Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure

Nature Communications

Volumn 6, Issue , 2015, Pages

  Wu, San Pin ^a,b   Kao, Chung Yang ^a   Wang, Leiming ^a   Creighton, Chad J ^a   Yang, Jin ^c   Donti, Taraka R ^a   Harmancey, Romain ^d   Vasquez, Hernan G ^d   Graham, Brett H ^a   Bellen, Hugo J ^a   Taegtmeyer, Heinrich ^d   Chang, Ching Pin ^c   Tsai, Ming Jer ^a   Tsai, Sophia Y ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b ADRIENNE HELIS MALVIN MEDICAL RESEARCH FOUNDATION   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR 2; GLUCOSE; MESSENGER RNA; MITOCHONDRIAL PROTEIN; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; REACTIVE OXYGEN METABOLITE; MULTIENZYME COMPLEX;

ADULT; CARDIOVASCULAR DISEASE; ENZYME ACTIVITY; GENE EXPRESSION; GLUCOSE; METABOLISM; MITOCHONDRION; OXYGEN CONSUMPTION; RODENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DETOXIFICATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; HAPLOINSUFFICIENCY; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE METABOLISM; HUMAN; HUMAN TISSUE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL GENE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OVERALL SURVIVAL; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RESPIRATORY CHAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSTHORACIC ECHOCARDIOGRAPHY; ANIMAL; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CELL RESPIRATION; DIAGNOSTIC IMAGING; ECHOCARDIOGRAPHY; GENETICS; HEART MITOCHONDRION; MALE; METABOLISM; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

ANIMALS; CALCINEURIN; CARDIOMYOPATHY, DILATED; CELL RESPIRATION; COUP TRANSCRIPTION FACTOR II; ECHOCARDIOGRAPHY; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; HEART FAILURE; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MITOCHONDRIAL DYNAMICS; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATIVE STRESS; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84941591704     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9245     Document Type: Article

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