA, G.G.C., ZONA, C., BRANCATI, A. & AVOLI, M. (1990). Low magnesium epileptogenesis in the rat hippocampal slice: Electrophysiological and pharmacological features. Brain Res., 511, 280-290.
    • (1990) Brain Res. , vol.511 , pp. 280-290
    • Tancredi, V.1    Hwa, G.G.C.2    Zona, C.3    Brancati, A.4    Avoli, M.5
  • 55
    • 0022996262 scopus 로고
    • Dextromethorphan and carbetapentane: Centrally acting non-opioid antitussive agents with novel anticonvulsant properties
    • TORTELLA, F.C. & MUSACCHIO, J.M. (1986). Dextromethorphan and carbetapentane: Centrally acting non-opioid antitussive agents with novel anticonvulsant properties. Brain Res., 383, 314-318.
    • (1986) Brain Res. , vol.383 , pp. 314-318
    • Tortella, F.C.1    Musacchio, J.M.2
  • 56
    • 0024397972 scopus 로고
    • Dextromethorphan and neuromodulation: Old drug coughs up new activities
    • TORTELLA, F.C., PELLICANO, M. & BOWERY, N.G. (1989). Dextromethorphan and neuromodulation: Old drug coughs up new activities. Trends Pharmacol. Sci., 10, 501-507.
    • (1989) Trends Pharmacol. Sci. , vol.10 , pp. 501-507
    • Tortella, F.C.1    Pellicano, M.2    Bowery, N.G.3
  • 57
    • 0023678755 scopus 로고
    • A non-opioid antitussive with potent anticonvulsant properties in rats
    • TORTELLA, F.C., WITKIN, J.M. & MUSACCHIO, J.M. (1988). A non-opioid antitussive with potent anticonvulsant properties in rats. Eur. J. Pharmacol., 155, 69-75.
    • (1988) Eur. J. Pharmacol. , vol.155 , pp. 69-75
    • Tortella, F.C.1    Witkin, J.M.2    Musacchio, J.M.3
  • 58
    • 0028040424 scopus 로고
    • Dextromethorphan: Cellular effects reducing neuronal hyperactivity
    • TRUBE, G. & NETZER, R. (1994). Dextromethorphan: Cellular effects reducing neuronal hyperactivity. Epilepsia. 35(Suppl.5), S62-S67.
    • (1994) Epilepsia. , vol.35 , Issue.5 SUPPL.
    • Trube, G.1    Netzer, R.2
  • 59
    • 0025267040 scopus 로고
    • Feed-forward inhibitory potentials and excitatory interactions in guinea-pig hippocampal pyramidal cells
    • TURNER, D.A. (1990). Feed-forward inhibitory potentials and excitatory interactions in guinea-pig hippocampal pyramidal cells. J. Physiol., 422, 333-350.
    • (1990) J. Physiol. , vol.422 , pp. 333-350
    • Turner, D.A.1
  • 61
    • 0030989748 scopus 로고    scopus 로고
    • Inhibition of synaptic transmission and epileptiform activity in central neurones by fluspirilene
    • WANG, S.-J., LU, K.-T. & GEAN, P.-W. (1997). Inhibition of synaptic transmission and epileptiform activity in central neurones by fluspirilene. Br. J. Pharmacol., 120, 1114-1118.
    • (1997) Br. J. Pharmacol. , vol.120 , pp. 1114-1118
    • Wang, S.-J.1    K-T, L.U.2    Gean, P.-W.3
  • 62
    • 0029014862 scopus 로고
    • Inhibitory mechanisms in epileptiform activity induced by low magnesium
    • WESTERHOFF, C.H.A., DOMANN, R. & WHITE, O.W. (1995). Inhibitory mechanisms in epileptiform activity induced by low magnesium. Pflügers Arch., 430, 238-245.
    • (1995) Pflügers Arch. , vol.430 , pp. 238-245
    • Westerhoff, C.H.A.1    Domann, R.2    White, O.W.3
  • 63
    • 0030867518 scopus 로고    scopus 로고
    • Antagonism of N-methyl-D-aspartate receptors by σ site ligands: Potency, subtype-selectivity and mechanisms of inhibition
    • WHITTEMORE, E.R., ILYIN, V.I. & WOODWARD, R.M. (1997). Antagonism of N-methyl-D-aspartate receptors by σ site ligands: Potency, subtype-selectivity and mechanisms of inhibition. J. Pharmacol. Exp. Ther., 282, 326-338.
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , pp. 326-338
    • Whittemore, E.R.1    Ilyin, V.I.2    Woodward, R.M.3
  • 64
    • 0028243567 scopus 로고
    • Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus
    • WU, L.-G. & SAGGAU, P. (1994). Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus. Neuron, 12, 1139-1148.
    • (1994) Neuron , vol.12 , pp. 1139-1148
    • Wu, L.-G.1    Saggau, P.2
  • 65
    • 0028861513 scopus 로고
    • Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via σ 1 site
    • YAMAMOTO, H., YAMAMOTO, T., SAGI, N., KLENEROVA, V., GOJI, K., KAWAI, N., BABA, A., TAKAMORI, E. & MOROJI, T. (1995). Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via σ 1 site. J. Neurosci., 15, 731-736.
    • (1995) J. Neurosci. , vol.15 , pp. 731-736
    • Yamamoto, H.1    Yamamoto, T.2    Sagi, N.3    Klenerova, V.4    Goji, K.5    Kawai, N.6    Baba, A.7    Takamori, E.8    Moroji, T.9


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